Identification and characterization of potent CYP2B6 inhibitors in Woohwangcheongsimwon suspension, an herbal preparation used in the treatment and prevention of apoplexy in Korea and China

Drug Metabolism and Disposition

Volumn 36, Issue 6, 2008, Pages 1010-1015

  Kim, Hyunmi ^a   Kim, Kwon Bok ^a   Ku, Hei Young ^a   Soo, Jin Park ^a   Choi, Hoon ^c   Moon, Joon Kwan ^c   Park, Byeoung Soo ^c   Kim, Jeong Han ^c   Sung, Su Yea ^a,b   Lee, Choong Hwan ^d   Hye, Suk Lee ^e   Shin, Jae Gook ^a   Liu, Kwang Hyeon ^a,b  

^a Inje University College of Medicine   (South Korea)

^b Inje University   (South Korea)

^c Seoul National University   (South Korea)

^d Konkuk University   (South Korea)

^e Wonkwang University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID ETHYL ESTER; AMFEBUTAMONE; BORNEOL; CHLORZOXAZONE; COUMARIN; CYTOCHROME P450 2B6; CYTOCHROME P450 2B6 INHIBITOR; DEXTROMETHORPHAN; DICHLOROMETHANE; EFAVIRENZ; EFAVIRENZ 8 HYDROXYLASE; HERBACEOUS AGENT; HEXANE; ISOBOMEOL; MIDAZOLAM; OXYGENASE; PHENACETIN; ROSIGLITAZONE; TERPENOID; THIOTEPA; TOLBUTAMIDE; WOOHWANGCHEONGSIMWON;

ARTICLE; CEREBROVASCULAR ACCIDENT; CHINA; CONTROLLED STUDY; DRUG ANALYSIS; DRUG HYDROXYLATION; DRUG IDENTIFICATION; DRUG INHIBITION; ENZYME INHIBITION; GAS CHROMATOGRAPHY; HERB DRUG INTERACTION; HUMAN; HUMAN TISSUE; KOREA; LIVER MICROSOME; MASS SPECTROMETRY; PRIORITY JOURNAL; PROPHYLAXIS;

ARYL HYDROCARBON HYDROXYLASES; BORNANES; CHINA; HERB-DRUG INTERACTIONS; HUMANS; KOREA; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; OXIDOREDUCTASES, N-DEMETHYLATING; PHYTOTHERAPY; PLANT PREPARATIONS; STROKE; SUSPENSIONS;

EID: 44149124305     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.107.019612     Document Type: Article

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