Comparative pharmacology of rat and human α7 nAChR conducted with net charge analysis

British Journal of Pharmacology

Volumn 137, Issue 1, 2002, Pages 49-61

  Papke, Roger L ^a   Porter Papke, Julia K ^a  

^a UNIVERSITY OF FLORIDA HEALTH   (United States)

Author keywords

Alpha7; Choline; Desensitization; Dose response; GTS 21; Kinetics; Nicotinic acetylcholine receptor; Xenopus oocyte

Indexed keywords

3 (2,4 DIMETHOXYBENZYLIDENE)ANABASEINE; 3 (4 HYDROXY 2 METHOXYBENZYLIDENE)ANABASEINE; 3 (4 METHOXYCINNAMILIDENE)ANABASEINE; ACETYLCHOLINE; ANABASINE DERIVATIVE; BUNGAROTOXIN RECEPTOR; CHOLINE; CYTISINE; NICOTINIC RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM HOMEOSTASIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; FEMALE; HUMAN; NERVE CELL; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; RAT;

ANABASINE; ANIMALS; BENZYLIDENE COMPOUNDS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; HUMANS; KINETICS; NICOTINIC AGONISTS; OOCYTES; PYRIDINES; RATS; RECEPTORS, NICOTINIC; XENOPUS LAEVIS;

EID: 0036729768     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704833     Document Type: Article

References (42)

1. Calcium permeability and modulation of nicotinic acetylcholine receptor-channels in rat parasympathetic neurons
2. Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. III. Agonist actions of the novel alkaloid epibatidine and analysis of type II current
3. Choline is a selective agonist of alpha7 nicotinic acetylcholine receptors in the rat brain neurons
4. Mechanism for modulation of nicotinic acetylcholine receptors that can influence synaptic transmission
5. Agonist pharmacology of the neuronal alpha 7 nicotinic receptor expressed in Xenopus oocytes
6. Pharmacological properties of the homomeric alpha 7 receptor
7. Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. IV. Regulation by external Ca + + of alpha-bungarotoxin-sensitive receptor function and of rectification induced by internal Mg + +
8. Functional characterization of the novel nicotinic receptor ligand GTS-21 in vitro and in vivo
9. Activation and inhibition of the human alpha7 nicotinic acetylcholine receptor by agonists
10. The effect of lecithin supplementation on plasma choline concentrations during a marathon
11. Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2, h alpha 2 beta 4, h alpha 3 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytes
12. A neuronal nicotinic acetylcholine receptor subunit (α7) is developmentally regulated and forms a homo-oligomeric channel blocked by α-btx
13. The alpha7 nicotinic acetylcholine receptor subtype mediates nicotine protection against NMDA excitotoxicity in primary hippocampal cultures through a Ca(2+) dependent mechanism
14. 125I]α-bungarotoxin receptor subtypes
15. Determination of plasma choline by high-performance liquid chromatography with a postcolumn enzyme reactor and electrochemical detection
16. Stable expression and pharmacological properties of the human α7 nicotinic acetylcholine receptor
17. Activity of cytisine and its brominated isosteres on recombinant human alpha7, alpha4beta2 and alpha4beta4 nicotinic acetylcholine receptors
18. Seizures increase acetylcholine and choline concentrations in rat brain regions
19. Nicotine protects cultured cortical neurons against glutamate-induced cytotoxicity via alpha7-neuronal receptors and neuronal CNS receptors
20. Agonist activation and alpha-bungarotoxin inhibition of wild type and mutant alpha7 nicotinic acetylcholine receptors
21. alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity
22. Uptake and metabolism of choline by rat brain after acute choline administration
23. Ivermectin: A positive allosteric effector of the alpha7 neuronal nicotinic acetylcholine receptor
24. Characterization of the neuroprotective and toxic effects of α7 nicotinic receptor activation in PC12 cells
25. Nicotinic acetylcholine receptors in health and disease
26. The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective alpha7 nicotinic receptor partial agonist
27. Analysis of 40H-GTS-21 selectivity and activity at human and rat α7 nicotinic receptors
28. Neuroprotective and memory-related actions of novel α7 nicotinic agents with different mixed agonist/antagonist properties
29. Nicotine exposure during a critical period of development leads to persistent changes in nicotinic acetylcholine receptors of adult rat brain
30. Choline and acetylcholine have similar kinetic properties of activation and desensitization on the alpha7 nicotinic receptors in rat hippocampal neurons
31. Open probability of homomeric murine 5-HT(3A) serotonin receptors depends on subunit occupancy
32. An evaluation of neuronal nicotinic acetylcholine receptor activation by quaternary nitrogen compounds indicates that choline is selective for the α7 subtype
33. Alpha7-selective agonists and modes of alpha7 receptor activation
34. The correction of alpha7 nicotinic acetylcholine receptor concentration-response relationships in Xenopus oocytes
35. Activation and inhibition of rat neuronal nicotinic receptors by ABT-418
36. The activation and inhibition of human nAChR by RJR-2403 indicate a selectivity for the α4β2 receptor subtype
37. Time-dependent changes in cerebral choline and acetylcholine induced by transient global ischemia in rats
38. Molecular cloning, functional properties and distribution of rat brain alpha 7: A nicotinic cation channel highly permeable to calcium
39. Nicotinic receptor-mediated protection against beta-amyloid neurotoxicity
40. Choline blocks AMPA-induced dark cell degeneration of Purkinje neurons: Potential role of the alpha7 nicotinic receptor
41. Activation and inhibition of native neuronal alpha-bungarotoxin-sensitive nicotinic ACh receptors
42. Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors