메뉴 건너뛰기




Volumn 93, Issue 2, 2015, Pages 149-157

Acetyl-lysine erasers and readers in the control of pulmonary hypertension and right ventricular hypertrophy1

Author keywords

Bromodomain; Epigenetics; HDAC; Pulmonary hypertension; RV hypertrophy

Indexed keywords

ACETYLATION; AMINO ACIDS; GENE EXPRESSION; PATHOLOGY;

EID: 84964225150     PISSN: 08298211     EISSN: 12086002     Source Type: Journal    
DOI: 10.1139/bcb-2014-0119     Document Type: Review
Times cited : (23)

References (93)
  • 1
    • 84881192460 scopus 로고    scopus 로고
    • BET bromodomains mediate transcriptional pause release in heart failure
    • 10.1016/j.cell.2013.07.013. 23911322
    • Anand P. Brown J.D. Lin C.Y. Qi J. Zhang R. Artero P.C. et al 2013. BET bromodomains mediate transcriptional pause release in heart failure. Cell, 154: 569-582. 10.1016/j.cell.2013.07.013. 23911322.
    • (2013) Cell , vol.154 , pp. 569-582
    • Anand, P.1    Brown, J.D.2    Lin, C.Y.3    Qi, J.4    Zhang, R.5    Artero, P.C.6
  • 2
    • 33745812011 scopus 로고    scopus 로고
    • CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy
    • 10.1172/JCI27438. 16767219
    • Backs J. Song K. Bezprozvannaya S. Chang S. Olson E.N. 2006. CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy. J. Clin. Invest. 116: 1853-1864. 10.1172/JCI27438. 16767219.
    • (2006) J. Clin. Invest. , vol.116 , pp. 1853-1864
    • Backs, J.1    Song, K.2    Bezprozvannaya, S.3    Chang, S.4    Olson, E.N.5
  • 3
    • 43249121693 scopus 로고    scopus 로고
    • Histone deacetylase 5 acquires calcium/calmodulin-dependent kinase II responsiveness by oligomerization with histone deacetylase 4
    • 10.1128/MCB.01611-07. 18332106
    • Backs J. Backs T. Bezprozvannaya S. McKinsey T.A. Olson E.N. 2008. Histone deacetylase 5 acquires calcium/calmodulin-dependent kinase II responsiveness by oligomerization with histone deacetylase 4. Mol. Cell. Biol. 28: 3437-3445. 10.1128/MCB.01611-07. 18332106.
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 3437-3445
    • Backs, J.1    Backs, T.2    Bezprozvannaya, S.3    McKinsey, T.A.4    Olson, E.N.5
  • 4
    • 35348816030 scopus 로고    scopus 로고
    • Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription
    • 10.1073/pnas.0705053104. 17690245
    • Bisgrove D.A. Mahmoudi T. Henklein P. Verdin E. 2007. Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription. Proc. Natl. Acad. Sci. U.S.A. 104: 13690-13695. 10.1073/pnas.0705053104. 17690245.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 13690-13695
    • Bisgrove, D.A.1    Mahmoudi, T.2    Henklein, P.3    Verdin, E.4
  • 5
    • 72449124776 scopus 로고    scopus 로고
    • Chronic pulmonary artery pressure elevation is insufficient to explain right heart failure
    • 10.1161/CIRCULATIONAHA.109.883843. 19884466
    • Bogaard H.J. Natarajan R. Henderson S.C. Long C.S. Kraskauskas D. Smithson L. et al 2009. Chronic pulmonary artery pressure elevation is insufficient to explain right heart failure. Circulation, 120: 1951-1960. 10.1161/CIRCULATIONAHA.109.883843. 19884466.
    • (2009) Circulation , vol.120 , pp. 1951-1960
    • Bogaard, H.J.1    Natarajan, R.2    Henderson, S.C.3    Long, C.S.4    Kraskauskas, D.5    Smithson, L.6
  • 6
    • 79956200230 scopus 로고    scopus 로고
    • Suppression of histone deacetylases worsens right ventricular dysfunction after pulmonary artery banding in rats
    • 10.1164/rccm.201007-1106OC. 21297075
    • Bogaard H.J. Mizuno S. Hussaini A.A. Toldo S. Abbate A. Kraskauskas D. et al 2011. Suppression of histone deacetylases worsens right ventricular dysfunction after pulmonary artery banding in rats. Am. J. Respir. Crit. Care Med. 183: 1402-1410. 10.1164/rccm.201007-1106OC. 21297075.
    • (2011) Am. J. Respir. Crit. Care Med. , vol.183 , pp. 1402-1410
    • Bogaard, H.J.1    Mizuno, S.2    Hussaini, A.A.3    Toldo, S.4    Abbate, A.5    Kraskauskas, D.6
  • 8
    • 76349122643 scopus 로고    scopus 로고
    • Protein acetylation in the cardiorenal axis: The promise of histone deacetylase inhibitors
    • 10.1161/CIRCRESAHA.109.209338. 20133912
    • Bush E.W. McKinsey T.A. 2010. Protein acetylation in the cardiorenal axis: the promise of histone deacetylase inhibitors. Circ. Res. 106: 272-284. 10.1161/CIRCRESAHA.109.209338. 20133912.
    • (2010) Circ. Res. , vol.106 , pp. 272-284
    • Bush, E.W.1    McKinsey, T.A.2
  • 9
    • 77955355838 scopus 로고    scopus 로고
    • Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A
    • 10.1021/ja102758v. 20614936
    • Butler K.V. Kalin J. Brochier C. Vistoli G. Langley B. Kozikowski A.P. 2010. Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A. J. Am. Chem. Soc. 132: 10842-10846. 10.1021/ja102758v. 20614936.
    • (2010) J. Am. Chem. Soc. , vol.132 , pp. 10842-10846
    • Butler, K.V.1    Kalin, J.2    Brochier, C.3    Vistoli, G.4    Langley, B.5    Kozikowski, A.P.6
  • 10
    • 84876888400 scopus 로고    scopus 로고
    • Sodium butyrate inhibits platelet-derived growth factor-induced proliferation and migration in pulmonary artery smooth muscle cells through Akt inhibition
    • 10.1111/febs.12227. 23463962
    • Cantoni S. Galletti M. Zambelli F. Valente S. Ponti F. Tassinari R. et al 2013. Sodium butyrate inhibits platelet-derived growth factor-induced proliferation and migration in pulmonary artery smooth muscle cells through Akt inhibition. FEBS J. 280: 2042-2055. 10.1111/febs.12227. 23463962.
    • (2013) FEBS J. , vol.280 , pp. 2042-2055
    • Cantoni, S.1    Galletti, M.2    Zambelli, F.3    Valente, S.4    Ponti, F.5    Tassinari, R.6
  • 11
    • 84863231352 scopus 로고    scopus 로고
    • Selective class i histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism
    • 10.1161/CIRCRESAHA.111.258426. 22282194
    • Cavasin M.A. Demos-Davies K. Horn T.R. Walker L.A. Lemon D.D. Birdsey N. et al 2012. Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism. Circ. Res. 110: 739-748. 10.1161/CIRCRESAHA.111.258426. 22282194.
    • (2012) Circ. Res. , vol.110 , pp. 739-748
    • Cavasin, M.A.1    Demos-Davies, K.2    Horn, T.R.3    Walker, L.A.4    Lemon, D.D.5    Birdsey, N.6
  • 12
    • 67650002873 scopus 로고    scopus 로고
    • Studies of benzamide-and thiol-based histone deacetylase inhibitors in models of oxidative-stress-induced neuronal death: Identification of some HDAC3-selective inhibitors
    • 10.1002/cmdc.200800461. 19350613
    • Chen Y. He R. Chen Y. D'Annibale M.A. Langley B. Kozikowski A.P. 2009. Studies of benzamide-and thiol-based histone deacetylase inhibitors in models of oxidative-stress-induced neuronal death: identification of some HDAC3-selective inhibitors. ChemMedChem, 4: 842-852. 10.1002/cmdc.200800461. 19350613.
    • (2009) ChemMedChem , vol.4 , pp. 842-852
    • Chen, Y.1    He, R.2    Chen, Y.3    D'Annibale, M.A.4    Langley, B.5    Kozikowski, A.P.6
  • 13
    • 77950683482 scopus 로고    scopus 로고
    • Sodium valproate, a histone deacetylase inhibitor, but not captopril, prevents right ventricular hypertrophy in rats
    • 10.1253/circj.CJ-09-0580. 20208383
    • Cho Y.K. Eom G.H. Kee H.J. Kim H.S. Choi W.Y. Nam K.I. et al 2010. Sodium valproate, a histone deacetylase inhibitor, but not captopril, prevents right ventricular hypertrophy in rats. Circ. J. 74: 760-770. 10.1253/circj.CJ-09-0580. 20208383.
    • (2010) Circ. J. , vol.74 , pp. 760-770
    • Cho, Y.K.1    Eom, G.H.2    Kee, H.J.3    Kim, H.S.4    Choi, W.Y.5    Nam, K.I.6
  • 14
    • 84862726998 scopus 로고    scopus 로고
    • Inhibition of histone deacetylase 3 protects beta cells from cytokine-induced apoptosis
    • 10.1016/j.chembiol.2012.05.010. 22726680
    • Chou D.H. Holson E.B. Wagner F.F. Tang A.J. Maglathlin R.L. Lewis T.A. et al 2012. Inhibition of histone deacetylase 3 protects beta cells from cytokine-induced apoptosis. Chem. Biol. 19: 669-673. 10.1016/j.chembiol.2012.05.010. 22726680.
    • (2012) Chem. Biol. , vol.19 , pp. 669-673
    • Chou, D.H.1    Holson, E.B.2    Wagner, F.F.3    Tang, A.J.4    Maglathlin, R.L.5    Lewis, T.A.6
  • 15
    • 68949212379 scopus 로고    scopus 로고
    • Lysine acetylation targets protein complexes and co-regulates major cellular functions
    • 10.1126/science.1175371. 19608861
    • Choudhary C. Kumar C. Gnad F. Nielsen M.L. Rehman M. Walther T.C. et al 2009. Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science, 325: 834-840. 10.1126/science.1175371. 19608861.
    • (2009) Science , vol.325 , pp. 834-840
    • Choudhary, C.1    Kumar, C.2    Gnad, F.3    Nielsen, M.L.4    Rehman, M.5    Walther, T.C.6
  • 16
    • 56049120057 scopus 로고    scopus 로고
    • Eloquent silence: Developmental functions of Class i histone deacetylases
    • 10.1016/j.gde.2008.10.001. 18929655
    • Cunliffe V.T. 2008. Eloquent silence: developmental functions of Class I histone deacetylases. Curr. Opin. Genet. Dev. 18: 404-410. 10.1016/j.gde.2008.10.001. 18929655.
    • (2008) Curr. Opin. Genet. Dev. , vol.18 , pp. 404-410
    • Cunliffe, V.T.1
  • 17
    • 85026337063 scopus 로고    scopus 로고
    • Histone deacetylase inhibition with trichostatin A does not reverse severe angioproliferative pulmonary hypertension in rats (2013 Grover Conference series)
    • 10.1086/675986. 25006442
    • De Raaf M.A. Hussaini A.A. Gomez-Arroyo J. Kraskaukas D. Farkas D. Happe C. et al 2014. Histone deacetylase inhibition with trichostatin A does not reverse severe angioproliferative pulmonary hypertension in rats (2013 Grover Conference series). Pulm. Circ. 4: 237-243. 10.1086/675986. 25006442.
    • (2014) Pulm. Circ. , vol.4 , pp. 237-243
    • De Raaf, M.A.1    Hussaini, A.A.2    Gomez-Arroyo, J.3    Kraskaukas, D.4    Farkas, D.5    Happe, C.6
  • 18
    • 84904293106 scopus 로고    scopus 로고
    • HDAC6 contributes to pathological responses of heart and skeletal muscle to chronic angiotensin-II signaling
    • 10.1152/ajpheart.00149.2014. 24858848
    • Demos-Davies K.M. Ferguson B.S. Cavasin M.A. Mahaffey J.H. Williams S.M. Spiltoir J.I. et al 2014. HDAC6 contributes to pathological responses of heart and skeletal muscle to chronic angiotensin-II signaling. Am. J. Physiol. Heart Circ. Physiol. 307: H252-H258. 10.1152/ajpheart.00149.2014. 24858848.
    • (2014) Am. J. Physiol. Heart Circ. Physiol. , vol.307 , pp. 252-H258
    • Demos-Davies, K.M.1    Ferguson, B.S.2    Cavasin, M.A.3    Mahaffey, J.H.4    Williams, S.M.5    Spiltoir, J.I.6
  • 19
    • 85047699941 scopus 로고    scopus 로고
    • Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling
    • 10.1038/sj.onc.1205108. 11821955
    • Deroanne C.F. Bonjean K. Servotte S. Devy L. Colige A. Clausse N. et al 2002. Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling. Oncogene, 21: 427-436. 10.1038/sj.onc.1205108. 11821955.
    • (2002) Oncogene , vol.21 , pp. 427-436
    • Deroanne, C.F.1    Bonjean, K.2    Servotte, S.3    Devy, L.4    Colige, A.5    Clausse, N.6
  • 20
    • 78651470146 scopus 로고    scopus 로고
    • Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin
    • 10.1021/ml1001954. 21874153
    • Fass D.M. Shah R. Ghosh B. Hennig K. Norton S. Zhao W.N. et al 2010. Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin. ACS Med. Chem. Lett. 2: 39-42. 10.1021/ml1001954. 21874153.
    • (2010) ACS Med. Chem. Lett. , vol.2 , pp. 39-42
    • Fass, D.M.1    Shah, R.2    Ghosh, B.3    Hennig, K.4    Norton, S.5    Zhao, W.N.6
  • 21
    • 78650847770 scopus 로고    scopus 로고
    • Selective inhibition of BET bromodomains
    • 10.1038/nature09504. 20871596
    • Filippakopoulos P. Qi J. Picaud S. Shen Y. Smith W.B. Fedorov O. et al 2010. Selective inhibition of BET bromodomains. Nature, 468: 1067-1073. 10.1038/nature09504. 20871596.
    • (2010) Nature , vol.468 , pp. 1067-1073
    • Filippakopoulos, P.1    Qi, J.2    Picaud, S.3    Shen, Y.4    Smith, W.B.5    Fedorov, O.6
  • 22
    • 0036161439 scopus 로고    scopus 로고
    • Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR
    • 10.1016/S1097-2765(01)00429-4. 11804585
    • Fischle W. Dequiedt F. Hendzel M.J. Guenther M.G. Lazar M.A. Voelter W. Verdin E. 2002. Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. Mol. Cell, 9: 45-57. 10.1016/S1097-2765(01)00429-4. 11804585.
    • (2002) Mol. Cell , vol.9 , pp. 45-57
    • Fischle, W.1    Dequiedt, F.2    Hendzel, M.J.3    Guenther, M.G.4    Lazar, M.A.5    Voelter, W.6    Verdin, E.7
  • 23
    • 84906791178 scopus 로고    scopus 로고
    • Dissecting histone deacetylase role in pulmonary arterial smooth muscle cell proliferation and migration
    • 10.1016/j.bcp.2014.07.011. 25063234
    • Galletti M. Cantoni S. Zambelli F. Valente S. Palazzini M. Manes A. et al 2014. Dissecting histone deacetylase role in pulmonary arterial smooth muscle cell proliferation and migration. Biochem. Pharmacol. 91: 181-190. 10.1016/j.bcp.2014.07.011. 25063234.
    • (2014) Biochem. Pharmacol. , vol.91 , pp. 181-190
    • Galletti, M.1    Cantoni, S.2    Zambelli, F.3    Valente, S.4    Palazzini, M.5    Manes, A.6
  • 24
    • 58149334793 scopus 로고    scopus 로고
    • Inactivation of CREB mediated gene transcription by HDAC8 bound protein phosphatase
    • 10.1016/j.bbrc.2008.11.135. 19070599
    • Gao J. Siddoway B. Huang Q. Xia H. 2009. Inactivation of CREB mediated gene transcription by HDAC8 bound protein phosphatase. Biochem. Biophys. Res. Commun. 379: 1-5. 10.1016/j.bbrc.2008.11.135. 19070599.
    • (2009) Biochem. Biophys. Res. Commun. , vol.379 , pp. 1-5
    • Gao, J.1    Siddoway, B.2    Huang, Q.3    Xia, H.4
  • 25
    • 1842578986 scopus 로고    scopus 로고
    • Molecular evolution of the histone deacetylase family: Functional implications of phylogenetic analysis
    • 10.1016/j.jmb.2004.02.006. 15050820
    • Gregoretti I.V. Lee Y.M. Goodson H.V. 2004. Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis. J. Mol. Biol. 338: 17-31. 10.1016/j.jmb.2004.02.006. 15050820.
    • (2004) J. Mol. Biol. , vol.338 , pp. 17-31
    • Gregoretti, I.V.1    Lee, Y.M.2    Goodson, H.V.3
  • 26
    • 0034608955 scopus 로고    scopus 로고
    • Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization
    • 10.1073/pnas.140199597. 10869435
    • Grozinger C.M. Schreiber S.L. 2000. Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization. Proc. Natl. Acad. Sci. U.S.A. 97: 7835-7840. 10.1073/pnas.140199597. 10869435.
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 7835-7840
    • Grozinger, C.M.1    Schreiber, S.L.2
  • 27
    • 0344640906 scopus 로고    scopus 로고
    • Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation
    • 10.1073/pnas.0430973100. 12677000
    • Haggarty S.J. Koeller K.M. Wong J.C. Grozinger C.M. Schreiber S.L. 2003. Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Proc. Natl. Acad. Sci. U.S.A. 100: 4389-4394. 10.1073/pnas.0430973100. 12677000.
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 4389-4394
    • Haggarty, S.J.1    Koeller, K.M.2    Wong, J.C.3    Grozinger, C.M.4    Schreiber, S.L.5
  • 28
    • 84904736595 scopus 로고    scopus 로고
    • BET-ting on chromatin-based therapeutics for heart failure
    • 10.1016/j.yjmcc.2014.05.002. 24838003
    • Haldar S.M. McKinsey T.A. 2014. BET-ting on chromatin-based therapeutics for heart failure. J. Mol. Cell. Cardiol. 74C: 98-102. 10.1016/j.yjmcc.2014.05.002. 24838003.
    • (2014) J. Mol. Cell. Cardiol. , vol.74 C , pp. 98-102
    • Haldar, S.M.1    McKinsey, T.A.2
  • 29
    • 33646161306 scopus 로고    scopus 로고
    • Regulation of cardiac stress signaling by protein kinase d1
    • 10.1128/MCB.26.10.3875-3888.2006. 16648482
    • Harrison B.C. Kim M.S. van Rooij E. Plato C.F. Papst P.J. Vega R.B. et al 2006. Regulation of cardiac stress signaling by protein kinase d1. Mol. Cell. Biol. 26: 3875-3888. 10.1128/MCB.26.10.3875-3888.2006. 16648482.
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 3875-3888
    • Harrison, B.C.1    Kim, M.S.2    Van Rooij, E.3    Plato, C.F.4    Papst, P.J.5    Vega, R.B.6
  • 31
    • 2942541475 scopus 로고    scopus 로고
    • Cellular and molecular pathobiology of pulmonary arterial hypertension
    • 10.1016/j.jacc.2004.02.029. 15194174
    • Humbert M. Morrell N.W. Archer S.L. Stenmark K.R. MacLean M.R. Lang I.M. et al 2004. Cellular and molecular pathobiology of pulmonary arterial hypertension. J. Am. Coll. Cardiol. 43: 13S-24S. 10.1016/j.jacc.2004.02.029. 15194174.
    • (2004) J. Am. Coll. Cardiol. , vol.43 , pp. 13S-24S
    • Humbert, M.1    Morrell, N.W.2    Archer, S.L.3    Stenmark, K.R.4    Maclean, M.R.5    Lang, I.M.6
  • 32
    • 28844475400 scopus 로고    scopus 로고
    • HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin
    • 10.1074/jbc.M508786200. 16192271
    • Iwata A. Riley B.E. Johnston J.A. Kopito R.R. 2005. HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin. J. Biol. Chem. 280: 40282-40292. 10.1074/jbc.M508786200. 16192271.
    • (2005) J. Biol. Chem. , vol.280 , pp. 40282-40292
    • Iwata, A.1    Riley, B.E.2    Johnston, J.A.3    Kopito, R.R.4
  • 33
    • 23744514308 scopus 로고    scopus 로고
    • The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription
    • 10.1016/j.molcel.2005.06.027. 16109376
    • Jang M.K. Mochizuki K. Zhou M. Jeong H.S. Brady J.N. Ozato K. 2005. The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription. Mol. Cell, 19: 523-534. 10.1016/j.molcel.2005.06.027. 16109376.
    • (2005) Mol. Cell , vol.19 , pp. 523-534
    • Jang, M.K.1    Mochizuki, K.2    Zhou, M.3    Jeong, H.S.4    Brady, J.N.5    Ozato, K.6
  • 34
    • 0030939040 scopus 로고    scopus 로고
    • Echocardiographic Assessment of Right Ventricular Volume and Function
    • 10.1111/j.1540-8175.1997.tb00711.x. 11174944
    • Jiang L. Levine R.A. Weyman A.E. 1997. Echocardiographic Assessment of Right Ventricular Volume and Function. Echocardiography, 14: 189-206. 10.1111/j.1540-8175.1997.tb00711.x. 11174944.
    • (1997) Echocardiography , vol.14 , pp. 189-206
    • Jiang, L.1    Levine, R.A.2    Weyman, A.E.3
  • 35
    • 0035861739 scopus 로고    scopus 로고
    • Mechanism for nucleocytoplasmic shuttling of histone deacetylase 7
    • 10.1074/jbc.M107631200. 11585834
    • Kao H.Y. Verdel A. Tsai C.C. Simon C. Juguilon H. Khochbin S. 2001. Mechanism for nucleocytoplasmic shuttling of histone deacetylase 7. J. Biol. Chem. 276: 47496-47507. 10.1074/jbc.M107631200. 11585834.
    • (2001) J. Biol. Chem. , vol.276 , pp. 47496-47507
    • Kao, H.Y.1    Verdel, A.2    Tsai, C.C.3    Simon, C.4    Juguilon, H.5    Khochbin, S.6
  • 36
    • 80053195080 scopus 로고    scopus 로고
    • Acetylation of heat shock protein 20 (Hsp20) regulates human myometrial activity
    • 10.1074/jbc.M111.278549. 21803775
    • Karolczak-Bayatti M. Sweeney M. Cheng J. Edey L. Robson S.C. Ulrich S.M. et al 2011. Acetylation of heat shock protein 20 (Hsp20) regulates human myometrial activity. J. Biol. Chem. 286: 34346-34355. 10.1074/jbc.M111.278549. 21803775.
    • (2011) J. Biol. Chem. , vol.286 , pp. 34346-34355
    • Karolczak-Bayatti, M.1    Sweeney, M.2    Cheng, J.3    Edey, L.4    Robson, S.C.5    Ulrich, S.M.6
  • 37
    • 36849004821 scopus 로고    scopus 로고
    • Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases
    • 10.1073/pnas.0706487104. 17956988
    • Lahm A. Paolini C. Pallaoro M. Nardi M.C. Jones P. Neddermann P. et al 2007. Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases. Proc. Natl. Acad. Sci. U.S.A. 104: 17335-17340. 10.1073/pnas.0706487104. 17956988.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 17335-17340
    • Lahm, A.1    Paolini, C.2    Pallaoro, M.3    Nardi, M.C.4    Jones, P.5    Neddermann, P.6
  • 38
    • 77649337122 scopus 로고    scopus 로고
    • HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy
    • 10.1038/emboj.2009.405. 20075865
    • Lee J.Y. Koga H. Kawaguchi Y. Tang W. Wong E. Gao Y.S. et al 2010. HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. EMBO J. 29: 969-980. 10.1038/emboj.2009.405. 20075865.
    • (2010) EMBO J. , vol.29 , pp. 969-980
    • Lee, J.Y.1    Koga, H.2    Kawaguchi, Y.3    Tang, W.4    Wong, E.5    Gao, Y.S.6
  • 39
    • 0034685893 scopus 로고    scopus 로고
    • MHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity
    • 10.1074/jbc.M908437199. 10748098
    • Lemercier C. Verdel A. Galloo B. Curtet S. Brocard M.P. Khochbin S. 2000. mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity. J. Biol. Chem. 275: 15594-15599. 10.1074/jbc.M908437199. 10748098.
    • (2000) J. Biol. Chem. , vol.275 , pp. 15594-15599
    • Lemercier, C.1    Verdel, A.2    Galloo, B.3    Curtet, S.4    Brocard, M.P.5    Khochbin, S.6
  • 40
    • 79956317095 scopus 로고    scopus 로고
    • Cardiac HDAC6 catalytic activity is induced in response to chronic hypertension
    • 10.1016/j.yjmcc.2011.04.005. 21539845
    • Lemon D.D. Horn T.R. Cavasin M.A. Jeong M.Y. Haubold K.W. Long C.S. et al 2011. Cardiac HDAC6 catalytic activity is induced in response to chronic hypertension. J. Mol. Cell. Cardiol. 51: 41-50. 10.1016/j.yjmcc.2011.04.005. 21539845.
    • (2011) J. Mol. Cell. Cardiol. , vol.51 , pp. 41-50
    • Lemon, D.D.1    Horn, T.R.2    Cavasin, M.A.3    Jeong, M.Y.4    Haubold, K.W.5    Long, C.S.6
  • 41
    • 80052667354 scopus 로고    scopus 로고
    • Emergence of fibroblasts with a proinflammatory epigenetically altered phenotype in severe hypoxic pulmonary hypertension
    • 10.4049/jimmunol.1100479. 21813768
    • Li M. Riddle S.R. Frid M.G. El Kasmi K.C. McKinsey T.A. Sokol R.J. et al 2011. Emergence of fibroblasts with a proinflammatory epigenetically altered phenotype in severe hypoxic pulmonary hypertension. J. Immunol. 187: 2711-2722. 10.4049/jimmunol.1100479. 21813768.
    • (2011) J. Immunol. , vol.187 , pp. 2711-2722
    • Li, M.1    Riddle, S.R.2    Frid, M.G.3    El Kasmi, K.C.4    McKinsey, T.A.5    Sokol, R.J.6
  • 42
    • 84895464034 scopus 로고    scopus 로고
    • Epigenetic regulation of fibrocyte differentiation?
    • 10.1016/j.yjmcc.2014.01.019. 24512845
    • Lishnevsky M. Haudek S.B. 2014. Epigenetic regulation of fibrocyte differentiation? J. Mol. Cell. Cardiol. 69: 85-87. 10.1016/j.yjmcc.2014.01.019. 24512845.
    • (2014) J. Mol. Cell. Cardiol. , vol.69 , pp. 85-87
    • Lishnevsky, M.1    Haudek, S.B.2
  • 43
    • 84879092346 scopus 로고    scopus 로고
    • Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group
    • 10.1038/nchembio.1223. 23524983
    • Lobera M. Madauss K.P. Pohlhaus D.T. Wright Q.G. Trocha M. Schmidt D.R. et al 2013. Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group. Nat. Chem. Biol. 9: 319-325. 10.1038/nchembio.1223. 23524983.
    • (2013) Nat. Chem. Biol. , vol.9 , pp. 319-325
    • Lobera, M.1    Madauss, K.P.2    Pohlhaus, D.T.3    Wright, Q.G.4    Trocha, M.5    Schmidt, D.R.6
  • 44
    • 33746578975 scopus 로고    scopus 로고
    • Histone deacetylase 3 localizes to the plasma membrane and is a substrate of Src
    • 10.1038/sj.onc.1209473. 16532030
    • Longworth M.S. Laimins L.A. 2006. Histone deacetylase 3 localizes to the plasma membrane and is a substrate of Src. Oncogene, 25: 4495-4500. 10.1038/sj.onc.1209473. 16532030.
    • (2006) Oncogene , vol.25 , pp. 4495-4500
    • Longworth, M.S.1    Laimins, L.A.2
  • 45
    • 0034635987 scopus 로고    scopus 로고
    • Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases
    • 10.1073/pnas.080064097. 10737771
    • Lu J. McKinsey T.A. Nicol R.L. Olson E.N. 2000 a. Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases. Proc. Natl. Acad. Sci. U.S.A. 97: 4070-4075. 10.1073/pnas.080064097. 10737771.
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 4070-4075
    • Lu, J.1    McKinsey, T.A.2    Nicol, R.L.3    Olson, E.N.4
  • 46
    • 0033635242 scopus 로고    scopus 로고
    • Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases
    • 10.1016/S1097-2765(00)00025-3. 10983972
    • Lu J. McKinsey T.A. Zhang C.L. Olson E.N. 2000 b. Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases. Mol. Cell, 6: 233-244. 10.1016/S1097-2765(00)00025-3. 10983972.
    • (2000) Mol. Cell , vol.6 , pp. 233-244
    • Lu, J.1    McKinsey, T.A.2    Zhang, C.L.3    Olson, E.N.4
  • 47
    • 84865726581 scopus 로고    scopus 로고
    • Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns
    • 10.1016/j.celrep.2012.07.006. 22902405
    • Lundby A. Lage K. Weinert B.T. Bekker-Jensen D.B. Secher A. Skovgaard T. et al 2012. Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Cell Rep. 2: 419-431. 10.1016/j.celrep.2012.07.006. 22902405.
    • (2012) Cell Rep. , vol.2 , pp. 419-431
    • Lundby, A.1    Lage, K.2    Weinert, B.T.3    Bekker-Jensen, D.B.4    Secher, A.5    Skovgaard, T.6
  • 48
    • 33846889551 scopus 로고    scopus 로고
    • Derepression of pathological cardiac genes by members of the CaM kinase superfamily
    • 10.1016/j.cardiores.2006.11.036. 17217938
    • McKinsey T.A. 2007. Derepression of pathological cardiac genes by members of the CaM kinase superfamily. Cardiovasc. Res. 73: 667-677. 10.1016/j.cardiores.2006.11.036. 17217938.
    • (2007) Cardiovasc. Res. , vol.73 , pp. 667-677
    • McKinsey, T.A.1
  • 49
    • 80052814243 scopus 로고    scopus 로고
    • Isoform-selective HDAC inhibitors: Closing in on translational medicine for the heart
    • 10.1016/j.yjmcc.2010.11.009. 21108947
    • McKinsey T.A. 2011. Isoform-selective HDAC inhibitors: closing in on translational medicine for the heart. J. Mol. Cell. Cardiol. 51: 491-496. 10.1016/j.yjmcc.2010.11.009. 21108947.
    • (2011) J. Mol. Cell. Cardiol. , vol.51 , pp. 491-496
    • McKinsey, T.A.1
  • 50
    • 84855875719 scopus 로고    scopus 로고
    • Therapeutic potential for HDAC inhibitors in the heart
    • 10.1146/annurev-pharmtox-010611-134712. 21942627
    • McKinsey T.A. 2012. Therapeutic potential for HDAC inhibitors in the heart. Annu. Rev. Pharmacol. Toxicol. 52: 303-319. 10.1146/annurev-pharmtox-010611-134712. 21942627.
    • (2012) Annu. Rev. Pharmacol. Toxicol. , vol.52 , pp. 303-319
    • McKinsey, T.A.1
  • 51
    • 0034597816 scopus 로고    scopus 로고
    • Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation
    • 10.1038/35040593. 11081517
    • McKinsey T.A. Zhang C.L. Lu J. Olson E.N. 2000 a. Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature, 408: 106-111. 10.1038/35040593. 11081517.
    • (2000) Nature , vol.408 , pp. 106-111
    • McKinsey, T.A.1    Zhang, C.L.2    Lu, J.3    Olson, E.N.4
  • 52
    • 0034687741 scopus 로고    scopus 로고
    • Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5
    • 10.1073/pnas.260501497. 11114197
    • McKinsey T.A. Zhang C.L. Olson E.N. 2000 b. Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5. Proc. Natl. Acad. Sci. U.S.A. 97: 14400-14405. 10.1073/pnas.260501497. 11114197.
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 14400-14405
    • McKinsey, T.A.1    Zhang, C.L.2    Olson, E.N.3
  • 53
    • 0035724044 scopus 로고    scopus 로고
    • Identification of a signal-responsive nuclear export sequence in class II histone deacetylases
    • 10.1128/MCB.21.18.6312-6321.2001. 11509672
    • McKinsey T.A. Zhang C.L. Olson E.N. 2001. Identification of a signal-responsive nuclear export sequence in class II histone deacetylases. Mol. Cell. Biol. 21: 6312-6321. 10.1128/MCB.21.18.6312-6321.2001. 11509672.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 6312-6321
    • McKinsey, T.A.1    Zhang, C.L.2    Olson, E.N.3
  • 54
    • 64849109410 scopus 로고    scopus 로고
    • ACCF/AHA 2009 expert consensus document on pulmonary hypertension a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association developed in collaboration with the American College of Chest Physicians; American Thoracic Society, Inc.; And the Pulmonary Hypertension Association
    • 10.1016/j.jacc.2009.01.004. 19389575
    • McLaughlin V.V. Archer S.L. Badesch D.B. Barst R.J. Farber H.W. Lindner J.R. et al 2009. ACCF/AHA 2009 expert consensus document on pulmonary hypertension a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association developed in collaboration with the American College of Chest Physicians; American Thoracic Society, Inc.; and the Pulmonary Hypertension Association. J. Am. Coll. Cardiol. 53: 1573-1619. 10.1016/j.jacc.2009.01.004. 19389575.
    • (2009) J. Am. Coll. Cardiol. , vol.53 , pp. 1573-1619
    • McLaughlin, V.V.1    Archer, S.L.2    Badesch, D.B.3    Barst, R.J.4    Farber, H.W.5    Lindner, J.R.6
  • 55
    • 38749136234 scopus 로고    scopus 로고
    • Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2)
    • 10.1016/j.bmcl.2007.12.031. 18182289
    • Methot J.L. Chakravarty P.K. Chenard M. Close J. Cruz J.C. Dahlberg W.K. et al 2008. Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2). Bioorg. Med. Chem. Lett. 18: 973-978. 10.1016/j.bmcl.2007.12.031. 18182289.
    • (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 973-978
    • Methot, J.L.1    Chakravarty, P.K.2    Chenard, M.3    Close, J.4    Cruz, J.C.5    Dahlberg, W.K.6
  • 56
    • 0033568028 scopus 로고    scopus 로고
    • HDAC4 deacetylase associates with and represses the MEF2 transcription factor
    • 10.1093/emboj/18.18.5099. 10487761
    • Miska E.A. Karlsson C. Langley E. Nielsen S.J. Pines J. Kouzarides T. 1999. HDAC4 deacetylase associates with and represses the MEF2 transcription factor. EMBO J. 18: 5099-5107. 10.1093/emboj/18.18.5099. 10487761.
    • (1999) EMBO J. , vol.18 , pp. 5099-5107
    • Miska, E.A.1    Karlsson, C.2    Langley, E.3    Nielsen, S.J.4    Pines, J.5    Kouzarides, T.6
  • 57
    • 74249106877 scopus 로고    scopus 로고
    • A novel kinase inhibitor establishes a predominant role for protein kinase D as a cardiac class IIa histone deacetylase kinase
    • 10.1016/j.febslet.2009.12.014. 20018189
    • Monovich L. Vega R.B. Meredith E. Miranda K. Rao C. Capparelli M. et al 2010. A novel kinase inhibitor establishes a predominant role for protein kinase D as a cardiac class IIa histone deacetylase kinase. FEBS Lett. 584: 631-637. 10.1016/j.febslet.2009.12.014. 20018189.
    • (2010) FEBS Lett. , vol.584 , pp. 631-637
    • Monovich, L.1    Vega, R.B.2    Meredith, E.3    Miranda, K.4    Rao, C.5    Capparelli, M.6
  • 58
    • 36148950575 scopus 로고    scopus 로고
    • Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity
    • 10.1021/jm701079h. 17941625
    • Moradei O.M. Mallais T.C. Frechette S. Paquin I. Tessier P.E. Leit S.M. et al 2007. Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. J. Med. Chem. 50: 5543-5546. 10.1021/jm701079h. 17941625.
    • (2007) J. Med. Chem. , vol.50 , pp. 5543-5546
    • Moradei, O.M.1    Mallais, T.C.2    Frechette, S.3    Paquin, I.4    Tessier, P.E.5    Leit, S.M.6
  • 59
    • 67649599147 scopus 로고    scopus 로고
    • Cellular and molecular basis of pulmonary arterial hypertension
    • 10.1016/j.jacc.2009.04.018. 19555855
    • Morrell N.W. Adnot S. Archer S.L. Dupuis J. Jones P.L. MacLean M.R. et al 2009. Cellular and molecular basis of pulmonary arterial hypertension. J. Am. Coll. Cardiol. 54: S20-S31. 10.1016/j.jacc.2009.04.018. 19555855.
    • (2009) J. Am. Coll. Cardiol. , vol.54 , pp. 20-S31
    • Morrell, N.W.1    Adnot, S.2    Archer, S.L.3    Dupuis, J.4    Jones, P.L.5    Maclean, M.R.6
  • 60
    • 80052290593 scopus 로고    scopus 로고
    • Histone deacetylases: Anti-angiogenic targets in cancer therapy
    • 10.2174/156800910793358014. 20718701
    • Mottet D. Castronovo V. 2010. Histone deacetylases: anti-angiogenic targets in cancer therapy. Curr. Cancer Drug Targets, 10: 898-913. 10.2174/156800910793358014. 20718701.
    • (2010) Curr. Cancer Drug Targets , vol.10 , pp. 898-913
    • Mottet, D.1    Castronovo, V.2
  • 61
    • 84873673503 scopus 로고    scopus 로고
    • New models of pulmonary hypertension based on VEGF receptor blockade-induced endothelial cell apoptosis
    • 10.4103/2045-8932.105031. 23372927
    • Nicolls M.R. Mizuno S. Taraseviciene-Stewart L. Farkas L. Drake J.I. Al Husseini A. et al 2012. New models of pulmonary hypertension based on VEGF receptor blockade-induced endothelial cell apoptosis. Pulm. Circ. 2: 434-442. 10.4103/2045-8932.105031. 23372927.
    • (2012) Pulm. Circ. , vol.2 , pp. 434-442
    • Nicolls, M.R.1    Mizuno, S.2    Taraseviciene-Stewart, L.3    Farkas, L.4    Drake, J.I.5    Al Husseini, A.6
  • 62
    • 73849103589 scopus 로고    scopus 로고
    • Targeting of HDAC8 and investigational inhibitors in neuroblastoma
    • 10.1517/14728220903241658. 19780707
    • Oehme I. Deubzer H.E. Lodrini M. Milde T. Witt O. 2009. Targeting of HDAC8 and investigational inhibitors in neuroblastoma. Expert Opin. Investig. Drugs, 18: 1605-1617. 10.1517/14728220903241658. 19780707.
    • (2009) Expert Opin. Investig. Drugs , vol.18 , pp. 1605-1617
    • Oehme, I.1    Deubzer, H.E.2    Lodrini, M.3    Milde, T.4    Witt, O.5
  • 63
    • 84908078772 scopus 로고    scopus 로고
    • An Unbiased Approach to Identify Endogenous Substrates of "histone" Deacetylase 8
    • 10.1021/cb500492r. 25089360
    • Olson D.E. Udeshi N.D. Wolfson N.A. Pitcairn C.A. Sullivan E.D. Jaffe J.D. et al 2014. An Unbiased Approach To Identify Endogenous Substrates of "Histone" Deacetylase 8. ACS Chem. Biol. 9: 2210-2216. 10.1021/cb500492r. 25089360.
    • (2014) ACS Chem. Biol. , vol.9 , pp. 2210-2216
    • Olson, D.E.1    Udeshi, N.D.2    Wolfson, N.A.3    Pitcairn, C.A.4    Sullivan, E.D.5    Jaffe, J.D.6
  • 64
    • 35948958216 scopus 로고    scopus 로고
    • HDAC6 at the intersection of autophagy, the ubiquitin-proteasome system and neurodegeneration
    • 10.4161/auto.5050. 17912024
    • Pandey U.B. Batlevi Y. Baehrecke E.H. Taylor J.P. 2007 a. HDAC6 at the intersection of autophagy, the ubiquitin-proteasome system and neurodegeneration. Autophagy, 3: 643-645. 10.4161/auto.5050. 17912024.
    • (2007) Autophagy , vol.3 , pp. 643-645
    • Pandey, U.B.1    Batlevi, Y.2    Baehrecke, E.H.3    Taylor, J.P.4
  • 65
    • 34250183177 scopus 로고    scopus 로고
    • HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS
    • 10.1038/nature05853. 17568747
    • Pandey U.B. Nie Z. Batlevi Y. McCray B.A. Ritson G.P. Nedelsky N.B. et al. 2007 b. HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature, 447: 860-864. 10.1038/nature05853. 17568747.
    • (2007) Nature , vol.447 , pp. 860-864
    • Pandey, U.B.1    Nie, Z.2    Batlevi, Y.3    McCray, B.A.4    Ritson, G.P.5    Nedelsky, N.B.6
  • 67
    • 84855353573 scopus 로고    scopus 로고
    • Heart disease and stroke statistics-2012 update: A report from the American Heart Association
    • 10.1161/CIR.0b013e31823ac046. 22179539
    • Roger V.L. Go A.S. Lloyd-Jones D.M. Benjamin E.J. Berry J.D. Borden W.B. et al 2012. Heart disease and stroke statistics-2012 update: a report from the American Heart Association. Circulation, 125: e2-e220. 10.1161/CIR.0b013e31823ac046. 22179539.
    • (2012) Circulation , vol.125 , pp. 2-e220
    • Roger, V.L.1    Go, A.S.2    Lloyd-Jones, D.M.3    Benjamin, E.J.4    Berry, J.D.5    Borden, W.B.6
  • 68
    • 79953133501 scopus 로고    scopus 로고
    • HDAC3-dependent reversible lysine acetylation of cardiac myosin heavy chain isoforms modulates their enzymatic and motor activity
    • 10.1074/jbc.M110.163865. 21177250
    • Samant S.A. Courson D.S. Sundaresan N.R. Pillai V.B. Tan M. Zhao Y. et al 2011. HDAC3-dependent reversible lysine acetylation of cardiac myosin heavy chain isoforms modulates their enzymatic and motor activity. J. Biol. Chem. 286: 5567-5577. 10.1074/jbc.M110.163865. 21177250.
    • (2011) J. Biol. Chem. , vol.286 , pp. 5567-5577
    • Samant, S.A.1    Courson, D.S.2    Sundaresan, N.R.3    Pillai, V.B.4    Tan, M.5    Zhao, Y.6
  • 69
    • 7244234259 scopus 로고    scopus 로고
    • Cyclin-dependent kinase-9: An RNAPII kinase at the nexus of cardiac growth and death cascades
    • 10.1161/01.RES.0000146675.88354.04. 15514168
    • Sano M. Schneider M.D. 2004. Cyclin-dependent kinase-9: an RNAPII kinase at the nexus of cardiac growth and death cascades. Circ. Res. 95: 867-876. 10.1161/01.RES.0000146675.88354.04. 15514168.
    • (2004) Circ. Res. , vol.95 , pp. 867-876
    • Sano, M.1    Schneider, M.D.2
  • 70
    • 0036851825 scopus 로고    scopus 로고
    • Activation and function of cyclin T-Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy
    • 10.1038/nm778. 12368904
    • Sano M. Abdellatif M. Oh H. Xie M. Bagella L. Giordano A. et al 2002. Activation and function of cyclin T-Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy. Nat. Med. 8: 1310-1317. 10.1038/nm778. 12368904.
    • (2002) Nat. Med. , vol.8 , pp. 1310-1317
    • Sano, M.1    Abdellatif, M.2    Oh, H.3    Xie, M.4    Bagella, L.5    Giordano, A.6
  • 71
    • 84901821841 scopus 로고    scopus 로고
    • The mechanisms behind the therapeutic activity of BET bromodomain inhibition
    • 10.1016/j.molcel.2014.05.016. 24905006
    • Shi J. Vakoc C.R. 2014. The mechanisms behind the therapeutic activity of BET bromodomain inhibition. Mol. Cell, 54: 728-736. 10.1016/j.molcel.2014.05.016. 24905006.
    • (2014) Mol. Cell , vol.54 , pp. 728-736
    • Shi, J.1    Vakoc, C.R.2
  • 72
    • 48949116262 scopus 로고    scopus 로고
    • MiR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells
    • 10.1186/1741-7015-6-14. 18577219
    • Silber J. Lim D.A. Petritsch C. Persson A.I. Maunakea A.K. Yu M. et al 2008. miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med. 6: 14. 10.1186/1741-7015-6-14. 18577219.
    • (2008) BMC Med. , vol.6 , pp. 14
    • Silber, J.1    Lim, D.A.2    Petritsch, C.3    Persson, A.I.4    Maunakea, A.K.5    Yu, M.6
  • 73
    • 0033568492 scopus 로고    scopus 로고
    • MEF-2 function is modified by a novel co-repressor, MITR
    • 10.1093/emboj/18.18.5085. 10487760
    • Sparrow D.B. Miska E.A. Langley E. Reynaud-Deonauth S. Kotecha S. Towers N. et al 1999. MEF-2 function is modified by a novel co-repressor, MITR. EMBO J. 18: 5085-5098. 10.1093/emboj/18.18.5085. 10487760.
    • (1999) EMBO J. , vol.18 , pp. 5085-5098
    • Sparrow, D.B.1    Miska, E.A.2    Langley, E.3    Reynaud-Deonauth, S.4    Kotecha, S.5    Towers, N.6
  • 74
    • 84883084726 scopus 로고    scopus 로고
    • BET acetyl-lysine binding proteins control pathological cardiac hypertrophy
    • 10.1016/j.yjmcc.2013.07.017. 23939492
    • Spiltoir J.I. Stratton M.S. Cavasin M.A. Demos-Davies K. Reid B.G. Qi J. et al 2013. BET acetyl-lysine binding proteins control pathological cardiac hypertrophy. J. Mol. Cell. Cardiol. 63: 175-179. 10.1016/j.yjmcc.2013.07.017. 23939492.
    • (2013) J. Mol. Cell. Cardiol. , vol.63 , pp. 175-179
    • Spiltoir, J.I.1    Stratton, M.S.2    Cavasin, M.A.3    Demos-Davies, K.4    Reid, B.G.5    Qi, J.6
  • 75
    • 84870021564 scopus 로고    scopus 로고
    • Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries
    • 10.1021/jm300837y. 23116147
    • Suzuki T. Ota Y. Ri M. Bando M. Gotoh A. Itoh Y. et al 2012. Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries. J. Med. Chem. 55: 9562-9575. 10.1021/jm300837y. 23116147.
    • (2012) J. Med. Chem. , vol.55 , pp. 9562-9575
    • Suzuki, T.1    Ota, Y.2    Ri, M.3    Bando, M.4    Gotoh, A.5    Itoh, Y.6
  • 76
    • 0035130107 scopus 로고    scopus 로고
    • Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension
    • 10.1096/fj.00-0343com. 11156958
    • Taraseviciene-Stewart L. Kasahara Y. Alger L. Hirth P. Mc Mahon G. Waltenberger J. et al 2001. Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension. FASEB J. 15: 427-438. 10.1096/fj.00-0343com. 11156958.
    • (2001) FASEB J. , vol.15 , pp. 427-438
    • Taraseviciene-Stewart, L.1    Kasahara, Y.2    Alger, L.3    Hirth, P.4    Mc Mahon, G.5    Waltenberger, J.6
  • 77
    • 70350142541 scopus 로고    scopus 로고
    • Structure-function studies for the panacea, valproic acid
    • 10.1042/BST0371126. 19754465
    • Terbach N. Williams R.S. 2009. Structure-function studies for the panacea, valproic acid. Biochem. Soc. Trans. 37: 1126-1132. 10.1042/BST0371126. 19754465.
    • (2009) Biochem. Soc. Trans. , vol.37 , pp. 1126-1132
    • Terbach, N.1    Williams, R.S.2
  • 78
    • 44649158252 scopus 로고    scopus 로고
    • HDAC6: A key regulator of cytoskeleton, cell migration and cell-cell interactions
    • 10.1016/j.tcb.2008.04.003. 18472263
    • Valenzuela-Fernandez A. Cabrero J.R. Serrador J.M. Sanchez-Madrid F. 2008. HDAC6: a key regulator of cytoskeleton, cell migration and cell-cell interactions. Trends Cell Biol. 18: 291-297. 10.1016/j.tcb.2008.04.003. 18472263.
    • (2008) Trends Cell Biol. , vol.18 , pp. 291-297
    • Valenzuela-Fernandez, A.1    Cabrero, J.R.2    Serrador, J.M.3    Sanchez-Madrid, F.4
  • 79
    • 4544315655 scopus 로고    scopus 로고
    • Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5
    • 10.1128/MCB.24.19.8374-8385.2004. 15367659
    • Vega R.B. Harrison B.C. Meadows E. Roberts C.R. Papst P.J. Olson E.N. McKinsey T.A. 2004. Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5. Mol. Cell. Biol. 24: 8374-8385. 10.1128/MCB.24.19.8374-8385.2004. 15367659.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 8374-8385
    • Vega, R.B.1    Harrison, B.C.2    Meadows, E.3    Roberts, C.R.4    Papst, P.J.5    Olson, E.N.6    McKinsey, T.A.7
  • 80
    • 65649146477 scopus 로고    scopus 로고
    • The right ventricle: Biologic insights and response to disease
    • 10.2174/157340309787048077. 20066144
    • Walker L.A. Buttrick P.M. 2009. The right ventricle: biologic insights and response to disease. Curr. Cardiol. Rev. 5: 22-28. 10.2174/157340309787048077. 20066144.
    • (2009) Curr. Cardiol. Rev. , vol.5 , pp. 22-28
    • Walker, L.A.1    Buttrick, P.M.2
  • 81
    • 20444487771 scopus 로고    scopus 로고
    • Histone deacetylase HDAC8 associates with smooth muscle alpha-actin and is essential for smooth muscle cell contractility
    • 10.1096/fj.04-2303fje. 15772115
    • Waltregny D. Glenisson W. Tran S.L. North B.J. Verdin E. Colige A. Castronovo V. 2005. Histone deacetylase HDAC8 associates with smooth muscle alpha-actin and is essential for smooth muscle cell contractility. FASEB J. 19: 966-968. 10.1096/fj.04-2303fje. 15772115.
    • (2005) FASEB J. , vol.19 , pp. 966-968
    • Waltregny, D.1    Glenisson, W.2    Tran, S.L.3    North, B.J.4    Verdin, E.5    Colige, A.6    Castronovo, V.7
  • 82
    • 0032696590 scopus 로고    scopus 로고
    • HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor
    • 10523670
    • Wang A.H. Bertos N.R. Vezmar M. Pelletier N. Crosato M. Heng H.H. et al 1999. HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor. Mol. Cell. Biol. 19: 7816-7827. 10523670.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 7816-7827
    • Wang, A.H.1    Bertos, N.R.2    Vezmar, M.3    Pelletier, N.4    Crosato, M.5    Heng, H.H.6
  • 83
    • 84892930632 scopus 로고    scopus 로고
    • MicroRNA-124 Controls the Proliferative, Migratory, and Inflammatory Phenotype of Pulmonary Vascular Fibroblasts
    • 10.1161/CIRCRESAHA.114.301633. 24122720
    • Wang D. Zhang H. Li M. Frid M.G. Flockton A.R. McKeon B.A. et al 2013. MicroRNA-124 Controls the Proliferative, Migratory, and Inflammatory Phenotype of Pulmonary Vascular Fibroblasts. Circ. Res. 114: 67-78. 10.1161/CIRCRESAHA.114.301633. 24122720.
    • (2013) Circ. Res. , vol.114 , pp. 67-78
    • Wang, D.1    Zhang, H.2    Li, M.3    Frid, M.G.4    Flockton, A.R.5    McKeon, B.A.6
  • 84
    • 84892850549 scopus 로고    scopus 로고
    • Class i HDACs regulate angiotensin II-dependent cardiac fibrosis via fibroblasts and circulating fibrocytes
    • 10.1016/j.yjmcc.2013.12.013. 24374140
    • Williams S.M. Golden-Mason L. Ferguson B.S. Schuetze K.B. Cavasin M.A. Demos-Davies K. et al 2014. Class I HDACs regulate angiotensin II-dependent cardiac fibrosis via fibroblasts and circulating fibrocytes. J. Mol. Cell. Cardiol. 67: 112-125. 10.1016/j.yjmcc.2013.12.013. 24374140.
    • (2014) J. Mol. Cell. Cardiol. , vol.67 , pp. 112-125
    • Williams, S.M.1    Golden-Mason, L.2    Ferguson, B.S.3    Schuetze, K.B.4    Cavasin, M.A.5    Demos-Davies, K.6
  • 85
    • 77954831404 scopus 로고    scopus 로고
    • An acetylation switch modulates the transcriptional activity of estrogen-related receptor alpha
    • 10.1210/me.2009-0441. 20484414
    • Wilson B.J. Tremblay A.M. Deblois G. Sylvain-Drolet G. Giguere V. 2010. An acetylation switch modulates the transcriptional activity of estrogen-related receptor alpha. Mol. Endocrinol. 24: 1349-1358. 10.1210/me.2009-0441. 20484414.
    • (2010) Mol. Endocrinol. , vol.24 , pp. 1349-1358
    • Wilson, B.J.1    Tremblay, A.M.2    Deblois, G.3    Sylvain-Drolet, G.4    Giguere, V.5
  • 86
    • 40849114307 scopus 로고    scopus 로고
    • Phenylglycine and phenylalanine derivatives as potent and selective HDAC1 inhibitors (SHI-1)
    • 10.1016/j.bmcl.2008.02.012. 18304810
    • Wilson K.J. Witter D.J. Grimm J.B. Siliphaivanh P. Otte K.M. Kral A.M. et al 2008. Phenylglycine and phenylalanine derivatives as potent and selective HDAC1 inhibitors (SHI-1). Bioorg. Med. Chem. Lett. 18: 1859-1863. 10.1016/j.bmcl.2008.02.012. 18304810.
    • (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 1859-1863
    • Wilson, K.J.1    Witter, D.J.2    Grimm, J.B.3    Siliphaivanh, P.4    Otte, K.M.5    Kral, A.M.6
  • 88
    • 84870012202 scopus 로고    scopus 로고
    • HDAC8 substrates: Histones and beyond
    • 10.1002/bip.22135. 23175386
    • Wolfson N.A. Ann P.C. Fierke C.A. 2013. HDAC8 substrates: Histones and beyond. Biopolymers, 99: 112-126. 10.1002/bip.22135. 23175386.
    • (2013) Biopolymers , vol.99 , pp. 112-126
    • Wolfson, N.A.1    Ann, P.C.2    Fierke, C.A.3
  • 89
    • 84890032856 scopus 로고    scopus 로고
    • An Update on Medical Therapy for Pulmonary Arterial Hypertension
    • 10.1007/s11906-013-0394-8. 24122306
    • Wu Y. O'Callaghan D.S. Humbert M. 2013. An Update on Medical Therapy for Pulmonary Arterial Hypertension. Curr. Hypertens. Rep. 15: 614-622. 10.1007/s11906-013-0394-8. 24122306.
    • (2013) Curr. Hypertens. Rep. , vol.15 , pp. 614-622
    • Wu, Y.1    O'Callaghan, D.S.2    Humbert, M.3
  • 90
    • 84880036835 scopus 로고    scopus 로고
    • HDAC-dependent ventricular remodeling
    • 10.1016/j.tcm.2012.12.006. 23499301
    • Xie M. Hill J.A. 2013. HDAC-dependent ventricular remodeling. Trends Cardiovasc. Med. 23: 229-235. 10.1016/j.tcm.2012.12.006. 23499301.
    • (2013) Trends Cardiovasc. Med. , vol.23 , pp. 229-235
    • Xie, M.1    Hill, J.A.2
  • 91
    • 84886733366 scopus 로고    scopus 로고
    • Role of histone deacetylases in regulation of phenotype of ovine newborn pulmonary arterial smooth muscle cells
    • 10.1111/cpr.12076. 24460719
    • Yang Q. Dahl M.J. Albertine K.H. Ramchandran R. Sun M. Raj J.U. 2013. Role of histone deacetylases in regulation of phenotype of ovine newborn pulmonary arterial smooth muscle cells. Cell Prolif. 46: 654-664. 10.1111/cpr.12076. 24460719.
    • (2013) Cell Prolif. , vol.46 , pp. 654-664
    • Yang, Q.1    Dahl, M.J.2    Albertine, K.H.3    Ramchandran, R.4    Sun, M.5    Raj, J.U.6
  • 92
    • 23744467035 scopus 로고    scopus 로고
    • Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4
    • 10.1016/j.molcel.2005.06.029. 16109377
    • Yang Z. Yik J.H. Chen R. He N. Jang M.K. Ozato K. Zhou Q. 2005. Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4. Mol. Cell, 19: 535-545. 10.1016/j.molcel.2005.06.029. 16109377.
    • (2005) Mol. Cell , vol.19 , pp. 535-545
    • Yang, Z.1    Yik, J.H.2    Chen, R.3    He, N.4    Jang, M.K.5    Ozato, K.6    Zhou, Q.7
  • 93
    • 84864290214 scopus 로고    scopus 로고
    • Histone deacetylation inhibition in pulmonary hypertension: Therapeutic potential of valproic acid and suberoylanilide hydroxamic acid
    • 10.1161/CIRCULATIONAHA.112.103176. 22711276
    • Zhao L. Chen C.N. Hajji N. Oliver E. Cotroneo E. Wharton J. et al 2012. Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. Circulation, 126: 455-467. 10.1161/CIRCULATIONAHA.112.103176. 22711276.
    • (2012) Circulation , vol.126 , pp. 455-467
    • Zhao, L.1    Chen, C.N.2    Hajji, N.3    Oliver, E.4    Cotroneo, E.5    Wharton, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.