The analgesic-like properties of the alpha7 nAChR silent agonist NS6740 is associated with non-conducting conformations of the receptor

Neuropharmacology

Volumn 91, Issue , 2015, Pages 34-42

  Papke, Roger L ^a   Bagdas, Deniz ^b,c   Kulkarni, Abhijit R ^d   Gould, Timothy ^e   Alsharari, Shakir D ^f   Thakur, Ganesh A ^d   Damaj, M Imad ^b  

^a UNIVERSITY OF FLORIDA   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ULUDAG UNIVERSITY   (Turkey)

^d NORTHEASTERN UNIVERSITY   (United States)

^e Department of Chemistry University of Florida ^*  (United States)

^f KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

alpha7; Inflammatory pain; Neuropathic pain; Nicotinic acetylcholine receptors; Silent agonist

Indexed keywords

ACETIC ACID; ANALGESIC AGENT; BUNGAROTOXIN RECEPTOR; FORMALDEHYDE; UNCLASSIFIED DRUG; [1,4 DIAZABICYCLO[3.2.2]NONAN 4 YL[5 (3 TRIFLUOROMETHYL) PHENYL]FURAN 2 YL] METHANONE; 1,4-DIAZABICYCLO(3.2.2)NONAN-4-YL(5-(3-(TRIFLUOROMETHYL)PHENYL)FURAN-2-YL)METHANONE; AZABICYCLO DERIVATIVE; FURAN DERIVATIVE; PROTEIN SUBUNIT;

ANALGESIC ACTIVITY; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DESENSITIZATION; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG RESPONSE; DRUG TARGETING; HUMAN; INFLAMMATORY PAIN; MALE; MOUSE; NONHUMAN; OOCYTE; PERIPHERAL NEUROPATHY; PROTEIN CONFORMATION; SIGNAL TRANSDUCTION; TASK PERFORMANCE; THERMAL INJURY; XENOPUS LAEVIS; AGONISTS; ANIMAL; DRUG EFFECTS; GENETICS; INSTITUTE FOR CANCER RESEARCH MOUSE; NEURALGIA; PAIN THRESHOLD; PHYSIOLOGY; PROTEIN SUBUNIT; XENOPUS;

ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR; ANALGESICS, NON-NARCOTIC; ANIMALS; AZABICYCLO COMPOUNDS; FURANS; HUMANS; MALE; MICE, INBRED ICR; NEURALGIA; PAIN THRESHOLD; PROTEIN CONFORMATION; PROTEIN SUBUNITS; XENOPUS;

EID: 84919625593     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2014.12.002     Document Type: Article

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