Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs

Journal of Pharmacology and Experimental Therapeutics

Volumn 287, Issue 2, 1998, Pages 800-805

  Urakami, Yumiko ^a   Okuda, Masahiro ^a   Masuda, Satohiro ^a   Saito, Hideyuki ^a   Inui, Ken Ichi ^a  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 4 (2 HYDROXYETHYL) 1 PIPERAZINEETHANESULFONIC ACID; CEFALEXIN; CIMETIDINE; GUANIDINE; N METHYLNICOTINAMIDE; NICOTINE; QUINIDINE; SULFONIC ACID DERIVATIVE; TETRYLAMMONIUM;

ACIDIFICATION; ANIMAL CELL; ARTICLE; CATION TRANSPORT; CELL CULTURE; DRUG ABSORPTION; DRUG EXCRETION; DRUG UPTAKE; GENETIC TRANSFECTION; HYDROPHILICITY; KIDNEY TUBULE ABSORPTION; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; RAT; TISSUE DISTRIBUTION; TISSUE SPECIFICITY; URINARY EXCRETION;

ANIMALS; BASE SEQUENCE; CARRIER PROTEINS; CATIONS; CELL LINE; CELL MEMBRANE; DNA PRIMERS; DOGS; KIDNEY TUBULES; MEMBRANE PROTEINS; ORGANIC CATION TRANSPORT PROTEINS; ORGANIC CATION TRANSPORTER 1; RATS; TETRAETHYLAMMONIUM;

EID: 0032456205     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
2. Brewer CB (1994) Cytomegalovirus plasmid vectors for permanent lines of polarized epithelial cells. Methods Cell Biol 43:233-245.
3. Chirgwin JM, Przybyla AE, MacDonald RJ and Rutter WJ (1979) Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294-5299.
4. Dantzler WH, Brokl OH and Wright SH (1989) Brush-border TEA transport in intact proximal tubules and isolated membrane vesicles. Am J Physiol 256:F290-F297.
5. +/organic cations in the rat proximal tubule: kinetics, dependence on pH; Specificity as compared with the contraluminal organic cation-transport system. Pflügers Arch Eur J Physiol 430:477-492.
6. Gorboulev V, Ulzheimer JC, Akhoundova A, Ulzheimer-Teuber I, Karbach U, Quester S, Baumann C, Lang F, Busch AE and Koepsell H (1997) Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol 16:871-881.
7. Gründemann D, Gorboulev V, Gambaryan S, Veyhl M and Koepsell H (1994) Drug excretion mediated by a new prototype of polyspecific transporter. Nature 372: 549-552.
8. 1 cells. J Biol Chem 272:10408-10413.
9. Handler JS, Perkins FM and Johnson JP (1980) Studies of renal cell function using cell culture techniques. Am J Physiol 238:F1-F9.
10. Holohan PD and Ross CH (1981) Mechanisms of organic cation transport in kidney plasma membrane vesicles: 2. ΔpH studies. J Pharmacol Exp Ther 216:294-298.
11. Hsyu P-H and Giacomini KM (1987) The pH gradient-dependent transport of organic cations in the renal brush border membrane. J Biol Chem 262:3964-3968.
12. Inui K, Okano T, Takano M, Kitazawa S and Hori R (1981) A simple method for the isolation of basolateral plasma membrane vesicles from rat kidney cortex. Biochem Biophys Acta 647:150-154.
13. 1. J Am Soc Nephrol 3:829.
14. Inui K, Takano M and Hori R (1991) Organic cation transport in the renal brush-border and basolateral membranes, in Nephrology (Hatano M, ed) pp 1391-1398, Springer-Verlag, Tokyo, Japan.
15. Kim YK and Dantzler WH (1997) Effects of pH on basolateral tetraethylammonium transport in snake renal proximal tubules. Am J Physiol 272:R955-R961.
16. Masuda S, Saito H, Nonoguchi H, Tomita K and Inui K (1997) mRNA distribution and membrane localization of the OAT-K1 organic anion transporter in rat renal tubules. FEBS Lett 407:127-131.
17. Miyamoto Y, Tiruppathi C, Ganapathy V and Leibach FH (1989) Multiple transport systems for organic cations in renal brush-border membrane vesicles. Am J Physiol 256:F540-F548.
18. Montrose-Rafizadeh C, Mingard F, Murer H and Roch-Ramel F (1989) Carrier-mediated transport of tetraethylammonium across rabbit renal basolateral membrane. Am J Physiol 257:F243-F251.
19. Okuda M, Saito H, Urakami Y, Takano M and Inui K (1996) cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2. Biochem Biophys Res Commun 224:500-507.
20. Paulusma CC, Bosma PJ, Zaman GJR, Bakker CTM, Otter M, Scheffer GL, Scheper RJ, Borst P and Oude Elferink RPJ (1996) Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene. Science 271:1126-1128.
21. Pritchard JB and Miller DS (1993) Mechanisms mediating renal secretion of organic anions and cations. Physiol Rev 73:765-796.
22. Sabolic I, Valenti G, Verbavatz J-M, Van Hoek AN, Verkman AS, Ausiello DA and Brown D (1992) Localization of the CHIP28 water channel in rat kidney. Am J Physiol 263:C1225-C1233.
23. +/peptide cotransporter mediating absorption of β-lactam antibiotics in the intestine and kidney. J Pharmacol Exp Ther 275:1631-1637.
24. 1. Am J Physiol 262:C59-C66.
25. Sokol PP and McKinney TD (1990) Mechanism of organic cation transport in rabbit renal basolateral membrane vesicles. Am J Physiol 258:F1599-F1607.
26. Takano M, Inui K, Okano T, Saito H and Hori R (1984) Carrier-mediated transport systems of tetraethylammonium in rat renal brush-border and basolateral membrane vesicles. Biochim Biophys Acta 773:113-124.
27. +/peptide cotransporter, PEPT1. FEBS Lett 394:196-200.
28. +/glucose cotransporter. Nature 350: 354-356.