Structurally similar allosteric modulators of α7 nicotinic acetylcholine receptors exhibit five distinct pharmacological effects

Journal of Biological Chemistry

Volumn 290, Issue 6, 2015, Pages 3552-3562

  Gill Thind, JasKiran K ^a   Dhankher, Persis ^a   D'Oyley, Jarryl M ^a   Sheppard, Tom D ^a   Millar, Neil S ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ACTIVATION; SULFUR COMPOUNDS;

ALLOSTERIC MODULATION; ALLOSTERIC MODULATORS; DIASTEREOISOMERS; EXPERIMENTAL EVIDENCE; MINIMAL EFFECTS; NICOTINIC ACETYLCHOLINE RECEPTORS; NICOTINIC ACETYLCHOLINE RECEPTORS (NACHRS); PHARMACOLOGICAL EFFECTS;

BINDING SITES;

4 (2,3 DIMETHYLPHENYL) 3A,4,5,9B TETRAHYDRO 3H CYCLOPENTA[C]QUINOLINE 8 SULFONAMIDE; 4 (2,3,4 TRIMETHYLPHENYL) 3A,4,5,9B TETRAHYDRO 3H CYCLOPENTA[C]QUINOLINE 8 SULFONAMIDE; 4 (2,3,4,5 TETRAMETHYLPHENYL) 3A,4,5,9B TETRAHYDRO 3H CYCLOPENTA[C]QUINOLINE 8 SULFONAMIDE; 4 (2,3,4,5,6 PENTAMETHYLPHENYL) 3A,4,5,9B TETRAHYDRO 3H CYCLOPENTA[C]QUINOLINE 8 SULFONAMIDE; 4 (2,3,4,6 TETRAMETHYLPHENYL) 3A,4,5,9B TETRAHYDRO 3H CYCLOPENTA[C]QUINOLINE 8 SULFONAMIDE; 4 (2,3,5 TRIMETHYLPHENYL) 3A,4,5,9B TETRAHYDRO 3H CYCLOPENTA[C]QUINOLINE 8 SULFONAMIDE; 4 (2,3,5,6 TETRAMETHYLPHENYL) 3A,4,5,9B TETRAHYDRO 3H CYCLOPENTA[C]QUINOLINE 8 SULFONAMIDE; 4 (2,3,6 TRIMETHYLPHENYL) 3A,4,5,9B TETRAHYDRO 3H CYCLOPENTA[C]QUINOLINE 8 SULFONAMIDE; 4 (2,4 DIMETHYLPHENYL) 3A,4,5,9B TETRAHYDRO 3H CYCLOPENTA[C]QUINOLINE 8 SULFONAMIDE; 4 (2,4,5 TRIMETHYLPHENYL) 3A,4,5,9B TETRAHYDRO 3H CYCLOPENTA[C]QUINOLINE 8 SULFONAMIDE; 4 (2,5 DIMETHYLPHENYL) 3A,4,5,9B TETRAHYDRO 3H CYCLOPENTA[C]QUINOLINE 8 SULFONAMIDE; 4 (2,6 DIMETHYLPHENYL) 3A,4,5,9B TETRAHYDRO 3H YCLOPENTA[C]QUINOLINE 8 SULFONAMIDE; 4 (3,4 DIMETHYLPHENYL) 3A,4,5,9B TETRAHYDRO 3H CYCLOPENTA[C]QUINOLINE 8 SULFONAMIDE; 4 (3,4,5 TRIMETHYLPHENYL) 3A,4,5,9B TETRAHYDRO 3H CYCLOPENTA[C]QUINOLINE 8 SULFONAMIDE; 4 (3,5 DIMETHYLPHENYL) 3A,4,5,9B TETRAHYDRO 3H CYCLOPENTA[C]QUINOLINE 8 SULFONAMIDE; 4 2 TOLYL 3A,4,5,9B TETRAHYDRO 3H CYCLOPENTA[C]QUINOLINE 8 SULFONAMIDE; 4 3 TOLYL 3A,4,5,9B TETRAHYDRO 3H CYCLOPENTA[C]QUINOLINE 8 SULFONAMIDE; 4 4 TOLYL 3A,4,5,9B TETRAHYDRO 3H CYCLOPENTA[C]QUINOLINE 8 SULFONAMIDENOLINE 8 SULFONAMIDE; 4 MESITYL 3A,4,5,9B TETRAHYDRO 3H CYCLOPENTA[C]QUINOLINE 8 SULFONAMIDE; ACETYLCHOLINE; BUNGAROTOXIN RECEPTOR; NICOTINIC AGENT; NICOTINIC RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; 4-P-TOLYL-3A,4,5,9B-TETRAHYDRO-3H-CYCLOPENTA(C)QUINOLINE-8-SULFONAMIDE; QUINOLINE DERIVATIVE; SULFONAMIDE;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIASTEREOISOMER; DRUG ACTIVITY; DRUG BINDING; DRUG BINDING SITE; DRUG CLASSIFICATION; DRUG DETERMINATION; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; EC50; ENZYME INHIBITION; EVOKED RESPONSE; FEMALE; GENE MUTATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIGAND BINDING; NONHUMAN; OOCYTE; RECEPTOR DOWN REGULATION; XENOPUS LAEVIS; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMISTRY; HEK293 CELL LINE; SYNTHESIS; XENOPUS;

ALLOSTERIC SITE; ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR; ANIMALS; HEK293 CELLS; HUMANS; NICOTINIC AGONISTS; NICOTINIC ANTAGONISTS; QUINOLINES; SULFONAMIDES; XENOPUS;

EID: 84922355484     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.619221     Document Type: Article

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