Effects of a synthetic PEG-ylated Tie-2 agonist peptide on endotoxemic lung injury and mortality

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 300, Issue 6, 2011, Pages

  David, Sascha ^a   Ghosh, Chandra C ^a   Kümpers, Philipp ^b   Shushakova, Nelli ^c   van Slyke, Paul ^d,e   Khankin, Eliyahu V ^a,f   Karumanchi, S Ananth ^a,f   Dumont, Dan ^d,e   Parikh, Samir M ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d Canada   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

^f HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Acute lung injury; Angiopoietins; Endothelial permeability; Endotoxin; Sepsis; Tie 2 TEK; Vascular leakage; Vasculotide

Indexed keywords

ALBUMIN; ANGIOPOIETIN 1; ANGIOPOIETIN RECEPTOR; HISTIDYLHISTIDYLHISTIDYLARGINYLHISTIDYLSERYLPHENYLALANINE; LIPOPOLYSACCHARIDE; PEPTIDE DERIVATIVE; POLYETHYLENE; PROTEIN KINASE B; UNCLASSIFIED DRUG; VASCULOTIDE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; ECHOCARDIOGRAPHY; ENDOTHELIUM; ENDOTOXEMIA; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VIVO STUDY; LUNG BLOOD VESSEL; LUNG INJURY; LUNG VASCULAR LEAKAGE; MALE; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SEPSIS; SURVIVAL;

ANIMALS; BLOTTING, WESTERN; CAPILLARY PERMEABILITY; ENDOTHELIUM, VASCULAR; ENDOTOXEMIA; ENDOTOXINS; HUMANS; IMMUNOENZYME TECHNIQUES; LIPOPOLYSACCHARIDES; LUNG INJURY; MALE; MICE; MICE, INBRED C57BL; PEPTIDE FRAGMENTS; POLYETHYLENE GLYCOLS; RECEPTOR, TIE-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SURVIVAL RATE;

EID: 79958231061     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00459.2010     Document Type: Article

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