Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via gata6-dependent dedifferentiation of acinar cells in mice

Gastroenterology

Volumn 147, Issue 5, 2014, Pages 1119-1133.e4

  Hermann, Patrick C ^a   Sancho, Patricia ^a   Cañamero, Marta ^a   Martinelli, Paola ^a   Madriles, Francesc ^a   Michl, Patrick ^b   Gress, Thomas ^b   De Pascual, Ricardo ^c   Gandia, Luis ^c   Guerra, Carmen ^a   Barbacid, Mariano ^a   Wagner, Martin ^d   Vieira, Catarina R ^a   Aicher, Alexandra ^a   Real, Francisco X ^a   Sainz, Bruno ^a   Heeschen, Christopher ^a,e  

^a Centro Nacional de Investigations Oncológicas   (Spain)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c INSTITUTO TEÓFILO HERNANDO   (Spain)

^d UNIVERSITY OF ULM   (Germany)

^e QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Metastasis; Mouse Model; Pancreas; Progenitor Cells

Indexed keywords

CRE RECOMBINASE; K RAS PROTEIN; LENTIVIRUS VECTOR; METFORMIN; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINE; TRANSCRIPTION FACTOR GATA 6; BUNGAROTOXIN RECEPTOR; CHRNA7 PROTEIN, MOUSE; GATA6 PROTEIN, MOUSE; KRAS2 PROTEIN, MOUSE; MYC PROTEIN; MYC PROTEIN, MOUSE; NICOTINIC AGENT; PROTEIN KINASE B; PROTEIN P21; PROTEIN P53;

ACINAR CELL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CANCER GROWTH; CANCER STEM CELL; CARCINOGENESIS; CELL COMPARTMENTALIZATION; CELL DEDIFFERENTIATION; CELL INFILTRATION; CELL LOSS; CELL MIGRATION; CELL PROLIFERATION; CIRCULATING TUMOR CELL; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME SYNTHESIS; EXPRESSION VECTOR; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; ONCOGENE C MYC; ONCOGENE K RAS; PANCREAS ADENOCARCINOMA; PROTEIN DEPLETION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMOKING; TRANSCRIPTION INITIATION; TRANSMISSION ELECTRON MICROSCOPY; TUMOR VOLUME; WILD TYPE; 129 MOUSE; ANIMAL; C57BL MOUSE; CARCINOMA, PANCREATIC DUCTAL; CELL TRANSFORMATION; CHEMICALLY INDUCED; DEFICIENCY; DRUG EFFECTS; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; HUMAN; KNOCKOUT MOUSE; LIVER TUMOR; METABOLISM; MUTATION; NUDE MOUSE; PANCREAS; PANCREATIC NEOPLASMS; PATHOLOGY; SECONDARY; TIME; TOXICITY; TUMOR CELL CULTURE; TUMOR CELL LINE; TUMOR EMBOLISM;

ACINAR CELLS; ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR; ANIMALS; CARCINOMA, PANCREATIC DUCTAL; CELL DEDIFFERENTIATION; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; EPITHELIAL-MESENCHYMAL TRANSITION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GATA6 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER NEOPLASMS; METFORMIN; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, NUDE; MUTATION; NEOPLASTIC CELLS, CIRCULATING; NEOPLASTIC STEM CELLS; NICOTINE; NICOTINIC AGONISTS; PANCREAS; PANCREATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-MYC; PROTO-ONCOGENE PROTEINS P21(RAS); SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84908295791     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2014.08.002     Document Type: Article

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