Nortriptyline E-10-hydroxylation in vitro is mediated by human CYP2D6 (high affinity) and CYP3A4 (low affinity): Implications for interactions with enzyme-inducing drugs

Journal of Clinical Pharmacology

Volumn 39, Issue 6, 1999, Pages 567-577

  Venkatakrishnan, K ^a   Von Moltke, L L ^a   Greenblatt, D J ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

10 HYDROXYNORTRIPTYLINE; CARBAMAZEPINE; CYTOCHROME P450 3A4; CYTOCHROME P450 INHIBITOR; DEBRISOQUINE; DEBRISOQUINE 4 HYDROXYLASE; ENZYME INDUCING AGENT; KETOCONAZOLE; NORTRIPTYLINE; PENTOBARBITAL; QUINIDINE; RIFAMPICIN;

ARTICLE; BINDING AFFINITY; CATALYSIS; CONTROLLED STUDY; DRUG CLEARANCE; DRUG HYDROXYLATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME KINETICS; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER MICROSOME; LYMPHOBLASTOID CELL; SIMULATION;

EID: 0033314052     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1177/00912709922008173     Document Type: Article

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