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Volumn 2, Issue 4, 2012, Pages 434-442

New models of pulmonary hypertension based on VEGF receptor blockade-induced endothelial cell apoptosis

Author keywords

Apoptosis; Chronic hypoxia; Pulmonary hypertension; Regulatory T cells; Su5416

Indexed keywords


EID: 84873673503     PISSN: 20458932     EISSN: 20458940     Source Type: Journal    
DOI: 10.4103/2045-8932.105031     Document Type: Review
Times cited : (98)

References (68)
  • 1
    • 46749142123 scopus 로고    scopus 로고
    • Molecular pathogenesis of pulmonary arterial hypertension
    • Rabinovitch M. Molecular pathogenesis of pulmonary arterial hypertension. J Clin Invest 2008;118:2372-9.
    • (2008) J Clin Invest , vol.118 , pp. 2372-2379
    • Rabinovitch, M.1
  • 2
    • 54049138069 scopus 로고    scopus 로고
    • Emerging concepts and translational priorities in pulmonary arterial hypertension
    • Michelakis ED, Wilkins MR, Rabinovitch M. Emerging concepts and translational priorities in pulmonary arterial hypertension. Circulation 2008;118:1486-95.
    • (2008) Circulation , vol.118 , pp. 1486-1495
    • Michelakis, E.D.1    Wilkins, M.R.2    Rabinovitch, M.3
  • 5
    • 76149089231 scopus 로고    scopus 로고
    • Endothelial progenitors in pulmonary hypertension: New pathophysiology and therapeutic implications
    • Fadini GP, Avogaro A, Ferraccioli G, Agostini C. Endothelial progenitors in pulmonary hypertension: New pathophysiology and therapeutic implications. Eur Respir J 2010;35:418-25.
    • (2010) Eur Respir J , vol.35 , pp. 418-425
    • Fadini, G.P.1    Avogaro, A.2    Ferraccioli, G.3    Agostini, C.4
  • 6
    • 34249302372 scopus 로고    scopus 로고
    • A meta-analysis of trials of pulmonary hypertension: A clinical condition looking for drugs and research methodology
    • Macchia A, Marchioli R, Marfisi R, Scarano M, Levantesi G, Tavazzi L, et al. A meta-analysis of trials of pulmonary hypertension: A clinical condition looking for drugs and research methodology. Am Heart J 2007;153:1037-47.
    • (2007) Am Heart J , vol.153 , pp. 1037-1047
    • Macchia, A.1    Marchioli, R.2    Marfisi, R.3    Scarano, M.4    Levantesi, G.5    Tavazzi, L.6
  • 7
    • 80051729086 scopus 로고    scopus 로고
    • Clinical Trials Using Vasodilators in Pulmonary Arterial Hypertension: Where Do We Go from Here?
    • Macchia A, Mariani J, Comignani PD, Tognoni G. Clinical Trials Using Vasodilators in Pulmonary Arterial Hypertension: Where Do We Go from Here? Rev Recent Clin Trials, 2011;6:228-34.
    • (2011) Rev Recent Clin Trials , vol.6 , pp. 228-234
    • Macchia, A.1    Mariani, J.2    Comignani, P.D.3    Tognoni, G.4
  • 8
    • 71949129187 scopus 로고    scopus 로고
    • Animal models of pulmonary arterial hypertension: The hope for etiological discovery and pharmacological cure
    • Stenmark KR, Meyrick B, Galie N, Mooi WJ, McMurtry IF. Animal models of pulmonary arterial hypertension: The hope for etiological discovery and pharmacological cure. Am J Physiol Lung Cell Mol Physiol 2009;297:L1013-L1032.
    • (2009) Am J Physiol Lung Cell Mol Physiol , vol.297 , pp. L1013-L1032
    • Stenmark, K.R.1    Meyrick, B.2    Galie, N.3    Mooi, W.J.4    McMurtry, I.F.5
  • 11
    • 0035130107 scopus 로고    scopus 로고
    • Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension
    • Taraseviciene-Stewart L, Kasahara Y, Alger L, Hirth P, Mc Mahon G, Waltenberger J, et al. Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension. Faseb J 2001;15:427-38.
    • (2001) Faseb J , vol.15 , pp. 427-438
    • Taraseviciene-Stewart, L.1    Kasahara, Y.2    Alger, L.3    Hirth, P.4    Mc Mahon, G.5    Waltenberger, J.6
  • 12
    • 0032893263 scopus 로고    scopus 로고
    • SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types
    • Fong TA, Shawver LK, Sun L, Tang C, App H, Powell TJ, et al. SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res 1999;59:99-106.
    • (1999) Cancer Res , vol.59 , pp. 99-106
    • Fong, T.A.1    Shawver, L.K.2    Sun, L.3    Tang, C.4    App, H.5    Powell, T.J.6
  • 14
    • 79952281574 scopus 로고    scopus 로고
    • The effects of antiangiogenic compound SU5416 in a rat model of pulmonary arterial hypertension
    • Sakao S, Tatsumi K. The effects of antiangiogenic compound SU5416 in a rat model of pulmonary arterial hypertension. Respiration 2011;81:253-61.
    • (2011) Respiration , vol.81 , pp. 253-261
    • Sakao, S.1    Tatsumi, K.2
  • 15
    • 0038389113 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma (PPARgamma) expression is decreased in pulmonary hypertension and affects endothelial cell growth
    • Ameshima S, Golpon H, Cool CD, Chan D, Vandivier RW, Gardai SJ, et al. Peroxisome proliferator-activated receptor gamma (PPARgamma) expression is decreased in pulmonary hypertension and affects endothelial cell growth. Circ Res 2003;92:1162-9.
    • (2003) Circ Res , vol.92 , pp. 1162-1169
    • Ameshima, S.1    Golpon, H.2    Cool, C.D.3    Chan, D.4    Vandivier, R.W.5    Gardai, S.J.6
  • 16
    • 80755128430 scopus 로고    scopus 로고
    • Design and validation of an endothelial progenitor cell capture chip and its application in patients with pulmonary arterial hypertension
    • Hansmann G, Plouffe BD, Hatch A, von Gise A, Sallmon H, Zamanian RT, et al. Design and validation of an endothelial progenitor cell capture chip and its application in patients with pulmonary arterial hypertension. J Mol Med (Berl) 2011;89:971-83.
    • (2011) J Mol Med (Berl) , vol.89 , pp. 971-983
    • Hansmann, G.1    Plouffe, B.D.2    Hatch, A.3    Von Gise, A.4    Sallmon, H.5    Zamanian, R.T.6
  • 17
    • 80053571093 scopus 로고    scopus 로고
    • Regulatory T Cells Limit Vascular Endothelial Injury and Prevent Pulmonary Hypertension
    • Tamosiuniene R, Tian W, Dhillon G, Wang L, Sung YK, Gera L, et al. Regulatory T Cells Limit Vascular Endothelial Injury and Prevent Pulmonary Hypertension. Circ Res 2011;109:867-79.
    • (2011) Circ Res , vol.109 , pp. 867-879
    • Tamosiuniene, R.1    Tian, W.2    Dhillon, G.3    Wang, L.4    Sung, Y.K.5    Gera, L.6
  • 18
    • 84455168708 scopus 로고    scopus 로고
    • Altered microRNA Processing in Heritable Pulmonary Arterial Hypertension: An Important Role for Smad-8
    • Drake KM, Zygmunt D, Mavrakis L, Harbor P, Wang L, Comhair SA, et al. Altered microRNA Processing in Heritable Pulmonary Arterial Hypertension: An Important Role for Smad-8. Am J Respir Crit Care Med 2011;184:1400-8.
    • (2011) Am J Respir Crit Care Med , vol.184 , pp. 1400-1408
    • Drake, K.M.1    Zygmunt, D.2    Mavrakis, L.3    Harbor, P.4    Wang, L.5    Comhair, S.A.6
  • 21
    • 79959229034 scopus 로고    scopus 로고
    • Inhibitory Effects of SU5416, a Selective Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, on Experimental Corneal Neovascularization
    • Keskin U, Totan Y, Karadağ R, Erdurmuş M, Aydın B. Inhibitory Effects of SU5416, a Selective Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, on Experimental Corneal Neovascularization. Ophthalmic Res 2011;47:13-8.
    • (2011) Ophthalmic Res , vol.47 , pp. 13-18
    • Keskin, U.1    Totan, Y.2    Karadağ, R.3    Erdurmuş, M.4    Aydın, B.5
  • 22
    • 79951690500 scopus 로고    scopus 로고
    • Prolonged hypoxic culture and trypsinization increase the pro-angiogenic potential of human adipose tissue-derived stem cells
    • Rasmussen JG, Frøbert O, Pilgaard L, Kastrup J, Simonsen U, Zachar V, et al. Prolonged hypoxic culture and trypsinization increase the pro-angiogenic potential of human adipose tissue-derived stem cells. Cytotherapy 2011;13:318-28.
    • (2011) Cytotherapy , vol.13 , pp. 318-328
    • Rasmussen, J.G.1    Frøbert, O.2    Pilgaard, L.3    Kastrup, J.4    Simonsen, U.5    Zachar, V.6
  • 23
    • 77956265222 scopus 로고    scopus 로고
    • Anti-vascular endothelial growth factor treatment in combination with chemotherapy delays hematopoietic recovery due to decreased proliferation of bone marrow hematopoietic progenitor cells
    • Novitskiy SV, Csiki I, Huang Y, Johnson DH, Harth EM, Carbone DP, et al. Anti-vascular endothelial growth factor treatment in combination with chemotherapy delays hematopoietic recovery due to decreased proliferation of bone marrow hematopoietic progenitor cells. J Thorac Oncol 2010;5:1410-5.
    • (2010) J Thorac Oncol , vol.5 , pp. 1410-1415
    • Novitskiy, S.V.1    Csiki, I.2    Huang, Y.3    Johnson, D.H.4    Harth, E.M.5    Carbone, D.P.6
  • 25
    • 77449131068 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-2 inhibition promotes cell death and limits endothelial cell proliferation in a neonatal rodent model of stroke
    • Shimotake J, Derugin N, Wendland M, Vexler ZS, Ferriero DM. Vascular endothelial growth factor receptor-2 inhibition promotes cell death and limits endothelial cell proliferation in a neonatal rodent model of stroke. Stroke 2010;41:343-9.
    • (2010) Stroke , vol.41 , pp. 343-349
    • Shimotake, J.1    Derugin, N.2    Wendland, M.3    Vexler, Z.S.4    Ferriero, D.M.5
  • 27
    • 77954243018 scopus 로고    scopus 로고
    • Formation of plexiform lesions in experimental severe pulmonary arterial hypertension
    • Abe K, Toba M, Alzoubi A, Ito M, Fagan KA, Cool CD, et al. Formation of plexiform lesions in experimental severe pulmonary arterial hypertension. Circulation 2010;121:2747-54.
    • (2010) Circulation , vol.121 , pp. 2747-2754
    • Abe, K.1    Toba, M.2    Alzoubi, A.3    Ito, M.4    Fagan, K.A.5    Cool, C.D.6
  • 28
    • 34147189502 scopus 로고    scopus 로고
    • Rho Kinase-Mediated Vasoconstriction Is Important in Severe Occlusive Pulmonary Arterial Hypertension in Rats
    • Oka M, Homma N, Taraseviciene-Stewart L, Morris KG, Kraskauskas D, Burns N, et al. Rho Kinase-Mediated Vasoconstriction Is Important in Severe Occlusive Pulmonary Arterial Hypertension in Rats. Circ Res 2007;100:923-9.
    • (2007) Circ Res , vol.100 , pp. 923-929
    • Oka, M.1    Homma, N.2    Taraseviciene-Stewart, L.3    Morris, K.G.4    Kraskauskas, D.5    Burns, N.6
  • 33
    • 0034018782 scopus 로고    scopus 로고
    • Athymic nude rats develop severe pulmonary hypertension following monocrotaline administration
    • Miyata M, Sakuma F, Ito M, Ohira H, Sato Y, Kasukawa R. Athymic nude rats develop severe pulmonary hypertension following monocrotaline administration. Int Arch Allergy Immunol 2000;121:246-52.
    • (2000) Int Arch Allergy Immunol , vol.121 , pp. 246-252
    • Miyata, M.1    Sakuma, F.2    Ito, M.3    Ohira, H.4    Sato, Y.5    Kasukawa, R.6
  • 35
  • 37
    • 38049153144 scopus 로고    scopus 로고
    • A novel thiol compound, N-acetylcysteine amide, attenuates allergic airway disease by regulating activation of NF-kappaB and hypoxia-inducible factor-1alpha
    • Lee KS, Kim SR, Park HS, Park SJ, Min KH, Lee KY, et al. A novel thiol compound, N-acetylcysteine amide, attenuates allergic airway disease by regulating activation of NF-kappaB and hypoxia-inducible factor-1alpha. Exp Mol Med 2007;39:756-68.
    • (2007) Exp Mol Med , vol.39 , pp. 756-768
    • Lee, K.S.1    Kim, S.R.2    Park, H.S.3    Park, S.J.4    Min, K.H.5    Lee, K.Y.6
  • 39
    • 85026314053 scopus 로고    scopus 로고
    • Vegf receptor inhibition in experimental lung fibrosis results in severe angioproliferative pulmonary hypertension and increased fibrogenic activity
    • Farkas L, et al. Vegf receptor inhibition in experimental lung fibrosis results in severe angioproliferative pulmonary hypertension and increased fibrogenic activity Am J Respir Crit Care Med 2010;181:A6315.
    • (2010) Am J Respir Crit Care Med , vol.181
    • Farkas, L.1
  • 40
    • 66449098872 scopus 로고    scopus 로고
    • VEGF ameliorates pulmonary hypertension through inhibition of endothelial apoptosis in experimental lung fibrosis in rats
    • Farkas L, Farkas D, Ask K, Möller A, Gauldie J, Margetts P, et al. VEGF ameliorates pulmonary hypertension through inhibition of endothelial apoptosis in experimental lung fibrosis in rats. J Clin Invest 2009;119:1298-311.
    • (2009) J Clin Invest , vol.119 , pp. 1298-1311
    • Farkas, L.1    Farkas, D.2    Ask, K.3    Möller, A.4    Gauldie, J.5    Margetts, P.6
  • 41
    • 85026305171 scopus 로고    scopus 로고
    • Caspase inhibition reduces severe pulmonary hypertension in the AdTGF-1β/SU5416 model of angioproliferative pulmonary hypertension and lung fibrosis
    • Farkas L, Farkas D, Kraskauskas D, Gauldie J, Kolb M, Voelkel N. Caspase inhibition reduces severe pulmonary hypertension in the AdTGF-1β/SU5416 model of angioproliferative pulmonary hypertension and lung fibrosis. Eur Respir J 2011;38:594s.
    • (2011) Eur Respir J , vol.38
    • Farkas, L.1    Farkas, D.2    Kraskauskas, D.3    Gauldie, J.4    Kolb, M.5    Voelkel, N.6
  • 42
    • 84878644800 scopus 로고    scopus 로고
    • The Pathobiology of the Complex Vascular Lesions in Severe Pulmonary Hypertension-Angiogenesis and Cancer
    • N.V. Ed, Editor. Connecticut: People’s Medical Publishing House Shelton
    • Voelkel NF, Cool CD. The Pathobiology of the Complex Vascular Lesions in Severe Pulmonary Hypertension-Angiogenesis and Cancer, in Pulmonary Hypertension: The Present and Future. N.V. Ed, Editor. Connecticut: People’s Medical Publishing House Shelton; 2011. p. 87-103.
    • (2011) Pulmonary Hypertension: The Present and Future , pp. 87
    • Voelkel, N.F.1    Cool, C.D.2
  • 43
    • 0036245561 scopus 로고    scopus 로고
    • Janus face of vascular endothelial growth factor: The obligatory survival factor for lung vascular endothelium controls precapillary artery remodeling in severe pulmonary hypertension
    • Voelkel NF, Cool C, Taraceviene-Stewart L, Geraci MW, Yeager M, Bull T, et al. Janus face of vascular endothelial growth factor: The obligatory survival factor for lung vascular endothelium controls precapillary artery remodeling in severe pulmonary hypertension. Crit Care Med 2002;30 (5 Suppl):S251-S256.
    • (2002) Crit Care Med , vol.30 , Issue.5
    • Voelkel, N.F.1    Cool, C.2    Taraceviene-Stewart, L.3    Geraci, M.W.4    Yeager, M.5    Bull, T.6
  • 47
    • 21744460365 scopus 로고    scopus 로고
    • Initial apoptosis is followed by increased proliferation of apoptosis-resistant endothelial cells
    • Sakao S, Taraseviciene-Stewart L, Lee JD, Wood K, Cool CD, Voelkel NF. Initial apoptosis is followed by increased proliferation of apoptosis-resistant endothelial cells. Faseb J 2005;19:1178-80.
    • (2005) Faseb J , vol.19 , pp. 1178-1180
    • Sakao, S.1    Taraseviciene-Stewart, L.2    Lee, J.D.3    Wood, K.4    Cool, C.D.5    Voelkel, N.F.6
  • 48
    • 33845343558 scopus 로고    scopus 로고
    • Vascular endothelial growth factor blockade reduces intratumoral regulatory T cells and enhances the efficacy of a GM-CSF-secreting cancer immunotherapy
    • Li B, Lalani AS, Harding TC, Luan B, Koprivnikar K, Huan Tu G, Prell R, et al. Vascular endothelial growth factor blockade reduces intratumoral regulatory T cells and enhances the efficacy of a GM-CSF-secreting cancer immunotherapy. Clin Cancer Res 2006;12:6808-16.
    • (2006) Clin Cancer Res , vol.12 , pp. 6808-6816
    • Li, B.1    Lalani, A.S.2    Harding, T.C.3    Luan, B.4    Koprivnikar, K.5    Huan Tu, G.6    Prell, R.7
  • 50
    • 77953988924 scopus 로고    scopus 로고
    • Targeting the tumour vasculature: Insights from physiological angiogenesis
    • Chung AS, Lee J, Ferrara N. Targeting the tumour vasculature: Insights from physiological angiogenesis. Nat Rev Cancer 2010;10:505-14.
    • (2010) Nat Rev Cancer , vol.10 , pp. 505-514
    • Chung, A.S.1    Lee, J.2    Ferrara, N.3
  • 51
    • 79953244361 scopus 로고    scopus 로고
    • Antiangiogenic therapy: Impact on invasion, disease progression, and metastasis
    • Ebos JM, Kerbel RS. Antiangiogenic therapy: Impact on invasion, disease progression, and metastasis. Nat Rev Clin Oncol 2011;8:210-21.
    • (2011) Nat Rev Clin Oncol , vol.8 , pp. 210
    • Ebos, J.M.1    Kerbel, R.S.2
  • 52
    • 0033558087 scopus 로고    scopus 로고
    • Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2
    • Soldi R, Mitola S, Strasly M, Defilippi P, Tarone G, Bussolino F. Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2. EMBO J 1999;18:882-92.
    • (1999) EMBO J , vol.18 , pp. 882-892
    • Soldi, R.1    Mitola, S.2    Strasly, M.3    Defilippi, P.4    Tarone, G.5    Bussolino, F.6
  • 53
    • 14244262503 scopus 로고    scopus 로고
    • Matrix-bound sixth Ig-like domain of cell adhesion molecule L1 acts as an angiogenic factor by ligating alphavbeta3-integrin and activating VEGF-R2
    • Hall H, Hubbell JA. Matrix-bound sixth Ig-like domain of cell adhesion molecule L1 acts as an angiogenic factor by ligating alphavbeta3-integrin and activating VEGF-R2. Microvasc Res 2004;68:169-78.
    • (2004) Microvasc Res , vol.68 , pp. 169-178
    • Hall, H.1    Hubbell, J.A.2
  • 54
    • 84872198058 scopus 로고    scopus 로고
    • Thyroid hormone is highly permissive in angioproliferative pulmonary arterial hypertension in rats
    • [In Press]
    • Al Husseini A, Bagnato G, Farkas L, Gomez-Arroyo J, Farkas D, Mizuno S, et al. Thyroid hormone is highly permissive in angioproliferative pulmonary arterial hypertension in rats. Eur Respir J 2012 [In Press].
    • (2012) Eur Respir J
    • Al Husseini, A.1    Bagnato, G.2    Farkas, L.3    Gomez-Arroyo, J.4    Farkas, D.5    Mizuno, S.6
  • 56
    • 85026308112 scopus 로고    scopus 로고
    • Endocrine aspects of pulmonary hypertension
    • Shelton, Connecticut: People’s Medical Publishing House
    • Sweeney L, Chhatwani L. Endocrine aspects of pulmonary hypertension, in Pulmonary hypertension: Present and future. Shelton, Connecticut: People’s Medical Publishing House; 2011. p. 239-49.
    • (2011) Pulmonary Hypertension: Present and Future , pp. 239
    • Sweeney, L.1    Chhatwani, L.2
  • 57
    • 77955056839 scopus 로고    scopus 로고
    • Cardiovascular involvement in patients with different causes of hyperthyroidism
    • Biondi B, Kahaly GJ. Cardiovascular involvement in patients with different causes of hyperthyroidism. Nat Rev Endocrinol 2010;6:431-43.
    • (2010) Nat Rev Endocrinol , vol.6 , pp. 431-443
    • Biondi, B.1    Kahaly, G.J.2
  • 58
    • 2942653137 scopus 로고    scopus 로고
    • Proangiogenic action of thyroid hormone is fibroblast growth factor-dependent and is initiated at the cell surface
    • Davis FB, Mousa SA, O’Connor L, Mohamed S, Lin HY, Cao HJ, et al. Proangiogenic action of thyroid hormone is fibroblast growth factor-dependent and is initiated at the cell surface. Circ Res 2004;94:1500-6.
    • (2004) Circ Res , vol.94 , pp. 1500-1506
    • Davis, F.B.1    Mousa, S.A.2    O’Connor, L.3    Mohamed, S.4    Lin, H.Y.5    Cao, H.J.6
  • 59
    • 0032498640 scopus 로고    scopus 로고
    • Integrin alphavbeta3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis
    • Eliceiri BP, Klemke R, Strömblad S, Cheresh DA. Integrin alphavbeta3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis. J Cell Biol 1998;140:1255-63.
    • (1998) J Cell Biol , vol.140 , pp. 1255-1263
    • Eliceiri, B.P.1    Klemke, R.2    Strömblad, S.3    Cheresh, D.A.4
  • 60
    • 84862768329 scopus 로고    scopus 로고
    • Predicting the Effects of Anti-angiogenic Agents Targeting Specific VEGF Isoforms
    • Finley SD, Popel AS. Predicting the Effects of Anti-angiogenic Agents Targeting Specific VEGF Isoforms. AAPS J 2012;14:500-9.
    • (2012) AAPS J , vol.14 , pp. 500-509
    • Finley, S.D.1    Popel, A.S.2
  • 61
    • 84859453770 scopus 로고    scopus 로고
    • Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling
    • Benedito R, Rocha SF, Woeste M, Zamykal M, Radtke F, Casanovas O, et al. Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling. Nature 2012;484:110-4.
    • (2012) Nature , vol.484 , pp. 110-114
    • Benedito, R.1    Rocha, S.F.2    Woeste, M.3    Zamykal, M.4    Radtke, F.5    Casanovas, O.6
  • 62
    • 2342486598 scopus 로고    scopus 로고
    • Internal and external autocrine VEGF/KDR loops regulate survival of subsets of acute leukemia through distinct signaling pathways
    • Santos SC, Dias S. Internal and external autocrine VEGF/KDR loops regulate survival of subsets of acute leukemia through distinct signaling pathways. Blood 2004;103:3883-9.
    • (2004) Blood , vol.103 , pp. 3883-3889
    • Santos, S.C.1    Dias, S.2
  • 64
    • 84861116064 scopus 로고    scopus 로고
    • VEGF-C Promotes Immune Tolerance in B16 Melanomas and Cross-Presentation of Tumor Antigen by Lymph Node Lymphatics
    • Lund AW, Duraes FV, Hirosue S, Raghavan VR, Nembrini C, Thomas SN, et al. VEGF-C Promotes Immune Tolerance in B16 Melanomas and Cross-Presentation of Tumor Antigen by Lymph Node Lymphatics. Cell Reports 2012;1:191-9.
    • (2012) Cell Reports , vol.1 , pp. 191-199
    • Lund, A.W.1    Duraes, F.V.2    Hirosue, S.3    Raghavan, V.R.4    Nembrini, C.5    Thomas, S.N.6
  • 66
    • 0030828893 scopus 로고    scopus 로고
    • Pulmonary hemodynamics modify the rat pulmonary artery response to injury. A neointimal model of pulmonary hypertension
    • Okada K, Tanaka Y, Bernstein M, Zhang W, Patterson GA, Botney MD. Pulmonary hemodynamics modify the rat pulmonary artery response to injury. A neointimal model of pulmonary hypertension. Am J Pathol 1997;151:1019-25.
    • (1997) Am J Pathol , vol.151 , pp. 1019-1025
    • Okada, K.1    Tanaka, Y.2    Bernstein, M.3    Zhang, W.4    Patterson, G.A.5    Botney, M.D.6
  • 67
    • 82755165210 scopus 로고    scopus 로고
    • Molecular signature of a right heart failure program in chronic severe pulmonary hypertension
    • Drake JI, Bogaard HJ, Mizuno S, Clifton B, Xie B, Gao Y, et al. Molecular signature of a right heart failure program in chronic severe pulmonary hypertension. Am J Respir Cell Mol Biol 2011;45:1239-47.
    • (2011) Am J Respir Cell Mol Biol , vol.45 , pp. 1239-1247
    • Drake, J.I.1    Bogaard, H.J.2    Mizuno, S.3    Clifton, B.4    Xie, B.5    Gao, Y.6
  • 68
    • 34547106845 scopus 로고    scopus 로고
    • Distinct roles of VEGFR-1 and VEGFR-2 in the aberrant hematopoiesis associated with elevated levels of VEGF
    • Huang Y, Chen X, Dikov MM, Novitskiy SV, Mosse CA, Yang L, et al. Distinct roles of VEGFR-1 and VEGFR-2 in the aberrant hematopoiesis associated with elevated levels of VEGF. Blood 2007;110:624-31.
    • (2007) Blood , vol.110 , pp. 624-631
    • Huang, Y.1    Chen, X.2    Dikov, M.M.3    Novitskiy, S.V.4    Mosse, C.A.5    Yang, L.6


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