Porous crosslinked poly(ε-caprolactone fumarate)/nanohydroxyapatite composites for bone tissue engineering

Journal of Biomedical Materials Research - Part A

Volumn 100 A, Issue 4, 2012, Pages 1051-1060

  Farokhi, M ^a,b   Sharifi, S ^c,d   Shafieyan, Y ^a,c   Bagher, Z ^a   Mottaghitalab, F ^a,e   Hatampoor, A ^a   Imani, M ^c   Shokrgozar, M A ^a  

^a PASTEUR INSTITUTE OF IRAN   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^d AMIRKABIR UNIVERSITY OF TECHNOLOGY   (Iran)

^e TARBIAT MODARES UNIVERSITY   (Iran)

Author keywords

biocompatibility; bone tissue engineering; mechanical properties; nano hydroxyapatite; nanocomposite scaffold; poly( caprolactone fumarate)

Indexed keywords

ALKALINE PHOSPHATASE ACTIVITY; BONE GRAFT; BONE SUBSTITUTION; BONE TISSUE ENGINEERING; CAPROLACTONE; CELL ATTACHMENTS; CELL-MATERIAL INTERACTION; CONTROL GROUPS; CROSSLINKED; CYCLIC LOADINGS; FILLER PHASE; FUMARATES; IN-VITRO; MTT ASSAYS; N-VINYL PYRROLIDONE; NANO-HYDROXYAPATITE; OSTEOBLASTIC CELLS; PARTICULATE LEACHING; REACTIVE DILUENTS; RESIN MATRIX; THERMAL CROSSLINKING; TISSUE CULTURE POLYSTYRENES;

BIOACTIVITY; BIOCOMPATIBILITY; BIOMECHANICS; BONE; FILLERS; LEACHING; MECHANICAL PROPERTIES; NANOCOMPOSITES; PHOSPHATASES; POLYSTYRENES; TISSUE CULTURE;

SCAFFOLDS (BIOLOGY);

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ALKALINE PHOSPHATASE; FILLER; HYDROXYAPATITE; NANOCOMPOSITE; POLY(EPSILON CAPROLACTONE FUMARATE); POLYSTYRENE; POROUS POLYMER; POVIDONE; RESIN; TISSUE SCAFFOLD; UNCLASSIFIED DRUG;

ARTICLE; BIOCOMPATIBILITY; BONE GRAFT; BONE TISSUE; CELL ADHESION; CELL ASSAY; CELL LINE; CELL PROLIFERATION; CELL SPREADING; COMPOSITE MATERIAL; CONTROLLED STUDY; CROSS LINKING; DRUG ACTIVITY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; LEACHING; NONHUMAN; OSTEOBLAST; STRENGTH; TISSUE CULTURE; TISSUE ENGINEERING; YOUNG MODULUS;

ALKALINE PHOSPHATASE; BIOCOMPATIBLE MATERIALS; BONE AND BONES; CELL LINE, TUMOR; DURAPATITE; FUMARATES; HUMANS; MICROSCOPY, ELECTRON, SCANNING; NANOPARTICLES; POLYESTERS; TISSUE ENGINEERING;

EID: 84857368364     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.33241     Document Type: Article

References (31)

1. Anselme K, Osteoblast adhesion on biomaterials. Biomaterials 2000; 21: 667-681.
2. Yang S, Leong KF, Du Z, Chua CK,. The design of scaffolds for use in tissue engineering. I. Traditional factors. Tissue Eng 2001; 7: 679-689.
3. Boccaccini AR, Blaker JJ,. Bioactive composite materials for tissue engineering scaffolds. Expert Rev Med Devices 2005; 2: 303-317.
4. Pezzotti G, Asmus SMF,. Fracture behavior of hydroxyapatite/polymer interpenetrating network composites prepared by in situ polymerization process. Mater Sci Eng A 2001; 316: 231-237.
5. Jabbari E, Wang SF, Lu LC, Gruetzmacher JA, Ameenuddin S, Hefferan TE, Currier BL, Windebank AJ, Yaszemski MJ,. Synthesis, material properties, and biocompatibility of a novel self-cross-linkable poly(caprolactone fumarate) as an injectable tissue engineering scaffold. Biomacromolecules 2005; 6: 2503-2511.
6. Jo S, Shin H, Shung AK, Fisher JP, Mikos AG,. Synthesis and characterization of oligo(poly(ethylene glycol) fumarate) macromer. Macromolecules 2001; 34: 2839-2844.
7. Suggs LJ, Payne RG, Yaszemski MJ, Alemany LB, Mikos AG,. Synthesis and characterization of a block copolymer consisting of poly(propylene fumarate) and poly(ethylene glycol). Macromolecules 1997; 30: 4318-4323.
8. Suggs LJ, Mikos AG,. Development of poly(propylene fumarate-co-ethylene glycol) as an injectable carrier for endothelial cells. Cell Transplant 1999; 8: 345-350.
9. Wang SF, Lu LC, Gruetzmacher JA, Currier BL, Yaszemski MJ,. Synthesis and characterizations of biodegradable and crosslinkable poly(epsilon-caprolactone fumarate), poly(ethylene glycol fumarate), and their amphiphilic copolymer. Biomaterials 2006; 27: 832-841.
10. Sharifi S, Imani M, Mirzadeh H, Atai M, Ziaee F, Bakhshi R,. Synthesis, characterization, and biocompatibility of novel injectable, biodegradable, and in situ crosslinkable polycarbonate-based macromers. J Biomed Mater Res A 2009; 90: 830-843.
11. Wang SF, Kempen DHR, Yaszemski MJ, Lu LC,. The roles of matrix polymer crystallinity and hydroxyapatite nanoparticles in modulating material properties of photo-crosslinked composites and bone marrow stromal cell responses. Biomaterials 2009; 30: 3359-3370.
12. Shafieyan Y, Sharifi S, Imani M, Shokrgozar MA, Aboudzadeh N, Atai M,. A biocompatible composite based on poly(ε-caprolactone fumarate) and hydroxyapatite. Polym Adv Technol 2011; 22: 2182-2190.
13. Misra SK, Mohn D, Brunner TJ, Stark WJ, Philip SE, Roy I, Salih V, Knowles JC, Boccaccini AR,. Boccaccini, Comparison of nanoscale and microscale bioactive glass on the properties of P(3HB)/Bioglass (R) composites. Biomaterials 2008; 29: 1750-1761.
14. Sharifi S, Mirzadeh H, Imani M, Ziaee F, Tajabadi M, Jamshidi A, Atai M,. Synthesis, photocrosslinking characteristics, and biocompatibility evaluation of N-vinyl pyrrolidone/polycaprolactone fumarate biomaterials using a new proton scavenger. Polym Adv Technol 2008; 19: 1828-1838.
15. Jamshidi A, Sharifi S,. HPTLC analysis of tamoxifen citrate in drug-release media during development of an in-situ-cross-linking delivery system. J Planar Chromatogr 2009; 22: 187-189.
16. Shokrgozar MA, Farokhi M, Rajaei F, Bagheri MHA, Azari SH, Ghasemi I, Mottaghitalab F, Azadmanesh K, Radfar J,. Biocompatibility evaluation of HDPE-UHMWPE reinforced β-TCP nanocomposites using highly purified human osteoblast cells. J Biomed Mater Res A 2010; 95: 1074-83.
17. Cai L, Wang SF,. Elucidating colorization in the functionalization of hydroxyl-containing polymers using unsaturated anhydrides/acyl chlorides in the presence of triethylamine. Biomacromolecules 2010; 11: 304-307.
18. Sharifi S, Mirzadeh H, Imani M, Atai M, Ziaee F,. Photopolymerization and shrinkage kinetics of in situ crosslinkable N-vinyl-pyrrolidone/poly(epsilon- caprolactone fumarate) networks. J Biomed Mater Res A 2008; 84: 545-556.
19. Klimisch HJ, Deckardt K, Gembardt C, Hildebrand B, Kuttler K, Roe FJC,. Subchronic inhalation and oral toxicity of N-vinylpyrrolidone-2. Studies in rodents. Food Chem Toxicol 1997; 35: 1061-1074.
20. Sharifi S, Mirzadeh H, Imani M, Rong Z, Jamshidi A, Shokrgozar M, Atai M, Roohpour N,. Injectable in situ forming drug delivery system based on poly(epsilon-caprolactone fumarate) for tamoxifen citrate delivery: Gelation characteristics, in vitro drug release and anti-cancer evaluation. Acta Biomater 2009; 5: 1966-1978.
21. Chen HY, Jacobs O, Wu W, Rudiger G, Schadel B,. Effect of dispersion method on tribological properties of carbon nanotube reinforced epoxy resin composites. Polym Test 2007; 26: 351-360.
22. Wang M, Hench LL, Bonfield W,. Bioglass (R) high density polyethylene composite for soft tissue applications: Preparation and evaluation. J Biomed Mater Res 1998; 42: 577-586.
23. Hou QP, Grijpma DW, Feijen J,. Creep-resistant elastomeric networks prepared by photocrosslinking fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers. Acta Biomater 2009; 5: 1543-1551.
24. Shishatskaya EI, Khlusov IA, Volova TG,. A hybrid PHB-hydroxyapatite composite for biomedical application: Production, in vitro and in vivo investigation. J Biomater Sci Polym Ed 2006; 17: 481-498.
25. Trombelli L, Penolazzi L, Torreggiani E, Farina R, Lambertini E, Vecchiatini R, Piva R,. Effect of hydroxyapatite-based biomaterials on human osteoblast phenotype. Minerva Stomatol 2010; 59: 103-115.
26. Li MY, Mondrinos MJ, Chen XS, Lelkes PI,. Co-electrospun poly (lactide-co-glycolide), gelatin, and elastin blends for tissue engineering scaffolds. Tissue Eng 2006; 12: 989.
27. Malaval L, Liu F, Roche P, Aubin JE,. Kinetics of osteoprogenitor proliferation and osteoblast differentiation in vitro. J Cell Biochem 1999; 74: 616-627.
28. Ogata K, Imazato S, Ehara A, Ebisu S, Kinomoto Y, Nakano T, Umakoshi Y,. Comparison of osteoblast responses to hydroxyapatite and hydroxyapatite/soluble calcium phosphate composites. J Biomed Mater Res A 2005; 72: 127-135.
29. Venugopal JR, Low S, Choon AT, Kumar AB, Ramakrishna S,. Nanobioengineered electrospun composite nanofibers and osteoblasts for bone regeneration. Artif Organs 2008; 32: 388-397.
30. Kim SS, Park MS, Jeon O, Choi CY, Kim BS,. Poly(lactide-co-glycolide)/ hydroxyapatite composite scaffolds for bone tissue engineering. Biomaterials 2006; 27: 1399-1409.
31. Lee KW, Wang SF, Yaszemski MJ, Lu LC,. Physical properties and cellular responses to crosslinkable poly(propylene fumarate)/hydroxyapatite nanocomposites. Biomaterials 2008; 29: 2839-2848.