Genistein protects the kidney from cisplatin-induced injury

Kidney International

Volumn 74, Issue 12, 2008, Pages 1538-1547

  Sung, Mi Jeong ^a   Kim, Duk Hoon ^b   Jung, Yu Jin ^b   Kang, Kyung Pyo ^b   Lee, Ae Sin ^b   Lee, Sik ^b   Kim, Won ^b   Davaatseren, Munkhtugs ^a   Hwang, Jin Taek ^a   Kim, Hyun Jin ^a   Kim, Myung Sunny ^a   Kwon, Dae Young ^a   Park, Sung Kwang ^b  

^a Korea Food Research Institute   (South Korea)

^b Chonbuk National University Medical School   (South Korea)

Author keywords

Cisplatin; Genistein; Inflammation; Nuclear factor B; Oxidative stress

Indexed keywords

CISPLATIN; GENISTEIN; INTERCELLULAR ADHESION MOLECULE 1; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN P53; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR RELA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; HUMAN; HUMAN CELL; KIDNEY INJURY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; RENAL PROTECTION;

ANIMALS; CELL ADHESION MOLECULES; CELL LINE; CISPLATIN; GENISTEIN; HUMANS; KIDNEY DISEASES; MICE; REACTIVE OXYGEN SPECIES; TRANSCRIPTION FACTOR RELA;

EID: 57049139332     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2008.409     Document Type: Article

References (28)

1. Osanto S, Bukman A, Van Hoek F et al. Long-term effects of chemotherapy in patients with testicular cancer. J Clin Oncol 1992; 10: 574-579.
2. Luke DR, Vadiei K, Lopez-Berestein G. Role of vascular congestion in cisplatin-induced acute renal failure in the rat. Nephrol Dial Transplant 1992; 7: 1-7.
3. Winston JA, Safirstein R. Reduced renal blood flow in early cisplatin-induced acute renal failure in the rat. Am J Physiol 1985; 249: F490-F496.
4. Ramesh G, Reeves WB. TNF-alpha mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity. J Clin Invest 2002; 110: 835-842.
5. Davis CA, Nick HS, Agarwal A. Manganese superoxide dismutase attenuates Cisplatin-induced renal injury: importance of superoxide. J Am Soc Nephrol 2001; 12: 2683-2690.
6. Rahman I, Biswas SK, Kirkham PA. Regulation of inflammation and redox signaling by dietary polyphenols. Biochem Pharmacol 2006; 72: 1439-1452.
7. Filipeanu CM, Brailoiu E, Huhurez G et al. Multiple effects of tyrosine kinase inhibitors on vascular smooth muscle contraction. Eur J Pharmacol 1995; 281: 29-35.
8. Whitsett Jr TG, Lamartiniere CA. Genistein and resveratrol: mammary cancer chemoprevention and mechanisms of action in the rat. Expert Rev Anticancer Ther 2006; 6: 1699-1706.
9. Sarkar FH, Adsule S, Padhye S et al. The role of genistein and synthetic derivatives of isoflavone in cancer prevention and therapy. Mini Rev Med Chem 2006; 6: 401-407.
10. Hernandez-Montes E, Pollard SE, Vauzour D et al. Activation of glutathione peroxidase via Nrf1 mediates genistein0s protection against oxidative endothelial cell injury. Biochem Biophys Res Commun 2006; 346: 851-859.
11. Verdrengh M, Jonsson IM, Holmdahl R et al. Genistein as an anti-inflammatory agent. Inflamm Res 2003; 52: 341-346.
12. Paradkar PN, Blum PS, Berhow MA et al. Dietary isoflavones suppress endotoxin-induced inflammatory reaction in liver and intestine. Cancer Lett 2004; 215: 21-28.
13. Lee S, Moon SO, Kim W et al. Protective role of L-2-oxothiazolidine-4-carboxylic acid in cisplatin-induced renal injury. Nephrol Dial Transplant 2006; 21: 2085-2095.
14. Wei Q, Dong G, Yang T et al. Activation and Involvement of p53 in Cisplatin-induced Nephrotoxicity. Am J Physiol Renal Physiol 2007; 293: F1282-F1291.
15. Wang J, Biju MP, Wang MH et al. Cytoprotective effects of hypoxia against cisplatin-induced tubular cell apoptosis: involvement of mitochondrial inhibition and p53 suppression. J Am Soc Nephrol 2006; 17: 1875-1885.
16. Adlercreutz H, Honjo H, Higashi A et al. Urinary excretion of lignans and isoflavonoid phytoestrogens in Japanese men and women consuming a traditional Japanese diet. Am J Clin Nutr 1991; 54: 1093-1100.
17. Bannwart C, Adlercreutz H, Wahala K et al. Identification of the phyto-oestrogen 3′,7-dihydroxyisoflavan, an isomer of equol, in human urine and cow's milk. Biomed Environ Mass Spectrom 1988; 17: 1-6.
18. Cooke PS, Selvaraj V, Yellayi S. Genistein, estrogen receptors, and the acquired immune response. J Nutr 2006; 136: 704-708.
19. Kabasakal L, Sehirli AO, Cetinel S et al. Mesna (2-mercaptoethane sulfonate) prevents ischemia/reperfusion induced renal oxidative damage in rats. Life Sci 2004; 75: 2329-2340.
20. Ratnam DV, Ankola DD, Bhardwaj V et al. Role of antioxidants in prophylaxis and therapy: a pharmaceutical perspective. J Control Release 2006; 113: 189-207.
21. Choi C, Cho H, Park J et al. Suppressive effects of genistein on oxidative stress and NFkappaB activation in RAW 264. 7 macrophages. Biosci Biotechnol Biochem 2003; 67: 1916-1922.
22. Mahn K, Borras C, Knock GA et al. Dietary soy isoflavone induced increases in antioxidant and eNOS gene expression lead to improved endothelial function and reduced blood pressure in vivo. FASEB J 2005; 19: 1755-1757.
23. Zhao JH, Arao Y, Sun SJ et al. Oral administration of soy-derived genistin suppresses lipopolysaccharide-induced acute liver inflammation but does not induce thymic atrophy in the rat. Life Sci 2006; 78: 812-819.
24. Lee S, Kim W, Kang KP et al. Agonist of peroxisome proliferator-activated receptor-gamma, rosiglitazone, reduces renal injury and dysfunction in a murine sepsis model. Nephrol Dial Transplant 2005; 20: 1057-1065.
25. Li S, Gokden N, Okusa MD et al. Anti-inflammatory effect of fibrate protects from cisplatin-induced ARF. Am J Physiol Renal Physiol 2005; 289: F469-F480.
26. Kang JL, Lee HW, Lee HS et al. Genistein prevents nuclear factor-kappa B activation and acute lung injury induced by lipopolysaccharide. Am J Respir Crit Care Med 2001; 164: 2206-2212.
27. Ruetten H, Thiemermann C. Effects of tyrphostins and genistein on the circulatory failure and organ dysfunction caused by endotoxin in the rat: a possible role for protein tyrosine kinase. Br J Pharmacol 1997; 122: 59-70.
28. Sung MJ, Kim W, Ahn SY et al. Protective effect of alpha-lipoic acid in lipopolysaccharide-induced endothelial fractalkine expression. Circ Res 2005; 97: 880-890.