메뉴 건너뛰기




Volumn 125, Issue 11, 2015, Pages 4042-4052

Intravital imaging of intestinal lacteals unveils lipid drainage through contractility

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; LIPID; COLORING AGENT; FAT INTAKE; FLUORESCENT DYE; GREEN FLUORESCENT PROTEIN; HOMEODOMAIN PROTEIN; NORADRENALIN; PROSPERO-RELATED HOMEOBOX 1 PROTEIN; TUMOR SUPPRESSOR PROTEIN;

EID: 84946724609     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI76509     Document Type: Article
Times cited : (96)

References (48)
  • 1
    • 76749083490 scopus 로고    scopus 로고
    • Lymphangiogenesis: Molecular mechanisms and future promise
    • Tammela T, Alitalo K. Lymphangiogenesis: molecular mechanisms and future promise. Cell. 2010;140(4):460-476.
    • (2010) Cell. , vol.140 , Issue.4 , pp. 460-476
    • Tammela, T.1    Alitalo, K.2
  • 2
    • 81255188905 scopus 로고    scopus 로고
    • The lymphatic vasculature in disease
    • Alitalo K. The lymphatic vasculature in disease. Nat Med. 2011;17(11):1371-1380.
    • (2011) Nat Med. , vol.17 , Issue.11 , pp. 1371-1380
    • Alitalo, K.1
  • 3
    • 78049500600 scopus 로고    scopus 로고
    • Mechanisms of chylomicron uptake into lacteals
    • Dixon JB. Mechanisms of chylomicron uptake into lacteals. Ann N Y Acad Sci. 2010; 1207(suppl 1):E52-E57.
    • (2010) Ann N y Acad Sci. , vol.1207 , pp. E52-E57
    • Dixon, J.B.1
  • 4
    • 33847394968 scopus 로고    scopus 로고
    • Lipids and lipid-based formulations: Optimizing the oral delivery of lipophilic drugs
    • Porter CJ, Trevaskis NL, Charman WN. Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs. Nat Rev Drug Discov. 2007;6(3):231-248.
    • (2007) Nat Rev Drug Discov. , vol.6 , Issue.3 , pp. 231-248
    • Porter, C.J.1    Trevaskis, N.L.2    Charman, W.N.3
  • 5
    • 77955271961 scopus 로고    scopus 로고
    • Lymphatic lipid transport: Sewer or subway?
    • Dixon JB. Lymphatic lipid transport: sewer or subway? Trends Endocrinol Me tab. 2010;21(8):480-487.
    • (2010) Trends Endocrinol Me Tab. , vol.21 , Issue.8 , pp. 480-487
    • Dixon, J.B.1
  • 6
    • 78049502039 scopus 로고    scopus 로고
    • Microanat-omy of the intestinal lymphatic system
    • Miller MJ, McDole JR, Newberry RD. Microanat-omy of the intestinal lymphatic system. Ann N Y Acad Sci. 2010;1207(suppl 1):E21-E28.
    • (2010) Ann N y Acad Sci. , vol.1207 , pp. E21-E28
    • Miller, M.J.1    McDole, J.R.2    Newberry, R.D.3
  • 7
    • 68149092112 scopus 로고    scopus 로고
    • A tissue-engineered model of the intestinal lacteal for evaluating lipid transport by lymphatics
    • Dixon JB, Raghunathan S, Swartz MA. A tissue-engineered model of the intestinal lacteal for evaluating lipid transport by lymphatics. Biotech-nol Bioeng. 2009;103(6):1224-1235.
    • (2009) Biotech-nol Bioeng. , vol.103 , Issue.6 , pp. 1224-1235
    • Dixon, J.B.1    Raghunathan, S.2    Swartz, M.A.3
  • 8
    • 77149142588 scopus 로고    scopus 로고
    • Modelling of drug disposition kinetics in in vitro intestinal absorption cell models
    • Heikkinen AT, Korjamo T, Monkkonen J. Modelling of drug disposition kinetics in in vitro intestinal absorption cell models. Basic Clin Pharmacol. 2010;106(3):180-188.
    • (2010) Basic Clin Pharmacol. , vol.106 , Issue.3 , pp. 180-188
    • Heikkinen, A.T.1    Korjamo, T.2    Monkkonen, J.3
  • 9
    • 0025149320 scopus 로고
    • Fat feeding increases size, but not number, of chylomicrons produced by small intestine
    • Hayashi H, Fujimoto K, Cardelli JA, Nutting DF, Bergstedt S, Tso P. Fat feeding increases size, but not number, of chylomicrons produced by small intestine. Am J Physiol. 1990; 259(5 pt 1):G709-G719.
    • (1990) Am J Physiol. , vol.259 , Issue.5 , pp. G709-G719
    • Hayashi, H.1    Fujimoto, K.2    Cardelli, J.A.3    Nutting, D.F.4    Bergstedt, S.5    Tso, P.6
  • 10
    • 0022475420 scopus 로고
    • Formation and transport of chy-lomicrons by enterocytes to the lymphatics
    • Tso P, Balint JA. Formation and transport of chy-lomicrons by enterocytes to the lymphatics. Am J Physiol. 1986;250(6 pt 1):G715-G726.
    • (1986) Am J Physiol. , vol.250 , Issue.6 , pp. G715-G726
    • Tso, P.1    Balint, J.A.2
  • 11
    • 0025936828 scopus 로고
    • Portal transport of absorbed lipids in rats
    • Mansbach CM II, Dowell RF, Pritchett D. Portal transport of absorbed lipids in rats. Am J Physiol. 1991;261(3 pt 1):G530-G538.
    • (1991) Am J Physiol. , vol.261 , Issue.3 , pp. G530-G538
    • Mansbach, C.M.1    Dowell, R.F.2    Pritchett, D.3
  • 12
    • 0027763397 scopus 로고
    • Luminal nutrients alter tight-junction permeability in the rat jejunum: An in vivo perfusion model
    • Sadowski DC, Meddings JB. Luminal nutrients alter tight-junction permeability in the rat jejunum: an in vivo perfusion model. Can J Physiol Pharmacol. 1993;71(10-11):835-839.
    • (1993) Can J Physiol Pharmacol. , vol.71 , Issue.10-11 , pp. 835-839
    • Sadowski, D.C.1    Meddings, J.B.2
  • 13
    • 77951634410 scopus 로고    scopus 로고
    • In vivo wide-area cellular imaging by side-view endomicroscopy
    • Kim P, et al. In vivo wide-area cellular imaging by side-view endomicroscopy. Nat Methods. 2010;7(4):303-305.
    • (2010) Nat Methods. , vol.7 , Issue.4 , pp. 303-305
    • Kim, P.1
  • 14
    • 84886077871 scopus 로고    scopus 로고
    • In vivo high spatiotemporal resolution visualization of circulating T lymphocytes in high endothelial venules of lymph nodes
    • Choe K, Hwang Y, Seo H, Kim P. In vivo high spatiotemporal resolution visualization of circulating T lymphocytes in high endothelial venules of lymph nodes. J Biomed Opt. 2013;18(3):036005.
    • (2013) J Biomed Opt. , vol.18 , Issue.3 , pp. 036005
    • Choe, K.1    Hwang, Y.2    Seo, H.3    Kim, P.4
  • 15
    • 78650983951 scopus 로고    scopus 로고
    • Visualization of lymphatic vessels by Prox1-promoter directed GFP reporter in a bacterial artificial chromosome-based transgenic mouse
    • Choi I, et al. Visualization of lymphatic vessels by Prox1-promoter directed GFP reporter in a bacterial artificial chromosome-based transgenic mouse. Blood. 2011;117(1):362-365.
    • (2011) Blood. , vol.117 , Issue.1 , pp. 362-365
    • Choi, I.1
  • 16
    • 0019140697 scopus 로고
    • Lymph fatty acid composition during constant infusion of saturated fats of different chain lengths in the rat
    • Chu SW, Hegsted DM. Lymph fatty acid composition during constant infusion of saturated fats of different chain lengths in the rat. J Nutr. 1980;110(11):2198-2206.
    • (1980) J Nutr. , vol.110 , Issue.11 , pp. 2198-2206
    • Chu, S.W.1    Hegsted, D.M.2
  • 17
    • 0000483832 scopus 로고
    • The portal transport of absorbed fatty acids
    • Kiyasu JY, Bloom B, Chaikoff IL. The portal transport of absorbed fatty acids. J Biol Chem. 1952;199(1):415-419.
    • (1952) J Biol Chem. , vol.199 , Issue.1 , pp. 415-419
    • Kiyasu, J.Y.1    Bloom, B.2    Chaikoff, I.L.3
  • 18
    • 0000832952 scopus 로고
    • Intestinal lymph as pathway for transport of absorbed fatty acids of different chain lengths
    • Bloom B, Chaikoff IL, Reinhardt. Intestinal lymph as pathway for transport of absorbed fatty acids of different chain lengths. Am J Physiol. 1951;166(2):451-455.
    • (1951) Am J Physiol. , vol.166 , Issue.2 , pp. 451-455
    • Bloom, B.1    Chaikoff, I.L.2    Reinhardt3
  • 19
    • 0025029073 scopus 로고
    • Absorption of polyethylene glycols 600 through 2000: The molecular weight dependence of gastrointestinal and nasal absorption
    • Donovan MD, Flynn GL, Amidon GL. Absorption of polyethylene glycols 600 through 2000: the molecular weight dependence of gastrointestinal and nasal absorption. Pharm Res. 1990;7(8):863-868.
    • (1990) Pharm Res. , vol.7 , Issue.8 , pp. 863-868
    • Donovan, M.D.1    Flynn, G.L.2    Amidon, G.L.3
  • 20
    • 0037393955 scopus 로고    scopus 로고
    • Challenges for the oral delivery of macromolecules
    • Goldberg M, Gomez-Orellana I. Challenges for the oral delivery of macromolecules. Nat Rev Drug Discov. 2003;2(4):289-295.
    • (2003) Nat Rev Drug Discov. , vol.2 , Issue.4 , pp. 289-295
    • Goldberg, M.1    Gomez-Orellana, I.2
  • 22
    • 0014730045 scopus 로고
    • The lymphatic pump of the intestinal villus of the rat
    • Collan Y, Kalima TV. The lymphatic pump of the intestinal villus of the rat. Scand J Gastroenterol. 1970;5(3):187-196.
    • (1970) Scand J Gastroenterol. , vol.5 , Issue.3 , pp. 187-196
    • Collan, Y.1    Kalima, T.V.2
  • 24
    • 0033667573 scopus 로고    scopus 로고
    • Anatomy and physiology of the enteric nervous system
    • Costa M, Brookes SJ, Hennig GW. Anatomy and physiology of the enteric nervous system. Gut. 2000;47(suppl 4):iv15-iv19.
    • (2000) Gut. , vol.47 , pp. iv15-iv19
    • Costa, M.1    Brookes, S.J.2    Hennig, G.W.3
  • 26
    • 0003687240 scopus 로고    scopus 로고
    • Lippincott's illustrated reviews
    • Baltimore Maryland USA: Wolters Kluwer Health/Lippincott Williams & Wilkins
    • Clark MA. Lippincott's Illustrated Reviews. Pharmacology. Baltimore, Maryland, USA: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2012.
    • (2012) Pharmacology
    • Clark, M.A.1
  • 27
    • 84862501292 scopus 로고    scopus 로고
    • The enteric nervous system and neurogastroenterology
    • Furness JB. The enteric nervous system and neurogastroenterology. Nat Rev Gastroen terol Hepatol. 2012;9(5):286-294.
    • (2012) Nat Rev Gastroen Terol Hepatol. , vol.9 , Issue.5 , pp. 286-294
    • Furness, J.B.1
  • 28
    • 2342623944 scopus 로고    scopus 로고
    • Pharmacology and function of nicotinic acetylcholine and P2X receptors in the enteric nervous system
    • Galligan JJ, North RA. Pharmacology and function of nicotinic acetylcholine and P2X receptors in the enteric nervous system. Neurogastroent Motil. 2004;16(suppl 1):64-70.
    • (2004) Neurogastroent Motil. , vol.16 , pp. 64-70
    • Galligan, J.J.1    North, R.A.2
  • 29
    • 64149102359 scopus 로고    scopus 로고
    • Interaction between voltage-gated sodium channels and the neurotoxin, tetro-dotoxin
    • Lee CH, Ruben PC. Interaction between voltage-gated sodium channels and the neurotoxin, tetro-dotoxin. Channels (Austin). 2008;2(6):407-412.
    • (2008) Channels (Austin) , vol.2 , Issue.6 , pp. 407-412
    • Lee, C.H.1    Ruben, P.C.2
  • 30
    • 0014066884 scopus 로고
    • Effects of tetrodotoxin on innervated smooth muscle preparations
    • Gershon MD. Effects of tetrodotoxin on innervated smooth muscle preparations. Br J Pharmacol Chemother. 1967;29(3):259-279.
    • (1967) Br J Pharmacol Chemother. , vol.29 , Issue.3 , pp. 259-279
    • Gershon, M.D.1
  • 31
    • 84868589001 scopus 로고    scopus 로고
    • Regulation of gastrointestinal motility - Insights from smooth muscle biology
    • Sanders KM, Koh SD, Ro S, Ward SM. Regulation of gastrointestinal motility - insights from smooth muscle biology. Nat Rev Gastroenterol Hepatol. 2012;9(11):633-645.
    • (2012) Nat Rev Gastroenterol Hepatol. , vol.9 , Issue.11 , pp. 633-645
    • Sanders, K.M.1    Koh, S.D.2    Ro, S.3    Ward, S.M.4
  • 32
    • 44449143412 scopus 로고    scopus 로고
    • Molecular regulation of lymphatic contractility
    • Muthuchamy M, Zawieja D. Molecular regulation of lymphatic contractility. Ann N Y Acad Sci. 2008;1131:89-99.
    • (2008) Ann N y Acad Sci. , vol.1131 , pp. 89-99
    • Muthuchamy, M.1    Zawieja, D.2
  • 34
    • 78049512780 scopus 로고    scopus 로고
    • Role of intestinal lymphatics in interstitial volume regulation and transmucosal water transport
    • Kvietys PR, Granger DN. Role of intestinal lymphatics in interstitial volume regulation and transmucosal water transport. Ann N Y Acad Sci. 2010;1207(suppl 1):E29-E43.
    • (2010) Ann N y Acad Sci. , vol.1207 , pp. E29-E43
    • Kvietys, P.R.1    Granger, D.N.2
  • 35
    • 35549008468 scopus 로고    scopus 로고
    • Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons
    • Van Dyck F, et al. Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons. Cell Metab. 2007;6(5):406-413.
    • (2007) Cell Metab. , vol.6 , Issue.5 , pp. 406-413
    • Van Dyck, F.1
  • 38
    • 34948814992 scopus 로고    scopus 로고
    • Functionally specialized junctions between endothelial cells of lymphatic vessels
    • Baluk P, et al. Functionally specialized junctions between endothelial cells of lymphatic vessels. J Exp Med. 2007;204(10):2349-2362.
    • (2007) J Exp Med. , vol.204 , Issue.10 , pp. 2349-2362
    • Baluk, P.1
  • 39
    • 0033991176 scopus 로고    scopus 로고
    • A proposed model for the assembly of chylomicrons
    • Hussain MM. A proposed model for the assembly of chylomicrons. Atherosclerosis. 2000;148(1):1-15.
    • (2000) Atherosclerosis , vol.148 , Issue.1 , pp. 1-15
    • Hussain, M.M.1
  • 40
    • 34248657981 scopus 로고    scopus 로고
    • Characterization of a BODIPY-labeled fluorescent fatty acid analogue. Binding to fatty acid-binding proteins, intra-cellular localization, and metabolism
    • Thumser AE, Storch J. Characterization of a BODIPY-labeled fluorescent fatty acid analogue. Binding to fatty acid-binding proteins, intra-cellular localization, and metabolism. Mol Cell Biochem. 2007;299(1-2):67-73.
    • (2007) Mol Cell Biochem. , vol.299 , Issue.1-2 , pp. 67-73
    • Thumser, A.E.1    Storch, J.2
  • 41
    • 84874952886 scopus 로고    scopus 로고
    • Dual-channel in-situ optical imaging system for quantifying lipid uptake and lymphatic pump function
    • Kassis T, et al. Dual-channel in-situ optical imaging system for quantifying lipid uptake and lymphatic pump function. J Biomed Opt. 2012;17(8):086005.
    • (2012) J Biomed Opt. , vol.17 , Issue.8 , pp. 086005
    • Kassis, T.1
  • 42
    • 0037903214 scopus 로고    scopus 로고
    • Live cell analysis and targeting of the lipid droplet-binding adipocyte differentiation-related protein
    • Targett-Adams P, et al. Live cell analysis and targeting of the lipid droplet-binding adipocyte differentiation-related protein. J Biol Chem. 2003;278(18):15998-16007.
    • (2003) J Biol Chem. , vol.278 , Issue.18 , pp. 15998-16007
    • Targett-Adams, P.1
  • 43
    • 77953523654 scopus 로고    scopus 로고
    • Altered lipid droplet dynamics in hepa-tocytes lacking triacylglycerol hydrolase expression
    • Wang H, Wei E, Quiroga AD, Sun X, Touret N, Lehner R. Altered lipid droplet dynamics in hepa-tocytes lacking triacylglycerol hydrolase expression. Mol Biol Cell. 2010;21(12):1991-2000.
    • (2010) Mol Biol Cell. , vol.21 , Issue.12 , pp. 1991-2000
    • Wang, H.1    Wei, E.2    Quiroga, A.D.3    Sun, X.4    Touret, N.5    Lehner, R.6
  • 45
    • 33845910419 scopus 로고    scopus 로고
    • Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement
    • Chieppa M, Rescigno M, Huang AYC, Germain RN. Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement. J Exp Med. 2006;203(13):2841-2852.
    • (2006) J Exp Med. , vol.203 , Issue.13 , pp. 2841-2852
    • Chieppa, M.1    Rescigno, M.2    Huang, A.Y.C.3    Germain, R.N.4
  • 46
    • 67650519372 scopus 로고    scopus 로고
    • A dynamic, cytoplasmic triacylglycerol pool in enterocytes revealed by ex vivo and in vivo coherent anti-Stokes Raman scattering imaging
    • Zhu JB, Lee BG, Buhman KK, Cheng JX. A dynamic, cytoplasmic triacylglycerol pool in enterocytes revealed by ex vivo and in vivo coherent anti-Stokes Raman scattering imaging. J Lipid Res. 2009;50(6):1080-1089.
    • (2009) J Lipid Res. , vol.50 , Issue.6 , pp. 1080-1089
    • Zhu, J.B.1    Lee, B.G.2    Buhman, K.K.3    Cheng, J.X.4
  • 47
    • 84863230541 scopus 로고    scopus 로고
    • Goblet cells deliver luminal antigen to CD103(+) dendritic cells in the small intestine
    • McDole JR, et al. Goblet cells deliver luminal antigen to CD103(+) dendritic cells in the small intestine. Nature. 2012;483(7389):345-349.
    • (2012) Nature , vol.483 , Issue.7389 , pp. 345-349
    • McDole, J.R.1
  • 48
    • 84865597512 scopus 로고    scopus 로고
    • Utilizing inherent fluorescence of therapeutics to analyze real-time uptake and multi-parametric effector kinetics
    • Wiench B, Eichhorn T, Korn B, Paulsen M, Efferth T. Utilizing inherent fluorescence of therapeutics to analyze real-time uptake and multi-parametric effector kinetics. Methods. 2012;57(3):376-382.
    • (2012) Methods. , vol.57 , Issue.3 , pp. 376-382
    • Wiench, B.1    Eichhorn, T.2    Korn, B.3    Paulsen, M.4    Efferth, T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.