Induction of cytochrome P450 2B6 activity by the herbal medicine baicalin as measured by bupropion hydroxylation

European Journal of Clinical Pharmacology

Volumn 65, Issue 4, 2009, Pages 403-409

  Fan, Lan ^a   Wang, Jin Chao ^a   Jiang, Feng ^b   Tan, Zhi Rong ^a   Chen, Yao ^a   Li, Qing ^a   Zhang, Wei ^a   Wang, Guo ^a   Lei, He Ping ^a   Hu, Dong Li ^a   Wang, Dan ^a   Zhou, Hong Hao ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b Inje University   (South Korea)

Author keywords

Baicalin; Bupropion; CYP2B6; Herb drug interaction; Hydroxybupropoion; Induction; Pharmacokinetics

Indexed keywords

AMFEBUTAMONE; BAICALIN; CYTOCHROME P450 2B6; PROPRANOLOL; RADAFAXINE;

ADULT; AREA UNDER THE CURVE; ARTICLE; CONFIDENCE INTERVAL; CONTROLLED STUDY; CYP2B6 GENE; DRUG EFFECT; DRUG ELIMINATION; DRUG HALF LIFE; DRUG HYDROXYLATION; DRUG METABOLISM; ENZYME ACTIVITY; GENE; GENOTYPE; HERBAL MEDICINE; HUMAN; HUMAN EXPERIMENT; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; SINGLE DRUG DOSE;

ADULT; AREA UNDER CURVE; ARYL HYDROCARBON HYDROXYLASES; BUPROPION; DOPAMINE UPTAKE INHIBITORS; ENZYME INDUCTION; FLAVONOIDS; GLUCURONIDASE; HAPLOTYPES; HERB-DRUG INTERACTIONS; HUMANS; HYDROXYLATION; MALE; OXIDOREDUCTASES, N-DEMETHYLATING; PLANT EXTRACTS; POLYMORPHISM, SINGLE NUCLEOTIDE; TIME FACTORS;

EID: 62549121605     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-008-0594-3     Document Type: Article

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