Polymeric micelles as new drug carriers

Advanced Drug Delivery Reviews

Volumn 21, Issue 2, 1996, Pages 107-116

  Kwon, Glen S ^a   Okano, Teruo ^b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

doxorubicin; drug targeting; nanoscopic drug carriers; poly( benzyl L aspartate); poly(ethylene oxide); poly(L actic acid); polymeric micelles

Indexed keywords

BIOCOMPATIBILITY; BIODEGRADATION; BLOCK COPOLYMERS; CARDIOVASCULAR SYSTEM; MICELLES; MOLECULES; ONCOLOGY; SOLUBILITY; SYNTHESIS (CHEMICAL);

DOXOHUBIN; DRUG TARGETING; HYDROPHOBIC DRUGS; NANOSCOPIC DRUG CARRIERS; POLYBENZYL ASPARTATE; POLYETHYLENE OXIDE; POLYLACTIC ACID;

CONTROLLED DRUG DELIVERY;

ANTINEOPLASTIC AGENT; COPOLYMER; DOXORUBICIN; DRUG CARRIER; INDOMETACIN; N,N DIMETHYLFORMAMIDE; PACLITAXEL; PHOSPHATIDYLETHANOLAMINE; POLYLACTIC ACID; POLYMER; POLYMETHACRYLIC ACID; POLYSTYRENE;

BIOCOMPATIBILITY; BIODEGRADATION; BLOOD VESSEL; DRUG CONJUGATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG SYNTHESIS; DRUG TARGETING; HOST RESISTANCE; HYDROPHOBICITY; MICELLE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SOLID TUMOR;

EID: 0030590446     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(96)00401-2     Document Type: Review

References (43)

1. [1] Kataoka, K., Kwon, G.S., Yokoyama, M., Okano, T. and Sakurai, Y. (1993) Block copolymer micelles as vehicles for drug delivery. J. Control. Rel. 24. 119-132.
2. [2] Woodle, M.C. and Lasic, D.D. (1992) Sterically stabilized liposomes. Biochim. Biophys. ACTA 1113, 171-199.
3. [3] Gref, R., Domb, A., Quellec, P., Blunk, T., Muller, R.H., Verbavatz, J.M. and Langer R. (1995) The controlled intravenous delivery of drugs using peg-coated sterically stabilized nanospheres. Adv. Drug Deliv. Rev. 16, 215-233.
4. [4] Bergin, C., O'Leary, A., McCreary, C., Sabra, K. and Mulcahy, F. (1995) Treatment of kaposi's sarcoma with liposomal doxorubicin. Am. J. Health-Sys. Pharm. 52, 201-204.
5. [5] Gregoriadis, G. and Florence, A.T. (1993) Recent advances in drug targeting. TIBTECH 11.
6. [6] Vansteenkiste, S., Schacht, E., Duncan, R., Seymour, L., Pawluczyk, I. and Baldwin, R. (1991) Fate of glycosylated dextrans after in vivo administration. J. Control. Rel. 16, 91-100.
7. [7] Reilly, R.M., Sandhu, J., Alvarez-Diez, T.M., Gallinger, S., Kirsh, J. and Stern, H. (1995) Problems of delivery of monoclonal antibodies. Clin. Pharmacokinet. 28, 126-142.
8. [8] Senter, P.D., Wallace, P.M., Svensson, H.P., Vrudhula, V.M. Kerr, D.E., Hellstrom, I. and Hellstrom, K.E. (1993) Generation of cytotoxic agents by targeted enzymes. Bioconj. Chem. 4, 3-9.
9. [9] Burrows, F.J. and Thorpe, P.E. (1994) Vascular targeting - a new approach to the therapy of solid tumors. Pharm. Ther. 64, 155-174.
10. [10] Weinstein, J.N. and Osdol, W. (1992) The macroscopic and microscopic pharmacology of monoclonal antibodies. Int. J. Immunopharm. 14, 457-463.
11. [11] Chu, B. (1995) Structure and dynamics of block copolymer colloids. Langmuir 11, 414-421.
12. [12] Yokoyama, M. (1992) Block copolymer micelles as drug carriers. Crit. Rev. Ther. Drug Carrier Sys. 9, 213-248.
13. [13] Yokoyama, M., Sugiyama, T., Okano, T., Sakurai, Y., Naito, M. and Kataoka, K. (1993) Analysis of micelle formation of an adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer by gel permeation chromatography. Pharm. Res. 10, 895-899.
14. [14] Tian, M.T., Qin, A., Ramireddy, C., Webber, S.E., Munk, P., Tuzar, Z. and Prochazka (1993) Hybridization of block copolymer micelles. Langmuir 9, 1741-1748.
15. [15] Kwon, G., Naito, M., Yokoyama, M., Okano, T., Sakurai, Y. and Kataoka, K. (1993) Micelles based on ab block copolymers of poly(ethylene oxide) and poly(β-benzyl 1-aspartate). Langmuir 9, 945-949.
16. [16] Prochaska, K., Kiserow, D., Ramireddy, C., Tuzar, Z., Munk, P. and Webber, S.E. (1992) Time-resolved fluorescence studies of the chain dynamics of naphthalene-labeled polystyrene-block-poly(methacrylic acid) micelles in aqueous media. Macromolecules 25, 454-460.
17. [17] Kiserow, D., Prochaska, K., Ramireddy, C., Tuzar, Z., Munk, P. and Webber, S.E. (1992) Fluorimetric and quasi-elastic light scattering study of the solubilization of nonpolar low-molar mass compounds into water-soluble block copolymer micelles. Macromolecules 25, 461-469.
18. [18] Wang, Y., Balaji, R., Quirk, P. and Mattice, W.L. (1992) Detection of the rate of exchange between micelles formed by diblock copolymers in aqueous solution. Polymer Bull. 28, 333-338.
19. [19] Wu, N.M., Da, D., Rudoll, T.L., Needham, D., Whorton, A.R. and Dehirst, M.W. (1993) Increased microvascular permeability contributes to preferential accumulation of steath liposomes in tumor tissue. Cancer Res. 53, 3765-3770.
20. [20] Maeda, H., Seymour, L.W. and Miyamoto, Y. (1992) Conjugates of anticancer agents and polymers: advantages of macromolecular therapeutics in vivo. Bioconj. Chem. 3, 351-362.
21. th Iketani Conf. 1, 202-203.
22. [22] Cammas, S. and Kataoka K. (1995) Functional poly-(ethylene oxide)-co-poly(β-benzyl-1-aspartate) polymeric micelles: block copolymer synthesis and micelle formation. Macromol. Chem. Phys. 196, 1899-1905.
23. [23] Scholz, C., Iijima, M., Nagasaki, Y. and Kataoka, K. (1995) A novel reactive polymeric micelle with aldehyde groups on its surface. Macromolecules 28, 7295-7297.
24. [24] Trubetskoy, V.S. and Torchilin, V.P. (1996) Polyethyleneglycol based micelles as therapeutic and diagnostic agents. STP Pharma. Sci. 6, 79-86.
25. [25] Zalipsky, S. (1995) Functionalized poly(ethylene glycol) for preparation of biologically relevant conjugates. Bioconj. Chem. 6, 150-165.
26. [26] O'Dwyer P.J. and Weiss, R.B. (1984) Hypersensitivity reactions induced by etoposide. Cancer Treatment Rep. 68, 959-961.
27. [27] Kwon, G.S., Naito, M., Kataoka, K., Yokoyama, M., Sakurai, Y. and Okano, T. (1994) Block copolymer micelles as vehicles for Hydrophobic drugs. Colloids Surfaces B: Biointerfaces 2, 429-434.
28. [28] Wilhelm, M., Zhao, C., Wang, Y., Xu, R., Winnik, M.A., Mura, J., Riess, G. and Croucher, M.D. (1991) Poly-(styrene-ethylene oxide) block copolymer micelle formation in water: a fluorescence probe study. Macromolecules 24, 1033-1040.
29. [29] Cao, T., Munk, P., Ramireddy, C., Tuzar, Z. and Webber, S.E. (1991) Fluorescence studies of amphiphilic poly(methacrylic add)-block-polystyrene-block-poly-(methacrylic acid) micelles. Macromolecules 24, 6300-6305.
30. [30] Kwon, G., Naito, M., Yokoyama, M., Okano, T., Sakurai, Y. and Kataoka, K. (1995) Physical entrapment of adriamycin in ab block copolymer micelles. Pharm. Res. 12, 200-203.
31. [31] Yokoyama, M., Okano, T., Sakurai, Y. and Kataoka, K. (1994) Improved synthesis of adriamycin-conjugated poly(ethylene oxide)-poly(aspartic acid) block copolymer and formation of unimodal micellar structure with controlled amount of physically entrapped adriamycin. J. Control. Rel. 32, 269-277.
32. [32] La, S.S., Okano, T. and Kataoka, K. (1996) Preparation and characterization of micelle-forming polymeric drug indomethacin-incorporated poly(ethylene oxide)-poly-(β-benzyl l-aspartate) block copolymer micelles. J. Pharm. Sci. 85, 85-90.
33. [33] Zhang, X. and Burt, H.M. (1995) Diblock copolymers of poly(dl-lactide-block-methoxy polyethylene glycol) as micellar carriers of taxol. Pharm. Res. 12, S-265.
34. [34] Trubetskoy, V.S., Frank-Kamenetsky, M.D. and Torchillin V. (1995) Micellar solubilization of poorly soluble or amphiphilic substances using polyoxyethylene-lipid conjugates. Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 22, 452-453.
35. [35] Woodle, M.C. (1995) Sterically stabilized liposome therapeutics. Adv. Drug Deliv. Rev. 16, 249-265.
36. [36] Turro, N.J., Gratzel, M. and Braun, A.M. (1980) Photophysical and photochemical processes in micellar systems. Angew. Chem. Int. Ed. Engl. 19, 675-696.
37. [37] Gabizon, A., Catane, R., Uziely, B., Kaufman, B., Safra, T., Cohen, R., Martin, F., Huang, A. and Barenholz, Y. (1994) Prolonged circulation time and enhanced accumulation in malignant exudates of DOX encapsulated in polyethylene-glycol coated liposomes. Cancer Res. 54, 987-992.
38. [38] Kwon, G.S., Suwa, S., Yokoyama, M., Okano, T., Sakurai, Y. and Kataoka, K. (1994) Enhanced tumor accumulation and prolonged circulation times of micelle-forming poly(ethylene oxide-aspartate) block copolymers-adriamycin conjugates. J. Control. Rel. 29, 17-23.
39. [39] Yokoyama, M., Okano, T., Sakurai, Y., Ekimoto, H., Shibazaki, C. and Kataoka, K. (1991) Toxicity and antitumor activity against solid tumors of micelle-forming polymeric anticancer drug and its extremely long circulation in blood. Cancer Res. 51, 3229-3236.
40. [40] Gangadharam, P.R.J., Ashtekar, D.R., Flasher, D.L. and Duzgunes (1995) Therapy of mycobacterium avium complex infections in beige mice with streptomycin encapsulated in sterically stabilized liposomes. Antimicrob. Agents Chemother. 39, 725-730.
41. [41] Kreuter, J. (1994) Drug targeting with nanoparticles. Eur. J. Drug Metab. Pharmacokin. 3, 253-256.
42. [42] Kwon, G.S., Yokoyama, M., Okano, T., Sakurai, Y. and Kataoka, K. (1993) Biodistribution of micelle-forming polymer-drug conjugates. Pharm. Res. 10, 970-974.
43. [43] Kabanov, A.V., Chekhonin, V.P., Alakhov, V.Y., Betrakova, E.V., Lebedev, A.S., Mellik-Nubarov, N.S., Arzhakov, S.A., Levashov, A.V., Morozov, G.V., Severin, E.S. and Kabanov, V.A. (1989) The neuroleptic activity of haloperidol increases after its solubilization in surfactant micelles. FEBS 258, 343-345.