Hormonal regulation of CYP1A expression Hormonal regulation of CYP1A expression Monostory et al.

Drug Metabolism Reviews

Volumn 41, Issue 4, 2009, Pages 547-572

  Monostory, Katalin ^a   Pascussi, Jean Marc ^b   Kóbori, László ^c   Dvorak, Zdenek ^d  

^a CHEMICAL RESEARCH CENTER   (Hungary)

^b INSERM   (France)

^c SEMMELWEIS UNIVERSITY   (Hungary)

^d PALACKÝ UNIVERSITY   (Czech Republic)

Author keywords

Aryl hydrocarbon receptor; CYP1A enzymes; Drug metabolism; Glucocorticoids; Insulin; Nuclear receptors; Retinoids; Sexual steroids; Thyroid hormones; Vitamin D

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 3 METHYLCHOLANTHRENE; ALPHA NAPHTHOFLAVONE; ANDROGEN; ANDROSTANOLONE; AROMATIC HYDROCARBON RECEPTOR; CELL NUCLEUS RECEPTOR; CYCLOHEXIMIDE; CYTOCHROME P450 1A; DEXAMETHASONE; ESTRADIOL; ESTROGEN; FLUTAMIDE; GLUCAGON; GLUCOCORTICOID; HEAT SHOCK PROTEIN 90; HORMONE RECEPTOR; INSULIN; OMEPRAZOLE; PANCREAS HORMONE; PRASTERONE; PROGESTERONE; RETINOID; SEX HORMONE; SILENCING MEDIATOR OF RETINOID AND THYROID HORMONE RECEPTOR; TAMOXIFEN; TESTOSTERONE; THYROID HORMONE; UNINDEXED DRUG; VITAMIN D;

DRUG ACTIVITY; DRUG INHIBITION; ENZYME INDUCTION; HORMONAL REGULATION; HUMAN; NONHUMAN; PROTEIN EXPRESSION; REVIEW; SEX DIFFERENCE; SIGNAL TRANSDUCTION; THYROID GLAND; TRANSCRIPTION REGULATION;

ANIMALS; CYTOCHROME P-450 CYP1A1; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HORMONES; HUMANS; MODELS, GENETIC; RECEPTOR CROSS-TALK;

EID: 70350075695     PISSN: 03602532     EISSN: 10979883     Source Type: Journal    
DOI: 10.1080/03602530903112284     Document Type: Review

References (289)

1. Abdelrahim, M., Ariazi, E., Kim, K., Khan, S., Barhoumi, R., Burghardt, R., et al. (2006). 3-methylcholanthrene and other aryl hydrocarbon receptor agonists directly activate estrogen receptor a. Cancer Res 66:2459-2467. (Pubitemid 43294962)
2. Abdel-Razak, Z., Corcos, L., Fautrel, A., Campion, J.-P., Guillouzo, A. (1994). Transforming growth factor-beta 1 downregulates basal and polycyclic aromatic hydrocarbon-induced cytochromes P-450 1A1 and 1A2 in adult human hepatocytes in primary culture. Mol Pharmacol 46:1100-1110.
3. Aklillu, E., Carrillo, J. A., Makonnen, E., Hellman, K., Pitarque, M., Bertilsson, L., et al. (2003). Genetic polymorphism of CYP1A2 in Ethiopians afecting induction and expression: characterization of novel haplotypes with single-nucleotide polymorphisms in intron 1. Mol Pharmacol 64:659-669.
4. Andreola, F., Fernandez-Salguero, P. M., Chiantore, M. V, Petkovich, M. P., Gonzalez, F. J., De Luca, L. M. (1997). Aryl hydrocarbon receptor knockout mice (AHR-/-) exhibit liver retinoid accumulation and reduced retinoic acid metabolism. Cancer Res 57:2835-2838. (Pubitemid 27315022)
5. Andreola, F., Calvisi, D. F., Elizondo, G., Jakowlew, S. B., Mariano, J., Gonzalez, F. J., et al. (2004a). Reversal of liver fbrosis in aryl hydrocarbon receptor null mice by dietary vitamin A depletion. Hepatology 39:157-166.
6. Andreola, F., Hayhurst, G. P., Luo, G., Ferguson, S. S., Gonzalez, F. J., Goldstein, J. A., et al. (2004b). Mouse liver CYP2C39 is a novel retinoic acid 4-hydroxylase. Its downregulation ofers a molecular basis for liver retinoid accumulation and fbrosis in aryl hydrocarbon receptor-null mice. J Biol Chem 279:3434-3438.
7. Aragones, J., Jones, D. R., Martin, S., San Juan, M. A., Alfranca, A., Vidal, F., et al. (2001). Evidence for the involvement of dia-cylglycerol kinase in the activation of hypoxia-inducible transcription factor 1 by low oxygen tension. J Biol Chem 276:10548-10555.
8. Baba, T., Mimura, J., Gradin, K., Kuroiwa, A., Watanabe, T., Matsuda, Y, et al. (2001). Structure and expression of the Ah receptor repressor gene. J Biol Chem 276:33101-33110.
9. Backer, J. M., Myers, M. G., Sun, X.-J., Chin, D. J., Shoelson, S. E., Miralpeix, M., et al. (1993). Association of IRS-1 with the insulin receptor and the phosphatidylinositol 3'-kinase. J Biol Chem 268:8204-8212.
10. Backlund, M., Johansson, I., Mkrtchian, S., Ingelman-Sundberg, M. (1997) Signal transduction-mediated activation of the aryl hydrocarbon receptor in rat hepatoma H4IIE cells. J Biol Chem 272:31755-31763.
11. Badawi, A. F., Cavalieri, E. L., Rogan, E. G. (2001). Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16a-hydroxylation of 17fj-estradiol. Metabolism 50:1001-1003.
12. Barker, C. W., Fagan, J. B., Pasco, D. S. (1994). Downregulation of P4501A1 and P4501A2 mRNA expression in isolated hepatocytes by oxidative stress. J Biol Chem 269:3985-3990.
13. Barnes-Ellerbe, S., Knudsen, K. E., Puga, A. (2004). 2,3,7,8-tetra- chlorodibenzo-p-dioxin blocks androgen-dependent cell proliferation of LNCaP cells through modulation of pRB phosphorylation. Mol Pharmacol 66:502-511.
14. Barnett, C. R., Rudd, S., Flatt, P. R., Ioannides, C. (1993). Sex diferences in the diabetes-induced modulation of rat hepatic cytochrome P450 proteins. Biochem Pharmacol 45:313-319.
15. Barouki, R., Coumoul, X., Fernandez-Salguero, P. M. (2007). Te aryl hydrocarbon receptor, more than a xenobiotic-interacting protein. FEBS Lett 581:3608-3615.
16. Bauer, E., Guo, Z., Ueng, Y. F., Bell, L. C, Zeldin, D., Guengerich, F. P. (1995). Oxidation of benzo [a] pyrene by recombinant human cytochrome P450 enzymes. Chem. Res. Toxical. 8: 136-142.
17. Beischlag, T. V, Wang, S., Rose, D. W., Torchia, J., Reisz-Porszasz, S., Muhammad, K., et al. (2002). Recruitment of the NcoA/SRC-1/ p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex. Mol Cell Biol 22:4319-4333.
18. Beischlag, T. V., Taylor, R. T., Rose, D. W., Yoon, D., Chen, Y, Lee, W. H., et al. (2004). Recruitment of thyroid hormone receptor/retinoblastoma- interacting protein 230 by the aryl hydrocarbon receptor nuclear translocator is required for the transcriptional response to both dioxin and hypoxia. J Biol Chem 279:54620-54628.
19. Beischlag, T. V., Perdew, G. H. (2005). ERa-AHR-ARNT protein-protein interactions mediate estradiol-dependent transre-pression of dioxin-inducible gene transcription. J Biol Chem 280:21607-21611.
20. Berger, J., Moller, D. E. (2002). Te mechanisms of action of PPARs. Annu Rev Med 53:409-435.
21. Bertazzi, P. A., Consonni, D., Bachetti, S., Rubagotti, M., Baccarelli, A., Zocchetti, C, et al. (2001). Health efects of dioxin exposure: a 20-year mortality study. Am J Epidemiol 153:1031-1044.
22. Boucher, P. D., Ruch, R. J., Hines, R. N. (1993). Specifc nuclear protein binding to a negative regulatory element on the human CYP1A1 gene. J Biol Chem 268:17384-17391.
23. Boucher, P. D., Piechocki, M. P., Hines, R. N. (1995). Partial characterization of the human CYP1A1 negatively acting transcription factor and mutational analysis of its cognate DNA recognition sequence. Mol Cell Biol 15:5144-5151.
24. Brtko, J., Talhamer, J. (2003). Renaissance of the biologically active vitamin A derivatives: established and novel directed therapies for cancer and chemoprevention. Curr Pharm Des 9:2067-2077.
25. Burbach. K. M., Poland, A., Bradfeld, C. A. (1992). Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor. Proc Natl Acad Sci U S A 89:8185-8189.
26. Butler, M. A., Iwasaki, M., Guengerich, F. P., Kadlubar, F. F. (1989). Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of cafeine and N-oxidation of carcinogenic arylamines. Proc Natl Acad Sci U S A 89:7696-7700.
27. Campbell, S. J., Carlotti, F., Hall, P. A., Clark, A. J., Wolf, C. R. (1996). Regulation of the CYP1A1 promoter in transgenic mice: an exquisitely sensitive on-of system for cell-specifc gene regulation. J Cell Sci 109:2619-2625.
28. Campbell, S. J., Henderson, C. J., Anthony, D. C, Davidson, D., Clark, A. J., Wolf, C. R. (2005). Te murine Cyp1a1 gene is expressed in a restricted spatial and temporal pattern during embryonic development. J Biol Chem 280:5828-5835.
29. Carriere, V, Chambaz, J., Rousset, M. (2001). Intestinal responses to xenobiotics. Toxicol In Vitro 15:373-378.
30. Cavailles, V., Dauvois, S., Danielian, P. S., Parker, M. G. (1994). Interaction of proteins with transcriptionally active estrogen receptors. Proc Natl Acad Sci U S A 91:10009-10013.
31. Cavailles, V, Dauvois, S., L'Horset, F., Lopez, G., Hoare, S., Krushner, P. J., et al. (1995). Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor. EMBO J 14:3741-3751.
32. Challis, J. R. G., Sloboda, D., Matthews, S. G., Holloway, A., Alfaidy, N, Patel, F. A., et al. (2001). Te fetal placental hypothalamic-pituitary- adrenal (HPA) axis, parturition, and postnatal health. Mol Cell Endocrinol 185:135-144.
33. Chan, W. K., Yao, G., Gu, Y Z., Bradfeld, C. A. (1999). Cross-talk between the aryl hydrocarbon receptor and hypoxia-inducible factor signaling pathways. Demonstration of competition and compensation. J Biol Chem 274:12115-12123.
34. Choudhary, D., Jansson, I., Stoilov, I., Sarfazi, M., Schenkman, J. B. (2005). Expression patterns of mouse and human CYP orthologs (families 1-4) during development and in diferent adult tissues. Arch Biochem Biophys 436:50-61.
35. Chung, I., Bresnick, E. (1997). Identifcation of positive and negative regulatory elements of the human cytochrome P4501A2 (CYP1A2) gene. Arch Biochem Biophys 338:220-226.
36. Ciolino, H. P., Yeh, G. C. (1999). Te steroid dehydroepiandrosterone inhibits CYP1A1 expression in vitro by a post-transcriptional mechanism. J Biol Chem 274:35186-35190.
37. Clarke, J., Flatt, P. R., Barnett, C. R. (1997). Cytochrome P450 1A-like proteins expressed in the islets of Langerhans and altered pancreatic fj-cell secretory responsiveness. Br J Pharmacol 121:389-394.
38. Conney, A. H., Miller, E. C, Miller, J. A. (1957). Substrate-induced synthesis and other properties of benzpyrene hydroxylase in rat liver. J Biol Chem 228:753-766.
39. Corchero, J., Pimprale, S., Kimura, S., Gonzalez, F. J. (2001). Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation. Pharmacogenetics 11:1-6.
40. Cranmer, M., Louie, S., Kennedz, R. H., Kern, P. A., Fonseca, V. A. (2000). Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is associated with hyperinsulinemia and insulin resistance. Toxicol Sci 56:431-436.
41. Davarinos, N. A., Pollenz, R. S. (1999). Aryl hydrocarbon receptor imported into the nucleus following ligand binding is rapidly degraded via the cytoplasmic proteasome following nuclear export. J Biol Chem 274:28708-28715.
42. Degawa, M., Kojima, M., Hishinuma, T, Hashimoto, Y (1985). Sex-dependent induction of hepatic enzymes for mutagenic activation of a tryptophan pyrolysate component, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]-indole, by feeding in mice. Cancer Res 45:96-102.
43. Degawa, M., Hishinuma, T, Yoshida, H., Hashimoto, Y (1987). Species, sex, and organ diferences in induction of a cytochrome P-450 isozyme responsible for carcinogen activation: efects of dietary hepatocarcinogenic tryptophane pyrolysate components in mice and rats. Carcinogenesis 8:1913-1918.
44. DeMarzo, A. M., Beck, C. A., Onate, S. A., Edwards, D. P. (1991). Dimerization of mammalian progesterone receptors occurs in the absence of DNA and is related to the release of the 90-kDa heat shock protein. Proc Natl Acad Sci U S A 88:72-76.
45. Denison, M. S., Pandini, A., Nagy, S. R., Baldwin, E. P., Bonati, L. (2002). Ligand binding and activation of the AhR receptor. Chem Biol Interact 141:3-24.
46. Denison, M. S., Nagy, S. R. (2003). Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annu Rev Pharmacol Toxicol 43:309-334.
47. Ding, X., Kaminski, L. S. (2003). Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts. Annu Rev Pharmacol Toxicol 43:149-173.
48. Dong, L., Ma, Q., Whitlock, J. P. (1996). DNA binding by the het-erodimeric Ah receptor. J Biol Chem 271:7942-7948.
49. Driscoll, M. D., Sathya, G., Muyan, M., Klinge, C. M., Hilf, R., Bambara, R. A. (1998). Sequence requirements for estrogen receptor binding to estrogen response elements. J Biol Chem 273:29321-29330. (Pubitemid 28509931)
50. Drocourt, L., Ourlin, J. C, Pascussi, J. M., Maurel, P., Vilarem, M. J. (2002). Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepato-cytes. J Biol Chem 277:25125-25132.
51. Duan, R., Porter, W., Samudio, I., Vyhlidal, C, Kladde, M., Safe, S. (1999). Transcriptional activation of c-fos protooncogene by 17(3-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition. Mol Endocrinol 13:1511-1521.
52. Dvorak, Z., Vrzal, R., Ulrichova, J., Macejova, D., Ondkova, S., Brtko, J. (2007). Expression, protein stability, and transcriptional activity of retinoic acid receptors are afected by microtubules interfering agents and all-trans-retinoic acid in primary rat hepatocytes. Mol Cell Endocrinol 267:89-96.
53. Dvorak, Z., Vrzal, R., Pavek, P., Ulrichova, J. (2008). An evidence for regulatory cross-talk between aryl hydrocarbon receptor and glucocorticoid receptor in HepG2 cells. Physiol Res 57:427-435.
54. Ellery, J. M., Nicholls, P. J. (2002). Alternate signalling pathways from the interleukin-2 receptor. Cytokine Growth Factor Rev 13:27-40.
55. Enan, E., Lasley, B., Stewart, D., Overstreet, J., Vandevoort, C. A. (1996). 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) modulates function of human luteinizing granulosa cells via cAMP signaling and early reduction of glucose transporting activity. Reprod Toxicol 10:191-198.
56. Eugster, H.-P., Probst, M., Würgler, F. E., Sengstag, C. (1993). Cafeine, estradiol, and progesterone interact with human CYP1A1 and CYP1A2. Drug Metab Dispos 21:43-49.
57. Evans, B. R., Karcher, S. I., Allan, L. L., Pollenz, R. S., Tanguay, R. L., Jenny, M. J., et al. (2008). Repression of aryl hydrocarbon receptor (AHR) signaling by AHR repressor: role of DNA binding and competition for AHR nuclear translocator. Mol Pharmacol 73:387-398.
58. Falkner, K. C, Rushmore, T. H., Linder, M. W., Prough, R. A. (1998). Negative regulation of the rat glutathione S-transferase A2 gene by glucocorticoids involves a canonical glucocorticoid consensus sequence. Mol Pharmacol 53:1016-1026.
59. Falkner, K. C, Xiao, G.-H., Pinaire, J. A., Pendleton, M. L., Lindahl, R., Prough, R. A. (1999). Te negative regulation of the rat aldehyde dehydrogenase 3 gene by glucocorticoids: involvement of a single imperfect palindromic glucocorticoid responsive element. Mol Pharmacol 55:649-657.
60. Fallone, F., Villard, P.-H., Sérée, E., Nguyen, Q. B., Bourgarel-Rey, V, Fouchier, F., et al. (2004). Retinoids repress Ah receptor CYP1A1 induction pathway through the SMRT corepressor. Biochem Biophys Res Commun 322:551-556.
61. Fallone, F., Villard, P.-H., Decome, L., Sérée, E., de Méo, M., Chacon, C, et al. (2005). PPARalpha activation potentiates AhR-induced CYP1A1 expression. Toxicology 216:122-128.
62. Fisher, D. A. (1986). Te unique endocrine millieu of the fetus. J Clin Invest 78:603-611.
63. Flamant, F., Baxter, J. D., Forrest, D., Refetof, S., Samuels, H., Scanlan, T. S., et al. (2006). International Union of Pharmacology. LIX. Te pharmacology and classifcation of the nuclear receptor superfamily: thyroid hormone receptors. Pharmacol Rev 58:705-711.
64. Fletcher, N., Hanberg, A., Hakansson, H. (2001). Hepatic vitamin a depletion is a sensitive marker of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure in four rodent species. Toxicol Sci 62:166-175.
65. Fradette, C, du Souich, P. (2003). Hypoxia-inducible factor-1 and activator protein-1 modulate the upregulation of CYP3A6 induced by hypoxia. Br J Pharmacol 140:1146-1154.
66. Fradette, C, du Souich, P. (2004). Efect of hypoxia on cytochrome P450 activity and expression. Curr Drug Metab 5:257-271.
67. Froidevaux, M. S., Berg, P., Seugnet, I., Decherf, S., Becker, N., Sachs, L. M., et al. (2006). Te co-chaperone XAP2 is required for activation of hypothalamic thyrotropin-releasing hormone transcription in vivo. EMBO Rep 7:1035-1039.
68. Fuhr, U., Doehmer J., Battula, N., Wölfel, C., Kudla, C., Keita, Y., et al. (1992). Biotransformation of cafein and theophylline in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms. Biochem Pharmacol 43:225-235.
69. Fujii-Kuriyama, Y., Mimura, J. (2005). Molecular mechanisms of AhR functions in the regulation of cytochrome P450 genes. Biochem Biophys Res Commun 338:311-317.
70. Fukunaga, B. N., Probst, M. R., Reisz-Porszasz, S., Hankinson, O. (1995). Identifcation of functional domains of the aryl hydrocarbon receptor. J Biol Chem 270:29270-29278.
71. Fukunaga, B. N., Hankinson, O. (1996). Identifcation of a novel domain in the aryl hydrocarbon receptor required for DNA binding. J Biol Chem 271:3743-3749.
72. Gambone, C. J., Hutcheson, J. M., Gabriel, J. L., Beard, R. L., Chandraratna, R. A., Soprano, K. J., et al. (2002). Unique property of some synthetic retinoids: activation of the aryl hydrocarbon receptor pathway. Mol Pharmacol 61:334-342.
73. Gauger, K. J., Giera, S., Sharlin, D. S., Bansal, R., Iannacone, E., Zoeller, R. T. (2007). Polychlorinated biphenyls 105 and 118 form thyroid hormone receptor agonists after cytochrome P4501A1 activation in rat pituitary GH3 cells. Environ Health Perspect 115:1623-1630.
74. Gilles-Gonzales, M.-A., Gonzales, G. (2004). Signal transduction by heme-containing PAS-domain proteins. J Appl Physiol 96:774-783.
75. Gray, L. E., Ostby, J. S., Kelce, W. R. (1997). A dose-response analysis of the reproductive efects of a single gestational dose of 2,3,7,8- tetrachlorodibenzo-p-dioxin in male Long Evans hooded rat ofspring. Toxicol Appl Pharmacol 146:11-20.
76. Greengard, O. (1975). Steroids and the maturation of rat tissues. J Steroid Biochem 6:639-642.
77. Gregoraszczuk, E. L., Wojtowicz, A. K., Zabielny, E., Grochowalski, A. (2000). Dose-and time-dependent efect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on progesterone secretion by porcine luteal cells cultured in vitro. J Physiol Pharmacol 51:127-135.
78. Gregoraszczuk, E. L., Zabielny, E., Ochwat, D. (2001). Aryl hydrocarbon receptor (AhR)-linked inhibition of luteal cell progesterone secretion in 2,3,7,8-tetrachlorodibenzo-p-dioxin treated cells. J Physiol Pharmacol 52:303-311.
79. Guengerich, F. P. (1993). Bioactivation and detoxication of toxic and carcinogenic chemicals. Drug Metab Dispos 21:1-6.
80. Ha, H. R., Chen, J., Freiburghaus, A. U., Follath, F. (1995). Metabolism of theophylline by cDNA-expressed human cytochromes P-450. Br J Clin Pharmac 39:321-326.
81. Haarmann-Stemmann, T., Abel, J. (2006). Te arylhydrocarbon receptor repressor (AhRR): structure, expression, and function. Biol Chem 387:1195-1199.
82. Haarmann-Stemmann, T., Bothe, H., Kohli, A., Sydlik, Ul., Abel, J., Fritsche, E. (2007). Analysis of the transcriptional regulation and molecular function of the aryl hydrocarbon receptor repressor in human cell lines. Drug Metab Dispos 35:2262-2269.
83. Hakkola, J., Pelkonen, O., Pasanen, M., Raunio, H. (1998). Xenobiotic-metabolizing cytochrome P450 enzymes in the human feto-placental unit: role in intrauterine toxicity. Crit Rev Toxicol 28:35-72.
84. Hall, J. M., Couse, J. F., Korach, K. S. (2001). Te multifaceted mechanisms of estradiol and estrogen receptor signaling. J Biol Chem 276:36869-36872.
85. Han, X.-M., Ouyang, D.-S., Chen, X.-P., Shu, Y., Jiang, C.-H., Tan, Z.-R., et al. (2002). Inducibility of CYP1A2 by omeprazole in vivo related to the genetic polymorphism of CYP1A2. Br J Clin Pharmacol 54:540-543.
86. Hankinson, O. (2005). Role of coactivators in transcriptional activation by the aryl hydrocarbon receptor. Arch Biochem Biophys 433:379-386.
87. Harper, N., Wang, X., Liu, H., Safe, S. (1994). Inhibition of estrogen-induced progesterone receptor in MCF-7 human breast cancer cells by aryl hydrocarbon (Ah) receptor agonists. Mol Cell Endocrinol 104:47-55. (Pubitemid 24233819)
88. Harper, P. A., Riddick, D. S. Okey, A. B. (2006). Regulating the regulator: factors that control levels and activity of the aryl hydrocarbon receptor. Biochem Pharmacol 72:267-279.
89. Harvey, C. B., Williams, G. R. (2002). Mechanism of thyroid hormone action. Tyroid 12:441-446.
90. Hayes, C. L., Spink, D. C, Spink, B. C, Cao, J. Q., Walker, N. J., Sutter, T. R. (1996). 17fj-estradiol hydroxylation catalyzed by human cytochrome P450 1B1. Proc Natl Acad Sci U S A 93:9776-9781.
91. Heemers, H. V., Tindall, D. J. (2007). Androgen receptor (AR) coregu-lators: a diversity of functions converging on and regulating the AR transcriptional complex. Endocr Rev 28: 778-808.
92. Henning, S. J. (1978). Plasma concentrations of total and free corticos-terone during development in the rat. Am J Physiol Endocrinol Metab 235:E451-E456.
93. Hihi, A. K., Michalik, L., Wahli, W. (2002). PPARs: transcriptional efectors of fatty acids and their derivatives. Cell Mol Life Sci 59:790-798.
94. Hoegberg, P., Schmidt, C. K., Fletcher, N., Nilsson, C. B., Trossvik, C, Schuur, A. G., et al. (2005). Retinoid status and responsiveness to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking retinoid binding protein or retinoid receptor forms. Chem Biol Interact 156:25-39.
95. Hoivik, D., Willett, K., Wilson, C, Safe, S. (1997). Estrogen does not inhibit 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated efects in MCF-7 and Hepa 1c1c7 cells. J Biol Chem 272:30270-30274.
96. Huang, P., Ceccatelli, S., Hoegberg, P., Shi, T.-J. S., Hakansson, H., Rannug, A. (2003). TCDD-induced expression of Ah receptor responsive genes in the pituitary and brain of cellular retinol-binding protein (CRBP-I) knockout mice. Toxicol Appl Pharmacol 192:262-274.
97. Ikeya, K., Jaiswal, A. K., Owens, R. A., Jones, J. E., Nebert, D. W., Kimura, S. (1989). Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and diferences in liver 1A2 mRNA expression. Mol Endocrinol 3:1399-1408.
98. Imataka, H., Sogawa, K., Yasumoto, K., Kikuchi, Y., Sasano, K., Kobayashi, A., et al. (1992). Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P-4501A1 gene. EMBO J 11:3663-3671.
99. Ioannides, C, Lewis, D. F. V. (2004). Cytochromes P450 in the bioacti-vation of chemicals. Curr Top Med Chem.4:1767-1788.
100. Jana, N. R., Sarkar, S., Ishizuka, M., Yonemoto, J., Tohyama, C, Sone, H. (1999a). Cross-talk between 2,3,7,8-tetrachlorodibenzo-p-dioxin and testosterone signal transduction pathways in LNCaP prostate cancer cells. Biochem Biophys Res Commun 256:462-468.
101. Jana, N. R., Sarkar, S., Ishizuka, M., Yonemoto, J., Tohyama, C, Sone, H. (1999b). Role of estradiol receptor-a in diferential expression of 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible genes in the RL95-2 and KLE human endometrial cancer cell lines. Arch Biochem Biophys 368:31-39.
102. Jana, N. R., Sarkar, S., Ishizuka, M., Yonemoto, J., Tohyama, C, Sone, H. (2000). Comparative efects of 2,3,7,8-tetrachlorod-ibenzo-p-dioxin on MCF-7, RL95-2, and LNCaP cells: role of target steroid hormones in cellular responsiveness to CYP1A1 induction. Mol Cell Biol Res Commun 4:174-180.
103. Jeong, H. G., Lee, S. S. (1998). Suppressive efects of estradiol on 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated transcriptional activation of murine Cyp1a-1 in mouse hepatoma Hepa 1c1c7 cells. Cancer Lett 133:177-184.
104. Johnson, E., Shorter, C, Bestervelt, L., Patterson, D., Needham, L., Piper, W., et al. (2001). Serum hormone levels in humans with low serum concentrations of 2,3,7,8-TCDD. Toxicol Ind Health 17:105-112.
105. Jones, S. A., Moore, L. B., Shenk, J. L., Wisely, G. B., Hamilton, G. A., McKee, D. D., et al. (2000). Te pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution. Mol Endocrinol 14:27-39.
106. Kaczynski, J., Zhang J.-S., Ellenrieder, V, Conley, A., Duenes, T, Kester, H., et al. (2001). Te Sp1-like protein, BTEB3, inhibits transcription via the basic transcription element box by interacting with mSin3A and HDAC-1 co-repressors and competing with Sp1. J Biol Chem 276:36749-36756.
107. Kaczynski, J., Conley, A., Fernandez Zapico, M., Delgado, S. M., Zhang J.-S., Urrutia, R. (2002). Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel SP1-like protein, reveals a subfamily of transcriptional repressors for the BTE site of the cytochrome P4501A1 gene promoter. Biochem J 366:873-882.
108. Kariagina, A., Aupperlee, M. D., Haslam, S. Z. (2008). Progesterone receptor isoform functions in normal breast development and breast cancer. Crit Rev Eukaryot Gene Expr 18:11-33.
109. Kazlauskas, A., Poellinger, L., Pongratz, I. (1999). Evidence that the co-chaperone, p23, regulates ligand responsiveness of the dioxin (aryl hydrocarbon) receptor. J Biol Chem 274:13519-13524.
110. Kazlauskas, A., Poellinger, L., Pongratz, I. (2000). Te immunophilin-like protein XAP2 regulates ubiquitination and subcellular localization of the dioxin receptor. J Biol Chem 275:41317-41324.
111. Kazlauskas, A., Sundstrom, S., Poellinger, L., Pongratz, I. (2001). Te hsp90 chaperone complex regulates intracellular localization of the dioxin receptor. Mol Cell Biol 21:2594-2607.
112. Kharat, I., Saatcioglu, F. (1996). Antiestrogenic efects of 2,3,7,8-tetra-chlorodibenzo-p-dioxin are mediated by direct transcriptional interference with the liganded estrogen receptor. J Biol Chem 271:10533-10537.
113. Kim, D., Guengerich, F. P. (2005). Cytochrome P450 activation of arylamines and heterocyclic amines. Annu Rev Pharmacol Toxicol 45:27-49.
114. Kim, H. G., Han, E. H., Jeong, H. G. (2008). Efect of troglitazone on CYP1A1 induction. Toxicology 246:166-171.
115. Kim, S. K., Novak, R. F. (2007). Te role of intracellular signaling in insulin-mediated regulation of drug-metabolizing enzyme gene and protein expression. Pharmacol Ter 113:88-120.
116. Kimura, S., Donovan, J. C, Nebert, D. W. (1987). Expression of the mouse P(1)450 gene during diferentiation without foreign chemical stimulation. J Exp Pathol 3:61-74.
117. Kizu, R., Okamura, K., Toriba, A., Kakishima, H., Mizokami, A., Burnstein, K. L., et al. (2003a). A role of aryl hydrocarbon receptor in the antiandrogenic efects of polycyclic aromatic hydrocarbons in LNCaP human prostate carcinoma cells. Arch Toxicol 77:335-343.
118. Kizu, R., Okamura, K., Toriba, A., Mizokami, A., Burnstein, K. L., Klinge, C. M., et al. (2003b). Antiandrogenic activities of diesel exhaust particle extracts in PC3/AR human prostate carcinoma cells. Toxicol Sci 76:299-309.
119. Klinge, C. M., Bowers, J. L., Kulakosky, P. C, Kamboj, K. K., Swanson, H. I. (1999). Te aryl hydrocarbon receptor (AHR)/ AHR nuclear translocator (ARNT) heterodimer interacts with naturally occuring estrogen response elements. Mol Cell Endocrinol 157:105-119.
120. Klinge, C. M., Kaur, K., Swanson, H. I. (2000). Te aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRa1. Arch Biochem Biophys 373:163-174.
121. Klinge, C. M. (2001). Estrogen receptor interaction with estrgen response elements. Nucleic Acids Res 29:2905-2919.
122. Ko, H. P., Okino, S. T, Ma, Q., Whitlock, J. P. (1996). Dioxin-induced CYP1A1 transcription in vivo: the aromatic hydrocarbon receptor mediates transactivation, enhancer-promoter communication, and changes in chromatin structure. Mol Cell Biol 16:430-436.
123. Ko, H. P., Okino, S. T, Ma, Q., Whitlock, J. P. (1997). Transactivation domains facilitate promoter occupancy for the dioxin-inducible CYP1A1 gene in vivo. Mol Cell Biol 17:3497-3507.
124. Ko, K., Teobald, H. M., Moore, R. W., Peterson, R. E. (2004). Evidence that inhibited prostatic epithelial bud formation in 2,3,7,8-tetrachlorodibenzo- p-dioxin-exposed C57BL/6J fetal mice is not due to interruption of androgen signaling in the urogenital sinus. Toxicol Sci 79:360-369.
125. Kobayashi, A., Sogawa, K., Imataka, H., Fujii-Kuriyama, Y (1995). Analysis of functional domains of a GC box-binding protein, BTEB. J Biochem 117:91-95.
126. Kobayashi, A., Sogawa, K., Fujii-Kuriyama, Y. (1996). Cooperative interaction between AhR.Arnt and Sp1 for the drug-inducible expression of CYP1A1 gene. J Biol Chem 271:12310-12316.
127. Kojima, M., Sekimoto, M., Degawa, M. (2008). A novel gender-related diference in the constitutive expression of hepatic cytochrome P4501A subfamily enzymes in Meishan pigs. Biochem Pharmacol 75:1076-1082.
128. Kohn, M. C. (2000). Efects of TCDD on thyroid hormone homeostasis in the rat. Drug Chem Toxicol 23:259-277.
129. Kohalmy, K., Tamási, V., Kóbori, L., Sárváry, E., Pascussi, J.-M., Porrogi, P., et al. (2007). Dehydroepiandrosterone induces human CYP2B6 through the constitutive androstane receptor. Drug Metab Dispos 35:1495-1501.
130. Krig, S. R., Rice, R. H. (2000). TCDD suppression of tissue transglutaminase stimulation by retinoids in malignant human keratinocytes. Toxicol Sci 56:357-364.
131. Krig, S. R., Chandraratna, R. A., Chang, M. M., Wu, R., Rice, R. H. (2002). Gene-specifc TCDD suppression of RARalpha-and RXR-mediated induction of tissue transglutaminase. Toxicol Sci 68:102-108.
132. Krishnan, V, Porter, W., Santostefano, M., Wang, X., Safe, S. (1995). Molecular mechanism of inhibition of estrogen-induced cathe-psin D gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in MCF-7 cells. Mol Cell Biol 15:6710-6719.
133. Kuil, C. W., Brouwer, A., van der Saag, P.T., van der Burg, B. (1998). Interference between progesterone and dioxin signal transduction pathways. Diferent mechanisms are involved in repression by the progesterone receptor A and B isoforms. J Biol Chem 273:8829-8834.
134. Kumar, M. B., Perdew, G. H. (1999a). Nuclear receptor coactivator SRC-1 interacts with the Q-rich subdomain of the AhR and modulates its transactivation potential. Gene Expr 8:273-286.
135. Kumar, M. B., Tarpey, R. W., Perdew, G. H. (1999b). Diferential recruitment of coactivator RIP140 by Ah and estrogen receptors. Absence of a role for LXXLL motifs. J Biol Chem 274:22155-22164.
136. Kurdi, J., Maurice, H., El-Kadi, A. O. S., Ong, H., Dalkara, S., Bélanger, P. M., et al. (1999). Efect of hypoxia alone or combined with infammation and 3-methylcholanthrene on hepatic cytochrome P450 in conscious rabbits. Br J Pharmacol 128:365-373.
137. Kuriyama, S. N., Wanner, A., Fidalgo-Neto, A. A., Talsness, C. E., Koerner, W., Chahoud, I. (2007). Developmental exposure to low-dose PBDE-99: tissue distribution and thyroid hormone levels. Toxicology 242:80-90.
138. Labrie, F., Belanger, A., Cusan, L., Gomez, J.-L., Candas, B. (1997). Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging. J Clin Endocrinol Metab 82:2396-2402.
139. Labrie, F., Luu-Te, V, Belanger, A., Lin, S.-X., Simard, J., Pelletier, G., et al. (2005). Is dehydroepiandrosterone a hormone? J Endocrinol 187:169-196.
140. Lai, K. P., Wong, M. H., Wong, C. K. C. (2004). Modulation of AhR-mediated CYP1A1 mRNA and EROD activities by 17fj-estradiol and dexametahsone in TCDD-induced H411E cells. Toxicol Sci 78:41-49.
141. Lania, L., Majello, B., de Luca, P. (1997). Transcriptional regulation by the Sp family proteins. Int J Biochem Cell Biol 29:1313-1323.
142. Lee, A. J., Cai, M. X., Tomas, P. E., Conney, A. H., Zhu, B. T. (2003). Characterization of the oxidative metabolites of 17fj-estradiol and estrone formed by 15 selectively expressed human cytochrome P450 isoforms. Endocrinology 144:3382-3398.
143. Lee, S. S., Jeong, H. G., Yang, K. H. (1998). Efects of estradiol and progesterone on cytochrome P4501A1 expression in Hepa 1c1c7 cells. Biochem Mol Biol Int 45:775-781.
144. Lees, M. J., Peet, D. J., Whitelaw, M. L. (2003). Defning the role for XAP2 in stabilization of the dioxin receptor. J Biol Chem 278:35878-35888.
145. L'Horset, F., Dauvois, S., Heery, D. M., Cavailles, V., Parker, M. G. (1996). RIP-140 interacts with multiple nuclear receptors by means of two distinct sites. Mol Cell Biol 16:6029-6036.
146. Lin, P., Chang, J. T, Ko, J. L., Liao, S. H., Lo, W.S. (2004). Reduction of androgen receptor expression by benzo[a]pyrene and 7,8-dihydro-9,10-epoxy-7, 8,9,10-tetrahydrobenzo[a]pyrene in human lung cells. Biochem Pharmacol 67:1523-1530.
147. Lin, T. M., Ko, K., Moore, R. W., Simanainen, U., Oberley, T. D., Peterson, R. E. (2002). Efects of aryl hydrocarbon receptor null mutation and in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on prostate and seminal vesicle development in C57BL/6 mice. Toxicol Sci 68:479-487.
148. Linder, M. W., Prough, R. A. (1993). Developmental aspects of glucocorticoid regulation of polycyclic aromatic hydrocarbon-inducible enzymes in rat liver. Arch Biochem Biophys 302:92-102.
149. Linder, M. W., Falkner, K. C, Srinivasan, G., Hines, R. N., Prough, R. A. (1999). Role of canonical glucocorticoid responsive elements in modulating expression of genes regulated by the arylhydrocar-bon receptor. Drug Metab Rev 31:247-271.
150. Liu, H., Safe, S. (1996). Efects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on insulin-induced responses in MCF-7 human breast cancer cells. Toxicol Appl Pharmacol 138:242-250.
151. Liu, S., Abdelrahim, M., Khan, S., Ariazi, E., Jordan, V. C, Safe, S. (2006). Aryl hydrocarbone receptor agonists directly activate estrogen receptor alpha in MCF-7 breast cancer cells. Biol Chem 387:1209-1213.
152. Lorick, K. L., Toscano, D. L., Toscano, W. A., Jr. (1998). 2,3,7,8-tetrachlorodibenzo-p-dioxin alters retinoic acid receptor function in human keratinocytes. Biochem Biophys Res Commun 243:749-752.
153. Lovekamp-Swan, T, Jetten, A. M., Davis, B. J. (2003). Dual activation of PPARalpha and PPARgamma by mono-(2-ethylhexyl) phthalate in rat ovarian granulosa cells. Mol Cell Endocrinol 201:133-141.
154. Ma, Q., Lu, A. Y H. (2007). CYP1A induction and human risk assessment: an evolving tale of in vitro and in vivo studies. Drug Metab Dispos 35:1009-1016.
155. MacPherson, L., Lo, R., Ahmed, S., Pansoy, A., Matthews, J. (2009). Activation faunction 2 mediates dioxin-induced recruitment of estrogen receptor alpha to CYP1A1 and CYP1B1. Biochem Biophys Res Commun (In press).
156. Masson, L. F., Sharp, L., Cotton, S. C, Little, J. (2005). Cytochrome P-450 1A1 gene polymorphisms and risk of breast cancer: a HuGE review. Am J Epidemiol 161:901-915.
157. Mathis, J. M., Prough, R. A., Hines, R. N., Bresnick, E., Simpson, E. R. (1986). Regulation of cytochrome P-450c by glucocorticoids and polycyclic aromatic hydrocarbons in cultured fetal rat hepato-cytes. Arch Biochem Biophys 246:439-448.
158. Mathis, J. M., Houser, W. H., Bresnick, E., Cidlowski, J. A., Hines, R. N., Prough, R. A., et al. (1989). Glucocorticoid regulation of the rat cytochrome P450c (P450IA1) gene: receptor binding within intron I. Arch Biochem Biophys 269:93-105.
159. Matsushita, N., Sogawa, K., Ema, M., Yoshida, A., Fujii-Kuriyama, Y (1993). A factor binding to the xenobiotic responsive element (XRE) of P-4501A1 gene consists of at least two helix-loop-helix proteins, Ah receptor, and Arnt. J Biol Chem 268:21002-21006.
160. Matthews, J., Wihlen, B., Tomsen, J., Gustafsson, J.-A. (2005). Aryl hydrocarbon receptor-mediated transcription: ligand-dependent recruitment of estrogen receptor a to 2,3,7,8-tetra-chlorodibenzo-p-dioxin-responsive promoters. Mol Cell Biol 25:5317-5328.
161. Matthews, J., Wihlen, B., Heldring, N., MacPherson, L., Treuter, E., Haldosen, L.-A., et al. (2007). Co-planar 3,3',4,4',5-pentachlorinated biphenyl and non-co-planar 2,2,'4,6,6'-pentachlorinated niphenyl diferentially induce recruitment of oestrogen receptor to aryl hydrocarbon receptor target genes. Biochem J 406:343-353.
162. McDougal, A., Wormke, M., Calvin, J., Safe, S. (2001). Tamoxifen-induced antitumorigenic/antiestrogenic action synergized by a selective aryl hydrocarbon receptor modulator. Cancer Res 61:3902-3907.
163. McInerney, E. M., Tsai, M.-J., O'Malley, B. W., Katzenellenbogen, B. S. (1996). Analysis of estrogen receptor transcriptional enhancement by a nuclear hormone receptor coactivator. Proc Natl Acad Sci U S A 93:10069-10073.
164. McRobie, D. J., Glover, D. D., Tracy, T. S. (1998). Efects of gestational and overt diabetes on human placental cytochromes P450 and glutathione S-transferase. Drug Metab Dispos 26:367-371.
165. Meyer, B. K., Perdew, G. H. (1999). Characterization of the AhR-hsp90-XAP2 core complex and the role of the immunophlin-related protein XAP2 in AhR stabilization. Biochemistry 38:8907-8917.
166. Michalek, J. E., Akhtar, F. Z., Kiel, J. L. (1999). Serum dioxin, insulin, fasting glucose, and sex hormone-binding globulin in veterans of Operation Ranch Hand. J Clin Endocrinol Metab 84:1540-1543.
167. Michiels, C., Arnould, T., Remacle, J. (2000). Endothelial cell responses to hypoxia: initiation of a cascade of cellular interactions. Biochim Biophys Acta 1497:1-10.
168. Miller, W. L. (2002). Androgen biosynthesis from cholesterol to DHEA. Mol Cell Endocrinol 198:7-14.
169. Mimura, J., Ema, M., Sogawa, K., Fujii-Kuriyama, Y. (1999). Identifcation of a novel mechanism of regulation of Ah (dioxin) receptor function. Genes Dev 13:20-25.
170. Mode, A., Gustafsson, J.-A. (2006). Sex and the liver-a journey through fve decades. Drug Metab Rev 38:197-207.
171. Monostory, K., Kohalmy, K., Prough, R. A., Kóbori, L., Vereczkey, L. (2005). Te efect of synthetic glucocorticoid, dexamethasone, on CYP1A1 inducibility in adult rat and human hepatocytes. FEBS Lett 579:229-235.
172. Moreau, A., Maurel, P., Vilarem, M. J., Pascussi J.-M. (2007). Constitutive androstane receptor-vitamin D receptor crosstalk: consequence on CYP24 gene expression. Biochem Biophys Res Commun 360:76-82.
173. Mufti, N. A., Shuler, M. L. (1996). Possible role of arachidonic acid in stress-induced cytochrome P450IA1 activity. Biotechnol Prog 12:847-854.
174. Mugford, C. A., Kedderis, G. L. (1998). Sex-dependent metabolism of xenobiotics. Drug Metab Rev 30:441-498.
175. Murphy, K. A., Quadro, L., White, L. A. (2007). Te intersection between the aryl hydrocarbon receptor (AhR)-and retinoic acid-signaling pathways. Vitam Horm 75:33-67.
176. Myers, M. G., Sun, X.-J., White, M. F. (1994). Te IRS-1 signaling system. Trends Biochem Sci 19:289-293.
177. Naldini, A., Carraro, F., Silvestri, S., Bocci, V. (1997). Hypoxia afects cytokine production and proliferative responses by human peripheral mononuclear cells. J Cell Physiol 173:335-342.
178. Nebert, D. W., Gelboin, H. V. (1970). Te role of ribonucleic acid and protein synthesis in microsomal aryl hydrocarbon hydroxylase induction in cell culture. J Biol Chem 245:160-168.
179. Nguyen, T. A., Hoivik, D., Lee, J. E., Safe, S. (1999). Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex. Arch Biochem Biophys 367:250-257. (Pubitemid 29394172)
180. Nilsson, C. B., Hakansson, H. (2002). Te retinoid signaling system-a target in dioxin toxicity. Crit Rev Toxicol 32:211-232.
181. Nishimura, N., Miyabara, Y., Sato, M., Yonemoto, J., Tohyama, C. (2002). Immunohistochemical localization of thyroid stimulating hormone induced by a low oral dose of 2,3,7,8-tetrachlo-rodibenzo-p-dioxin in female Sprague-Dawley rats. Toxicology 171:73-82.
182. Nishimura, N., Yonemoto, J., Miyabara, Y., Sato, M., Tohyama, C. (2003). Rat thyroid hyperplasia induced by gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Endocrinology 144:2075-2083.
183. Nishimura, N., Yonemoto, J., Nishimura, H., Ikushiro, S., Tohyama, C. (2005a). Disruption of thyroid hormone homeostasis at weaning of Holtzman rats by lactational but not in utero exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci 85:607-614.
184. Nishimura, N., Yonemoto, J., Miyabara, Y., Fujii-Kuriyama, Y., Tohyama, C. (2005b). Altered thyroxin and retinoid metabolic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin in aryl hydrocarbon receptor-null mice. Arch Toxicol 79:260-267.
185. Nishiumi, S., Yabushita, Y., Furuyashiki, T., Fukuda, I., Ashida, H. (2008). Involvement of SREBPs in 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced disruption of lipid metabolism in male guinea pig. Toxicol Appl Pharmacol 229:281-289.
186. Nollert, M. U., Hall, E. R., Eskin, S. G., McIntire, L. V. (1989). Te efect of shear stress on the uptake and metabolism of arachi-donic acid by human endothelial cells. Biochem Biophys Acta 1005:72-78.
187. Oda, Y., Aryal, P., Terashita, T., Gillam, E. M. J., Guengerich, F. P., Shimada, T. (2001). Metabolic activation of heterocyclic amines and other procarcinogens in Salmonella typhimurium umu tester strains expressing human cytochrome P4501A1, 1A2, 1B1, 2C9, 2D6, 2E1, and 3A4 and human NADPH-P450 reductase and bacterial O-acetyltransferase. Mutat Res 492:81-90.
188. Ohtake, F., Takeyama, K.-I., Matsumoto, T., Kitagawa, H., Yamamoto, Y., Nohara, K., et al. (2003). Modulation of oestrogen receptor signalling by association with the activated dioxin receptor. Nature 423:545-550.
189. Okamura, K., Kizu, R., Toriba, A., Murahashi, T., Mizokami, A., Burnstein, K. L., et al. (2004). Antiandrogenic activity of extracts of diesel exhaust particles emitted from diesel-engine truck under diferent engine loads and speeds. Toxicology 195:243-254. (Pubitemid 38125123)
190. Omiecinski, C. J., Redlich, C. A., Costa, P. (1990). Induction and developmental expression of cytochrome P450IA1 messenger RNA in rat and human tissues: detection by polymerase chain reaction. Cancer Res 50:4315-4321.
191. Pasanen, M., Haaparanta, T., Sundin, M., Sivonen, P., Vakakangas, K., Raunio, H., et al. (1990). Immunochemical and molecular biological studies on human placental cigarette smoke-inducible cytochrome P-450-dependent monooxygenase activities. Toxicology 62:175-187.
192. Pascussi, J.-M., Drocourt, L., Fabre, J. M., Maurel, P., Vilarem, M. J. (2000). Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators. Mol Pharmacol 58:361-372.
193. Pascussi, J.-M., Gerbal-Chaloin, S., Drocourt, L., Maurel, P., Vilarem, M. J. (2003a). Te expression of CYP2B6, CYP2C9, and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors. Biochim Biophys Acta 1619:243-253.
194. Pascussi, J.-M., Busson-Le Coniat, M., Maurel, P., Vilarem, M. J. (2003b). Transcriptional analysis of the orphan nuclear receptor constitutive androstane receptor (NR1I3) gene promoter: identifcation of a distal glucocorticoid response element. Mol Endocrinol 17:42-55.
195. Pascussi, J.-M., Robert, A., Nguyen, M., Walrant-Debray, O., Garabedian, M., Martin, P., et al. (2005). Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia. J Clin Invest 115:177-186.
196. Pascussi, J.-M., Gerbal-Chaloin, S., Duret, C, Daujat-Chavanieu, M., Vilarem, M. J., Maurel, P. (2008). Te tangle of nuclear receptors that controls xenobiotic metabolism and transport: crosstalk and consequences. Annu Rev Pharmacol Toxicol 48:1-32.
197. Pearce, S. T, Liu, H., Radhakrishnan I., Abdelrahim, M., Safe, S., Jordan, V. C. (2004). Interaction of the aryl hydrocarbon receptor ligand 6-methyl-1,3,8-trichlorobenzofuran with estrogen receptor a. Cancer Res 64:2889-2897.
198. Peraza, M. A., Burdick, A. D., Marin, H. E., Gonzalez, F. J., Peters, J. M. (2006). Te toxicology of ligands for peroxisome proliferator-activated receptors (PPAR). Toxicol Sci 90:269-295.
199. Persson, I., Johansson, I., Ingelman-Sundberg, M. (1997). In vitro kinetics of two human CYP1A1 variant enzymes suggested to be associated with interindividual diferences in cancer susceptibility. Biochem Biophys Res Commun 231:227-230.
200. Petrulis, J. R., Perdew, G. H. (2002). Te role of chaperon proteins in the aryl hydrocarbon receptor core complex. Chem Biol Interact 141:25-40.
201. Piafsky, K. M., Sitar, D. S., Rangno, R. E., Ogilvie, R. I. (1977). Teophylline kinetics in acute pulmonary edema. Clin Pharmacol Ter 21:310-316.
202. Piechocki, M. P., Hines, R. N. (1998). Functional characterization of the human CYP1A1 negative regulatory element: modulation of Ah-receptor-mediated transcriptional activity. Carcinogenesis 19:771-780.
203. Pocar, P., Klonisch, T, Brandsch, C, Eder, K., Frohlich, C, Hoang-Vu, C, et al. (2006). AhR-agonist-induced transcriptional changes of genes involved in thyroid function in primary porcine thyrocytes. Toxicol Sci 89:408-414.
204. Poch, M. T, Al-Kassim, L., Smolinski, S. M., Hines, R. N. (2004). Two distinct classes of CCAAT box elements that bind nuclear factor-Y/a-actinin-4: potential role in human CYP1A1 regulation. Toxicol Appl Pharmacol 199:239-250.
205. Pollenz, R. S., (2002). Te mechanism of AH receptro protein down-regulation (degradation) and its impact on AH receptor-mediated gene regulation. Chem. Biol. Interact. 141: 41-61.
206. Polzer, R. J., Cofng, S. L., Marcus, C. B., Park, S. S., Gelboin, H. V., Baird, W. M. (1995). Inhibition of benzo[a]pyrene metabolism by insulin, FITC-insulin, and an FITC-insulin-antibody conjugate in the human hepatoma cell line, HepG2. Chem Biol Interact 97:307-318.
207. Pongratz, I., Mason, G. G. F., Poellinger, L. (1992). Dual roles of the 90-kDa heat shock protein, hsp90, in modulating functional activities of the dioxin receptor. J Biol Chem 267:13728-13734.
208. Porter, W., Wang, F., Qin, C, Castro-Rivera, E., Kim, K., Safe, S. (2001). Transcriptional activation of heat shock protein 27 gene expression by 17fj-estradiol and modulation by antiestrogens and aryl hydrocarbon receptor agonists. J Mol Endocrinol 26:31-42.
209. Prough, R. A., Linder, M. W., Pinaire, J. A., Xiao, G.-H., Falkner, K. C. (1996). Hormonal regulation of hepatic enzymes involved in foreign compound metabolism. FASEB J 10:1369-1377.
210. Reisz-Porszasz, S., Reyes, H., DeLuca, H. F., Prahl, J. M., Hankinson, O. (1993). Investigation on the potential role of the Ah-receptor nuclear translocator protein in vitamin D receptor action. J Recept Res 13:1147-1159. (Pubitemid 23289845)
211. Reisz-Porszasz, S., Probst, M. R., Fukunaga, B. N., Hankinson, O. (1994). Identifcation of functional domains of the aryl hydrocarbon receptor nuclear translocator protein (ARNT). Mol Cell Biol 14:6075-6086. (Pubitemid 24264437)
212. Ripp, S. L., Fitzpatrick, J. L., Peters, J. M., Prough, R. A. (2002). Induction of CYP3A expression by dehydroepiandrosterone: involvement of the pregnane X receptor. Drug Metab Dispos 30:570-575.
213. Roberts, B. J., Whitelaw, M. L. (1999). Degradation of the basic helix-loop-helix/Per-ARNT-Sim homology domain dioxin receptor via the ubiquitin/proteasome pathway. J Biol Chem 274:36351-36356.
214. Roberts, E. S., Vaz, A. D. N., Coon, M. J. (1992). Role of isozymes of rabbit microsomal cytochrome P-450 in the metabolism of retinoic acid, retinol, and retinal. Mol Pharmacol 41:427-433.
215. Roman, B. L., Peterson, R. E. (1998). In utero and lactational exposure of the male rat to 2,3,7,8-tetrachlorodibenzo-p-dioxin impairs prostate development. 1. Efects on gene expression. Toxicol Appl Pharmacol 150:240-253.
216. Romkes, M., Safe, S. (1988). Comparative activities of 2,3,7,8-tetra-chlorodibenzo-p-dioxin and progesterone as antiestrogens in the female rat uterus. Toxicol Appl Pharmacol 92:368-380. (Pubitemid 18087525)
217. Roy, A. K., Tyagi, R. K., Song, C. S., Lavrovsky, Y., Ahn, S. C, Oh, T. S., et al. (2001). Androgen receptor: structural domains and functional dynamics after ligand-receptor interaction. Ann N Y Acad Sci 949:44-57.
218. Rubin, A. L., Rice, R. H. (1988). 2,3,7,8-tetrachlorodibenzo-p-dioxin and polycyclic aromatic hydrocarbons suppress retinoid-induced tissue transglutaminase in SCC-4 cultured human squamous carcinoma cells. Carcinogenesis 9:1067-1070.
219. Rushing, S. R., Denison, M. S. (2002). Te silencing mediator of retinoic acid and thyroid hormone receptors can interact with the aryl hydrocarbon (Ah) receptor but fails to repress Ah-receptor-dependent gene expression. Arch Biochem Biophys 403:189-201.
220. Sachse, C, Brockmoller, J., Bauer, S., Roots, I. (1999). Functional signifcance of a C > A polymorphism in intron I of the cytochrome P450 CYP1A2 gene tested with cafeine. Br J Clin Pharmacol 47:445-449.
221. Safe, S., Wang, F., Porter, W., Duan, R., McDougal, A. (1998). Ah-receptor agonists as endocrine disruptors: antiestrogenic activity and mechanisms. Toxicol Lett 102-103: 343-347.
222. Semenza, G. L. (2000). Oxygen-regulated transcription factors and their role in pulmonary disease. Respir Res 1:159-162.
223. Sérée, E., Villard, P. H., Pascussi, J.-M., Pineau, T, Maurel, P., Nguyen, O. B., et al. (2004). Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites. Gastroenterology 127:1436-1445.
224. Shen, E. S., Whitlock, J. P. (1992). Protein-DNA interactions at a dioxin-responsive enhancer. J Biol Chem 267:6815-6819.
225. Sherratt, A. J., Banet, D. E., Linder, M. W., Prough, R. A. (1989). Potentiation of 3-methylcholanthrene induction of rat hepatic cytochrome P450IA1 by dexamethasone in vivo. J Pharmacol Exp Ter 249:667-672.
226. Sherratt, A. J., Banet, D. E., Prough, R. A. (1990). Glucocorticoid regulation of polycyclic aromatic hydrocarbon induction of cytochrome P450IA1, glutathione S-transferases, and NAD(P) H:quinone oxidoreductase in cultured fetal rat hepatocytes. Mol Pharmacol 37:198-205.
227. Shet, M. S., McPhaul, M., Fisher, C. W., Stallings, N. R., Estabrook, R. W. (1997). Metabolism of the antiandrogenic drug (Flutamide) by human CYP1A2. Drug Metab Dispos 25:1298-1303.
228. Shibata, H., Spencer, T. E., Onate, S. A., Jenster, G., Tsai, S. Y, Tsai, M. J., et al. (1997). Role of co-activators and co-repressors in the mechanism of steroid/thyroid receptor action. Recent Prog Horm Res 52:141-164.
229. Shimada, T, Oda, Y, Gillam, E. M. J., Guengerich, F. P., Inoue, K. (2001). Metabolic activation of polycyclic aromatic hydrocarbons and other procarcinogens by cytochromes P450 1A1 and P450 1B1 allelic variants and other human cytochromes P450 in Salmonella typhimurium NM2009. Drug Metab Dispos 29:1176-1182.
230. Shipley, J. M., Waxman, D. J. (2006). Aryl hydrocarbon receptor-independent activation of estrogen receptor-dependent transcription by 3-methylcholanthrene. Toxicol Appl Pharmacol 213:87-97.
231. Shou, M., Gonzalez, F. J., Gelboin, H. V. (1996). Stereoselective epoxidation and hydration at the k-region of polycylic aromatic hydrocarbons by cDNA-expressed cytochromes P450 1A1, 1A2, and epoxide hydrolase. Biochemistry 35: 15807-15813.
232. Sidhu, J. S., Omiecinski, C. J. (1995a). Modulation of xenobiotic-inducible cytochrome P450 gene expression by dexamethasone in primary rat hepatocytes. Pharmacogenetics 5:24-36.
233. Sidhu, J. S., Omiecinski, C. J. (1995b). cAMP-associated inhibition of phenobarbital-inducible cytochrome P450 gene expression in primary rat hepatocyte cultures. J Biol Chem 270:12762-12773.
234. Sidhu, J. S., Omiecinski, C. J. (1999). Insulin-mediated modulation of cytochrome P450 gene induction profles in primary rat hepatocyte cultures. J Biochem Mol Toxicol 13:1-9.
235. Silver, G., Reid, L. M., Krauter, K. S. (1990). Dexamethasone-mediated regulation of 3-methylcholanthrene-induced cytochrome P-450d mRNA accumulation in primary rat hepatocyte cultures. J Biol Chem 265:3134-3138.
236. Sonneveld, E., Jonas, A., Meijer, O. C, Brouwer, A., van der Burg, B. (2007). Glucocorticoid-enhanced expression of dioxin tart-get genes through regulation of the aryl hydrocarbon receptor. Toxicol Sci 99:455-469.
237. Sonnier, M., Cresteil, T. (1998). Delayed ontogenesis of CYP1A2 in the human liver. Eur J Biochem 251:893-898.
238. Spink, D. C, Lincoln, D. W., Dickerman, H. W., Gierthy, J. F. (1990). 2,3,7,8-tetrachlorodibenzo-p-dioxin causes en extensive alteration of 17fj-estradiol metabolism in MCF-7 breast tumor cells. Proc Natl Acad Sci U S A 87:6917-6921.
239. Spink, D. C, Eugster, H. P., Lincoln, D. W., Schutz, J. D., Schutz, E. G., Johnson, J. A., et al. (1992). 17fj-estradiol hydroxylation catalyzed by human cytochrome P450 1A1: a comparison of the activities induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 cells with those from heterologous expression of the cDNA. Arch Biochem Biophys 293:342-348.
240. Spink, D. C, Hayes, C. L., Young, N. R., Christou, M., Sutter, T. R., Jefcoate, C. R., et al. (1994). Te efects of 2,3,7,8-tetrachlo-rodibenzo-p- dioxin on estrogen metabolism in MCF-7 breast cancer cells: evidence for induction of a novel 17fj-estradiol 4-hydroxylase. J Steroid Biochem Mol Biol 51:251-258.
241. Spink, D. C, Katz, B. H., Hussain, M. M., Pentecost, B. T, Cao, Z., Spink, B. C. (2003). Estrogen regulates Ah responsiveness in MCF-7 breast cancer cells. Carcinogenesis 24:1941-1950.
242. Spurr, N. K., Gough, A. C, Stevenson, K., Wolf, C. R. (1987). Msp-1 polymorphism detected with a cDNA probe for the P-450 I family on chromosome 15. Nucl Acids Res 15:5901.
243. Stahl, B. U., Beer, D. G., Weber, L. W., Rozman K. (1992). Decrease in phosphoenolpyruvate carboxykinase gene expression after 2,3,7,8- tetrachlorodibenzo-p-dioxin treatment: implications for the acute toxicity of chlorinated dibenzo-p-dioxins in the rat. Arch Toxicol (Suppl) 15:151-155.
244. Stahl, B. U., Beer, D. G., Weber, L. W., Rozman K. (1993). Reduction of hepatic phosphoenolpyruvate carboxykinase (PEPCK) activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is due to decreased mRNA levels. Toxicology 79:81-95.
245. Stahl, B. U. (1995). 2,3,7,8-tetrachlorodibenzo-p-dioxin blocks the physiological regulation of hepatic phosphoenolpyruvate car-boxykinase activity in primary rat hepatocytes. Toxicology 103:45-52.
246. Swanson, H. I., Chan, W. K., Bradfeld, C. A. (1995). DNA binding specifcities and pairing rules of the Ah receptor, ARNT, and SIM proteins. J Biol Chem 270:26292-26302.
247. Swanson, H. I., Yang, J.-H. (1998). Te aryl hydrocarbon receptor interacts with transcription factor IIB. Mol Pharmacol 54:671-677.
248. Tamaki, H., Sakuma, T., Uchida, Y., Jaruchotikamol, A., Nemoto, N. (2005). Activation of CYP1A1 gene expression during primary culture of mouse hepatocytes. Toxicology 216: 224-231.
249. Tackaberry, E. A., Bedrick, E. J., Goens, M. B., Danielson, L., Lund, A. K., Gabaldon, D., et al. (2003). Insulin regulation in AhR-null mice: embryonic cardiac enlargement, neonatal macrosomia, and altered insulin regulation and response in pregnant and aging AhR-null females. Toxicol Sci 76:407-417.
250. Tomsen, J. S., Wang, X., Hines, R. N., Safe, S. (1994). Restoration of aryl hydrocarbon (Ah) responsiveness in MDA-MB-231 human breast cancer cells by transient expression of the estrogen receptor. Carcinogenesis 15:933-937. (Pubitemid 24156892)
251. Tummel, K. E., Brimer, C., Yasuda, K., Tottassery, J., Senn, T., Lin, Y., et al. (2001). Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3. Mol Pharmacol 60:1399-1406.
252. Tian, Y., Ke, S., Denison, M. S., Rabson, A. B., Gallo, M. A. (1999). Ah-receptor and NF-kappaB interactions, a potential mechanism for dioxin toxicity. J Biol Chem 274:510-515.
253. Tomita, S., Tsujita, M., Matsuto, Y., Yubisui, T., Ichikawa, Y. (1993). Identifcation of a microsomal retinoic acid synthase as a micro-somal cytochrome P-450-linked monooxygenase system. Int J Biochem 25:1775-1784.
254. Tseng, L. H., Li, M. H., Tsai, S. S., Lee, C. W., Pan, M. H., Yao, W. J., et al. (2008). Developmental exposure to decabromodiphenyl ether (PBDE 209): efects on thyroid hormone and hepatic enzyme activity in male mouse ofspring. Chemosphere 70:640-647.
255. Turesky, R. J., Constable, A., Richoz, J., Varga, N., Markovic, J., Martin, M. V., et al. (1998). Activation of heterocyclic aromatic amines by rat and human liver microsomes and by puri-fed rat and human cytochrome P450 1A2. Chem Res Toxicol 11:925-936.
256. Ullrich, A., Schlessinger, J. (1990). Signal transduction by receptors with tyrosine kinase activity. Cell 61:203-212.
257. Vecchini, F., Lenoir-Viale, M. C., Cathelineau, C., Magdalou, J., Bernard, B. A., Shroot, B. (1994). Presence of a retinoic responsive element in the promoter region of the human cytochrome P4501A1 gene. Biochem Biophys Res Commun 201:1205-1212.
258. Viitala, P., Posti, K., Lindfors, A., Pelkonen, O., Raunio, H. (2001). cAMP-mediated upregulation of CYP2A5 in mouse hepatocytes. Biochem Biophys Res Commun 280:761-767.
259. Vinggaard, A. M., Hnida, C., Larsen, J. C. (2000). Environmental poly-cyclic aromatic hydrocarbons afect androgen-receptor activation in vitro. Toxicology 145:173-183. (Pubitemid 30385999)
260. Voskoboinik, I., Ooi, S. G., Drew, R., Ahokas, J. T. (1997). Peroxisome proliferators increase the formation of BPDE-DNA adducts in isolated rat hepatocytes. Toxicology 122:81-91.
261. Vozeh, S., Powell, J. R., Costello, J. F., Sheiner, L. B., Hopewell, P. C. (1978). Changes in theophylline clearance during acute illness. JAMA 240:1882-1884.
262. Vrzal, R., Daujat-Chavanieu, M., Pascussi, J.-M., Ulrichova, J., Maurel, P., Dvorak, Z. (2008). Microtubules-interfering agents restrict aryl hydrocarbon receptor-mediated CYP1A2 induction in primary cultures of human hepatocytes via c-jun-N-terminal kinase and glucocorticoid receptor. Eur J Pharmacol 581:244-254.
263. Vrzal, R., Stejskalova, L., Monostory, K., Maurel, P., Bachleda, P., Pavek, P., et al. (2009). Dexamethasone controls aryl hydrocarbon receptor (AhR)-mediated CYP1A1 and CYP1A2 expression and activity in primary cultures of human hepatocytes. Chem Biol Interact 179:288-296.
264. Wang, X., Porter, W., Krishnan, V, Narasimhan, T. R., Safe, S. (1993). Mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated decrease of the nuclear estrogen receptor in MCF-7 human breast cancer cells. Mol Cell Endocrinol 96:159-166. (Pubitemid 23292675)
265. Wang, F., Samudio, I., Safe, S. (2001). Transcriptional activation of cathepsin D gene expression by 17fj-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition. Mol Cell Endocrinol 172:91-103. (Pubitemid 32101395)
266. Wanner, R., Brommer, S., Czarnetzki, B. M., Rosenbach, T. (1995). Te diferentiation-related upregulation of aryl hydrocarbon receptor transcript levels is suppressed by retinoic acid. Biochem Biophys Res Commun 209:706-711.
267. Wanner, R., Panteleyev, A., Henz, B. M., Rosenbach, T. (1996). Retinoic acid afects the expression rate of the diferentiation-related genes aryl hydrocarbon receptor, ARNT, and keratin 4 in proliferative keratinocytes only. Biochim Biophys Acta 1317:105-111.
268. Webb, S. J., Geoghegan, T. E., Prough, R. A., Miller, K. K. M. (2006). Te biological actions of dehydroepiandrosterone involves multiple receptors. Drug Metab Rev 38:89-116.
269. Wei, C, Caccavale, R. J., Kehoe, J. J., Tomas, P. E., Iba, M. M. (2001). CYP1A2 is expressed along with CYP1A1 in the human lung. Cancer Lett 171:113-120. (Pubitemid 32727362)
270. Wesselborg, S., Bauer, M. K. A., Vogt, M., Schmitz, M. L., Schulze-Osthof, K. (1997). Activation of transcription factor NF-kappaB and p38 mitogen-activated protein kinase is mediated by distinct and separate stress efector pathways. J Biol Chem 272:12422-12429.
271. White, T. E. K., Gasiewicz, T. A. (1993). Te human estrogen receptor structural gene contains a DNA sequence that binds activated mouse and human Ah receptors: a possible mechanism of estrogen receptor regulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochem Biophys Res Commun 193:956-962.
272. Whitelaw, M., Pongratz, I., Wilhelmsson, A., Gustafsson, J.-A., Poellinger, L. (1993). Ligand-dependent recruitment of the Arnt coregulator determines DNA recognition by the dioxin receptor. Mol Cell Biol 13:2504-2514.
273. Whitlock, J. P. (1999). Induction of CYP1A1. Annu Rev Pharmacol Toxicol 39:103-125.
274. Widerak, M., Ghoneim, C, Dumontier, M. F., Quesne, M., Corvol, M. T, Savouret, J. F. (2006). Te aryl hydrocarbon receptor activates the retinoic acid receptoralpha through SMRT antagonism. Biochimie 88:387-397.
275. Wölfe, D., Becker, E., Schmutte, C. (1993). Growth stimulation of primary rat hepatocytes by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Cell Biol Toxicol 9:15-31.
276. Wormke, M., Stoner, M., Saville, B., Safe, S. (2000). Crosstalk between estrogen receptor a and the aryl hydrocarbon receptor in breast cancer cells involves unidirectional activation of proteasomes. FEBS Lett 478:109-112.
277. Wormke, M., Stoner, M., Saville, B., Walker, K., Abdelrahim, M., Burghardt, R., et al. (2003). Te aryl hydrocarbon receptor mediates degradation of estrogen receptor a through activation of proteasomes. Mol Cell Biol 23:1843-1855.
278. Wu, H.-Q., Masset-Brown, J., Tweedie, D. J., Milewich, L., Frenkel, R. A., Martin-Wixtrom, C, et al. (1989). Induction of microsomal NADPH-cytochrome P-450 reductase and cytochrome P-450IVA1 (P-450LAM) by dehydroepiandrosterone in rats: a possible peroxisomal proliferators. Cancer Res 49:2337-2343.
279. Xiao, G.-H., Pinaire, J. A., Rodrigues, A. D., Prough, R. A. (1995). Regulation of the Ah gene battery via Ah receptor-dependent and independent processes in cultured adult rat hepatocytes. Drug Metab Dispos 23:642-650.
280. Xiao, G.-H., Falkner, K. C, Xie, Y., Lindahl, R. G., Prough, R. A. (1997). cAMP-dependent negative regulation of rat aldehyde dehydrogenase class 3 gene expression. J Biol Chem 272:3238-3245.
281. Yamazaki, H., Shimada, T. (1999). Efects of arachidonic acid, prostaglandins, retinol, retinoic acid, and cholecalciferol on xenobi-otic oxidations catalysed by human cytochrome P450 enzymes. Xenobiotica 29:231-241.
282. Yanagida, A., Sogawa, K., Yasumoto, K., Fujii-Kuriyama, Y (1990). A novel cis-acting DNA element required for a high level of inducible expression of the rat P-450c gene. Mol Cell Biol 10:1470-1475.
283. Yang, H.-Y. L., Namkung, M. J., Juchau, M. R. (1995). Expression of functional cytochrome P4501A1 in human embryonic hepatic tissues during organogenesis. Biochem Pharmacol 49:717-726.
284. Yang, Y. M., Huang, D. Y., Liu, G. F., Zhong, J. C., Du, K., Li, Y. F., et al. (2005). Inhibitory efects of vitamin A on TCDD-induced cyto-chrome P-450 1A1 enzyme activity and expression. Toxicol Sci 85:727-734.
285. Yen, P. M. (2001). Physiological and molecular basis of thyroid hormone action. Physiol Rev 81:1097-1142.
286. Yim, S., Choi, S. M., Choi, Y., Lee, N., Chung, J., Park, H. (2003). Insulin and hypoxia share common target genes but not the hypoxia-inducible factor-1a. J Biol Chem 278:38260-38268.
287. Zacharewski, T. R., Bondy, K. L., McDonell, P., Wu, Z. F. (1994). Antiestrogenic efect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on 17fj-estradiol-induced pS2 expression. Cancer Res 54:2707-2713.
288. Zelzer, E., Levy, Y, Kahana, C, Shilo, B. Z., Rubinstein, M., Cohen, B. (1998). Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1a/ARNT. EMBO J 17:5085-5094.
289. Zhang, Z., Fasco, M. J., Huang, Z., Guengerich, F. P., Kaminsky, L. S. (1995). Human cytochrome P4501A1 and P4501A2: R-warfarin metabolism as a probe. Drug Metab Dispos 23:1339-1346.