Intrinsically low open probability of α7 nicotinic acetylcholine receptors can be overcome by positive allosteric modulation and serum factors leading to the generation of excitotoxic currents at physiological temperatures

Molecular Pharmacology

Volumn 82, Issue 4, 2012, Pages 746-759

  Williams, Dustin K ^a   Peng, Can ^a   Kimbrell, Matthew R ^a   Papke, Roger L ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUNGAROTOXIN RECEPTOR; N (5 CHLORO 2,4 DIMETHOXYPHENYL) N (5 METHYL 3 ISOXAZOLYL)UREA; UNCLASSIFIED DRUG; UREA;

ALLOSTERISM; ARTICLE; BIOEQUIVALENCE; BODY TEMPERATURE; CONTROLLED STUDY; CYTOTOXICITY; HIGH TEMPERATURE; HIPPOCAMPUS; HUMAN; HUMAN CELL; HYPOTHALAMUS; IN VITRO STUDY; IN VIVO STUDY; NERVE CELL; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; XENOPUS LAEVIS;

ACETYLCHOLINE; ALLOSTERIC REGULATION; ANIMALS; CATTLE; CYTOTOXINS; DRUG SYNERGISM; HEK293 CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ISOXAZOLES; PATCH-CLAMP TECHNIQUES; PHENYLUREA COMPOUNDS; RADIOLIGAND ASSAY; RECEPTORS, NICOTINIC; SERUM ALBUMIN, BOVINE; TEMPERATURE; TRANSFECTION;

EID: 84866876418     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.112.080317     Document Type: Article

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