Broken barriers: A new take on sepsis pathogenesis

Science Translational Medicine

Volumn 3, Issue 88, 2011, Pages

  Goldenberg, Neil M ^a   Steinberg, Benjamin E ^a   Slutsky, Arthur S ^b,c,d   Lee, Warren L ^b,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b ST MICHAEL'S HOSPITAL   (Canada)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; ANGIOPOIETIN 1; ATRIAL NATRIURETIC FACTOR; CADHERIN; CATENIN; ENDOTHELIAL PROTEIN C RECEPTOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; PROTEIN CDC42; PROTEIN P120; RAC PROTEIN; RAS PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SLIT2 PROTEIN; SLIT2N PROTEIN; SPHINGOSINE 1 PHOSPHATE; THROMBIN; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; VASCULOTROPIN;

CELL ACTIVATION; CELL ADHESION; CELL JUNCTION; CELL MEMBRANE PERMEABILITY; CYTOSKELETON; DRUG ACTIVITY; ENDOTHELIUM; HUMAN; INFLAMMATION; INTERNALIZATION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REVIEW; SEPSIS; STRATEGIC PLANNING; SURVIVAL; TIGHT JUNCTION; ANIMAL; ARTICLE; CLINICAL TRIAL (TOPIC); CYTOLOGY; DISEASE MODEL; METABOLISM; MICROBIOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; CLINICAL TRIALS AS TOPIC; CYTOSKELETON; DISEASE MODELS, ANIMAL; ENDOTHELIUM; HUMANS; INTERCELLULAR JUNCTIONS; SEPSIS;

EID: 79959407347     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3002011     Document Type: Review

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47. Acknowledgments: We apologize to the many investigators whose work we could not cite because of space limitations. We thank W. C. Liles for thoughtful review of our manuscript. Funding: N.M.G. is supported by a Vision Science Grant. B.E.S. is supported by M.D./Ph.D. studentships from the Canadian Institutes of Health Research and the McLaughlin Centre for Molecular Medicine. W.L.L. is supported by the Canadian Institutes of Health Research, the Ontario Thoracic Society, the Physicians Services Incorporated Foundation, and the Keenan Research Center of the Li Ka Shing Knowledge Institute, St. Michael's Hospital (Toronto). Competing interests: The authors declare no competing interests.