Alpha 7 nicotinic acetylcholine receptor agonist GTS-21 mitigates isoflurane-induced cognitive impairment in aged rats

Journal of Surgical Research

Volumn 194, Issue 1, 2015, Pages 255-261

  Kong, Fei Juan ^a,b   Ma, Lei Lei ^c   Zhang, Hong Hai ^b   Zhou, Jia Qiang ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

Aged rats; Alpha 7 nicotinic acetylcholine receptor; Apoptosis; Isoflurane; Learning and memory

Indexed keywords

3 (2,4 DIMETHOXYBENZYLIDENE)ANABASEINE; DNA NUCLEOTIDYLEXOTRANSFERASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; ISOFLURANE; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA; 3-(2,4-DIMETHOXYBENZYLIDENE)ANABASEINE; BENZYLIDENE DERIVATIVE; IL1B PROTEIN, RAT; INHALATION ANESTHETIC AGENT; NICOTINIC AGENT; PYRIDINE DERIVATIVE;

AGED; AMNESIA; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; ATTENUATION; BRAIN CORTEX; CELL DENSITY; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG EFFICACY; DRUG EXPOSURE; ENZYME LINKED IMMUNOSORBENT ASSAY; HIPPOCAMPAL CA1 REGION; HIPPOCAMPUS; LEARNING DISORDER; MALE; MEMORY DISORDER; NERVE CELL; NICK END LABELING; NISSL STAINING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPATIAL LEARNING; SPATIAL MEMORY; ANIMAL; CHEMICALLY INDUCED; CHEMISTRY; COGNITION DISORDERS; DRUG EFFECTS; SPRAGUE DAWLEY RAT;

ANESTHETICS, INHALATION; ANIMALS; APOPTOSIS; BENZYLIDENE COMPOUNDS; COGNITION DISORDERS; HIPPOCAMPUS; INTERLEUKIN-1BETA; ISOFLURANE; MALE; NICOTINIC AGONISTS; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84924751903     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2014.09.043     Document Type: Article

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