MEF-2 function is modified by a novel co-repressor, MITR

EMBO Journal

Volumn 18, Issue 18, 1999, Pages 5085-5098

  Sparrow, Duncan B ^c   Miska, Eric A ^a   Langley, Emma ^a   Reynaud Deonauth, Sorogini ^b   Kotecha, Surendra ^c   Towers, Norma ^c   Spohr, Georges ^b   Kouzarides, Tony ^a   Mohun, Timothy J ^d  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF GENEVA   (Switzerland)

^c NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^d NONE

Author keywords

Co repressor; HDAC1; Histone deacetylase; MEF 2; mHDA1

Indexed keywords

REPRESSOR PROTEIN; SERUM RESPONSE FACTOR; TRANSCRIPTION FACTOR;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; MYOTOME; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN MODIFICATION; SOMITE; TRANSCRIPTION REGULATION; XENOPUS; YEAST;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CARRIER PROTEINS; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION; HISTONE DEACETYLASES; HUMANS; IN SITU HYBRIDIZATION; MADS DOMAIN PROTEINS; MOLECULAR SEQUENCE DATA; MUSCLE, SKELETAL; MUTATION; MYOGENIC REGULATORY FACTORS; REPRESSOR PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TWO-HYBRID SYSTEM TECHNIQUES; XENOPUS; XENOPUS PROTEINS;

ANIMALIA;

EID: 0033568492     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/18.18.5085     Document Type: Article

References (71)

1. Ayer, D.E., Lawrence, Q.A. and Eisenman, R.N. (1995) Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3. Cell, 80, 767-776.
2. Bartel, P.L., Chien, C.-T., Sternglanz, R. and Fields, S. (1993) Using the Two Hybrid System to Detect Protein-Protein Interactions in Development: A Practical Approach. Oxford University Press, Oxford, UK.
3. Bisbee, C.A., Baker, M.A., Wilson, A.C., Hadji-Azimi, J. and Fischberg, M. (1977) Albumin phylogeny for clawed frogs (Xenopus). Science, 195, 785-787.
4. Black, B.L. and Olson, E.N. (1998) Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins. Annu. Rev. Cell Der. Biol., 14, 167-196.
5. Black, B.L., Ligon, K.L., Zhang, Y. and Olson, E.N. (1996) Cooperative transcriptional activation by the neurogenic basic helix-loop-helix protein MASH1 and members of the myocyte enhancer factor-2 (MEF2) family. J. Biol. Chem., 271, 26659-26663.
6. Breeden, L. and Nasmyth, K. (1985) Regulation of the yeast HO gene. Cold Spring Harbor Symp. Quant. Biol., 50, 643-650.
7. Brehm, A., Miska, E.A., McCance, D.J., Reid, J.L., Bannister, A.J. and Kouzarides, T. (1998) Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature, 391, 597-601.
8. Casey, E.S., O'Reilly, M.A., Conlon, F.L. and Smith, J.C. (1998) The T-box transcription factor Brachyury regulates expression of eFGF through binding to a non-palindromic response element Development, 125, 3887-3894.
9. Chambers, A.E., Kotecha, S., Towers, N. and Mohun, T.J. (1992) Muscle-specific expression of SRF-related genes in the early embryo of Xenopus laevis. EMBO J., 11, 4981-4991.
10. Chambers, A.E., Logan, M., Kotecha, S., Towers, T., Sparrow, D.B. and Mohun, T.J. (1994) The RSRF/MEF2 protein SL1 regulates cardiac muscle-specific transcription of a myosin light-chain gene in Xenopus embryos. Genes Dev., 8, 1324-1334.
11. Chen, J.D. and Evans, R.M. (1995) A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature, 377, 454-457.
12. Chen, J.D., Umesono, K. and Evans, R.M. (1996) SMRT isoforms mediate repression and anti-repression of nuclear receptor heterodimers. Proc. Natl Acad. Sci. USA, 93, 7567-7571.
13. Cleaver, O.B., Patterson, K.D. and Krieg, P.A. (1996) Overexpression of the tinman-related genes Xnkx-2.5 and XNkx-2.3 in Xenopus embryos results in myocardial hyperplasia. Development, 122, 3549-3556.
14. Cserjesi, P. and Olson, E.N. (1991) Myogenin induces the myocyte-specific enhancer binding factor MEF-2 independently of other muscle-specific gene products. Mol. Cell. Biol., 11, 4854-4862.
15. Dodou, E. and Treisman, R. (1997) The Saccharomyces cerevisiae MADS-box transcription factor Rlm1 is a target for the Mpk1 mitogen-activated protein kinase pathway. Mol. Cell. Biol., 17, 1848-1859.
16. Dodou, E., Sparrow, D.B., Mohun, T.J. and Treisman, R. (1995) MEF2 proteins, including MEF2A, are expressed in both muscle and non-muscle cells. Nucleic Acids Res., 23, 4267-4274.
17. Eckner, R., Yao, T.P., Oldread, E. and Livingston, D.M. (1996) Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation. Genes Dev., 10, 2478-2490.
18. el Ghouzzi, V. et al. (1997) Mutations of the TWIST gene in the Saethre-Chotzen syndrome. Nature Genet., 15, 42-46.
19. Fields, S. and Sternglanz, R. (1994) The two-hybrid system: an assay for protein-protein interactions. Trends Genet., 10, 286-292.
20. Fischle, W., Emiliani, S., Hendzel, M.J., Nagase, T., Nomura, N., Voelter, W. and Verdin, E. (1999) A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p. J. Biol. Chem., 274, 11713-11720.
21. Grozinger, C.M., Hassig, C.A. and Schreiber, S.L. (1999) Three proteins define a class of human histone deacetylases related to yeast Hda1p. Proc. Natl Acad. Sci. USA, 96, 4868-4873.
22. Hagemeier, C., Bannister, A.J., Cook, A. and Kouzarides, T. (1993) The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB. Proc. Natl Acad. Sci. USA, 90, 1580-1584.
23. Hamilton, L. (1969) The formation of somites in Xenopus. J. Embryol. Exp. Morph., 22, 253-264.
24. Harland, R.M. (1991) In situ hybridisation: an improved whole mount method for Xenopus embryos. In Kay, B.K. and Peng, H.B. (eds), Xenopus laevis: Practical Uses in Cell and Molecular Biology. Academic Press, London, UK, pp. 658-695.
25. Hassig, C.A., Fleischer, T.C., Billin, A.N., Schreiber, S.L. and Ayer, D.E. (1997) Histone deacetylase activity is required for full transcriptional repression by mSin3A. Cell, 89, 341-347.
26. Henikoff, S. (1984) Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing. Gene, 28, 351-359.
27. Horlein, A.J. et al. (1995) Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature, 377, 397-404.
28. Howard, T.D. et al. (1997) Mutations in TWIST, a basic helix-loop-helix transcription factor, in Saethre-Chotzen syndrome. Nature Genet., 15, 36-41.
29. Johnson, A.L., Barker, D.G. and Johnston, L.H. (1986) Induction of yeast DNA ligase genes in exponential and stationary phase cultures in response to DNA damaging agents. Curr. Genet., 11, 107-112.
30. Kadosh, D. and Struhl, K. (1997) Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters. Cell, 89, 365-371.
31. Kaushal, S., Schneider, J.W., Nadal-Ginard, B. and Mahdavi, V. (1994) Activation of the myogenic lineage by MEF2A, a factor that induces and cooperates with MyoD. Science, 266, 1236-1240.
32. Kintner, C.R. and Melton, D.A. (1987) Expression of Xenopus N-CAM RNA in ectoderm is an early response to neural induction. Development, 99, 311-325.
33. Laherty, C.D., Yang, W.M., Sun, J.M., Davie, J.R., Seto, E. and Eisenman, R.N. (1997) Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression. Cell, 89, 349-356.
34. Lee, Y., Nadal-Ginard, B., Mahdavi, V. and Izumo, S. (1997) Myocyte-specific enhancer factor 2 and thyroid hormone receptor associate and synergistically activate the α-cardiac myosin heavy-chain gene. Mol. Cell. Biol., 17, 2745-2755.
35. Lin, S.C., Lin, M.H., Horvath, P., Reddy, K.L. and Storti, R.V. (1997) PDP1, a novel Drosophila PAR domain bZIP transcription factor expressed in developing mesoderm, endoderm and ectoderm, is a transcriptional regulator of somatic muscle genes. Development, 124, 4685-4696.
36. Logan, M. and Mohun, T.J. (1993) Induction of cardiac muscle differentation in isolated animal pole explants of Xenopus laevis embryos. Development, 118, 865-875.
37. Luo, R.X., Postigo, A.A. and Dean, D.C. (1998) Rb interacts with histone deacetylase to repress transcription. Cell, 92, 463-173.
38. Magnaghi-Jaulin, L., Groisman, R., Naguibneva, I., Robin, P., Lorain, S., Le Villain, J.P., Troalen, F., Trouche, D. and Harel-Bellan, A. (1998) Retinoblastoma protein represses transcription by recruiting a histone deacetylase. Nature, 391, 601-605.
39. Mao, Z. and Nadal-Ginard, B. (1996) Functional and physical interactions between mammalian achaete-scute homolog 1 and myocyte enhancer factor 2A. J. Biol. Chem., 271, 14371-14375.
40. Martin, K., Trouche, D., Hagemeier, C. and Kouzarides, T. (1995) Regulation of transcription by E2F/DP1. J. Cell Sci. Suppl., 19, 91-94.
41. Miska, E.A., Karlsson, C., Langley, E., Nielsen, S., Pines, J. and Kouzarides, T. (1999) HDAC4 deacetylase associates with and represses the MEF2 transcription factor. EMBO J., 18, 5099-5107.
42. Mohun, T., Garrett, N. and Treisman, R. (1987) Xenopus cytoskeletal actin and human C-fos gene promoters share a conserved protein-binding site. EMBO J., 6, 667-673.
43. Molkentin, J.D., Black, B.L., Martin, J.F. and Olson, E.N. (1995) Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins. Cell, 83, 1125-1136.
44. Molkentin, J.D., Black, B.L., Martin, J.F. and Olson, E.N. (1996) Mutational analysis of the DNA binding, dimerization and transcriptional activation domains of MEF2C. Mol. Cell. Biol., 16, 2627-2636.
45. Morkel, M., Wenkel, J., Bannister, A.J., Kouzarides, T. and Hagemeier, C. (1997) An E2F-like repressor of transcription. Nature, 390, 567-568.
46. Nagase, T., Ishikawa, K., Suyama, M., Kikuno, R., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N. and Ohara, O. (1998) Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res., 5, 277-286
47. Nagy, L., Kao, H.Y., Chakravarti, D., Lin, R.J., Hassig, C.A., Ayer, D.E., Schreiber, S.L. and Evans, R.M. (1997) Nuclear receptor repression mediated by a complex containing SMRT, mSin3A and histone deacetylase. Cell, 89, 373-380.
48. Nurrish, S.J. and Treisman, R. (1995) DNA binding specificity determinants in MADS-box transcription factors. Mol. Cell. Biol., 15, 4076-4085.
49. Ornatsky, O.I. and McDermott, J.C. (1996) MEF2 protein expression, DNA binding specificity and complex composition and transcriptional activity in muscle and non-muscle cells. J. Biol. Chem., 271, 24927-24933.
50. Pazin, M.J. and Kadonaga, J.T. (1997) What's up and down with histone deacetylation and transcription? Cell, 89, 325-328.
51. Principaud, E. and Spohr, G. (1991) Xenopus laevis C-myc I and II genes: molecular structure and developmental expression. Nucleic Acids Res., 19, 3081-3088.
52. Sande, S. and Privalsky, M.L. (1996) Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with and modulate the activity of. nuclear hormone receptors. Mol. Endocrinol., 10, 813-825.
53. Sartorelli, V., Huang, J., Hamamori, Y. and Kedes, L. (1997) Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C. Mol. Cell. Biol., 17, 1010-1026.
54. Scanlan, M.J. et al. (1998) Characterization of human colon cancer antigens recognized by autologous antibodies. Int. J. Cancer, 76, 652-658.
55. Schiestl, R.H. and Gietz, R.D. (1989) High efficiency transformation of intact yeast cells using single-stranded nucleic acids as carrier. Curr. Genet., 16, 339-346.
56. Schreiber-Agus, N., Chin, L., Chen, K., Torres, R., Rao, G., Guida, P., Skoultchi, A.I. and DePinho, R.A. (1995) An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3. Cell, 80, 777-786.
57. Seed, B. and Sheen, J.Y. (1988) A simple phase-extraction assay for chloramphenicol acyltransferase activity. Gene, 67, 271-277.
58. Smith, D.B. and Johnson, K.S. (1988) Single-step purification of polypeptides expressed in Escherichia coli as fusion with glutathione S-transferase. Gene, 67, 31-40.
59. Sparrow, D.B., Kotecha, S., Towers, N. and Mohun, T.J. (1998a) Xenopus eHAND: a marker for the developing cardiovascular system of the embryo that is regulated by bone morphogenetic proteins. Mech. Dev., 71, 151-163.
60. Sparrow, D.B., Jen, W.C., Kotecha, S., Towers, N., Kintner, C. and Mohun, T.J. (1998b) Thylacine 1 is expressed segmentally within the paraxial mesoderm of the Xenopus embryo and interacts with the Notch pathway. Development. 125, 2041-2051.
61. Spicer, D.B., Rhee, J., Cheung, W.L. and Lassar, A.B. (1996) Inhibition of myogenic bHLH and MEF2 transcription factors by the bHLH protein Twist. Science, 272, 1476-1480.
62. Strahl, K. (1998) Histone acetylation and transcriptional regulatory mechanisms. Genes Dev., 12, 599-606.
63. Taylor, J.M., Dupont-Versteegden, E.E., Davies, J.D., Hassell, J.A., Houle, J.D., Gurley, C.M. and Peterson, C.A. (1997) A role for the ETS domain transcription factor PEA3 in myogenic differentiation. Mol. Cell. Biol., 17, 5550-5558.
64. Tonissen, K.F. and Krieg, P.A. (1994) Analysis of a variant Max sequence expressed in Xenopus laevis. Oncogene, 9, 33-38.
65. Verdel, A. and Khochbin, S. (1999) Identification of a new family of higher eukaryotic histone deacetylases. Coordinate expression of differentiation-dependent chromatin modifiers. J. Biol. Chem., 274, 2440-2445.
66. Wang, A.H., Bertos, N.R., Vezmar, M., Pelletier, N., Crosanto, M., Heng, H.H., Th'ng, J., Han, J. and Yang, X.-J. (1999) HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor. Mol. Cell. Biol., in press.
67. Watanabe, Y., Irie, K. and Matsumoto, K. (1995) Yeast RLM1 encodes a serum response factor-like protein that may function downstream of the Mpk1 (Slt2) mitogen-activated protein kinase pathway. Mol. Cell, Biol., 15, 5740-5749.
68. Watanabe, Y., Takaesu, G., Hagiwara, M., Irie, K. and Mastumoto, K. (1997) Characterisation of a serum response factor-like protein in Saccharomyces cerevisiae, Rlm1, which has transcriptional activity regulated by the Mpk1 (Slt2) mitogen-activated protein kinase pathway. Mol. Cell. Biol., 17, 2615-2623.
69. Wong, J., Patterton, D., Imhof, A., Guschin, D., Shi, Y.B. and Wolffe, A.P. (1998) Distinct requirements for chromatin assembly in transcriptional repression by thyroid hormone receptor and histone deacetylase. EMBO J., 17, 520-534.
70. Wong, M.W., Pisegna, M., Lu, M.F., Leibham, D. and Perry, M. (1994) Activation of Xenopus MyoD transcription by members of the MEF2 protein family. Dev. Biol., 166, 683-695.
71. Yang, W.M., Yao, Y.L., Sun, J.M., Davie, J.R. and Seto, E. (1997) Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family. J. Biol. Chem., 272, 28001-28007