메뉴 건너뛰기




Volumn 55, Issue 11, 2016, Pages 1353-1368

Pharmacokinetic Drug Interactions with Tobacco, Cannabinoids and Smoking Cessation Products

Author keywords

[No Author keywords available]

Indexed keywords

AMFEBUTAMONE; BAICALIN; CAFFEINE; CANNABIDIOL; CANNABIS; CARBAMAZEPINE; CHLORPROMAZINE; CLONIDINE; CLOPIDOGREL; CLOZAPINE; CYTISINE; CYTOCHROME P450; EFAVIRENZ; ESTRADIOL; FLECAINIDE; FLUVOXAMINE; HYPERICUM PERFORATUM EXTRACT; LOPINAVIR; NICOTINE; NORTRIPTYLINE; ORAL CONTRACEPTIVE AGENT; POLYCYCLIC AROMATIC HYDROCARBON; RADAFAXINE; RIFAMPICIN; RITONAVIR; TICLOPIDINE; TOBACCO SMOKE; UNINDEXED DRUG; VALPROIC ACID; VARENICLINE; CANNABINOID; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2 INDUCER; CYTOCHROME P450 2C19 INHIBITOR; CYTOCHROME P450 3A; DRONABINOL; NICOTINE GUM;

EID: 84964290965     PISSN: 03125963     EISSN: 11791926     Source Type: Journal    
DOI: 10.1007/s40262-016-0400-9     Document Type: Review
Times cited : (114)

References (142)
  • 2
    • 84912575738 scopus 로고    scopus 로고
    • Current cigarette smoking among adults—United States, 2005–2013
    • Centers for Disease Control and Prevention. Current cigarette smoking among adults—United States, 2005–2013. Morb Mortal Wkly Rep. 2014;63(47):1108–12.
    • (2014) Morb Mortal Wkly Rep , vol.63 , Issue.47 , pp. 1108-1112
    • Centers for Disease Control and Prevention1
  • 3
    • 84948990397 scopus 로고    scopus 로고
    • Prevalence of marijuana use disorders in the United States between 2001–2002 and 2012–2013
    • PID: 26502112
    • Hasin DS, Saha TD, Kerridge BT, et al. Prevalence of marijuana use disorders in the United States between 2001–2002 and 2012–2013. JAMA Psychiatry. 2015;72(12):1235–42.
    • (2015) JAMA Psychiatry , vol.72 , Issue.12 , pp. 1235-1242
    • Hasin, D.S.1    Saha, T.D.2    Kerridge, B.T.3
  • 4
    • 84991554212 scopus 로고    scopus 로고
    • Vienna: United Nations Office on Drugs and Crime
    • United Nations Office on Drugs and Crime. World drug report 2012. Vienna: United Nations Office on Drugs and Crime; 2012. https://www.unodc.org/documents/data-and-analysis/WDR2012/WDR_2012_web_small.pdf. Accessed 7 Dec 2015.
    • (2012) World drug report , vol.2012
  • 5
    • 84908295791 scopus 로고    scopus 로고
    • Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via Gata6-dependent dedifferentiation of acinar cells in mice
    • COI: 1:CAS:528:DC%2BC2cXhsl2ks7bL, PID: 25127677
    • Hermann PC, Sancho P, Canamero M, et al. Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via Gata6-dependent dedifferentiation of acinar cells in mice. Gastroenterology. 2014;147(5):1119–33 e4.
    • (2014) Gastroenterology. , vol.147 , Issue.5 , pp. 1110-1119
    • Hermann, P.C.1    Sancho, P.2    Canamero, M.3
  • 6
    • 84857225346 scopus 로고    scopus 로고
    • Pancreatic cancer cells and normal pancreatic duct epithelial cells express an autocrine catecholamine loop that is activated by nicotinic acetylcholine receptors alpha3, alpha5, and alpha7
    • COI: 1:CAS:528:DC%2BC38XjtFahs78%3D, PID: 22188668
    • Al-Wadei MH, Al-Wadei HA, Schuller HM. Pancreatic cancer cells and normal pancreatic duct epithelial cells express an autocrine catecholamine loop that is activated by nicotinic acetylcholine receptors alpha3, alpha5, and alpha7. Mol Cancer Res. 2012;10(2):239–49.
    • (2012) Mol Cancer Res , vol.10 , Issue.2 , pp. 239-249
    • Al-Wadei, M.H.1    Al-Wadei, H.A.2    Schuller, H.M.3
  • 7
    • 80052747360 scopus 로고    scopus 로고
    • Nicotine promotes cell migration through alpha7 nicotinic acetylcholine receptor in gastric cancer cells
    • PID: 21347787
    • Lien YC, Wang W, Kuo LJ, et al. Nicotine promotes cell migration through alpha7 nicotinic acetylcholine receptor in gastric cancer cells. Ann Surg Oncol. 2011;18(9):2671–9.
    • (2011) Ann Surg Oncol , vol.18 , Issue.9 , pp. 2671-2679
    • Lien, Y.C.1    Wang, W.2    Kuo, L.J.3
  • 8
    • 0023687412 scopus 로고
    • A form of cytochrome P450 in man, orthologous to form D in the rat, catalyses the O-deethylation of phenacetin and is inducible by cigarette smoking
    • COI: 1:CAS:528:DyaL1MXhvFOgsw%3D%3D, PID: 3190986
    • Sesardic D, Boobis AR, Edwards RJ, et al. A form of cytochrome P450 in man, orthologous to form D in the rat, catalyses the O-deethylation of phenacetin and is inducible by cigarette smoking. Br J Clin Pharmacol. 1988;26(4):363–72.
    • (1988) Br J Clin Pharmacol , vol.26 , Issue.4 , pp. 363-372
    • Sesardic, D.1    Boobis, A.R.2    Edwards, R.J.3
  • 9
    • 0028558737 scopus 로고
    • Induction of cytochrome P4501A by smoking or omeprazole in comparison with UDP-glucuronosyltransferase in biopsies of human duodenal mucosa
    • COI: 1:STN:280:DyaK2M3jslalsg%3D%3D, PID: 7720765
    • Buchthal J, Grund KE, Buchmann A, et al. Induction of cytochrome P4501A by smoking or omeprazole in comparison with UDP-glucuronosyltransferase in biopsies of human duodenal mucosa. Eur J Clin Pharmacol. 1995;47(5):431–5.
    • (1995) Eur J Clin Pharmacol , vol.47 , Issue.5 , pp. 431-435
    • Buchthal, J.1    Grund, K.E.2    Buchmann, A.3
  • 10
    • 0034908211 scopus 로고    scopus 로고
    • Human lung microsomal cytochrome P4501A1 (CYP1A1) activities: impact of smoking status and CYP1A1, aryl hydrocarbon receptor, and glutathione S-transferase M1 genetic polymorphisms
    • COI: 1:CAS:528:DC%2BD3MXmsF2rur4%3D
    • Smith GB, Harper PA, Wong JM, et al. Human lung microsomal cytochrome P4501A1 (CYP1A1) activities: impact of smoking status and CYP1A1, aryl hydrocarbon receptor, and glutathione S-transferase M1 genetic polymorphisms. Cancer Epidemiol Biomark Prev. 2001;10(8):839–53.
    • (2001) Cancer Epidemiol Biomark Prev. , vol.10 , Issue.8 , pp. 839-853
    • Smith, G.B.1    Harper, P.A.2    Wong, J.M.3
  • 11
    • 0242382793 scopus 로고    scopus 로고
    • Effects of cigarette smoking and carbon monoxide on chlorzoxazone and caffeine metabolism
    • COI: 1:CAS:528:DC%2BD3sXos1Cjur8%3D, PID: 14586387
    • Benowitz NL, Peng M, Jacob P 3rd. Effects of cigarette smoking and carbon monoxide on chlorzoxazone and caffeine metabolism. Clin Pharmacol Ther. 2003;74(5):468–74.
    • (2003) Clin Pharmacol Ther , vol.74 , Issue.5 , pp. 468-474
    • Benowitz, N.L.1    Peng, M.2    Jacob, P.3
  • 12
    • 84937972337 scopus 로고    scopus 로고
    • CYP2E1 epigenetic regulation in chronic, low-level toluene exposure: relationship with oxidative stress and smoking habit
    • COI: 1:CAS:528:DC%2BC2MXotlGns7g%3D, PID: 25963742
    • Jimenez-Garza O, Baccarelli AA, Byun HM, et al. CYP2E1 epigenetic regulation in chronic, low-level toluene exposure: relationship with oxidative stress and smoking habit. Toxicol Appl Pharmacol. 2015;286(3):207–15.
    • (2015) Toxicol Appl Pharmacol , vol.286 , Issue.3 , pp. 207-215
    • Jimenez-Garza, O.1    Baccarelli, A.A.2    Byun, H.M.3
  • 13
    • 12944322221 scopus 로고    scopus 로고
    • Tobacco smoke-dependent changes in cytochrome P450 1A1, 1A2, and 2E1 protein expressions in fetuses, newborns, pregnant rats, and human placenta
    • COI: 1:CAS:528:DC%2BD2MXkvFGgtw%3D%3D, PID: 15448981
    • Czekaj P, Wiaderkiewicz A, Florek E, et al. Tobacco smoke-dependent changes in cytochrome P450 1A1, 1A2, and 2E1 protein expressions in fetuses, newborns, pregnant rats, and human placenta. Arch Toxicol. 2005;79(1):13–24.
    • (2005) Arch Toxicol , vol.79 , Issue.1 , pp. 13-24
    • Czekaj, P.1    Wiaderkiewicz, A.2    Florek, E.3
  • 14
    • 1642575105 scopus 로고    scopus 로고
    • Nicotine-related alkaloids and metabolites as inhibitors of human cytochrome P-450 2A6
    • COI: 1:CAS:528:DC%2BD2cXnvVCqtA%3D%3D, PID: 14757175
    • Denton TT, Zhang X, Cashman JR. Nicotine-related alkaloids and metabolites as inhibitors of human cytochrome P-450 2A6. Biochem Pharmacol. 2004;67(4):751–6.
    • (2004) Biochem Pharmacol , vol.67 , Issue.4 , pp. 751-756
    • Denton, T.T.1    Zhang, X.2    Cashman, J.R.3
  • 15
    • 75149166653 scopus 로고    scopus 로고
    • Effects of nicotine on cytochrome P450 2A6 and 2E1 activities
    • COI: 1:CAS:528:DC%2BC3cXis1WmsLk%3D, PID: 20233178
    • Hukkanen J, Jacob Iii P, Peng M, et al. Effects of nicotine on cytochrome P450 2A6 and 2E1 activities. Br J Clin Pharmacol. 2010;69(2):152–9.
    • (2010) Br J Clin Pharmacol , vol.69 , Issue.2 , pp. 152-159
    • Hukkanen, J.1    Jacob Iii, P.2    Peng, M.3
  • 16
    • 80054920309 scopus 로고    scopus 로고
    • The ability of polycyclic aromatic hydrocarbons to alter physiological factors underlying drug disposition
    • COI: 1:CAS:528:DC%2BC3MXhtlGlt7%2FL, PID: 21823901
    • Elsherbiny ME, Brocks DR. The ability of polycyclic aromatic hydrocarbons to alter physiological factors underlying drug disposition. Drug Metab Rev. 2011;43(4):457–75.
    • (2011) Drug Metab Rev , vol.43 , Issue.4 , pp. 457-475
    • Elsherbiny, M.E.1    Brocks, D.R.2
  • 17
    • 0037478407 scopus 로고    scopus 로고
    • Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts
    • COI: 1:CAS:528:DC%2BD3sXitFWqsbs%3D, PID: 12171978
    • Ding X, Kaminsky LS. Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts. Annu Rev Pharmacol Toxicol. 2003;43:149–73.
    • (2003) Annu Rev Pharmacol Toxicol , vol.43 , pp. 149-173
    • Ding, X.1    Kaminsky, L.S.2
  • 18
    • 70350075695 scopus 로고    scopus 로고
    • Hormonal regulation of CYP1A expression
    • COI: 1:CAS:528:DC%2BD1MXht1KqurfM, PID: 19627176
    • Monostory K, Pascussi JM, Kobori L, et al. Hormonal regulation of CYP1A expression. Drug Metab Rev. 2009;41(4):547–72.
    • (2009) Drug Metab Rev , vol.41 , Issue.4 , pp. 547-572
    • Monostory, K.1    Pascussi, J.M.2    Kobori, L.3
  • 19
    • 66449111462 scopus 로고    scopus 로고
    • Insights into the structure, function, and regulation of human cytochrome P450 1A2
    • COI: 1:CAS:528:DC%2BC3cXhsFKlu7g%3D, PID: 19702529
    • Zhou SF, Chan E, Zhou ZW, et al. Insights into the structure, function, and regulation of human cytochrome P450 1A2. Curr Drug Metab. 2009;10(7):713–29.
    • (2009) Curr Drug Metab , vol.10 , Issue.7 , pp. 713-729
    • Zhou, S.F.1    Chan, E.2    Zhou, Z.W.3
  • 20
    • 0027367307 scopus 로고
    • Cloning and expression of a human Ah receptor cDNA
    • COI: 1:CAS:528:DyaK2cXis1enurg%3D, PID: 8246913
    • Dolwick KM, Schmidt JV, Carver LA, et al. Cloning and expression of a human Ah receptor cDNA. Mol Pharmacol. 1993;44(5):911–7.
    • (1993) Mol Pharmacol , vol.44 , Issue.5 , pp. 911-917
    • Dolwick, K.M.1    Schmidt, J.V.2    Carver, L.A.3
  • 21
    • 77951447009 scopus 로고    scopus 로고
    • Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2
    • COI: 1:CAS:528:DC%2BC3cXkvFehsL0%3D, PID: 19961320
    • Zhou SF, Wang B, Yang LP, et al. Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2. Drug Metab Rev. 2010;42(2):268–354.
    • (2010) Drug Metab Rev , vol.42 , Issue.2 , pp. 268-354
    • Zhou, S.F.1    Wang, B.2    Yang, L.P.3
  • 22
    • 0017401901 scopus 로고
    • Nitrogen containing compounds in tobacco and tobacco smoke
    • COI: 1:CAS:528:DyaE2sXktleqtLw%3D
    • Schmeltz I, Hoffmann D. Nitrogen containing compounds in tobacco and tobacco smoke. Chem Rev. 1977;77(3):295–311.
    • (1977) Chem Rev , vol.77 , Issue.3 , pp. 295-311
    • Schmeltz, I.1    Hoffmann, D.2
  • 23
    • 0001567368 scopus 로고
    • The alkaloid contents of sixty Nicotiana species
    • COI: 1:CAS:528:DyaL2MXitFygu7w%3D
    • Saitoh F, Noma M, Kawashima N. The alkaloid contents of sixty Nicotiana species. Phytochemistry. 1985;24(3):477–80.
    • (1985) Phytochemistry , vol.24 , Issue.3 , pp. 477-480
    • Saitoh, F.1    Noma, M.2    Kawashima, N.3
  • 24
    • 0041360577 scopus 로고    scopus 로고
    • Percent free base nicotine in the tobacco smoke particulate matter of selected commercial and reference cigarettes
    • COI: 1:CAS:528:DC%2BD3sXls1egtL0%3D, PID: 12924929
    • Pankow JF, Tavakoli AD, Luo W, et al. Percent free base nicotine in the tobacco smoke particulate matter of selected commercial and reference cigarettes. Chem Res Toxicol. 2003;16(8):1014–8.
    • (2003) Chem Res Toxicol , vol.16 , Issue.8 , pp. 1014-1018
    • Pankow, J.F.1    Tavakoli, A.D.2    Luo, W.3
  • 25
    • 14144253640 scopus 로고    scopus 로고
    • Metabolism and disposition kinetics of nicotine
    • COI: 1:CAS:528:DC%2BD2MXis1Gmtro%3D, PID: 15734728
    • Hukkanen J, Jacob P 3rd, Benowitz NL. Metabolism and disposition kinetics of nicotine. Pharmacol Rev. 2005;57(1):79–115.
    • (2005) Pharmacol Rev , vol.57 , Issue.1 , pp. 79-115
    • Hukkanen, J.1    Jacob, P.2    Benowitz, N.L.3
  • 26
    • 40949084426 scopus 로고    scopus 로고
    • Clinical pharmacology of nicotine: implications for understanding, preventing, and treating tobacco addiction
    • COI: 1:CAS:528:DC%2BD1cXjsFCksrk%3D, PID: 18305452
    • Benowitz NL. Clinical pharmacology of nicotine: implications for understanding, preventing, and treating tobacco addiction. Clin Pharmacol Ther. 2008;83(4):531–41.
    • (2008) Clin Pharmacol Ther , vol.83 , Issue.4 , pp. 531-541
    • Benowitz, N.L.1
  • 27
    • 0142150014 scopus 로고    scopus 로고
    • N-Glucuronidation of nicotine and cotinine by human liver microsomes and heterologously expressed UDP-glucuronosyltransferases
    • COI: 1:CAS:528:DC%2BD3sXosV2qur0%3D, PID: 14570768
    • Kuehl GE, Murphy SE. N-Glucuronidation of nicotine and cotinine by human liver microsomes and heterologously expressed UDP-glucuronosyltransferases. Drug Metab Dispos. 2003;31(11):1361–8.
    • (2003) Drug Metab Dispos , vol.31 , Issue.11 , pp. 1361-1368
    • Kuehl, G.E.1    Murphy, S.E.2
  • 28
    • 9244235029 scopus 로고    scopus 로고
    • Simultaneous and sensitive measurement of anabasine, nicotine, and nicotine metabolites in human urine by liquid chromatography–tandem mass spectrometry
    • COI: 1:CAS:528:DC%2BD2cXhtVersrbK, PID: 15472033
    • Xu X, Iba MM, Weisel CP. Simultaneous and sensitive measurement of anabasine, nicotine, and nicotine metabolites in human urine by liquid chromatography–tandem mass spectrometry. Clin Chem. 2004;50(12):2323–30.
    • (2004) Clin Chem , vol.50 , Issue.12 , pp. 2323-2330
    • Xu, X.1    Iba, M.M.2    Weisel, C.P.3
  • 29
    • 85027958455 scopus 로고    scopus 로고
    • Glucuronidation of trans-3′-hydroxycotinine by UGT2B17 and UGT2B10
    • COI: 1:CAS:528:DC%2BC38XhvVOhsrw%3D, PID: 22228205
    • Chen G, Giambrone NE, Lazarus P. Glucuronidation of trans-3′-hydroxycotinine by UGT2B17 and UGT2B10. Pharmacogenet Genomics. 2012;22(3):183–90.
    • (2012) Pharmacogenet Genomics , vol.22 , Issue.3 , pp. 183-190
    • Chen, G.1    Giambrone, N.E.2    Lazarus, P.3
  • 30
    • 50949113663 scopus 로고    scopus 로고
    • Adaptive evolution of UGT2B17 copy-number variation
    • COI: 1:CAS:528:DC%2BD1cXhtFOitr7M, PID: 18760392
    • Xue Y, Sun D, Daly A, et al. Adaptive evolution of UGT2B17 copy-number variation. Am J Hum Genet. 2008;83(3):337–46.
    • (2008) Am J Hum Genet , vol.83 , Issue.3 , pp. 337-346
    • Xue, Y.1    Sun, D.2    Daly, A.3
  • 31
    • 84880970493 scopus 로고    scopus 로고
    • Variation in trans-3′-hydroxycotinine glucuronidation does not alter the nicotine metabolite ratio or nicotine intake
    • COI: 1:CAS:528:DC%2BC3sXht12mt7vK, PID: 23936477
    • Zhu AZ, Zhou Q, Cox LS, et al. Variation in trans-3′-hydroxycotinine glucuronidation does not alter the nicotine metabolite ratio or nicotine intake. PLoS One. 2013;8(8):e70938.
    • (2013) PLoS One , vol.8 , Issue.8
    • Zhu, A.Z.1    Zhou, Q.2    Cox, L.S.3
  • 32
    • 72949119129 scopus 로고    scopus 로고
    • Structure, function, regulation and polymorphism of human cytochrome P450 2A6
    • COI: 1:CAS:528:DC%2BC3cXhsFKlu7Y%3D, PID: 19702528
    • Di YM, Chow VD, Yang LP, et al. Structure, function, regulation and polymorphism of human cytochrome P450 2A6. Curr Drug Metab. 2009;10(7):754–80.
    • (2009) Curr Drug Metab , vol.10 , Issue.7 , pp. 754-780
    • Di, Y.M.1    Chow, V.D.2    Yang, L.P.3
  • 33
    • 77952322356 scopus 로고    scopus 로고
    • CYP2B6, CYP2A6 and UGT2B7 genetic polymorphisms are predictors of efavirenz mid-dose concentration in HIV-infected patients
    • COI: 1:CAS:528:DC%2BD1MXht1KisL%2FJ, PID: 19779319
    • Kwara A, Lartey M, Sagoe KW, et al. CYP2B6, CYP2A6 and UGT2B7 genetic polymorphisms are predictors of efavirenz mid-dose concentration in HIV-infected patients. AIDS. 2009;23(16):2101–6.
    • (2009) AIDS. , vol.23 , Issue.16 , pp. 2101-2106
    • Kwara, A.1    Lartey, M.2    Sagoe, K.W.3
  • 34
    • 40849119970 scopus 로고    scopus 로고
    • Selegiline is a mechanism-based inactivator of CYP2A6 inhibiting nicotine metabolism in humans and mice
    • COI: 1:CAS:528:DC%2BD1cXivVajs7s%3D, PID: 18065502
    • Siu EC, Tyndale RF. Selegiline is a mechanism-based inactivator of CYP2A6 inhibiting nicotine metabolism in humans and mice. J Pharmacol Exp Ther. 2008;324(3):992–9.
    • (2008) J Pharmacol Exp Ther , vol.324 , Issue.3 , pp. 992-999
    • Siu, E.C.1    Tyndale, R.F.2
  • 35
    • 77649232072 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled, randomized clinical trial of oral selegiline hydrochloride for smoking cessation in nicotine-dependent cigarette smokers
    • COI: 1:CAS:528:DC%2BC3cXhs1Kju7s%3D, PID: 19939587
    • Weinberger AH, Reutenauer EL, Jatlow PI, et al. A double-blind, placebo-controlled, randomized clinical trial of oral selegiline hydrochloride for smoking cessation in nicotine-dependent cigarette smokers. Drug Alcohol Depend. 2010;107(2–3):188–95.
    • (2010) Drug Alcohol Depend , vol.107 , Issue.2-3 , pp. 188-195
    • Weinberger, A.H.1    Reutenauer, E.L.2    Jatlow, P.I.3
  • 36
    • 84863229239 scopus 로고    scopus 로고
    • Selegiline transdermal system (STS) as an aid for smoking cessation
    • COI: 1:CAS:528:DC%2BC38Xisl2qt7c%3D, PID: 21846661
    • Kahn R, Gorgon L, Jones K, et al. Selegiline transdermal system (STS) as an aid for smoking cessation. Nicotine Tob Res. 2012;14(3):377–82.
    • (2012) Nicotine Tob Res , vol.14 , Issue.3 , pp. 377-382
    • Kahn, R.1    Gorgon, L.2    Jones, K.3
  • 37
    • 0033055995 scopus 로고    scopus 로고
    • Drug interactions with tobacco smoking: an update
    • COI: 1:CAS:528:DyaK1MXkvFeju7k%3D, PID: 10427467
    • Zevin S, Benowitz NL. Drug interactions with tobacco smoking: an update. Clin Pharmacokinet. 1999;36(6):425–38.
    • (1999) Clin Pharmacokinet , vol.36 , Issue.6 , pp. 425-438
    • Zevin, S.1    Benowitz, N.L.2
  • 38
    • 0035293495 scopus 로고    scopus 로고
    • Cytochrome P450 isoforms involved in melatonin metabolism in human liver microsomes
    • COI: 1:CAS:528:DC%2BD3MXitFehsrw%3D, PID: 11317475
    • Facciola G, Hidestrand M, von Bahr C, et al. Cytochrome P450 isoforms involved in melatonin metabolism in human liver microsomes. Eur J Clin Pharmacol. 2001;56(12):881–8.
    • (2001) Eur J Clin Pharmacol , vol.56 , Issue.12 , pp. 881-888
    • Facciola, G.1    Hidestrand, M.2    von Bahr, C.3
  • 39
    • 0344512430 scopus 로고    scopus 로고
    • Effects of caffeine intake on the pharmacokinetics of melatonin, a probe drug for CYP1A2 activity
    • PID: 14616429
    • Hartter S, Nordmark A, Rose DM, et al. Effects of caffeine intake on the pharmacokinetics of melatonin, a probe drug for CYP1A2 activity. Br J Clin Pharmacol. 2003;56(6):679–82.
    • (2003) Br J Clin Pharmacol , vol.56 , Issue.6 , pp. 679-682
    • Hartter, S.1    Nordmark, A.2    Rose, D.M.3
  • 40
    • 20044396960 scopus 로고    scopus 로고
    • Influence of cigarette smoking on melatonin levels in man
    • COI: 1:CAS:528:DC%2BD2MXktlCntrY%3D, PID: 15824912
    • Ursing C, von Bahr C, Brismar K, et al. Influence of cigarette smoking on melatonin levels in man. Eur J Clin Pharmacol. 2005;61(3):197–201.
    • (2005) Eur J Clin Pharmacol , vol.61 , Issue.3 , pp. 197-201
    • Ursing, C.1    von Bahr, C.2    Brismar, K.3
  • 41
    • 0033810675 scopus 로고    scopus 로고
    • Metabolism of the antidepressant mirtazapine in vitro: contribution of cytochromes P-450 1A2, 2D6, and 3A4
    • COI: 1:CAS:528:DC%2BD3cXntVSltro%3D, PID: 10997935
    • Stormer E, von Moltke LL, Shader RI, et al. Metabolism of the antidepressant mirtazapine in vitro: contribution of cytochromes P-450 1A2, 2D6, and 3A4. Drug Metab Dispos. 2000;28(10):1168–75.
    • (2000) Drug Metab Dispos , vol.28 , Issue.10 , pp. 1168-1175
    • Stormer, E.1    von Moltke, L.L.2    Shader, R.I.3
  • 42
    • 57449096759 scopus 로고    scopus 로고
    • Steady-state concentrations of mirtazapine, N-desmethylmirtazapine, 8-hydroxymirtazapine and their enantiomers in relation to cytochrome P450 2D6 genotype, age and smoking behaviour
    • COI: 1:CAS:528:DC%2BD1MXis12ntL8%3D, PID: 19071885
    • Lind AB, Reis M, Bengtsson F, et al. Steady-state concentrations of mirtazapine, N-desmethylmirtazapine, 8-hydroxymirtazapine and their enantiomers in relation to cytochrome P450 2D6 genotype, age and smoking behaviour. Clin Pharmacokinet. 2009;48(1):63–70.
    • (2009) Clin Pharmacokinet , vol.48 , Issue.1 , pp. 63-70
    • Lind, A.B.1    Reis, M.2    Bengtsson, F.3
  • 43
    • 84865861502 scopus 로고    scopus 로고
    • Multicenter study on the clinical effectiveness, pharmacokinetics, and pharmacogenetics of mirtazapine in depression
    • PID: 22926595
    • Jaquenoud Sirot E, Harenberg S, Vandel P, et al. Multicenter study on the clinical effectiveness, pharmacokinetics, and pharmacogenetics of mirtazapine in depression. J Clin Psychopharmacol. 2012;32(5):622–9.
    • (2012) J Clin Psychopharmacol. , vol.32 , Issue.5 , pp. 622-629
    • Jaquenoud Sirot, E.1    Harenberg, S.2    Vandel, P.3
  • 44
    • 84947928791 scopus 로고    scopus 로고
    • Factors affecting steady-state plasma concentrations of enantiomeric mirtazapine and its desmethylated metabolites in Japanese psychiatric patients
    • COI: 1:CAS:528:DC%2BC2MXhvFWhur7P, PID: 26595747
    • Hayashi Y, Watanabe T, Aoki A, et al. Factors affecting steady-state plasma concentrations of enantiomeric mirtazapine and its desmethylated metabolites in Japanese psychiatric patients. Pharmacopsychiatry. 2015;48(7):279–85.
    • (2015) Pharmacopsychiatry. , vol.48 , Issue.7 , pp. 279-285
    • Hayashi, Y.1    Watanabe, T.2    Aoki, A.3
  • 45
    • 38049035557 scopus 로고    scopus 로고
    • Effects of gender and moderate smoking on the pharmacokinetics and effects of the CYP1A2 substrate tizanidine
    • COI: 1:CAS:528:DC%2BD1cXjsFyhsw%3D%3D, PID: 17955229
    • Backman JT, Schroder MT, Neuvonen PJ. Effects of gender and moderate smoking on the pharmacokinetics and effects of the CYP1A2 substrate tizanidine. Eur J Clin Pharmacol. 2008;64(1):17–24.
    • (2008) Eur J Clin Pharmacol , vol.64 , Issue.1 , pp. 17-24
    • Backman, J.T.1    Schroder, M.T.2    Neuvonen, P.J.3
  • 46
    • 1542329740 scopus 로고    scopus 로고
    • Tizanidine is mainly metabolized by cytochrome p450 1A2 in vitro
    • COI: 1:CAS:528:DC%2BD2cXis1Kit7w%3D, PID: 14998432
    • Granfors MT, Backman JT, Laitila J, et al. Tizanidine is mainly metabolized by cytochrome p450 1A2 in vitro. Br J Clin Pharmacol. 2004;57(3):349–53.
    • (2004) Br J Clin Pharmacol , vol.57 , Issue.3 , pp. 349-353
    • Granfors, M.T.1    Backman, J.T.2    Laitila, J.3
  • 47
    • 77954943905 scopus 로고    scopus 로고
    • Metabolism of ramelteon in human liver microsomes and correlation with the effect of fluvoxamine on ramelteon pharmacokinetics
    • COI: 1:CAS:528:DC%2BC3cXhtVWktrnO, PID: 20478852
    • Obach RS, Ryder TF. Metabolism of ramelteon in human liver microsomes and correlation with the effect of fluvoxamine on ramelteon pharmacokinetics. Drug Metab Dispos. 2010;38(8):1381–91.
    • (2010) Drug Metab Dispos , vol.38 , Issue.8 , pp. 1381-1391
    • Obach, R.S.1    Ryder, T.F.2
  • 48
    • 34547702828 scopus 로고    scopus 로고
    • Rasagiline—a novel MAO B inhibitor in Parkinson’s disease therapy
    • COI: 1:CAS:528:DC%2BD2sXps1Cqtro%3D, PID: 18488080
    • Lecht S, Haroutiunian S, Hoffman A, et al. Rasagiline—a novel MAO B inhibitor in Parkinson’s disease therapy. Ther Clin Risk Manag. 2007;3(3):467–74.
    • (2007) Ther Clin Risk Manag , vol.3 , Issue.3 , pp. 467-474
    • Lecht, S.1    Haroutiunian, S.2    Hoffman, A.3
  • 49
    • 73149119363 scopus 로고    scopus 로고
    • Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite
    • COI: 1:CAS:528:DC%2BD1MXhs1aqsr7L, PID: 19812348
    • Kazui M, Nishiya Y, Ishizuka T, et al. Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite. Drug Metab Dispos. 2010;38(1):92–9.
    • (2010) Drug Metab Dispos , vol.38 , Issue.1 , pp. 92-99
    • Kazui, M.1    Nishiya, Y.2    Ishizuka, T.3
  • 50
    • 84862504147 scopus 로고    scopus 로고
    • Clopidogrel efficacy and cigarette smoking status
    • COI: 1:CAS:528:DC%2BC38XhtVCkurfL, PID: 22797448
    • Gurbel PA, Nolin TD, Tantry US. Clopidogrel efficacy and cigarette smoking status. JAMA. 2012;307(23):2495–6.
    • (2012) JAMA , vol.307 , Issue.23 , pp. 2495-2496
    • Gurbel, P.A.1    Nolin, T.D.2    Tantry, U.S.3
  • 51
    • 49849097496 scopus 로고    scopus 로고
    • Smoking behaviour modulates pharmacokinetics of orally administered clopidogrel
    • COI: 1:CAS:528:DC%2BD1cXpvVWlsro%3D, PID: 18613862
    • Yousef AM, Arafat T, Bulatova NR, et al. Smoking behaviour modulates pharmacokinetics of orally administered clopidogrel. J Clin Pharm Ther. 2008;33(4):439–49.
    • (2008) J Clin Pharm Ther , vol.33 , Issue.4 , pp. 439-449
    • Yousef, A.M.1    Arafat, T.2    Bulatova, N.R.3
  • 52
    • 84881112989 scopus 로고    scopus 로고
    • The influence of smoking status on the pharmacokinetics and pharmacodynamics of clopidogrel and prasugrel: the PARADOX study
    • COI: 1:CAS:528:DC%2BC3sXht1WrtL3K, PID: 23602770
    • Gurbel PA, Bliden KP, Logan DK, et al. The influence of smoking status on the pharmacokinetics and pharmacodynamics of clopidogrel and prasugrel: the PARADOX study. J Am Coll Cardiol. 2013;62(6):505–12.
    • (2013) J Am Coll Cardiol , vol.62 , Issue.6 , pp. 505-512
    • Gurbel, P.A.1    Bliden, K.P.2    Logan, D.K.3
  • 53
    • 80053920172 scopus 로고    scopus 로고
    • Effect of nicotine on cytochrome P450 1A2 activity
    • COI: 1:CAS:528:DC%2BC3MXhsFamsrrO, PID: 21599724
    • Hukkanen J, Jacob P 3rd, Peng M, et al. Effect of nicotine on cytochrome P450 1A2 activity. Br J Clin Pharmacol. 2011;72(5):836–8.
    • (2011) Br J Clin Pharmacol , vol.72 , Issue.5 , pp. 836-838
    • Hukkanen, J.1    Jacob, P.2    Peng, M.3
  • 54
    • 84875468108 scopus 로고    scopus 로고
    • Effect of nicotine on the pharmacokinetics of levodopa
    • COI: 1:CAS:528:DC%2BC3sXktF2rurs%3D, PID: 23503546
    • Kyaw WT, Nagai M, Kaneta M, et al. Effect of nicotine on the pharmacokinetics of levodopa. Clin Neuropharmacol. 2013;36(2):46–51.
    • (2013) Clin Neuropharmacol , vol.36 , Issue.2 , pp. 46-51
    • Kyaw, W.T.1    Nagai, M.2    Kaneta, M.3
  • 55
    • 3543019165 scopus 로고    scopus 로고
    • Time response of cytochrome P450 1A2 activity on cessation of heavy smoking
    • COI: 1:CAS:528:DC%2BD2cXmt1Ogu7w%3D, PID: 15289794
    • Faber MS, Fuhr U. Time response of cytochrome P450 1A2 activity on cessation of heavy smoking. Clin Pharmacol Ther. 2004;76(2):178–84.
    • (2004) Clin Pharmacol Ther , vol.76 , Issue.2 , pp. 178-184
    • Faber, M.S.1    Fuhr, U.2
  • 56
    • 23244442895 scopus 로고    scopus 로고
    • Increased clozapine plasma concentrations and side effects induced by smoking cessation in 2 CYP1A2 genotyped patients
    • COI: 1:CAS:528:DC%2BD2MXmsV2is7w%3D, PID: 16044115
    • Bondolfi G, Morel F, Crettol S, et al. Increased clozapine plasma concentrations and side effects induced by smoking cessation in 2 CYP1A2 genotyped patients. Ther Drug Monit. 2005;27(4):539–43.
    • (2005) Ther Drug Monit , vol.27 , Issue.4 , pp. 539-543
    • Bondolfi, G.1    Morel, F.2    Crettol, S.3
  • 57
    • 0036238160 scopus 로고    scopus 로고
    • Tobacco and cannabis smoking cessation can lead to intoxication with clozapine or olanzapine
    • COI: 1:STN:280:DC%2BD383ktlansQ%3D%3D, PID: 11981356
    • Zullino DF, Delessert D, Eap CB, et al. Tobacco and cannabis smoking cessation can lead to intoxication with clozapine or olanzapine. Int Clin Psychopharmacol. 2002;17(3):141–3.
    • (2002) Int Clin Psychopharmacol , vol.17 , Issue.3 , pp. 141-143
    • Zullino, D.F.1    Delessert, D.2    Eap, C.B.3
  • 58
    • 51549110138 scopus 로고    scopus 로고
    • Adverse effects of ropinirole-treated restless leg syndrome (RLS) during smoking cessation
    • PID: 18763430
    • Juergens TM. Adverse effects of ropinirole-treated restless leg syndrome (RLS) during smoking cessation. J Clin Sleep Med. 2008;4(4):371–2.
    • (2008) J Clin Sleep Med , vol.4 , Issue.4 , pp. 371-372
    • Juergens, T.M.1
  • 59
    • 67649243667 scopus 로고    scopus 로고
    • Methadone-nicotine interactions in methadone maintenance treatment patients
    • COI: 1:CAS:528:DC%2BD1MXlvV2hsbY%3D, PID: 19440076
    • Elkader AK, Brands B, Selby P, et al. Methadone-nicotine interactions in methadone maintenance treatment patients. J Clin Psychopharmacol. 2009;29(3):231–8.
    • (2009) J Clin Psychopharmacol , vol.29 , Issue.3 , pp. 231-238
    • Elkader, A.K.1    Brands, B.2    Selby, P.3
  • 60
    • 43049179515 scopus 로고    scopus 로고
    • Artemisinin and CYP2A6 activity in healthy subjects
    • COI: 1:CAS:528:DC%2BD1cXitVSis7c%3D, PID: 18064444
    • Asimus S, Hai TN, Van Huong N, et al. Artemisinin and CYP2A6 activity in healthy subjects. Eur J Clin Pharmacol. 2008;64(3):283–92.
    • (2008) Eur J Clin Pharmacol , vol.64 , Issue.3 , pp. 283-292
    • Asimus, S.1    Hai, T.N.2    Van Huong, N.3
  • 61
    • 34748881453 scopus 로고    scopus 로고
    • Human CYP2A6 is induced by estrogen via estrogen receptor
    • COI: 1:CAS:528:DC%2BD2sXhtFansbfE, PID: 17646279
    • Higashi E, Fukami T, Itoh M, et al. Human CYP2A6 is induced by estrogen via estrogen receptor. Drug Metab Dispos. 2007;35(10):1935–41.
    • (2007) Drug Metab Dispos , vol.35 , Issue.10 , pp. 1935-1941
    • Higashi, E.1    Fukami, T.2    Itoh, M.3
  • 62
    • 33646475252 scopus 로고    scopus 로고
    • Female sex and oral contraceptive use accelerate nicotine metabolism
    • COI: 1:CAS:528:DC%2BD28XktVegsb8%3D, PID: 16678549
    • Benowitz NL, Lessov-Schlaggar CN, Swan GE, et al. Female sex and oral contraceptive use accelerate nicotine metabolism. Clin Pharmacol Ther. 2006;79(5):480–8.
    • (2006) Clin Pharmacol Ther , vol.79 , Issue.5 , pp. 480-488
    • Benowitz, N.L.1    Lessov-Schlaggar, C.N.2    Swan, G.E.3
  • 63
    • 34047227949 scopus 로고    scopus 로고
    • Sex-based and hormonal contraception effects on the metabolism of nicotine among adolescent tobacco-dependent smokers
    • COI: 1:CAS:528:DC%2BD2sXlsVCgsbs%3D, PID: 17454704
    • Berlin I, Gasior MJ, Moolchan ET. Sex-based and hormonal contraception effects on the metabolism of nicotine among adolescent tobacco-dependent smokers. Nicotine Tob Res. 2007;9(4):493–8.
    • (2007) Nicotine Tob Res , vol.9 , Issue.4 , pp. 493-498
    • Berlin, I.1    Gasior, M.J.2    Moolchan, E.T.3
  • 64
    • 52649090660 scopus 로고    scopus 로고
    • CYP2A6 activity in a healthy Spanish population: effect of age, sex, smoking, and oral contraceptives
    • COI: 1:STN:280:DC%2BD1crjs1ChtQ%3D%3D, PID: 18715882
    • Sinues B, Fanlo A, Mayayo E, et al. CYP2A6 activity in a healthy Spanish population: effect of age, sex, smoking, and oral contraceptives. Hum Exp Toxicol. 2008;27(5):367–72.
    • (2008) Hum Exp Toxicol , vol.27 , Issue.5 , pp. 367-372
    • Sinues, B.1    Fanlo, A.2    Mayayo, E.3
  • 65
    • 27844525479 scopus 로고    scopus 로고
    • Chemical constituents of marijuana: the complex mixture of natural cannabinoids
    • COI: 1:CAS:528:DC%2BD2MXht1ejsrfJ, PID: 16199061
    • Elsohly MA, Slade D. Chemical constituents of marijuana: the complex mixture of natural cannabinoids. Life Sci. 2005;78(5):539–48.
    • (2005) Life Sci , vol.78 , Issue.5 , pp. 539-548
    • Elsohly, M.A.1    Slade, D.2
  • 66
    • 0037255987 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of cannabinoids
    • COI: 1:CAS:528:DC%2BD3sXjsFWis7g%3D, PID: 12648025
    • Grotenhermen F. Pharmacokinetics and pharmacodynamics of cannabinoids. Clin Pharmacokinet. 2003;42(4):327–60.
    • (2003) Clin Pharmacokinet , vol.42 , Issue.4 , pp. 327-360
    • Grotenhermen, F.1
  • 67
    • 84945273580 scopus 로고    scopus 로고
    • Cannabidiol is a negative allosteric modulator of the type 1 cannabinoid receptor
    • COI: 1:CAS:528:DC%2BC2MXhs1CntL7P, PID: 26218440
    • Laprairie RB, Bagher AM, Kelly ME, et al. Cannabidiol is a negative allosteric modulator of the type 1 cannabinoid receptor. Br J Pharmacol. 2015;172(20):4790–805.
    • (2015) Br J Pharmacol , vol.172 , Issue.20 , pp. 4790-4805
    • Laprairie, R.B.1    Bagher, A.M.2    Kelly, M.E.3
  • 68
    • 33847653702 scopus 로고    scopus 로고
    • Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro
    • COI: 1:CAS:528:DC%2BD2sXisVeis7Y%3D, PID: 17245363
    • Thomas A, Baillie GL, Phillips AM, et al. Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro. Br J Pharmacol. 2007;150(5):613–23.
    • (2007) Br J Pharmacol , vol.150 , Issue.5 , pp. 613-623
    • Thomas, A.1    Baillie, G.L.2    Phillips, A.M.3
  • 69
    • 84925488635 scopus 로고    scopus 로고
    • Cannabidiol (CBD) and its analogs: a review of their effects on inflammation
    • COI: 1:CAS:528:DC%2BC2MXisVSqtrw%3D, PID: 25703248
    • Burstein S. Cannabidiol (CBD) and its analogs: a review of their effects on inflammation. Bioorg Med Chem. 2015;23(7):1377–85.
    • (2015) Bioorg Med Chem. , vol.23 , Issue.7 , pp. 1377-1385
    • Burstein, S.1
  • 70
    • 33646734889 scopus 로고    scopus 로고
    • Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression
    • COI: 1:CAS:528:DC%2BD28XlsVGksbo%3D, PID: 16672367
    • Carrier EJ, Auchampach JA, Hillard CJ. Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression. Proc Natl Acad Sci. 2006;103(20):7895–900.
    • (2006) Proc Natl Acad Sci. , vol.103 , Issue.20 , pp. 7895-7900
    • Carrier, E.J.1    Auchampach, J.A.2    Hillard, C.J.3
  • 71
    • 0018963804 scopus 로고
    • Plasma delta-9 tetrahydrocannabinol concentrations and clinical effects after oral and intravenous administration and smoking
    • COI: 1:CAS:528:DyaL3cXlvFOnu70%3D, PID: 6250760
    • Ohlsson A, Lindgren JE, Wahlen A, et al. Plasma delta-9 tetrahydrocannabinol concentrations and clinical effects after oral and intravenous administration and smoking. Clin Pharmacol Ther. 1980;28(3):409–16.
    • (1980) Clin Pharmacol Ther , vol.28 , Issue.3 , pp. 409-416
    • Ohlsson, A.1    Lindgren, J.E.2    Wahlen, A.3
  • 72
    • 24344435153 scopus 로고    scopus 로고
    • CYP2C-catalyzed delta9-tetrahydrocannabinol metabolism: kinetics, pharmacogenetics and interaction with phenytoin
    • COI: 1:CAS:528:DC%2BD2MXpvFegsrY%3D, PID: 16112652
    • Bland TM, Haining RL, Tracy TS, et al. CYP2C-catalyzed delta9-tetrahydrocannabinol metabolism: kinetics, pharmacogenetics and interaction with phenytoin. Biochem Pharmacol. 2005;70(7):1096–103.
    • (2005) Biochem Pharmacol , vol.70 , Issue.7 , pp. 1096-1103
    • Bland, T.M.1    Haining, R.L.2    Tracy, T.S.3
  • 73
    • 33847633815 scopus 로고    scopus 로고
    • Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes
    • COI: 1:CAS:528:DC%2BD2sXislKgt7k%3D, PID: 17303175
    • Watanabe K, Yamaori S, Funahashi T, et al. Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes. Life Sci. 2007;80(15):1415–9.
    • (2007) Life Sci , vol.80 , Issue.15 , pp. 1415-1419
    • Watanabe, K.1    Yamaori, S.2    Funahashi, T.3
  • 74
    • 0016598585 scopus 로고
    • Action of delta-9-tetrahydrocannabinol: an approach to the active metabolite hypothesis
    • COI: 1:CAS:528:DyaE28XmvFGksw%3D%3D, PID: 1204277
    • Hollister LE, Gillespie HK. Action of delta-9-tetrahydrocannabinol: an approach to the active metabolite hypothesis. Clin Pharmacol Ther. 1975;18(06):714–9.
    • (1975) Clin Pharmacol Ther , vol.18 , Issue.6 , pp. 714-719
    • Hollister, L.E.1    Gillespie, H.K.2
  • 75
    • 60449089830 scopus 로고    scopus 로고
    • Interindividual variation in the pharmacokinetics of Delta9-tetrahydrocannabinol as related to genetic polymorphisms in CYP2C9
    • COI: 1:CAS:528:DC%2BD1MXit1Ogurk%3D, PID: 19005461
    • Sachse-Seeboth C, Pfeil J, Sehrt D, et al. Interindividual variation in the pharmacokinetics of Delta9-tetrahydrocannabinol as related to genetic polymorphisms in CYP2C9. Clin Pharmacol Ther. 2009;85(3):273–6.
    • (2009) Clin Pharmacol Ther , vol.85 , Issue.3 , pp. 273-276
    • Sachse-Seeboth, C.1    Pfeil, J.2    Sehrt, D.3
  • 77
    • 80051794688 scopus 로고    scopus 로고
    • Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes
    • COI: 1:CAS:528:DC%2BC3MXptVaitbo%3D, PID: 21704641
    • Jiang R, Yamaori S, Takeda S, et al. Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes. Life Sci. 2011;89(5–6):165–70.
    • (2011) Life Sci , vol.89 , Issue.5-6 , pp. 165-170
    • Jiang, R.1    Yamaori, S.2    Takeda, S.3
  • 79
    • 0025836819 scopus 로고
    • Assay of plasma cannabidiol by capillary gas chromatography/ion trap mass spectroscopy following high-dose repeated daily oral administration in humans
    • COI: 1:CAS:528:DyaK38XjsFOqsg%3D%3D, PID: 1666917
    • Consroe P, Kennedy K, Schram K. Assay of plasma cannabidiol by capillary gas chromatography/ion trap mass spectroscopy following high-dose repeated daily oral administration in humans. Pharmacol Biochem Behav. 1991;40(3):517–22.
    • (1991) Pharmacol Biochem Behav , vol.40 , Issue.3 , pp. 517-522
    • Consroe, P.1    Kennedy, K.2    Schram, K.3
  • 80
    • 0019855492 scopus 로고
    • Interactions of delta 1-tetrahydrocannabinol with cannabinol and cannabidiol following oral administration in man: assay of cannabinol and cannabidiol by mass fragmentography
    • COI: 1:CAS:528:DyaL38XhvF0%3D, PID: 6273208
    • Agurell S, Carlsson S, Lindgren JE, et al. Interactions of delta 1-tetrahydrocannabinol with cannabinol and cannabidiol following oral administration in man: assay of cannabinol and cannabidiol by mass fragmentography. Experientia. 1981;37(10):1090–2.
    • (1981) Experientia , vol.37 , Issue.10 , pp. 1090-1092
    • Agurell, S.1    Carlsson, S.2    Lindgren, J.E.3
  • 81
    • 84879459582 scopus 로고    scopus 로고
    • A phase I study to assess the single and multiple dose pharmacokinetics of THC/CBD oromucosal spray
    • COI: 1:CAS:528:DC%2BC3sXntVajtL8%3D, PID: 23179176
    • Stott CG, White L, Wright S, et al. A phase I study to assess the single and multiple dose pharmacokinetics of THC/CBD oromucosal spray. Eur J Clin Pharmacol. 2013;69(5):1135–47.
    • (2013) Eur J Clin Pharmacol , vol.69 , Issue.5 , pp. 1135-1147
    • Stott, C.G.1    White, L.2    Wright, S.3
  • 82
    • 84893293360 scopus 로고    scopus 로고
    • Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review
    • COI: 1:CAS:528:DC%2BC2cXhvVylu7Y%3D, PID: 24160757
    • Stout SM, Cimino NM. Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review. Drug Metab Rev. 2014;46(1):86–95.
    • (2014) Drug Metab Rev , vol.46 , Issue.1 , pp. 86-95
    • Stout, S.M.1    Cimino, N.M.2
  • 83
    • 0035095986 scopus 로고    scopus 로고
    • Induction and regulation of the carcinogen-metabolizing enzyme CYP1A1 by marijuana smoke and delta (9)-tetrahydrocannabinol
    • COI: 1:CAS:528:DC%2BD3MXitleltbs%3D, PID: 11245634
    • Roth MD, Marques-Magallanes JA, Yuan M, et al. Induction and regulation of the carcinogen-metabolizing enzyme CYP1A1 by marijuana smoke and delta (9)-tetrahydrocannabinol. Am J Respir Cell Mol Biol. 2001;24(3):339–44.
    • (2001) Am J Respir Cell Mol Biol , vol.24 , Issue.3 , pp. 339-344
    • Roth, M.D.1    Marques-Magallanes, J.A.2    Yuan, M.3
  • 84
    • 84937403119 scopus 로고    scopus 로고
    • Cannabidiol induces expression of human cytochrome P450 1A1 that is possibly mediated through aryl hydrocarbon receptor signaling in HepG2 cells
    • COI: 1:CAS:528:DC%2BC2MXhtFOkt7%2FI, PID: 26187180
    • Yamaori S, Kinugasa Y, Jiang R, et al. Cannabidiol induces expression of human cytochrome P450 1A1 that is possibly mediated through aryl hydrocarbon receptor signaling in HepG2 cells. Life Sci. 2015;136:87–93.
    • (2015) Life Sci , vol.136 , pp. 87-93
    • Yamaori, S.1    Kinugasa, Y.2    Jiang, R.3
  • 85
    • 84880409258 scopus 로고    scopus 로고
    • Cannabidiol is a potent inhibitor of the catalytic activity of cytochrome P450 2C19
    • COI: 1:CAS:528:DC%2BC3sXhsF2ktrvF, PID: 23318708
    • Jiang R, Yamaori S, Okamoto Y, et al. Cannabidiol is a potent inhibitor of the catalytic activity of cytochrome P450 2C19. Drug Metab Pharmacokinet. 2013;28(4):332–8.
    • (2013) Drug Metab Pharmacokinet , vol.28 , Issue.4 , pp. 332-338
    • Jiang, R.1    Yamaori, S.2    Okamoto, Y.3
  • 86
    • 84861620136 scopus 로고    scopus 로고
    • Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity
    • COI: 1:CAS:528:DC%2BC38Xht1GiurvN, PID: 22166891
    • Yamaori S, Koeda K, Kushihara M, et al. Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. Drug Metab Pharmacokinet. 2012;27(3):294–300.
    • (2012) Drug Metab Pharmacokinet , vol.27 , Issue.3 , pp. 294-300
    • Yamaori, S.1    Koeda, K.2    Kushihara, M.3
  • 87
    • 0030094638 scopus 로고    scopus 로고
    • Theophylline metabolism in human liver microsomes: inhibition studies
    • COI: 1:CAS:528:DyaK28XhslSgtro%3D, PID: 8786569
    • Tjia JF, Colbert J, Back DJ. Theophylline metabolism in human liver microsomes: inhibition studies. J Pharmacol Exp Ther. 1996;276(3):912–7.
    • (1996) J Pharmacol Exp Ther , vol.276 , Issue.3 , pp. 912-917
    • Tjia, J.F.1    Colbert, J.2    Back, D.J.3
  • 88
    • 77956230131 scopus 로고    scopus 로고
    • Main contribution of the cytochrome P450 isoenzyme 1A2 (CYP1A2) to N-demethylation and 5-sulfoxidation of the phenothiazine neuroleptic chlorpromazine in human liver—a comparison with other phenothiazines
    • COI: 1:CAS:528:DC%2BC3cXhtFals73F, PID: 20615392
    • Wojcikowski J, Boksa J, Daniel WA. Main contribution of the cytochrome P450 isoenzyme 1A2 (CYP1A2) to N-demethylation and 5-sulfoxidation of the phenothiazine neuroleptic chlorpromazine in human liver—a comparison with other phenothiazines. Biochem Pharmacol. 2010;80(8):1252–9.
    • (2010) Biochem Pharmacol , vol.80 , Issue.8 , pp. 1252-1259
    • Wojcikowski, J.1    Boksa, J.2    Daniel, W.A.3
  • 89
    • 0018023314 scopus 로고
    • Enhanced biotransformation of theophylline in marihuana and tobacco smokers
    • COI: 1:STN:280:DyaE1M%2Fgt1GltQ%3D%3D, PID: 688731
    • Jusko WJ, Schentag JJ, Clark JH, et al. Enhanced biotransformation of theophylline in marihuana and tobacco smokers. Clin Pharmacol Ther. 1978;24(4):405–10.
    • (1978) Clin Pharmacol Ther , vol.24 , Issue.4 , pp. 405-410
    • Jusko, W.J.1    Schentag, J.J.2    Clark, J.H.3
  • 90
    • 0018671732 scopus 로고
    • Factors affecting theophylline clearances: age, tobacco, marijuana, cirrhosis, congestive heart failure, obesity, oral contraceptives, benzodiazepines, barbiturates, and ethanol
    • COI: 1:CAS:528:DyaL3cXjtlOhtQ%3D%3D, PID: 41932
    • Jusko WJ, Gardner MJ, Mangione A, et al. Factors affecting theophylline clearances: age, tobacco, marijuana, cirrhosis, congestive heart failure, obesity, oral contraceptives, benzodiazepines, barbiturates, and ethanol. J Pharm Sci. 1979;68(11):1358–66.
    • (1979) J Pharm Sci , vol.68 , Issue.11 , pp. 1358-1366
    • Jusko, W.J.1    Gardner, M.J.2    Mangione, A.3
  • 91
    • 0020608423 scopus 로고
    • Effects of tobacco smoking and oral contraceptive use on theophylline disposition
    • COI: 1:CAS:528:DyaL3sXls12js7c%3D, PID: 6626419
    • Gardner MJ, Tornatore KM, Jusko WJ, et al. Effects of tobacco smoking and oral contraceptive use on theophylline disposition. Br J Clin Pharmacol. 1983;16(3):271–80.
    • (1983) Br J Clin Pharmacol , vol.16 , Issue.3 , pp. 271-280
    • Gardner, M.J.1    Tornatore, K.M.2    Jusko, W.J.3
  • 92
    • 0028129874 scopus 로고
    • Smoking and body weight influence the clearance of chlorpromazine
    • COI: 1:STN:280:DyaK2M%2FoslKltQ%3D%3D, PID: 7995319
    • Chetty M, Miller R, Moodley SV. Smoking and body weight influence the clearance of chlorpromazine. Eur J Clin Pharmacol. 1994;46(6):523–6.
    • (1994) Eur J Clin Pharmacol , vol.46 , Issue.6 , pp. 523-526
    • Chetty, M.1    Miller, R.2    Moodley, S.V.3
  • 93
    • 0029683112 scopus 로고    scopus 로고
    • Antipyrine as a probe for human oxidative drug metabolism: identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation
    • COI: 1:CAS:528:DyaK28XksFemurg%3D, PID: 8681486
    • Engel G, Hofmann U, Heidemann H, et al. Antipyrine as a probe for human oxidative drug metabolism: identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation. Clin Pharmacol Ther. 1996;59:613–23.
    • (1996) Clin Pharmacol Ther , vol.59 , pp. 613-623
    • Engel, G.1    Hofmann, U.2    Heidemann, H.3
  • 94
    • 0015568827 scopus 로고
    • Inhibition of drug metabolism in man
    • COI: 1:CAS:528:DyaE2MXisFGjug%3D%3D, PID: 4129869
    • Vesell ES, Passananti GT. Inhibition of drug metabolism in man. Drug Metab Dispos. 1973;1(1):402–10.
    • (1973) Drug Metab Dispos , vol.1 , Issue.1 , pp. 402-410
    • Vesell, E.S.1    Passananti, G.T.2
  • 95
    • 0017414445 scopus 로고
    • Effects of delta-9-tetrahydrocannabinol on drug distribution and metabolism: antipyrine, pentobarbital, and ethanol
    • COI: 1:CAS:528:DyaE2sXlvFemtrw%3D, PID: 891094
    • Benowitz NL, Jones RT. Effects of delta-9-tetrahydrocannabinol on drug distribution and metabolism: antipyrine, pentobarbital, and ethanol. Clin Pharmacol Ther. 1977;22(3):259–68.
    • (1977) Clin Pharmacol Ther , vol.22 , Issue.3 , pp. 259-268
    • Benowitz, N.L.1    Jones, R.T.2
  • 96
    • 34247165002 scopus 로고    scopus 로고
    • Nicotine metabolism and CYP2A6 activity in a population of black African descent: impact of gender and light smoking
    • COI: 1:CAS:528:DC%2BD2sXkslCgsbs%3D, PID: 17161559
    • Mwenifumbo JC, Sellers EM, Tyndale RF. Nicotine metabolism and CYP2A6 activity in a population of black African descent: impact of gender and light smoking. Drug Alcohol Depend. 2007;89(1):24–33.
    • (2007) Drug Alcohol Depend , vol.89 , Issue.1 , pp. 24-33
    • Mwenifumbo, J.C.1    Sellers, E.M.2    Tyndale, R.F.3
  • 97
    • 0032955402 scopus 로고    scopus 로고
    • Pharmacokinetics and potential interactions amongst antiretroviral agents used to treat patients with HIV infection
    • COI: 1:CAS:528:DyaK1MXjtFCku7k%3D, PID: 10320951
    • Barry M, Mulcahy F, Merry C, et al. Pharmacokinetics and potential interactions amongst antiretroviral agents used to treat patients with HIV infection. Clin Pharmacokinet. 1999;36(4):289–304.
    • (1999) Clin Pharmacokinet , vol.36 , Issue.4 , pp. 289-304
    • Barry, M.1    Mulcahy, F.2    Merry, C.3
  • 98
    • 19944432901 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of nelfinavir and its metabolite M8 in human immunodeficiency virus (HIV)-positive and HIV–hepatitis C virus–coinfected subjects
    • COI: 1:CAS:528:DC%2BD2MXht12ntLw%3D, PID: 15673746
    • Regazzi M, Maserati R, Villani P, et al. Clinical pharmacokinetics of nelfinavir and its metabolite M8 in human immunodeficiency virus (HIV)-positive and HIV–hepatitis C virus–coinfected subjects. Antimicrob Agents Chemother. 2005;49(2):643–9.
    • (2005) Antimicrob Agents Chemother , vol.49 , Issue.2 , pp. 643-649
    • Regazzi, M.1    Maserati, R.2    Villani, P.3
  • 99
    • 0037040369 scopus 로고    scopus 로고
    • The effects of cannabinoids on the pharmacokinetics of indinavir and nelfinavir
    • COI: 1:CAS:528:DC%2BD38XivVyhsro%3D, PID: 11872997
    • Kosel BW, Aweeka FT, Benowitz NL, et al. The effects of cannabinoids on the pharmacokinetics of indinavir and nelfinavir. AIDS. 2002;16(4):543–50.
    • (2002) AIDS. , vol.16 , Issue.4 , pp. 543-550
    • Kosel, B.W.1    Aweeka, F.T.2    Benowitz, N.L.3
  • 100
    • 6944252142 scopus 로고    scopus 로고
    • In vitro characterization of clobazam metabolism by recombinant cytochrome P450 enzymes: importance of CYP2C19
    • COI: 1:CAS:528:DC%2BD2cXovFCktbk%3D, PID: 15483195
    • Giraud C, Tran A, Rey E, et al. In vitro characterization of clobazam metabolism by recombinant cytochrome P450 enzymes: importance of CYP2C19. Drug Metab Dispos. 2004;32(11):1279–86.
    • (2004) Drug Metab Dispos , vol.32 , Issue.11 , pp. 1279-1286
    • Giraud, C.1    Tran, A.2    Rey, E.3
  • 101
    • 84938748697 scopus 로고    scopus 로고
    • Drug-drug interaction between clobazam and cannabidiol in children with refractory epilepsy
    • COI: 1:CAS:528:DC%2BC2MXht1yqsbbN, PID: 26114620
    • Geffrey AL, Pollack SF, Bruno PL, et al. Drug-drug interaction between clobazam and cannabidiol in children with refractory epilepsy. Epilepsia. 2015;56(8):1246–51.
    • (2015) Epilepsia. , vol.56 , Issue.8 , pp. 1246-1251
    • Geffrey, A.L.1    Pollack, S.F.2    Bruno, P.L.3
  • 102
    • 33645851325 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled study about the effects of cannabidiol (CBD) on the pharmacokinetics of delta9-tetrahydrocannabinol (THC) after oral application of THC verses standardized cannabis extract
    • COI: 1:CAS:528:DC%2BD2MXht1Cit7vF, PID: 16306858
    • Nadulski T, Pragst F, Weinberg G, et al. Randomized, double-blind, placebo-controlled study about the effects of cannabidiol (CBD) on the pharmacokinetics of delta9-tetrahydrocannabinol (THC) after oral application of THC verses standardized cannabis extract. Ther Drug Monit. 2005;27(6):799–810.
    • (2005) Ther Drug Monit , vol.27 , Issue.6 , pp. 799-810
    • Nadulski, T.1    Pragst, F.2    Weinberg, G.3
  • 103
    • 84878802805 scopus 로고    scopus 로고
    • A phase I, open-label, randomized, crossover study in three parallel groups to evaluate the effect of rifampicin, ketoconazole, and omeprazole on the pharmacokinetics of THC/CBD oromucosal spray in healthy volunteers
    • PID: 23750331
    • Stott C, White L, Wright S, et al. A phase I, open-label, randomized, crossover study in three parallel groups to evaluate the effect of rifampicin, ketoconazole, and omeprazole on the pharmacokinetics of THC/CBD oromucosal spray in healthy volunteers. Springerplus. 2013;2(1):236.
    • (2013) Springerplus. , vol.2 , Issue.1 , pp. 236
    • Stott, C.1    White, L.2    Wright, S.3
  • 104
    • 0019774065 scopus 로고
    • Pharmacokinetics of bupropion, a novel antidepressant agent, following oral administration to healthy subjects
    • COI: 1:CAS:528:DyaL38Xmt1Gnsg%3D%3D, PID: 6804243
    • Findlay JW, Van Wyck Fleet J, Smith PG, et al. Pharmacokinetics of bupropion, a novel antidepressant agent, following oral administration to healthy subjects. Eur J Clin Pharmacol. 1981;21(2):127–35.
    • (1981) Eur J Clin Pharmacol , vol.21 , Issue.2 , pp. 127-135
    • Findlay, J.W.1    Van Wyck, F.J.2    Smith, P.G.3
  • 105
    • 0142188754 scopus 로고    scopus 로고
    • Bupropion and 4-OH-bupropion pharmacokinetics in relation to genetic polymorphisms in CYP2B6
    • COI: 1:CAS:528:DC%2BD3sXns1aruro%3D, PID: 14515060
    • Kirchheiner J, Klein C, Meineke I, et al. Bupropion and 4-OH-bupropion pharmacokinetics in relation to genetic polymorphisms in CYP2B6. Pharmacogenetics. 2003;13(10):619–26.
    • (2003) Pharmacogenetics. , vol.13 , Issue.10 , pp. 619-626
    • Kirchheiner, J.1    Klein, C.2    Meineke, I.3
  • 106
    • 40749104678 scopus 로고    scopus 로고
    • Stereoselective bupropion hydroxylation as an in vivo phenotypic probe for cytochrome P4502B6 (CYP2B6) activity
    • COI: 1:CAS:528:DC%2BD1cXkslKntLg%3D, PID: 18287571
    • Kharasch ED, Mitchell D, Coles R. Stereoselective bupropion hydroxylation as an in vivo phenotypic probe for cytochrome P4502B6 (CYP2B6) activity. J Clin Pharmacol. 2008;48(4):464–74.
    • (2008) J Clin Pharmacol , vol.48 , Issue.4 , pp. 464-474
    • Kharasch, E.D.1    Mitchell, D.2    Coles, R.3
  • 107
    • 29144510522 scopus 로고    scopus 로고
    • Bupropion for major depressive disorder: pharmacokinetic and formulation considerations
    • COI: 1:CAS:528:DC%2BD28XntlWntQ%3D%3D, PID: 16368442
    • Jefferson JW, Pradko JF, Muir KT. Bupropion for major depressive disorder: pharmacokinetic and formulation considerations. Clin Ther. 2005;27(11):1685–95.
    • (2005) Clin Ther , vol.27 , Issue.11 , pp. 1685-1695
    • Jefferson, J.W.1    Pradko, J.F.2    Muir, K.T.3
  • 108
    • 77955654070 scopus 로고    scopus 로고
    • Role of transporter-mediated efflux in the placental biodisposition of bupropion and its metabolite, OH-bupropion
    • COI: 1:CAS:528:DC%2BC3cXhtVeku7bK, PID: 20599802
    • Hemauer SJ, Patrikeeva SL, Wang X, et al. Role of transporter-mediated efflux in the placental biodisposition of bupropion and its metabolite, OH-bupropion. Biochem Pharmacol. 2010;80(7):1080–6.
    • (2010) Biochem Pharmacol. , vol.80 , Issue.7 , pp. 1080-1086
    • Hemauer, S.J.1    Patrikeeva, S.L.2    Wang, X.3
  • 109
    • 46449138007 scopus 로고    scopus 로고
    • An in vitro mechanistic study to elucidate the desipramine/bupropion clinical drug-drug interaction
    • COI: 1:CAS:528:DC%2BD1cXotVegtbc%3D, PID: 18420781
    • Reese MJ, Wurm RM, Muir KT, et al. An in vitro mechanistic study to elucidate the desipramine/bupropion clinical drug-drug interaction. Drug Metab Dispos. 2008;36(7):1198–201.
    • (2008) Drug Metab Dispos , vol.36 , Issue.7 , pp. 1198-1201
    • Reese, M.J.1    Wurm, R.M.2    Muir, K.T.3
  • 110
    • 0030940622 scopus 로고    scopus 로고
    • A possible bupropion and imipramine interaction
    • COI: 1:STN:280:DC%2BD3cvitFWnsQ%3D%3D, PID: 10950476
    • Shad MU, Preskorn SH. A possible bupropion and imipramine interaction. J Clin Psychopharmacol. 1997;17(2):118–9.
    • (1997) J Clin Psychopharmacol , vol.17 , Issue.2 , pp. 118-119
    • Shad, M.U.1    Preskorn, S.H.2
  • 111
    • 0036101557 scopus 로고    scopus 로고
    • Combining bupropion SR with venlafaxine, paroxetine, or fluoxetine: a preliminary report on pharmacokinetic, therapeutic, and sexual dysfunction effects
    • COI: 1:CAS:528:DC%2BD38XjtFSitLw%3D, PID: 11926715
    • Kennedy SH, McCann SM, Masellis M, et al. Combining bupropion SR with venlafaxine, paroxetine, or fluoxetine: a preliminary report on pharmacokinetic, therapeutic, and sexual dysfunction effects. J Clin Psychiatry. 2002;63(3):181–6.
    • (2002) J Clin Psychiatry , vol.63 , Issue.3 , pp. 181-186
    • Kennedy, S.H.1    McCann, S.M.2    Masellis, M.3
  • 112
    • 0036001244 scopus 로고    scopus 로고
    • Change from the CYP2D6 extensive metabolizer to the poor metabolizer phenotype during treatment with bupropion
    • PID: 12021638
    • Guzey C, Norstrom A, Spigset O. Change from the CYP2D6 extensive metabolizer to the poor metabolizer phenotype during treatment with bupropion. Ther Drug Monit. 2002;24(3):436–7.
    • (2002) Ther Drug Monit , vol.24 , Issue.3 , pp. 436-437
    • Guzey, C.1    Norstrom, A.2    Spigset, O.3
  • 113
    • 18844458608 scopus 로고    scopus 로고
    • Inhibition of CYP2D6 activity by bupropion
    • COI: 1:CAS:528:DC%2BD2MXjvVyhtbk%3D, PID: 15876900
    • Kotlyar M, Brauer LH, Tracy TS, et al. Inhibition of CYP2D6 activity by bupropion. J Clin Psychopharmacol. 2005;25(3):226–9.
    • (2005) J Clin Psychopharmacol , vol.25 , Issue.3 , pp. 226-229
    • Kotlyar, M.1    Brauer, L.H.2    Tracy, T.S.3
  • 114
    • 0028886358 scopus 로고
    • Carbamazepine but not valproate induces bupropion metabolism
    • COI: 1:STN:280:DyaK287hs1Smsg%3D%3D, PID: 8830063
    • Ketter TA, Jenkins JB, Schroeder DH, et al. Carbamazepine but not valproate induces bupropion metabolism. J Clin Psychopharmacol. 1995;15(5):327–33.
    • (1995) J Clin Psychopharmacol , vol.15 , Issue.5 , pp. 327-333
    • Ketter, T.A.1    Jenkins, J.B.2    Schroeder, D.H.3
  • 115
    • 33745678731 scopus 로고    scopus 로고
    • Cytochrome P450 2B6 activity as measured by bupropion hydroxylation: effect of induction by rifampin and ethnicity
    • COI: 1:CAS:528:DC%2BD28Xms1enu7c%3D, PID: 16815319
    • Loboz KK, Gross AS, Williams KM, et al. Cytochrome P450 2B6 activity as measured by bupropion hydroxylation: effect of induction by rifampin and ethnicity. Clin Pharmacol Ther. 2006;80(1):75–84.
    • (2006) Clin Pharmacol Ther , vol.80 , Issue.1 , pp. 75-84
    • Loboz, K.K.1    Gross, A.S.2    Williams, K.M.3
  • 116
    • 78650737749 scopus 로고    scopus 로고
    • Effects of pregnane X receptor (NR1I2) and CYP2B6 genetic polymorphisms on the induction of bupropion hydroxylation by rifampin
    • COI: 1:CAS:528:DC%2BC3MXls1elsg%3D%3D, PID: 20876786
    • Chung JY, Cho JY, Lim HS, et al. Effects of pregnane X receptor (NR1I2) and CYP2B6 genetic polymorphisms on the induction of bupropion hydroxylation by rifampin. Drug Metab Dispos. 2011;39(1):92–7.
    • (2011) Drug Metab Dispos , vol.39 , Issue.1 , pp. 92-97
    • Chung, J.Y.1    Cho, J.Y.2    Lim, H.S.3
  • 117
    • 37349061699 scopus 로고    scopus 로고
    • Drug interactions in the management of HIV infection: an update
    • COI: 1:CAS:528:DC%2BD2sXhtlSmtbfE, PID: 18001255
    • Robertson SM, Penzak SR, Pau A. Drug interactions in the management of HIV infection: an update. Expert Opin Pharmacother. 2007;8(17):2947–63.
    • (2007) Expert Opin Pharmacother , vol.8 , Issue.17 , pp. 2947-2963
    • Robertson, S.M.1    Penzak, S.R.2    Pau, A.3
  • 118
    • 42949134269 scopus 로고    scopus 로고
    • Rapid clinical induction of hepatic cytochrome P4502B6 activity by ritonavir
    • COI: 1:CAS:528:DC%2BD1cXls1ajtbk%3D, PID: 18285471
    • Kharasch ED, Mitchell D, Coles R, et al. Rapid clinical induction of hepatic cytochrome P4502B6 activity by ritonavir. Antimicrob Agents Chemother. 2008;52(5):1663–9.
    • (2008) Antimicrob Agents Chemother , vol.52 , Issue.5 , pp. 1663-1669
    • Kharasch, E.D.1    Mitchell, D.2    Coles, R.3
  • 119
    • 33645785875 scopus 로고    scopus 로고
    • Ritonavir has minimal impact on the pharmacokinetic disposition of a single dose of bupropion administered to human volunteers
    • COI: 1:CAS:528:DC%2BD28Xksl2ms7c%3D, PID: 16638740
    • Hesse LM, Greenblatt DJ, von Moltke LL, et al. Ritonavir has minimal impact on the pharmacokinetic disposition of a single dose of bupropion administered to human volunteers. J Clin Pharmacol. 2006;46(5):567–76.
    • (2006) J Clin Pharmacol , vol.46 , Issue.5 , pp. 567-576
    • Hesse, L.M.1    Greenblatt, D.J.2    von Moltke, L.L.3
  • 120
    • 33846039806 scopus 로고    scopus 로고
    • Lopinavir/ritonavir reduces bupropion plasma concentrations in healthy subjects
    • COI: 1:CAS:528:DC%2BD2sXht1aqsbs%3D, PID: 17186001
    • Hogeland GW, Swindells S, McNabb JC, et al. Lopinavir/ritonavir reduces bupropion plasma concentrations in healthy subjects. Clin Pharmacol Ther. 2007;81(1):69–75.
    • (2007) Clin Pharmacol Ther , vol.81 , Issue.1 , pp. 69-75
    • Hogeland, G.W.1    Swindells, S.2    McNabb, J.C.3
  • 121
    • 62749169219 scopus 로고    scopus 로고
    • Efavirenz induces CYP2B6-mediated hydroxylation of bupropion in healthy subjects
    • COI: 1:CAS:528:DC%2BD1MXkt1Grtg%3D%3D, PID: 18989234
    • Robertson SM, Maldarelli F, Natarajan V, et al. Efavirenz induces CYP2B6-mediated hydroxylation of bupropion in healthy subjects. J Acquir Immune Defic Syndr. 2008;49(5):513–9.
    • (2008) J Acquir Immune Defic Syndr , vol.49 , Issue.5 , pp. 513-519
    • Robertson, S.M.1    Maldarelli, F.2    Natarajan, V.3
  • 122
    • 20444458419 scopus 로고    scopus 로고
    • Effect of clopidogrel and ticlopidine on cytochrome P450 2B6 activity as measured by bupropion hydroxylation
    • COI: 1:CAS:528:DC%2BD2MXlt1Gqt7k%3D, PID: 15961986
    • Turpeinen M, Tolonen A, Uusitalo J, et al. Effect of clopidogrel and ticlopidine on cytochrome P450 2B6 activity as measured by bupropion hydroxylation. Clin Pharmacol Ther. 2005;77(6):553–9.
    • (2005) Clin Pharmacol Ther , vol.77 , Issue.6 , pp. 553-559
    • Turpeinen, M.1    Tolonen, A.2    Uusitalo, J.3
  • 123
    • 0141706942 scopus 로고    scopus 로고
    • Inhibition of cytochrome P450 2B6 activity by hormone replacement therapy and oral contraceptive as measured by bupropion hydroxylation
    • COI: 1:CAS:528:DC%2BD3sXnvVyksrs%3D, PID: 14534519
    • Palovaara S, Pelkonen O, Uusitalo J, et al. Inhibition of cytochrome P450 2B6 activity by hormone replacement therapy and oral contraceptive as measured by bupropion hydroxylation. Clin Pharmacol Ther. 2003;74(4):326–33.
    • (2003) Clin Pharmacol Ther , vol.74 , Issue.4 , pp. 326-333
    • Palovaara, S.1    Pelkonen, O.2    Uusitalo, J.3
  • 124
    • 77949471545 scopus 로고    scopus 로고
    • Effect of St. John’s wort supplementation on the pharmacokinetics of bupropion in healthy male Chinese volunteers
    • COI: 1:CAS:528:DC%2BC3cXjtVyhs7w%3D, PID: 20102294
    • Lei HP, Yu XY, Xie HT, et al. Effect of St. John’s wort supplementation on the pharmacokinetics of bupropion in healthy male Chinese volunteers. Xenobiotica. 2010;40(4):275–81.
    • (2010) Xenobiotica , vol.40 , Issue.4 , pp. 275-281
    • Lei, H.P.1    Yu, X.Y.2    Xie, H.T.3
  • 125
    • 62549121605 scopus 로고    scopus 로고
    • Induction of cytochrome P450 2B6 activity by the herbal medicine baicalin as measured by bupropion hydroxylation
    • COI: 1:CAS:528:DC%2BD1MXjt1Shs78%3D, PID: 19066872
    • Fan L, Wang JC, Jiang F, et al. Induction of cytochrome P450 2B6 activity by the herbal medicine baicalin as measured by bupropion hydroxylation. Eur J Clin Pharmacol. 2009;65(4):403–9.
    • (2009) Eur J Clin Pharmacol , vol.65 , Issue.4 , pp. 403-409
    • Fan, L.1    Wang, J.C.2    Jiang, F.3
  • 126
    • 44149124305 scopus 로고    scopus 로고
    • Identification and characterization of potent CYP2B6 inhibitors in Woohwangcheongsimwon suspension, an herbal preparation used in the treatment and prevention of apoplexy in Korea and China
    • COI: 1:CAS:528:DC%2BD1cXmsVOmtb0%3D, PID: 18332082
    • Kim H, Kim KB, Ku HY, et al. Identification and characterization of potent CYP2B6 inhibitors in Woohwangcheongsimwon suspension, an herbal preparation used in the treatment and prevention of apoplexy in Korea and China. Drug Metab Dispos. 2008;36(6):1010–5.
    • (2008) Drug Metab Dispos , vol.36 , Issue.6 , pp. 1010-1015
    • Kim, H.1    Kim, K.B.2    Ku, H.Y.3
  • 127
    • 0036951332 scopus 로고    scopus 로고
    • Ginkgo biloba extract markedly induces pentoxyresorufin O-dealkylase activity in rats
    • COI: 1:CAS:528:DC%2BD3sXitlOqsw%3D%3D, PID: 12501011
    • Umegaki K, Saito K, Kubota Y, et al. Ginkgo biloba extract markedly induces pentoxyresorufin O-dealkylase activity in rats. Jpn J Pharmacol. 2002;90(4):345–51.
    • (2002) Jpn J Pharmacol , vol.90 , Issue.4 , pp. 345-351
    • Umegaki, K.1    Saito, K.2    Kubota, Y.3
  • 128
    • 68449095081 scopus 로고    scopus 로고
    • Effects of Ginkgo biloba extract on the pharmacokinetics of bupropion in healthy volunteers
    • COI: 1:CAS:528:DC%2BD1MXhtFGmtLbM, PID: 19694739
    • Lei HP, Ji W, Lin J, et al. Effects of Ginkgo biloba extract on the pharmacokinetics of bupropion in healthy volunteers. Br J Clin Pharmacol. 2009;68(2):201–6.
    • (2009) Br J Clin Pharmacol , vol.68 , Issue.2 , pp. 201-206
    • Lei, H.P.1    Ji, W.2    Lin, J.3
  • 129
    • 77953504763 scopus 로고    scopus 로고
    • Effects of woohwangcheongsimwon suspension on the pharmacokinetics of bupropion and its active metabolite, 4-hydroxybupropion, in healthy subjects
    • COI: 1:CAS:528:DC%2BC3cXps1ems7s%3D, PID: 20642555
    • Kim H, Bae SK, Park SJ, et al. Effects of woohwangcheongsimwon suspension on the pharmacokinetics of bupropion and its active metabolite, 4-hydroxybupropion, in healthy subjects. Br J Clin Pharmacol. 2010;70(1):126–31.
    • (2010) Br J Clin Pharmacol , vol.70 , Issue.1 , pp. 126-131
    • Kim, H.1    Bae, S.K.2    Park, S.J.3
  • 130
    • 78349277396 scopus 로고    scopus 로고
    • A review of the clinical pharmacokinetics and pharmacodynamics of varenicline for smoking cessation
    • COI: 1:CAS:528:DC%2BC3MXltlGnug%3D%3D, PID: 21053991
    • Faessel HM, Obach RS, Rollema H, et al. A review of the clinical pharmacokinetics and pharmacodynamics of varenicline for smoking cessation. Clin Pharmacokinet. 2010;49(12):799–816.
    • (2010) Clin Pharmacokinet , vol.49 , Issue.12 , pp. 799-816
    • Faessel, H.M.1    Obach, R.S.2    Rollema, H.3
  • 131
    • 40949148698 scopus 로고    scopus 로고
    • Effect of human renal cationic transporter inhibition on the pharmacokinetics of varenicline, a new therapy for smoking cessation: an in vitro–in vivo study
    • COI: 1:CAS:528:DC%2BD1cXjsFClu7g%3D, PID: 17971819
    • Feng B, Obach RS, Burstein AH, et al. Effect of human renal cationic transporter inhibition on the pharmacokinetics of varenicline, a new therapy for smoking cessation: an in vitro–in vivo study. Clin Pharmacol Ther. 2008;83(4):567–76.
    • (2008) Clin Pharmacol Ther , vol.83 , Issue.4 , pp. 567-576
    • Feng, B.1    Obach, R.S.2    Burstein, A.H.3
  • 132
    • 35448972134 scopus 로고    scopus 로고
    • Lack of pharmacokinetic and pharmacodynamic interactions between a smoking cessation therapy, varenicline, and warfarin: an in vivo and in vitro study
    • COI: 1:CAS:528:DC%2BD2sXhtlGru7jN, PID: 17962429
    • Burstein AH, Clark DJ, O’Gorman M, et al. Lack of pharmacokinetic and pharmacodynamic interactions between a smoking cessation therapy, varenicline, and warfarin: an in vivo and in vitro study. J Clin Pharmacol. 2007;47(11):1421–9.
    • (2007) J Clin Pharmacol , vol.47 , Issue.11 , pp. 1421-1429
    • Burstein, A.H.1    Clark, D.J.2    O’Gorman, M.3
  • 133
    • 55349087223 scopus 로고    scopus 로고
    • Lack of a pharmacokinetic interaction between a new smoking cessation therapy, varenicline, and digoxin in adult smokers
    • COI: 1:CAS:528:DC%2BD1cXhtlShu7vJ, PID: 18661125
    • Faessel HM, Burstein AH, Troutman MD, et al. Lack of a pharmacokinetic interaction between a new smoking cessation therapy, varenicline, and digoxin in adult smokers. Eur J Clin Pharmacol. 2008;64(11):1101–9.
    • (2008) Eur J Clin Pharmacol , vol.64 , Issue.11 , pp. 1101-1109
    • Faessel, H.M.1    Burstein, A.H.2    Troutman, M.D.3
  • 134
    • 0032456205 scopus 로고    scopus 로고
    • Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs
    • COI: 1:CAS:528:DyaK1cXnsVerurk%3D, PID: 9808712
    • Urakami Y, Okuda M, Masuda S, et al. Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs. J Pharmacol Exp Ther. 1998;287(2):800–5.
    • (1998) J Pharmacol Exp Ther , vol.287 , Issue.2 , pp. 800-805
    • Urakami, Y.1    Okuda, M.2    Masuda, S.3
  • 135
    • 36749002231 scopus 로고    scopus 로고
    • Cytisine for smoking cessation: a research agenda
    • COI: 1:CAS:528:DC%2BD2sXhsVWjsr%2FP, PID: 17825502
    • Etter JF, Lukas RJ, Benowitz NL, et al. Cytisine for smoking cessation: a research agenda. Drug Alcohol Depend. 2008;92(1–3):3–8.
    • (2008) Drug Alcohol Depend , vol.92 , Issue.1-3 , pp. 3-8
    • Etter, J.F.1    Lukas, R.J.2    Benowitz, N.L.3
  • 136
    • 84927645316 scopus 로고    scopus 로고
    • Agonist and antagonist effects of cytisine in vivo
    • COI: 1:CAS:528:DC%2BC2MXmtVant7o%3D, PID: 25839895
    • Radchenko EV, Dravolina OA, Bespalov AY. Agonist and antagonist effects of cytisine in vivo. Neuropharmacology. 2015;95:206–14.
    • (2015) Neuropharmacology , vol.95 , pp. 206-214
    • Radchenko, E.V.1    Dravolina, O.A.2    Bespalov, A.Y.3
  • 137
    • 84930241644 scopus 로고    scopus 로고
    • Pharmacokinetics of cytisine, an alpha4 beta2 nicotinic receptor partial agonist, in healthy smokers following a single dose
    • COI: 1:CAS:528:DC%2BC2MXpt1eit7c%3D, PID: 25231024
    • Jeong SH, Newcombe D, Sheridan J, et al. Pharmacokinetics of cytisine, an alpha4 beta2 nicotinic receptor partial agonist, in healthy smokers following a single dose. Drug Test Anal. 2015;7(6):475–82.
    • (2015) Drug Test Anal. , vol.7 , Issue.6 , pp. 475-482
    • Jeong, S.H.1    Newcombe, D.2    Sheridan, J.3
  • 138
    • 77951683231 scopus 로고    scopus 로고
    • Pre-clinical properties of the alpha4beta2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence
    • COI: 1:CAS:528:DC%2BC3cXpslyqsLo%3D, PID: 20331614
    • Rollema H, Shrikhande A, Ward KM, et al. Pre-clinical properties of the alpha4beta2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence. Br J Pharmacol. 2010;160(2):334–45.
    • (2010) Br J Pharmacol , vol.160 , Issue.2 , pp. 334-345
    • Rollema, H.1    Shrikhande, A.2    Ward, K.M.3
  • 139
    • 84891791619 scopus 로고    scopus 로고
    • Pharmacological interventions for smoking cessation: an overview and network meta-analysis
    • PID: 23728690
    • Cahill K, Stevens S, Perera R, et al. Pharmacological interventions for smoking cessation: an overview and network meta-analysis. Cochrane Database Syst Rev. 2013;5:CD009329.
    • (2013) Cochrane Database Syst Rev. , vol.5 , pp. CD009329
    • Cahill, K.1    Stevens, S.2    Perera, R.3
  • 140
    • 84893124172 scopus 로고    scopus 로고
    • Pharmacotherapy for smoking cessation: pharmacological principles and clinical practice
    • COI: 1:CAS:528:DC%2BC2cXhtlart7k%3D, PID: 23488726
    • Aubin HJ, Luquiens A, Berlin I. Pharmacotherapy for smoking cessation: pharmacological principles and clinical practice. Br J Clin Pharmacol. 2014;77(2):324–36.
    • (2014) Br J Clin Pharmacol , vol.77 , Issue.2 , pp. 324-336
    • Aubin, H.J.1    Luquiens, A.2    Berlin, I.3
  • 141
    • 0030992855 scopus 로고    scopus 로고
    • Hydroxylation and demethylation of the tricyclic antidepressant nortriptyline by cDNA-expressed human cytochrome P-450 isozymes
    • COI: 1:CAS:528:DyaK2sXktFGht7k%3D, PID: 9193876
    • Olesen OV, Linnet K. Hydroxylation and demethylation of the tricyclic antidepressant nortriptyline by cDNA-expressed human cytochrome P-450 isozymes. Drug Metab Dispos. 1997;25(6):740–4.
    • (1997) Drug Metab Dispos , vol.25 , Issue.6 , pp. 740-744
    • Olesen, O.V.1    Linnet, K.2
  • 142
    • 0033314052 scopus 로고    scopus 로고
    • Nortriptyline E-10-hydroxylation in vitro is mediated by human CYP2D6 (high affinity) and CYP3A4 (low affinity): implications for interactions with enzyme-inducing drugs
    • COI: 1:CAS:528:DC%2BD3cXivFahsA%3D%3D, PID: 10354960
    • Venkatakrishnan K, von Moltke LL, Greenblatt DJ. Nortriptyline E-10-hydroxylation in vitro is mediated by human CYP2D6 (high affinity) and CYP3A4 (low affinity): implications for interactions with enzyme-inducing drugs. J Clin Pharmacol. 1999;39(6):567–77.
    • (1999) J Clin Pharmacol , vol.39 , Issue.6 , pp. 567-577
    • Venkatakrishnan, K.1    von Moltke, L.L.2    Greenblatt, D.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.