Improved proteostasis in the secretory pathway rescues Alzheimer's disease in the mouse

Brain

Volumn 139, Issue 3, 2016, Pages 937-952

  Peng, Yajing ^a   Kim, Mi Jin ^b   Hullinger, Rikki ^a,c   O'Riordan, Kenneth J ^a,e   Burger, Corinna ^a,c   Pehar, Mariana ^b   Puglielli, Luigi ^a,c,d  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

^e TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Alzheimer's disease; AT 1 SLC33A1; ATase; Autophagy; Lysine acetylation; Proteostasis

Indexed keywords

ACYLTRANSFERASE; ACYLTRANSFERASE 1; ACYLTRANSFERASE 2; ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN; LYSINE; MUTANT PROTEIN; OLIGOMER; PROTEIN AGGREGATE; UNCLASSIFIED DRUG; CARRIER PROTEIN;

ACETYLATION; ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; EMBRYO; ENDOPLASMIC RETICULUM; ENZYME INHIBITION; FEMALE; HAPLOINSUFFICIENCY; HUNTINGTON CHOREA; LONG TERM POTENTIATION; MALE; MOUSE; MOUSE MODEL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN HOMEOSTASIS; SECRETORY PATHWAY; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; CHO CELL LINE; CRICETULUS; HAMSTER; HUMAN; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROTEIN PROCESSING; PROTEIN SYNTHESIS; TRANSGENIC MOUSE; TUMOR CELL LINE;

ALZHEIMER DISEASE; ANIMALS; CELL LINE, TUMOR; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, TRANSGENIC; PROTEIN BIOSYNTHESIS; PROTEIN PROCESSING, POST-TRANSLATIONAL; SECRETORY PATHWAY;

EID: 84964578106     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awv385     Document Type: Article

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