Cysteine accessibility analysis of the human alpha7 nicotinic acetylcholine receptor ligand-binding domain identifies L119 as a gatekeeper

Neuropharmacology

Volumn 60, Issue 1, 2011, Pages 159-171

  Papke, Roger L ^a   Stokes, Clare ^a   Williams, Dustin K ^a   Wang, Jingyi ^b   Horenstein, Nicole A ^b  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b University of Florida ^*  (United States)

Author keywords

Electrophysiology; Ligand gated ion channels; Molecular modeling; Signal transduction; Site directed mutations; Voltage clamp

Indexed keywords

2 (TRIBUTYLAMMONIUM)ETHYL METHANETHIOSULFONATE; 2 METHOXY 4 HYDROXYBENZYLIDENE ANABASEINE; 3 (2,4 DIMETHOXYBENZYLIDENE)ANABASEINE; [2 (TRIMETHYLAMMONIUM)ETHYL]METHANETHIOSULFONATE; [4 (TRIMETHYLAMMONIUM)BENZYL]METHANETHIOSULFONATE; BUNGAROTOXIN RECEPTOR; CYSTEINE; ION CHANNEL; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DISULFIDE BOND; HYDROPHOBICITY; LIGAND BINDING; MEMBRANE ELECTROPHYSIOLOGY; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MODIFICATION; PROTEIN STRUCTURE; QUALITATIVE RESEARCH; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; VOLTAGE CLAMP; XENOPUS;

ANIMALS; BINDING SITES; CYSTEINE; ELECTROPHYSIOLOGY; HUMANS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, NICOTINIC; SIGNAL TRANSDUCTION; XENOPUS LAEVIS;

EID: 78149496131     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2010.07.014     Document Type: Article

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