Cannabidiol induces expression of human cytochrome P450 1A1 that is possibly mediated through aryl hydrocarbon receptor signaling in HepG2 cells

Life Sciences

Volumn 136, Issue , 2015, Pages 87-93

  Yamaori, Satoshi ^a   Kinugasa, Yuka ^b   Jiang, Rongrong ^b   Takeda, Shuso ^b   Yamamoto, Ikuo ^c   Watanabe, Kazuhito ^b  

^a SHINSHU UNIVERSITY HOSPITAL   (Japan)

^b HOKURIKU UNIVERSITY   (Japan)

^c KYUSHU UNIVERSITY OF HEALTH AND WELFARE   (Japan)

Author keywords

AhR; Cannabidiol; CYP1A1; Induction; Marijuana; Protein tyrosine kinase

Indexed keywords

3 METHYLCHOLANTHRENE; AROMATIC HYDROCARBON RECEPTOR; CANNABIDIOL; CANNABIDIOL DIMETHYL ETHER; CANNABIDIOL METHYL ETHER; CANNABINOL; CYTOCHROME P450 1A1; HERBIMYCIN A; MESSENGER RNA; NABIXIMOLS; OLIVETOL; OMEPRAZOLE; PHENOL; PROTEIN TYROSINE KINASE; SMALL INTERFERING RNA; TETRAHYDROCANNABINOL; CYP1A1 PROTEIN, HUMAN;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME INDUCTION; GENE EXPRESSION; GENE SILENCING; HEPG2 CELL LINE; HUMAN; HUMAN CELL; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; DRUG EFFECTS; GENETICS; METABOLISM;

CANNABIS SATIVA;

CANNABIDIOL; CYTOCHROME P-450 CYP1A1; ENZYME INDUCTION; HEP G2 CELLS; HUMANS; RECEPTORS, ARYL HYDROCARBON; SIGNAL TRANSDUCTION;

EID: 84937403119     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2015.07.007     Document Type: Article

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