Clopidogrel efficacy and cigarette smoking status

JAMA

Volumn 307, Issue 23, 2012, Pages 2495-2496

  Gurbel, Paul A ^a   Nolin, Thomas D ^b   Tantry, Udaya S ^a  

^a SINAI CENTER FOR THROMBOSIS RESEARCH   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; CLOPIDOGREL; CYTOCHROME P450 1A2; PLACEBO;

CARDIOVASCULAR MORTALITY; CIGARETTE SMOKING; DRUG COST; DRUG EFFICACY; DRUG MEGADOSE; DRUG METABOLISM; DRUG RESPONSE; ENZYME ACTIVITY; HIGH RISK PATIENT; HUMAN; INCIDENCE; LOADING DRUG DOSE; METABOLIC ACTIVATION; OUTCOME ASSESSMENT; PHARMACODYNAMICS; PRIORITY JOURNAL; SHORT SURVEY; SMOKING HABIT; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; STROKE; UNSTABLE ANGINA PECTORIS;

EID: 84862504147     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2012.5930     Document Type: Short Survey

References (7)

1. Ferreiro JL, Bhatt D, Ueno M, et al. Differential effect of smoking on long-term outcomes in patients with atherosclerotic vascular disease treated with aspirin or clopidogrel: insights from the Clopidogrel Versus Aspirin in Patients at Risk of Ischemic Events Trial [abstract]. J Am Coll Cardiol. 2012;59:A62.
2. Salek FS. Relationship between clopidogrel and cigarette smoking status in patients with acute coronary syndromes without ST-segment elevation myocardial infarction [abstract]. Pharmacotherapy. 2010;30:154e.
3. Saraff KY, Steinhubl SR, Hsu AP, Topol EJ. Smoking influences the effectiveness of dual antiplatelet therapy on long-term outcomes following PCI [abstract]. J Am Coll Cardiol. 2006;47(4):36B.
4. Desai NR, Mega JL, Jiang S, Cannon CP, Sabatine MS. Interaction between cigarette smoking and clinical benefit of clopidogrel. J Am Coll Cardiol. 2009;53(15):1273-1278.
5. Mehta SR, Tanguay JF, Eikelboom JW, et al; CURRENT-OASIS 7 trial investigators. Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial. Lancet. 2010;376(9748):1233-1243.
6. Bliden KP, Dichiara J, Lawal L, et al. The association of cigarette smoking with enhanced platelet inhibition by clopidogrel. J Am Coll Cardiol. 2008;52(7):531-533.
7. Berger JS, Bhatt DL, Steinhubl SR, et al CHARISMA Investigators. Smoking, clopidogrel, and mortality in patients with established cardiovascular disease. Circulation. 2009;120(23):2337-2344.