Silk fibroin nanoparticle as a novel drug delivery system

Journal of Controlled Release

Volumn 206, Issue , 2015, Pages 161-176

  Mottaghitalab, Fatemeh ^a   Farokhi, Mehdi ^b   Shokrgozar, Mohammad Ali ^b   Atyabi, Fatemeh ^c   Hosseinkhani, Hossein ^d  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b PASTEUR INSTITUTE OF IRAN   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d NATIONAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

Author keywords

Drug delivery; Nanoparticles; Silk fibroin

Indexed keywords

FUNCTIONAL POLYMERS; NANOPARTICLES;

DELIVERY METHODS; DRUG DELIVERY SYSTEM; DRUG DELIVERY VEHICLES; EFFICIENT DRUG DELIVERY; NATURALLY OCCURRING; PROTEIN POLYMERS; SILK FIBROIN; THERAPEUTIC AGENTS;

DRUG DELIVERY;

ANTINEOPLASTIC AGENT; BOVINE SERUM ALBUMIN; DENDRIMER; DOXORUBICIN; DRUG ADMINISTRATION; DRUG CARRIER; FERRITIN; FIBROBLAST GROWTH FACTOR; FIBROIN; FLUORESCEIN ISOTHIOCYANATE; FULLERENE DERIVATIVE; LIPOSOME; LYSOZYME; MICROSPHERE; NANOPARTICLE; NANOSPHERE; OPSONIN; PACLITAXEL; PACLITAXEL POLIGLUMEX; PLATELET DERIVED GROWTH FACTOR; POLYMER; POLYVINYL ALCOHOL; PROTEIN; QUANTUM DOT; SERICIN; SILK FIBROIN; TETRAMETHYLRHODAMINE; TRANSFORMING GROWTH FACTOR; VASCULOTROPIN;

ANIMAL; ATOMIC FORCE MICROSCOPY; BETA SHEET; BIODEGRADABILITY; BIODEGRADATION; BOMBYX; BOMBYX MORI; CHEMISTRY; CONFORMATIONAL TRANSITION; CROSS LINKING; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG ACCUMULATION; DRUG ACTIVITY; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; DRUG RELEASE; DRUG RESISTANCE; DRUG SAFETY; DRUG SOLUBILITY; DRUG STABILITY; ELECTROSPINNING; ENCAPSULATION; ENZYMATIC DEGRADATION; ENZYME IMMOBILIZATION; GENETIC MANIPULATION; HUMAN; HYDROGEL; HYDROGEN BOND; HYDROPHILICITY; HYDROPHOBICITY; IMMUNOGENICITY; IONIC STRENGTH; MACROPHAGE; MICELLE; MOLECULAR WEIGHT; MULBERRY; NANOTECHNOLOGY; NONHUMAN; OPSONIZATION; PARTICLE SIZE; PH; PRIORITY JOURNAL; PROCEDURES; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN HYDROLYSIS; REVIEW; STATIC ELECTRICITY; SURFACE CHARGE; SURFACE PROPERTY; SUSTAINED DRUG RELEASE; TUMOR CELL LINE; ULTRASTRUCTURE; ZETA POTENTIAL;

ADMINISTRATION AND DOSAGE; ANIMALS; ANTINEOPLASTIC AGENTS; BOMBYX; CELL LINE, TUMOR; CHEMISTRY; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; FIBROINS; HUMANS; METHODS; NANOPARTICLES; PROTEINS; ULTRASTRUCTURE;

EID: 84964310768     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.03.020     Document Type: Review

References (247)

1. J. Lehár, A.S. Krueger, W. Avery, A.M. Heilbut, L.M. Johansen, E.R. Price, R.J. Rickles, G.F. Short Iii, J.E. Staunton, and X. Jin Synergistic drug combinations tend to improve therapeutically relevant selectivity Nat. Biotechnol. 27 2009 659 666
2. J. Wei, F. Chen, J.-W. Shin, H. Hong, C. Dai, J. Su, and C. Liu Preparation and characterization of bioactive mesoporous wollastonite-polycaprolactone composite scaffold Biomaterials 30 2009 1080 1088
3. T.P. Richardson, M.C. Peters, A.B. Ennett, and D.J. Mooney Polymeric system for dual growth factor delivery Nat. Biotechnol. 19 2001 1029 1034
4. Z. Ghasemi, R. Dinarvand, F. Mottaghitalab, M. Esfandyari-Manesh, E. Sayari, and F. Atyabi Aptamer decorated hyaluronan/chitosan nanoparticles for targeted delivery of 5-fluorouracil to MUC1 overexpressing adenocarcinomas Carbohydr. Polym. 121 2015 190 198
5. Y. Zhang, H.F. Chan, and K.W. Leong Advanced materials and processing for drug delivery: the past and the future Adv. Drug Deliv. Rev. 65 2013 104 120
6. L.S. Nair, and C.T. Laurencin Polymers as biomaterials for tissue engineering and controlled drug delivery Tissue engineering I 2006 Springer 47 90
7. N. Aboudzadeh, M. Imani, M.A. Shokrgozar, A. Khavandi, J. Javadpour, Y. Shafieyan, and M. Farokhi Fabrication and characterization of poly (D, Llactidecoglycolide)/hydroxyapatite nanocomposite scaffolds for bone tissue regeneration J. Biomed. Mater. Res. Part A 94 2010 137 145
8. M. Farokhi, S. Sharifi, Y. Shafieyan, Z. Bagher, F. Mottaghitalab, A. Hatampoor, M. Imani, and M. Shokrgozar Porous crosslinked poly (εcaprolactone fumarate)/nanohydroxyapatite composites for bone tissue engineering J. Biomed. Mater. Res. Part A 100 2012 1051 1060
9. S. Mao, C. Guo, Y. Shi, and L.C. Li Recent advances in polymeric microspheres for parenteral drug delivery-part 1 Expert Opin. Drug Deliv. 9 2012 1161 1176
10. T. Yucel, M.L. Lovett, and D.L. Kaplan Silk-based biomaterials for sustained drug delivery J. Control. Release 190 2014 381 397
11. T. Estey, J. Kang, S.P. Schwendeman, and J.F. Carpenter BSA degradation under acidic conditions: a model for protein instability during release from PLGA delivery systems J. Pharm. Sci. 95 2006 1626 1639
12. A. Giteau, M.-C. Venier-Julienne, A. Aubert-Pouëssel, and J.-P. Benoit How to achieve sustained and complete protein release from PLGA-based microparticles? Int. J. Pharm. 350 2008 14 26
13. H. Tamber, P. Johansen, H.P. Merkle, and B. Gander Formulation aspects of biodegradable polymeric microspheres for antigen delivery Adv. Drug Deliv. Rev. 57 2005 357 376
14. C.F. van der Walle, G. Sharma, and M. Ravi Kumar Current approaches to stabilising and analysing proteins during microencapsulation in PLGA 2009
15. A.O. Elzoghby, W.M. Samy, and N.A. Elgindy Protein-based nanocarriers as promising drug and gene delivery systems J. Control. Release 161 2012 38 49
16. P.B. Malafaya, G.A. Silva, and R.L. Reis Natural-origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications Adv. Drug Deliv. Rev. 59 2007 207 233
17. J. Mano, G. Silva, H.S. Azevedo, P. Malafaya, R. Sousa, S. Silva, L. Boesel, J.M. Oliveira, T. Santos, and A. Marques Natural origin biodegradable systems in tissue engineering and regenerative medicine: present status and some moving trends J. R. Soc. Interface 4 2007 999 1030
18. H. Hosseinkhani, M. Hosseinkhani, and H. Kobayashi Design of tissue-engineered nanoscaffold through self-assembly of peptide amphiphile J. Bioact. Compat. Polym. 21 2006 277 296
19. H. Hosseinkhani, T. Kushibiki, K. Matsumoto, T. Nakamura, and Y. Tabata Enhanced suppression of tumor growth using a combination of NK4 plasmid DNA-PEG engrafted cationized dextran complex and ultrasound irradiation Cancer Gene Ther. 13 2006 479 489
20. H. Hosseinkhani, T. Aoyama, O. Ogawa, and Y. Tabata Ultrasound enhances the transfection of plasmid DNA by non-viral vectors Curr. Pharm. Biotechnol. 4 2003 109 122
21. M. Konishi, Y. Tabata, M. Kariya, H. Hosseinkhani, A. Suzuki, K. Fukuhara, M. Mandai, K. Takakura, and S. Fujii In vivo anti-tumor effect of dual release of cisplatin and adriamycin from biodegradable gelatin hydrogel J. Control. Release 103 2005 7 19
22. Y. Tabata Tissue regeneration based on growth factor release Tissue Eng. 9 2003 5 15
23. F. Mottaghitalab, M. Farokhi, V. Mottaghitalab, M. Ziabari, A. Divsalar, and M.A. Shokrgozar Enhancement of neural cell lines proliferation using nano-structured chitosan/poly (vinyl alcohol) scaffolds conjugated with nerve growth factor Carbohydr. Polym. 86 2011 526 535
24. M.A. Shokrgozar, F. Mottaghitalab, V. Mottaghitalab, and M. Farokhi Fabrication of porous chitosan/poly (vinyl alcohol) reinforced single-walled carbon nanotube nanocomposites for neural tissue engineering J. Biomed. Nanotechnol. 7 2011 276 284
25. E. Wenk, H.P. Merkle, and L. Meinel Silk fibroin as a vehicle for drug delivery applications J. Control. Release 150 2011 128 141
26. A.D. Bangham Membrane models with phospholipids Prog. Biophys. Mol. Biol. 18 1968 29 95
27. 75 Se] norcholestenol Int. J. Pharm. 16 1983 105 113
28. D. Scherer Einfluß von Polybutylcyanoacrylat-Nanopartikeln auf die orale Absorption von Arzneistoffen 1992 Johann Wolfgang Goethe Universitèat
29. C.S. Maia, W. Mehnert, and M. Schäfer-Korting Solid lipid nanoparticles as drug carriers for topical glucocorticoids Int. J. Pharm. 196 2000 165 167
30. B. Müller, and J. Kreuter Enhanced transport of nanoparticle associated drugs through natural and artificial membranes - a general phenomenon? Int. J. Pharm. 178 1999 23 32
31. M. Ricci, C. Puglia, F. Bonina, C.D. Giovanni, S. Giovagnoli, and C. Rossi Evaluation of indomethacin percutaneous absorption from nanostructured lipid carriers (NLC): in vitro and in vivo studies J. Pharm. Sci. 94 2005 1149 1159
32. C. Burda, X. Chen, R. Narayanan, and M.A. El-Sayed Chemistry and properties of nanocrystals of different shapes Chem. Rev. 105 2005 1025 1102
33. A.K. Boal, and V.M. Rotello Fabrication and self-optimization of multivalent receptors on nanoparticle scaffolds J. Am. Chem. Soc. 122 2000 734 735
34. C. Murray, D.J. Norris, and M.G. Bawendi Synthesis and characterization of nearly monodisperse CdE (E = sulfur, selenium, tellurium) semiconductor nanocrystallites J. Am. Chem. Soc. 115 1993 8706 8715
35. J. McKinnie Nanobiotechnology offers a promising solution overcoming common drug delivery failures Drug Deliv. Technol. 5 2006 11 15
36. S.M. Moghimi, A.C. Hunter, and J.C. Murray Long-circulating and target-specific nanoparticles: theory to practice Pharmacol. Rev. 53 2001 283 318
37. M.R. Avadi, A.M.M. Sadeghi, N. Mohammadpour, S. Abedin, F. Atyabi, R. Dinarvand, and M. Rafiee-Tehrani Preparation and characterization of insulin nanoparticles using chitosan and Arabic gum with ionic gelation method Nanomed. Nanotechnol. Biol. Med. 6 2010 58 63
38. H. Hosseinzadeh, F. Atyabi, R. Dinarvand, and S.N. Ostad Chitosan-Pluronic nanoparticles as oral delivery of anticancer gemcitabine: preparation and in vitro study Int. J. Nanomedicine 7 2012 1851
39. A. Tahamtan, A. Tabarraei, A. Moradi, M. Dinarvand, M. Kelishadi, A. Ghaemi, and F. Atyabi Chitosan nanoparticles as a potential nonviral gene delivery for HPV-16 E7 into mammalian cells Artif. Cells Nanomed. Biotechnol. 2014 1 7
40. H. Hosseinkhani, and Y. Tabata Self assembly of DNA nanoparticles with polycations for the delivery of genetic materials into cells J. Nanosci. Nanotechnol. 6 2006 2320 2328
41. S. Abdullah, W.Y. Wendy-Yeo, H. Hosseinkhani, M. Hosseinkhani, E. Masrawa, R. Ramasamy, R. Rosli, S.A. Rahman, and A.J. Domb Gene transfer into the lung by nanoparticle dextran-spermine/plasmid DNA complexes Biomed. Res. Int. 2010 2010
42. T. Lammers, F. Kiessling, W.E. Hennink, and G. Storm Drug targeting to tumors: principles, pitfalls and (pre-) clinical progress J. Control. Release 161 2012 175 187
43. Y. Ding, S. Li, and G. Nie Nanotechnological strategies for therapeutic targeting of tumor vasculature Nanomedicine 8 2013 1209 1222
44. S. Nie, Y. Xing, G.J. Kim, and J.W. Simons Nanotechnology applications in cancer Annu. Rev. Biomed. Eng. 9 2007 257 288
45. F. Alexis, E.M. Pridgen, R. Langer, and O.C. Farokhzad Nanoparticle technologies for cancer therapy Drug Delivery 2010 Springer 55 86
46. M. Kanapathipillai, A. Brock, and D.E. Ingber Nanoparticle targeting of anti-cancer drugs that alter intracellular signaling or influence the tumor microenvironment Adv. Drug Deliv. Rev. 79 2014 108 117
47. S.A. Galindo-Rodriguez, E. Allemann, H. Fessi, and E. Doelker Polymeric nanoparticles for oral delivery of drugs and vaccines: a critical evaluation of in vivo studies Crit. Rev. Ther. Drug Carrier Syst. 22 2005
48. D.F. Emerich, and C.G. Thanos The pinpoint promise of nanoparticle-based drug delivery and molecular diagnosis Biomol. Eng. 23 2006 171 184
49. J. Shi, A.R. Votruba, O.C. Farokhzad, and R. Langer Nanotechnology in drug delivery and tissue engineering: from discovery to applications Nano Lett. 10 2010 3223 3230
50. D.W. Bartlett, H. Su, I.J. Hildebrandt, W.A. Weber, and M.E. Davis Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging Proc. Natl. Acad. Sci. 104 2007 15549 15554
51. M.P. Desai, V. Labhasetwar, E. Walter, R.J. Levy, and G.L. Amidon The mechanism of uptake of biodegradable microparticles in Caco-2 cells is size dependent Pharm. Res. 14 1997 1568 1573
52. J. Panyam, S.K. Sahoo, S. Prabha, T. Bargar, and V. Labhasetwar Fluorescence and electron microscopy probes for cellular and tissue uptake of poly (d, l-lactide-co-glycolide) nanoparticles Int. J. Pharm. 262 2003 1 11
53. F. Greco, and M.J. Vicent Combination therapy: opportunities and challenges for polymer-drug conjugates as anticancer nanomedicines Adv. Drug Deliv. Rev. 61 2009 1203 1213
54. S. Mitragotri Synergistic effect of enhancers for transdermal drug delivery Pharm. Res. 17 2000 1354 1359
55. C. Walsh Molecular mechanisms that confer antibacterial drug resistance Nature 406 2000 775 781
56. M.P. Desai, V. Labhasetwar, G.L. Amidon, and R.J. Levy Gastrointestinal uptake of biodegradable microparticles: effect of particle size Pharm. Res. 13 1996 1838 1845
57. B.D. Chithrani, and W.C. Chan Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes Nano Lett. 7 2007 1542 1550
58. R. Singh, and J.W. Lillard Jr. Nanoparticle-based targeted drug delivery Exp. Mol. Pathol. 86 2009 215 223
59. I. Brigger, C. Dubernet, and P. Couvreur Nanoparticles in cancer therapy and diagnosis Adv. Drug Deliv. Rev. 54 2002 631 651
60. R. Müller, S. Maaben, H. Weyhers, and W. Mehnert Phagocytic uptake and cytotoxicity of solid lipid nanoparticles (SLN) sterically stabilized with poloxamine 908 and poloxamer 407 J. Drug Target. 4 1996 161 170
61. M. Roser, D. Fischer, and T. Kissel Surface-modified biodegradable albumin nano-and microspheres. II: effect of surface charges on in vitro phagocytosis and biodistribution in rats Eur. J. Pharm. Biopharm. 46 1998 255 263
62. D.A. Tomalia, H. Baker, J. Dewald, M. Hall, G. Kallos, S. Martin, J. Roeck, J. Ryder, and P. Smith A new class of polymers: starburst-dendritic macromolecules Polym. J. 17 1985 117 132
63. G.S. Kwon, and T. Okano Polymeric micelles as new drug carriers Adv. Drug Deliv. Rev. 21 1996 107 116
64. E. Locatelli, and M.C. Franchini Biodegradable PLGA-b-PEG polymeric nanoparticles: synthesis, properties, and nanomedical applications as drug delivery system J. Nanoparticle Res. 14 2012 1 17
65. S.J. Holland, B.J. Tighe, and P.L. Gould Polymers for biodegradable medical devices. 1. The potential of polyesters as controlled macromolecular release systems J. Control. Release 4 1986 155 180
66. M. Roussaki, A. Gaitanarou, P.C. Diamanti, S. Vouyiouka, C. Papaspyrides, P. Kefalas, and A. Detsi Encapsulation of the natural antioxidant aureusidin in biodegradable PLA nanoparticles Polym. Degrad. Stab. 108 2014 182 187
67. M. Chen, H. Ouyang, S. Zhou, J. Li, and Y. Ye PLGA-nanoparticle mediated delivery of anti-OX40 monoclonal antibody enhances anti-tumor cytotoxic T cell responses Cell. Immunol. 287 2014 91 99
68. J.S. Chawla, and M.M. Amiji Biodegradable poly (ε-caprolactone) nanoparticles for tumor-targeted delivery of tamoxifen Int. J. Pharm. 249 2002 127 138
69. T. Akagi, T. Kaneko, T. Kida, and M. Akashi Preparation and characterization of biodegradable nanoparticles based on poly (γ-glutamic acid) with l-phenylalanine as a protein carrier J. Control. Release 108 2005 226 236
70. J.K. Li, N. Wang, and X.S. Wu Poly (vinyl alcohol) nanoparticles prepared by freezing-thawing process for protein/peptide drug delivery J. Control. Release 56 1998 117 126
71. K. Kisich, S. Gelperina, M. Higgins, S. Wilson, E. Shipulo, E. Oganesyan, and L. Heifets Encapsulation of moxifloxacin within poly (butyl cyanoacrylate) nanoparticles enhances efficacy against intracellular Mycobacterium tuberculosis Int. J. Pharm. 345 2007 154 162
72. B. Petri, A. Bootz, A. Khalansky, T. Hekmatara, R. Müller, R. Uhl, J. Kreuter, and S. Gelperina Chemotherapy of brain tumour using doxorubicin bound to surfactant-coated poly (butyl cyanoacrylate) nanoparticles: revisiting the role of surfactants J. Control. Release 117 2007 51 58
73. M. Peracchia, E. Fattal, D. Desmaele, M. Besnard, J. Noel, J. Gomis, M. Appel, J. d'Angelo, and P. Couvreur Stealth® PEGylated polycyanoacrylate nanoparticles for intravenous administration and splenic targeting J. Control. Release 60 1999 121 128
74. M. Hans, and A. Lowman Biodegradable nanoparticles for drug delivery and targeting Curr. Opinion Solid State Mater. Sci. 6 2002 319 327
75. K. Löw, M. Wacker, S. Wagner, K. Langer, and H. von Briesen Targeted human serum albumin nanoparticles for specific uptake in EGFR-Expressing colon carcinoma cells Nanomed. Nanotechnol. Biol. Med. 7 2011 454 463
76. L. Zhao, Y. Zhou, Y. Gao, S. Ma, C. Zhang, J. Li, D. Wang, X. Li, C. Li, and Y. Liu Bovine serum albumin nanoparticles for delivery of tacrolimus to reduce its kidney uptake and functional nephrotoxicity Int. J. Pharm. 483 2015 180 187
77. M. Nicklas, W. Schatton, S. Heinemann, T. Hanke, and J. Kreuter Preparation and characterization of marine sponge collagen nanoparticles and employment for the transdermal delivery of 17β-estradiol-hemihydrate Drug Dev. Ind. Pharm. 35 2009 1035 1042
78. Z. Lu, T.-K. Yeh, M. Tsai, J.L.-S. Au, and M.G. Wientjes Paclitaxel-loaded gelatin nanoparticles for intravesical bladder cancer therapy Clin. Cancer Res. 10 2004 7677 7684
79. I. Pali-Schöll, H. Szöllösi, P. Starkl, B. Scheicher, C. Stremnitzer, A. Hofmeister, F. Roth-Walter, A. Lukschal, S.C. Diesner, and A. Zimmer Protamine nanoparticles with CpG-oligodeoxynucleotide prevent an allergen-induced Th2-response in BALB/c mice Eur. J. Pharm. Biopharm. 85 2013 656 664
80. I. Ezpeleta, J.M. Irache, S. Stainmesse, C. Chabenat, J. Gueguen, Y. Popineau, and A.-M. Orecchioni Gliadin nanoparticles for the controlled release of all-trans-retinoic acid Int. J. Pharm. 131 1996 191 200
81. R. Penalva, I. Esparza, M. Agüeros, C.J. Gonzalez-Navarro, C. Gonzalez-Ferrero, and J.M. Irache Casein nanoparticles as carriers for the oral delivery of folic acid Food Hydrocoll. 44 2015 399 406
82. T. Mirshahi, J. Irache, J. Gueguen, and A. Orecchioni Development of drug delivery systems from vegetal proteins: legumin nanoparticles Drug Dev. Ind. Pharm. 22 1996 841 846
83. P.C. Bessa, R. Machado, S. Nürnberger, D. Dopler, A. Banerjee, A.M. Cunha, J.C. Rodríguez-Cabello, H. Redl, M. van Griensven, and R.L. Reis Thermoresponsive self-assembled elastin-based nanoparticles for delivery of BMPs J. Control. Release 142 2010 312 318
84. A.M. De Campos, A. Sánchez, and M.a.J. Alonso Chitosan nanoparticles: a new vehicle for the improvement of the delivery of drugs to the ocular surface. Application to cyclosporin A Int. J. Pharm. 224 2001 159 168
85. J.O. You, and C.A. Peng Calciumalginate nanoparticles formed by reverse microemulsion as gene carriers Macromolecular Symposia 2005 Wiley Online Library 147 153
86. C. Chittasupho, M. Jaturanpinyo, and S. Mangmool Pectin nanoparticle enhances cytotoxicity of methotrexate against hepG2 cells Drug Deliv. 20 2013 1 9
87. D. Song, Y.S. Thio, and Y. Deng Starch nanoparticle formation via reactive extrusion and related mechanism study Carbohydr. Polym. 85 2011 208 214
88. K. Kaewprapan, P. Inprakhon, E. Marie, and A. Durand Enzymatically degradable nanoparticles of dextran esters as potential drug delivery systems Carbohydr. Polym. 88 2012 875 881
89. H. Guo, Y. Liu, Y. Wang, J. Wu, X. Yang, R. Li, Y. Wang, and N. Zhang pH-sensitive pullulan-based nanoparticle carrier for adriamycin to overcome drug-resistance of cancer cells Carbohydr. Polym. 111 2014 908 917
90. K.Y. Choi, H. Chung, K.H. Min, H.Y. Yoon, K. Kim, J.H. Park, I.C. Kwon, and S.Y. Jeong Self-assembled hyaluronic acid nanoparticles for active tumor targeting Biomaterials 31 2010 106 114
91. K. Numata, and D.L. Kaplan Silk-based delivery systems of bioactive molecules Adv. Drug Deliv. Rev. 62 2010 1497 1508
92. S. Kundu Silk Biomaterials for Tissue Engineering and Regenerative Medicine 2014 Elsevier
93. B. Mahendran, S.K. Ghosh, and S.C. Kundu Molecular phylogeny of silk producing insects based on internal transcribed spacer DNA1 J. Biochem. Mol. Biol. 39 2006 522
94. M.S. Jolly, S. Sen, and M.M. Ahsan Tasar Culture 1974 Ambika publishers Bombay
95. G.H. Altman, F. Diaz, C. Jakuba, T. Calabro, R.L. Horan, J. Chen, H. Lu, J. Richmond, and D.L. Kaplan Silk-based biomaterials Biomaterials 24 2003 401 416
96. K. McGrath, and D. Kaplan Protein-based Materials 1997 Springer
97. S. Inoue, K. Tanaka, F. Arisaka, S. Kimura, K. Ohtomo, and S. Mizuno Silk fibroin of Bombyx mori is secreted, assembling a high molecular mass elementary unit consisting of H-chain, l-chain, and P25, with a 6: 6: 1 molar ratio J. Biol. Chem. 275 2000 40517 40528
98. E. Bini, D.P. Knight, and D.L. Kaplan Mapping domain structures in silks from insects and spiders related to protein assembly J. Mol. Biol. 335 2004 27 40
99. T. Gamo, T. Inokuchi, and H. Laufer Polypeptides of fibroin and sericin secreted from the different sections of the silk gland in Bombyx mori Insect Biochem. 7 1977 285 295
100. M. Zurovec, C. Yang, D. KodrIÍk, and F. Sehnal Identification of a novel type of silk protein and regulation of its expression J. Biol. Chem. 273 1998 15423 15428
101. M.-p. Ho, H. Wang, and K.-t. Lau Effect of degumming time on silkworm silk fibre for biodegradable polymer composites Appl. Surf. Sci. 258 2012 3948 3955
102. S. Hofmann, C. Wong Po Foo, F. Rossetti, M. Textor, G. Vunjak-Novakovic, D. Kaplan, H. Merkle, and L. Meinel Silk fibroin as an organic polymer for controlled drug delivery J. Control. Release 111 2006 219 227
103. O. Kratky, E. Schauenstein, and A. Sekora An unstable lattice in silk fibroin Nature 165 1950 319 320
104. L.F. Drummy, D.M. Phillips, M.O. Stone, B. Farmer, and R.R. Naik Thermally induced α-helix to β-sheet transition in regenerated silk fibers and films Biomacromolecules 6 2005 3328 3333
105. T. Asakura, J. Ashida, T. Yamane, T. Kameda, Y. Nakazawa, K. Ohgo, and K. Komatsu A repeated β-turn structure in Poly (Ala-Gly) as a model for silk I of Bombyx mori silk fibroin studied with two-dimensional spin-diffusion NMR under off magic angle spinning and rotational echo double resonance J. Mol. Biol. 306 2001 291 305
106. J.P. Anderson Morphology and Crystal Structure of a Recombinant Silk-like Molecule, SLP4 1998
107. C. Zhao, J. Yao, H. Masuda, R. Kishore, and T. Asakura Structural characterization and artificial fiber formation of Bombyx mori silk fibroin in hexafluoroisopropanol solvent system Biopolymers 69 2003 253 259
108. P. Garside, and P. Wyeth Crystallinity and degradation of silk: correlations between analytical signatures and physical condition on ageing Appl. Phys. A 89 2007 871 876
109. P. Monti, G. Freddi, A. Bertoluzza, N. Kasai, and M. Tsukada Raman spectroscopic studies of silk fibroin from Bombyx mori J. Raman Spectrosc. 29 1998 297 304
110. E. Wenk, A.J. Wandrey, H.P. Merkle, and L. Meinel Silk fibroin spheres as a platform for controlled drug delivery J. Control. Release 132 2008 26 34
111. A. Motta, L. Fambri, and C. Migliaresi Regenerated silk fibroin films: thermal and dynamic mechanical analysis Macromol. Chem. Phys. 203 2002 1658 1665
112. J. Nam, and Y.H. Park Morphology of regenerated silk fibroin: effects of freezing temperature, alcohol addition, and molecular weight J. Appl. Polym. Sci. 81 2001 3008 3021
113. F. Xie, H. Zhang, H. Shao, and X. Hu Effect of shearing on formation of silk fibers from regenerated Bombyx mori silk fibroin aqueous solution Int. J. Biol. Macromol. 38 2006 284 288
114. X.-H. Zong, P. Zhou, Z.-Z. Shao, S.-M. Chen, X. Chen, B.-W. Hu, F. Deng, and W.-H. Yao Effect of pH and copper (II) on the conformation transitions of silk fibroin based on EPR, NMR, and Raman spectroscopy Biochemistry 43 2004 11932 11941
115. K.S. Soppimath, T.M. Aminabhavi, A.R. Kulkarni, and W.E. Rudzinski Biodegradable polymeric nanoparticles as drug delivery devices J. Control. Release 70 2001 1 20
116. K.A. Athanasiou, A.R. Shah, R.J. Hernandez, and R.G. LeBaron Basic science of articular cartilage repair Clin. Sports Med. 20 2001 223 247
117. E. Dawson, G. Mapili, K. Erickson, S. Taqvi, and K. Roy Biomaterials for stem cell differentiation Adv. Drug Deliv. Rev. 60 2008 215 228
118. M. Farokhi, F. Mottaghitalab, J. Hadjati, R. Omidvar, M. Majidi, A. Amanzadeh, M. Azami, S.M. Tavangar, M.A. Shokrgozar, and J. Ai Structural and functional changes of silk fibroin scaffold due to hydrolytic degradation J. Appl. Polym. Sci. 131 2014
119. E. Wenk, A.J. Meinel, S. Wildy, H.P. Merkle, and L. Meinel Microporous silk fibroin scaffolds embedding PLGA microparticles for controlled growth factor delivery in tissue engineering Biomaterials 30 2009 2571 2581
120. R.L. Horan, K. Antle, A.L. Collette, Y. Wang, J. Huang, J.E. Moreau, V. Volloch, D.L. Kaplan, and G.H. Altman In vitro degradation of silk fibroin Biomaterials 26 2005 3385 3393
121. Y. Wang, D.D. Rudym, A. Walsh, L. Abrahamsen, H.-J. Kim, H.S. Kim, C. Kirker-Head, and D.L. Kaplan In vivo degradation of three-dimensional silk fibroin scaffolds Biomaterials 29 2008 3415 3428
122. H. Hosseinkhani, and M. Hosseinkhani Biodegradable polymer-metal complexes for gene and drug delivery Curr. Drug Saf. 4 2009 79 83
123. K. Subramani, H. Hosseinkhani, A. Khraisat, M. Hosseinkhani, and Y. Pathak Targeting nanoparticles as drug delivery systems for cancer treatment Curr. Nanosci. 5 2009 135 140
124. H. Hosseinkhani, M. Hosseinkhani, E.V. Farahani, and M.N. Haghighi In vitro sustained release and degradation study of biodegradable poly (d, l-lactic acid) microspheres loading theophylline Adv. Sci. Lett. 2 2009 70 77
125. M. Mahmoudi, H. Hosseinkhani, M. Hosseinkhani, S. Boutry, A. Simchi, W.S. Journeay, K. Subramani, and S. Laurent Magnetic resonance imaging tracking of stem cells in vivo using iron oxide nanoparticles as a tool for the advancement of clinical regenerative medicine Chem. Rev. 111 2010 253 280
126. R. Amini, H. Hosseinkhani, A. Jalilian, S. Abdullah, and R. Rosli Engineered smart biomaterials for gene delivery Gene Ther. Mol. Biol. 14 2012 72 86
127. H. Hosseinkhani 3D in vitro technology for drug discovery Curr. Drug Saf. 7 2012 37 43
128. K. Subramani, S. Pathak, and H. Hosseinkhani Recent trends in diabetes treatment using nanotechnology Dig. J. Nanomater. Biostruct. 7 2012 85 95
129. H. Hosseinkhani, P.-D. Hong, and D.-S. Yu Self-assembled proteins and peptides for regenerative medicine Chem. Rev. 113 2013 4837 4861
130. C.R. Wittmer, X. Hu, P.-C. Gauthier, S. Weisman, D.L. Kaplan, and T.D. Sutherland Production, structure and in vitro degradation of electrospun honeybee silk nanofibers Acta Biomater. 7 2011 3789 3795
131. S.-H. Park, E.S. Gil, H. Shi, H.J. Kim, K. Lee, and D.L. Kaplan Relationships between degradability of silk scaffolds and osteogenesis Biomaterials 31 2010 6162 6172
132. M. Lovett, C. Cannizzaro, L. Daheron, B. Messmer, G. Vunjak-Novakovic, and D.L. Kaplan Silk fibroin microtubes for blood vessel engineering Biomaterials 28 2007 5271 5279
133. Y. Yang, Y. Zhao, Y. Gu, X. Yan, J. Liu, F. Ding, and X. Gu Degradation behaviors of nerve guidance conduits made up of silk fibroin in vitro and in vivo Polym. Degrad. Stab. 94 2009 2213 2220
134. M. Li, M. Ogiso, and N. Minoura Enzymatic degradation behavior of porous silk fibroin sheets Biomaterials 24 2003 357 365
135. J. Zhou, C. Cao, X. Ma, L. Hu, L. Chen, and C. Wang In vitro and in vivo degradation behavior of aqueous-derived electrospun silk fibroin scaffolds Polym. Degrad. Stab. 95 2010 1679 1685
136. F. Chiellini, A.M. Piras, C. Errico, and E. Chiellini Micro/nanostructured Polymeric Systems for Biomedical and Pharmaceutical Applications 2008
137. D.S. Kohane Microparticles and nanoparticles for drug delivery Biotechnol. Bioeng. 96 2007 203 209
138. M. Vandelli, F. Rivasi, P. Guerra, F. Forni, and R. Arletti Gelatin microspheres crosslinked with d, l-glyceraldehyde as a potential drug delivery system: preparation, characterisation, in vitro and in vivo studies Int. J. Pharm. 215 2001 175 184
139. R. Arshady Review: biodegradable microcapsular drug delivery systems: manufacturing methodology, release control and targeting prospects J. Bioact. Compat. Polym. 5 1990 315 342
140. G.A. Digenis, T.B. Gold, and V.P. Shah Crosslinking of gelatin capsules and its relevance to their in vitroin vivo performance J. Pharm. Sci. 83 1994 915 921
141. J. Gosline, P. Guerette, C. Ortlepp, and K. Savage The mechanical design of spider silks: from fibroin sequence to mechanical function J. Exp. Biol. 202 1999 3295 3303
142. Y. Horikawa, K. Ohtomo, Finely powdered fibroin and process for producing same, in, Google Patents, 1980.
143. D. Akiyama, and K. Hirabayashi Effect of preparation method of powdered silk on the mechanical properties of moulded silk Polymer 35 1994 2355 2358
144. T. Hino, M. Tanimoto, and S. Shimabayashi Change in secondary structure of silk fibroin during preparation of its microspheres by spray-drying and exposure to humid atmosphere J. Colloid Interface Sci. 266 2003 68 73
145. J.-H. Yeo, K.-G. Lee, Y.-W. Lee, and S.Y. Kim Simple preparation and characteristics of silk fibroin microsphere Eur. Polym. J. 39 2003 1195 1199
146. A. Gholami, H. Tavanai, and A. Moradi Production of fibroin nanopowder through electrospraying J. Nanoparticle Res. 13 2011 2089 2098
147. P. Shi, and J.C. Goh Self-assembled silk fibroin particles: tunable size and appearance Powder Technol. 215 2012 85 90
148. X. Wang, E. Wenk, A. Matsumoto, L. Meinel, C. Li, and D.L. Kaplan Silk microspheres for encapsulation and controlled release J. Control. Release 117 2007 360 370
149. J.G. Hardy, and T.R. Scheibel Composite materials based on silk proteins Prog. Polym. Sci. 35 2010 1093 1115
150. C. Fu, Z. Shao, and V. Fritz Animal silks: their structures, properties and artificial production Chem. Commun. 2009 6515 6529
151. M. Kazemimostaghim, R. Rajkhowa, T. Tsuzuki, and X. Wang Production of submicron silk particles by milling Powder Technol. 241 2013 230 235
152. R. Rajkhowa, L. Wang, and X. Wang Ultra-fine silk powder preparation through rotary and ball milling Powder Technol. 185 2008 87 95
153. A.S. Lammel, X. Hu, S.-H. Park, D.L. Kaplan, and T.R. Scheibel Controlling silk fibroin particle features for drug delivery Biomaterials 31 2010 4583 4591
154. P. Shi, and J.C. Goh Release and cellular acceptance of multiple drugs loaded silk fibroin particles Int. J. Pharm. 420 2011 282 289
155. Y. Baimark, P. Srihanam, Y. Srisuwan, and P. Phinyocheep Preparation of porous silk fibroin microparticles by a waterinoil emulsificationdiffusion method J. Appl. Polym. Sci. 118 2010 1127 1133
156. Z. Cao, X. Chen, J. Yao, L. Huang, and Z. Shao The preparation of regenerated silk fibroin microspheres Soft Matter 3 2007 910 915
157. Y. Srisuwan, P. Srihanam, and Y. Baimark Preparation of silk fibroin microspheres and its application to protein adsorption J. Macromol. Sci. Part A Pure Appl. Chem. 46 2009 521 525
158. X. Wang, T. Yucel, Q. Lu, X. Hu, and D.L. Kaplan Silk nanospheres and microspheres from silk/pva blend films for drug delivery Biomaterials 31 2010 1025 1035
159. V. Karageorgiou, L. Meinel, S. Hofmann, A. Malhotra, V. Volloch, and D. Kaplan Bone morphogenetic protein2 decorated silk fibroin films induce osteogenic differentiation of human bone marrow stromal cells J. Biomed. Mater. Res. Part A 71 2004 528 537
160. V. Karageorgiou, M. Tomkins, R. Fajardo, L. Meinel, B. Snyder, K. Wade, J. Chen, G. VunjakNovakovic, and D.L. Kaplan Porous silk fibroin 3D scaffolds for delivery of bone morphogenetic protein2 in vitro and in vivo J. Biomed. Mater. Res. Part A 78 2006 324 334
161. B. Kundu, R. Rajkhowa, S.C. Kundu, and X. Wang Silk fibroin biomaterials for tissue regenerations Adv. Drug Deliv. Rev. 65 2013 457 470
162. R. Rajkhowa, X. Wang, and S. Kundu Silk powder for regenerative medicine Silk Biomaterials for Tissue Engineering and Regenerative Medicine 2014 191
163. K. Jastrzebska, K. Kucharczyk, A. Florczak, E. Dondajewska, A. Mackiewicz, and H. Dams-Kozlowska Silk as an innovative biomaterial for cancer therapy Rep. Pract. Oncol. Radiother. 20 2014 87 98
164. F.P. Seib, G.T. Jones, J. RnjakKovacina, Y. Lin, and D.L. Kaplan pHdependent anticancer drug release from silk nanoparticles Adv. Healthcare Mater. 2 2013 1606 1611
165. A.B. Mathur, and V. Gupta Silk fibroin-derived nanoparticles for biomedical applications Nanomedicine 5 2010 807 820
166. J. Kundu, Y.-I. Chung, Y.H. Kim, G. Tae, and S. Kundu Silk fibroin nanoparticles for cellular uptake and control release Int. J. Pharm. 388 2010 242 250
167. K.P.R. Chowdary, and Y. Srinivasa Rao Mucoadhesive microspheres for controlled drug delivery Biol. Pharm. Bull. 27 2004 1717 1724
168. P.H. Hoet, I. Brüske-Hohlfeld, and O.V. Salata Nanoparticles-known and unknown health risks J. Nanobiotechnol. 2 2004 12
169. R.C. Mundargi, V.R. Babu, V. Rangaswamy, P. Patel, and T.M. Aminabhavi Nano/micro technologies for delivering macromolecular therapeutics using poly (d, l-lactide-co-glycolide) and its derivatives J. Control. Release 125 2008 193 209
170. E. Rytting, J. Nguyen, X. Wang, and T. Kissel Biodegradable Polymeric Nanocarriers for Pulmonary Drug Delivery 2008
171. J.A. Champion, Y.K. Katare, and S. Mitragotri Particle shape: a new design parameter for micro-and nanoscale drug delivery carriers J. Control. Release 121 2007 3 9
172. Y.-Q. Zhang, W.-D. Shen, R.-L. Xiang, L.-J. Zhuge, W.-J. Gao, and W.-B. Wang Formation of silk fibroin nanoparticles in water-miscible organic solvent and their characterization J. Nanoparticle Res. 9 2007 885 900
173. K. Numata 19 - Silk hydrogels for tissue engineering and dual-drug delivery S.C. Kundu, Silk Biomaterials for Tissue Engineering and Regenerative Medicine 2014 Woodhead Publishing 503 518
174. X. Hu, Q. Lu, L. Sun, P. Cebe, X. Wang, X. Zhang, and D.L. Kaplan Biomaterials from ultrasonication-induced silk fibroin - hyaluronic acid hydrogels Biomacromolecules 11 2010 3178 3188
175. X. Wang, J.A. Kluge, G.G. Leisk, and D.L. Kaplan Sonication-induced gelation of silk fibroin for cell encapsulation Biomaterials 29 2008 1054 1064
176. U.-J. Kim, J. Park, C. Li, H.-J. Jin, R. Valluzzi, and D.L. Kaplan Structure and properties of silk hydrogels Biomacromolecules 5 2004 786 792
177. P.C. Bessa, E.R. Balmayor, H.S. Azevedo, S. Nürnberger, M. Casal, M. Van Griensven, R. Reis, and H. Redl Silk fibroin microparticles as carriers for delivery of human recombinant BMPs. Physical characterization and drug release J. Tissue Eng. Regen. Med. 4 2010 349 355
178. L.-Y. Wang, Y.-H. Gu, Z.-G. Su, and G.-H. Ma Preparation and improvement of release behavior of chitosan microspheres containing insulin Int. J. Pharm. 311 2006 187 195
179. U. Bilati, E. Allémann, and E. Doelker Strategic approaches for overcoming peptide and protein instability within biodegradable nano-and microparticles Eur. J. Pharm. Biopharm. 59 2005 375 388
180. M. Hofer, G. Winter, and J. Myschik Recombinant spider silk particles for controlled delivery of protein drugs Biomaterials 33 2012 1554 1562
181. N.A. Guziewicz, A.J. Massetti, B.J. Perez-Ramirez, and D.L. Kaplan Mechanisms of monoclonal antibody stabilization and release from silk biomaterials Biomaterials 34 2013 7766 7775
182. A. Matsumoto, J. Chen, A.L. Collette, U.-J. Kim, G.H. Altman, P. Cebe, and D.L. Kaplan Mechanisms of silk fibroin sol-gel transitions J. Phys. Chem. B 110 2006 21630 21638
183. O. Germershaus, V. Werner, M. Kutscher, and L. Meinel Deciphering the mechanism of protein interaction with silk fibroin for drug delivery systems Biomaterials 35 2014 3427 3434
184. L.M. Holle Pegaspargase: an alternative? Ann. Pharmacother. 31 1997 616 624
185. S.L. Berg, F.M. Balis, C.L. McCully, K.S. Godwin, and D.G. Poplack Pharmacokinetics of PEG-l-asparaginase and plasma and cerebrospinal fluidl-asparagine concentrations in the rhesus monkey Cancer Chemother. Pharmacol. 32 1993 310 314
186. M.J. Keating, R. Holmes, S. Lerner, and D.H. Ho l-asparaginase and PEG asparaginase-past, present, and future Leuk. Lymphoma 10 1993 153 157
187. L. Grasset, D. Cordier, and A. Ville Woven silk as a carrier for the immobilization of enzymes Biotechnol. Bioeng. 19 1977 611 618
188. S. Inoue, Y. Matsunaga, H. Iwane, M. Sotomura, and T. Nose Entrapment of phenylalanine ammonia-lyase in silk fibroin for protection from proteolytic attack Biochem. Biophys. Res. Commun. 141 1986 165 170
189. H.-B. Yan, Y.-Q. Zhang, Y.-L. Ma, and L.-X. Zhou Biosynthesis of insulin-silk fibroin nanoparticles conjugates and in vitro evaluation of a drug delivery system J. Nanoparticle Res. 11 2009 1937 1946
190. Y.-Q. Zhang, R.-L. Xiang, H.-B. Yan, and X.-X. Chen Preparation of silk fibroin nanoparticles and their application to immobilization of l-asparaginase Chem. J. Chin. Univ. 29 2008 628 633
191. Z.Z. Zhou, and Y.Q. Zhang Biosynthesis of β-glucosidase-silk fibroin nanoparticles conjugates and enzymatic characteristics Adv. Mater. Res. 175 2011 186 191
192. Y.-Q. Zhang, Y.-J. Wang, H.-Y. Wang, L. Zhu, and Z.-Z. Zhou Highly efficient processing of silk fibroin nanoparticle-l-asparaginase bioconjugates and their characterization as a drug delivery system Soft Matter 7 2011 9728 9736
193. M. Grellier, L. Bordenave, and J. Amedee Cell-to-cell communication between osteogenic and endothelial lineages: implications for tissue engineering Trends Biotechnol. 27 2009 562 571
194. J.J. Moon, and J.L. West Vascularization of engineered tissues: approaches to promote angio-genesis in biomaterials Curr. Top. Med. Chem. 8 2008 300
195. S. Yang, K.-F. Leong, Z. Du, and C.-K. Chua The design of scaffolds for use in tissue engineering. Part I. Traditional factors Tissue Eng. 7 2001 679 689
196. R.E. Unger, A. Sartoris, K. Peters, A. Motta, C. Migliaresi, M. Kunkel, U. Bulnheim, J. Rychly, and C. James Kirkpatrick Tissue-like self-assembly in cocultures of endothelial cells and osteoblasts and the formation of microcapillary-like structures on three-dimensional porous biomaterials Biomaterials 28 2007 3965 3976
197. J. Rouwkema, J.D. Boer, and C.A.V. Blitterswijk Endothelial cells assemble into a 3-dimensional prevascular network in a bone tissue engineering construct Tissue Eng. 12 2006 2685 2693
198. D. Kaigler, Z. Wang, K. Horger, D.J. Mooney, and P.H. Krebsbach VEGF scaffolds enhance angiogenesis and bone regeneration in irradiated osseous defects J. Bone Miner. Res. 21 2006 735 744
199. M. Farokhi, F. Mottaghitalab, M.A. Shokrgozar, J. Ai, J. Hadjati, and M. Azami Bio-hybrid silk fibroin/calcium phosphate/PLGA nanocomposite scaffold to control the delivery of vascular endothelial growth factor Mater. Sci. Eng. C 35 2014 401 410
200. N. Ferrara, H.-P. Gerber, and J. LeCouter The biology of VEGF and its receptors Nat. Med. 9 2003 669 676
201. M. Farokhi, F. Mottaghitalab, J. Ai, and M.A. Shokrgozar Sustained release of platelet-derived growth factor and vascular endothelial growth factor from silk/calcium phosphate/PLGA based nanocomposite scaffold Int. J. Pharm. 454 2013 216 225
202. L. Uebersax, M. Mattotti, M. Papaloïzos, H.P. Merkle, B. Gander, and L. Meinel Silk fibroin matrices for the controlled release of nerve growth factor (NGF) Biomaterials 28 2007 4449 4460
203. L. Uebersax, H.P. Merkle, and L. Meinel Insulin-like growth factor I releasing silk fibroin scaffolds induce chondrogenic differentiation of human mesenchymal stem cells J. Control. Release 127 2008 12 21
204. E. Wenk, A.R. Murphy, D.L. Kaplan, L. Meinel, H.P. Merkle, and L. Uebersax The use of sulfonated silk fibroin derivatives to control binding, delivery and potency of FGF-2 in tissue regeneration Biomaterials 31 2010 1403 1413
205. C. Kirker-Head, V. Karageorgiou, S. Hofmann, R. Fajardo, O. Betz, H. Merkle, M. Hilbe, B. Von Rechenberg, J. McCool, and L. Abrahamsen BMP-silk composite matrices heal critically sized femoral defects Bone 41 2007 247 255
206. C. Szybala, E.M. Pritchard, T.A. Lusardi, T. Li, A. Wilz, D.L. Kaplan, and D. Boison Antiepileptic effects of silk-polymer based adenosine release in kindled rats Exp. Neurol. 219 2009 126 135
207. E.S. Gil, B. Panilaitis, E. Bellas, and D.L. Kaplan Functionalized silk biomaterials for wound healing Adv. Healthcare Mater. 2 2013 206 217
208. R.-D. Hofheinz, S.U. Gnad-Vogt, U. Beyer, and A. Hochhaus Liposomal encapsulated anti-cancer drugs Anticancer Drugs 16 2005 691 707
209. R. Duncan The dawning era of polymer therapeutics Nat. Rev. Drug Discov. 2 2003 347 360
210. R. Duncan Polymer conjugates as anticancer nanomedicines Nat. Rev. Cancer 6 2006 688 701
211. D.J. Bharali, M. Khalil, M. Gurbuz, T.M. Simone, and S.A. Mousa Nanoparticles and cancer therapy: a concise review with emphasis on dendrimers Int. J. Nanomedicine 4 2009 1
212. Z.G. Chen Small-molecule delivery by nanoparticles for anticancer therapy Trends Mol. Med. 16 2010 594 602
213. C. Li Poly (l-glutamic acid)-anticancer drug conjugates Adv. Drug Deliv. Rev. 54 2002 695 713
214. P. Sabbatini, C. Aghajanian, D. Dizon, S. Anderson, J. Dupont, J.V. Brown, W.A. Peters, A. Jacobs, A. Mehdi, and S. Rivkin Phase II study of CT-2103 in patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal carcinoma J. Clin. Oncol. 22 2004 4523 4531
215. K. Cho, X. Wang, S. Nie, and D.M. Shin Therapeutic nanoparticles for drug delivery in cancer Clin. Cancer Res. 14 2008 1310 1316
216. J. Homsi, G.R. Simon, C.R. Garrett, G. Springett, R. De Conti, A.A. Chiappori, P.N. Munster, M.K. Burton, S. Stromatt, and C. Allievi Phase I trial of poly-l-glutamate camptothecin (CT-2106) administered weekly in patients with advanced solid malignancies Clin. Cancer Res. 13 2007 5855 5861
217. A.S. Gobin, R. Rhea, R.A. Newman, and A.B. Mathur Silk-fibroin-coated liposomes for long-term and targeted drug delivery Int. J. Nanomedicine 1 2006 81
218. X. Wang, X. Hu, A. Daley, O. Rabotyagova, P. Cebe, and D.L. Kaplan Nanolayer biomaterial coatings of silk fibroin for controlled release J. Control. Release 121 2007 190 199
219. E.M. Pritchard, T. Valentin, B. Panilaitis, F. Omenetto, and D.L. Kaplan Antibioticreleasing silk biomaterials for infection prevention and treatment Adv. Funct. Mater. 23 2013 854 861
220. C.M. Owens, C. Mawhinney, J.M. Grenier, R. Altmeyer, M.S. Lee, A.A. Borisy, J. Lehár, and L.M. Johansen Chemical combinations elucidate pathway interactions and regulation relevant to Hepatitis C replication Mol. Syst. Biol. 6 2010
221. K. Karthikeyan, S. Guhathakarta, R. Rajaram, and P.S. Korrapati Electrospun zein/eudragit nanofibers based dual drug delivery system for the simultaneous delivery of aceclofenac and pantoprazole Int. J. Pharm. 438 2012 117 122
222. J.K. Oh, D.J. Siegwart, and K. Matyjaszewski Synthesis and biodegradation of nanogels as delivery carriers for carbohydrate drugs Biomacromolecules 8 2007 3326 3331
223. M.S. Muthu, M.K. Rawat, A. Mishra, and S. Singh PLGA nanoparticle formulations of risperidone: preparation and neuropharmacological evaluation Nanomed. Nanotechnol. Biol. Med. 5 2009 323 333
224. J.T. Zhang, S.W. Huang, Y.N. Xue, and R.X. Zhuo Poly (Nisopropylacrylamide) nanoparticleincorporated PNIPAAm hydrogels with fast shrinking kinetics Macromol. Rapid Commun. 26 2005 1346 1350
225. K. Numata, S. Yamazaki, and N. Naga Biocompatible and biodegradable dual-drug release system based on silk hydrogel containing silk nanoparticles Biomacromolecules 13 2012 1383 1389
226. D.N. Rockwood, R.C. Preda, T. Yücel, X. Wang, M.L. Lovett, and D.L. Kaplan Materials fabrication from Bombyx mori silk fibroin Nat. Protoc. 6 2011 1612 1631
227. M.E. Davis Nanoparticle therapeutics: an emerging treatment modality for cancer Nat. Rev. Drug Discov. 7 2008 771 782
228. X. Wang, E. Wenk, X. Hu, G.R. Castro, L. Meinel, X. Wang, C. Li, H. Merkle, and D.L. Kaplan Silk coatings on PLGA and alginate microspheres for protein delivery Biomaterials 28 2007 4161 4169
229. J. Ferlay, H.R. Shin, F. Bray, D. Forman, C. Mathers, and D.M. Parkin Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008 Int. J. Cancer 127 2010 2893 2917
230. A. Jemal, R. Siegel, E. Ward, Y. Hao, J. Xu, T. Murray, and M.J. Thun Cancer statistics, 2008 CA Cancer J. Clin. 58 2008 71 96
231. L. Brannon-Peppas, and J.O. Blanchette Nanoparticle and targeted systems for cancer therapy Adv. Drug Deliv. Rev. 64 2012 206 212
232. S.-S. Feng Nanoparticles of Biodegradable Polymers for New-concept Chemotherapy 2004
233. X. Jia, and L. Jia Nanoparticles improve biological functions of phthalocyanine photosensitizers used for photodynamic therapy Curr. Drug Metab. 13 2012 1119 1122
234. J. Shao, Y. Dai, W. Zhao, J. Xie, J. Xue, J. Ye, and L. Jia Intracellular distribution and mechanisms of actions of photosensitizer Zinc (II)-phthalocyanine solubilized in Cremophor EL against human hepatocellular carcinoma HepG2 cells Cancer Lett. 330 2013 49 56
235. Y. Gao, J. Xie, H. Chen, S. Gu, R. Zhao, J. Shao, and L. Jia Nanotechnology-based intelligent drug design for cancer metastasis treatment Biotechnol. Adv. 32 2013 761 777
236. X. Wang, L. Yang, Z.G. Chen, and D.M. Shin Application of nanotechnology in cancer therapy and imaging CA Cancer J. Clin. 58 2008 97 110
237. O.C. Farokhzad, and R. Langer Impact of nanotechnology on drug delivery ACS Nano 3 2009 16 20
238. S. Biswas, and V.P. Torchilin Nanopreparations for organelle-specific delivery in cancer Adv. Drug Deliv. Rev. 66 2014 26 41
239. J.K. Vasir, and V. Labhasetwar Targeted drug delivery in cancer therapy Technol. Cancer Res. Treat. 4 2005 363 374
240. V. Gupta, A. Aseh, C.N. Ríos, B.B. Aggarwal, and A.B. Mathur Fabrication and characterization of silk fibroin-derived curcumin nanoparticles for cancer therapy Int. J. Nanomedicine 4 2009 115
241. X.-X. Xia, M. Wang, Y. Lin, Q. Xu, and D.L. Kaplan Hydrophobic drug-triggered self-assembly of nanoparticles from silk-elastin-like protein polymers for drug delivery Biomacromolecules 15 2014 908 914
242. B. Subia, S. Chandra, S. Talukdar, and S.C. Kundu Folate conjugated silk fibroin nanocarriers for targeted drug delivery Integr. Biol. 6 2014 203 214
243. P. Wu, Q. Liu, R. Li, J. Wang, X. Zhen, G. Yue, H. Wang, F. Cui, F. Wu, and M. Yang Facile preparation of paclitaxel loaded silk fibroin nanoparticles for enhanced antitumor efficacy by locoregional drug delivery ACS Appl. Mater. Interfaces 5 2013 12638 12645
244. M. Chen, Z. Shao, and X. Chen Paclitaxelloaded silk fibroin nanospheres J. Biomed. Mater. Res. Part A 100 2012 203 210
245. N. Vadia, and S. Rajput Study on formulation variables of methotrexate loaded mesoporous MCM-41 nanoparticles for dissolution enhancement Eur. J. Pharm. Sci. 45 2012 8 18
246. A. Taheri, R. Dinarvand, F.S. Nouri, M.R. Khorramizadeh, A.T. Borougeni, P. Mansoori, and F. Atyabi Use of biotin targeted methotrexate-human serum albumin conjugated nanoparticles to enhance methotrexate antitumor efficacy Int. J. Nanomedicine 6 2011 1863
247. B. Subia, and S. Kundu Drug loading and release on tumor cells using silk fibroin-albumin nanoparticles as carriers Nanotechnology 24 2013 035103