HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor

Molecular and Cellular Biology

Volumn 19, Issue 11, 1999, Pages 7816-7827

  Wang, Audrey H ^a   Bertos, Nicholas R ^a   Vezmar, Marko ^a   Pelletier, Nadine ^a   Crosato, Milena ^b   Heng, Henry H ^c   Th'ng, John ^b   Han, Jiahuai ^d   Yang, Xiang Jiao ^a,e  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c YORK UNIVERSITY   (Canada)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

^e ROYAL VICTORIA HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEACETYLASE;

ACETYLATION; AMINO TERMINAL SEQUENCE; ARTICLE; DOWN REGULATION; GENE EXPRESSION REGULATION; HUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; REPRESSOR GENE; TRANSCRIPTION REGULATION;

EID: 0032696590     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.11.7816     Document Type: Article

References (63)

1. Altschul, S. F., T. L. Madden, A. A. Schaffer, J. Zhang, Z. Zhang, W. Miller, and D. J. Lipman. 1997. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25:3389-3402.
2. Ausio, J., and K. E. van Holde. 1986. Histone hyperacetylation: its effects on nucleosome conformation and stability. Biochemistry 25:1421-1428.
3. Bartholomew, C., A. Kilbey, A. M. Clark, and M. Walker. 1997. The Evi-1 proto-oncogene encodes a transcriptional represser activity associated with transformation. Oncogene 14:569-577.
4. Black, B. L., and E. N. Olson. 1998. Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins. Annu. Rev. Cell Dev. Biol. 14:167-196.
5. Brehm, A., E. A. Miska, D. J. McCance, J. L. Reid, A. J. Bannister, and T. Kouzarides. 1998. Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature 391:597-601.
6. Carmen, A. A., S. E. Rundlett, and M. Grunstein. 1996. HDA1 and HDA3 are components of a yeast histone deacetylase (HDA) complex. J. Biol. Chem. 271:15837-15844.
7. Clarke, N., N. Arenzana, T. Hai, A. Minden, and R. Prywes. 1998. Epidermal growth factor induction of the c-Jun promoter by a Rac pathway. Mol. Cell. Biol. 18:1065-1073.
8. Conrad, B., G. Dewald, E. Christensen, M. Lopez, J. Higgins, and M. E. Pierpont. 1995. Clinical phenotype associated with terminal 2q37 deletion. Clin. Genet. 48:134-139.
9. Coso, O. A., S. Montaner, C. Frosman, J. C. Lacal, R. Prywes, H. Teramoto, and J. S. Gutkind. 1997. Signaling from G protein-coupled receptors to the c-jun promoter involves the MEF2 transcription factor. J. Biol. Chem. 272: 20691-20697.
10. Emiliani, S., W. Fischle, C. Van Lint, Y. Al-Abed, and E. Verdin. 1998. Characterization of a human RPD3 ortholog, HDAC3. Proc. Natl. Acad. Sci. USA 95:2795-2800.
11. Fischle, W., S. Emilian, M. J. Hendzel, T. Nagase, N. Nomura, W. Voelter, and E. Verdin. 1999. A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p. J. Biol. Chem. 274:11713-11720.
12. Fisher, A. L., and M. Candy. 1998. Groucho proteins: transcriptional corepressors for specific subsets of DNA-binding transcription factors in vertebrates and invertebrates. Genes Dev. 12:1931-1940.
13. Grozinger, C. M., C. A. Hassig, and S. L. Schreiber. 1999. Three proteins define a class of human histone deacetylases related to yeast Hda1p. Proc. Natl. Acad. Sci. USA 96:4868-4873.
14. Grunstein, M. 1997. Histone acetylation in chromatin structure and transcription. Nature 389:349-352.
15. Han, J., Y. Jiang, Z. Li, V. V. Kravchenko, and R. J. Ulevitch. 1997. Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation. Nature 386:296-299.
16. Han, T.-H., and R. Prywes. 1995. Regulatory role of MEF2D in serum induction of the c-Jun promoter. Mol. Cell. Biol. 15:2907-2915.
17. Harada, K., D. Dufort, C. Denis-Larose, and A. Nepveu. 1994. Conserved Cut repeats in the human Cut homeodomain protein function as DNA binding domains. J. Biol. Chem. 269:2062-2067.
18. Hassig, C. A., J. K. Tong, T. C. Fleischer, T. Owa, P. G. Grable, D. E. Ayer, and S. L. Schreiber. 1998. A role for histone deacetylase activity in HDAC1-mediated transcriptional repression. Proc. Natl. Acad. Sci. USA 95:3519-3524.
19. Hata, A., R. S. Lo, D. Wotton, G. Lagna, and J. Massague. 1997. Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4. Nature 388:82-87.
20. Hendzel, M. J., G. P. Delcuve, and J. R. Davie. 1991. Histone deacetylase is a component of the internal nuclear matrix. J. Biol. Chem. 266:21936-21942.
21. Heng, H. H., J. Squire, and L.-C. Tsui. 1992. High resolution mapping of mammalian genes by in situ hybridization to free chromatin. Proc. Natl. Acad. Sci. USA 89:9509-9513.
22. Henzel, M. J., W. K. Nishioka, Y. Raymond, D. Bazett-Jones, and J. P. H. Th'ng. 1998. Chromatin condensation is not associated with apotosis. J. Biol. Chem. 273:24470-24478.
23. Inoue, A., and D. Fujimoto. 1970. Histone deacetylase from calf thymus. Biochim. Biophy Acta 220:307-316.
24. Kadosh, D., and K. Strahl. 1998. Histone deacetylase activity of Rpd3 is important for transcriptional repression in vivo. Genes Dev. 12:797-805.
25. Kadosh, D., and K. Strahl. 1998. Targeted recruitment of the Sin3-Rpd3 histone deacetylase complex generates a highly localized domain of repressed chromatin in vivo. Mol. Cell. Biol. 18:5121-5127.
26. Kato, Y., V. V. Kravchenko, R. I. Tapping, J. Han, R. J. Ulevitch, and J.-D. Lee. 1997. BMK1/ERK5 regulate serum-induced early gene expression through transcription factor MEF2C. EMBO J. 16:7054-7066.
27. Kuo, M.-H., and C. D. Allis. 1998. Roles of histone acetyltransferases and deacetylases in gene regulation. Bioessays 20:615-626.
28. Laible, G., A. Wolf, R. Dorn, G. Reuter, C. Nislow, A. Lebersorger, D. Popkin, L. Pillus, and T. Jenuwein. 1997. Mammalian homologues of the Polycomb-group gene Enhancer of Zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres. EMBO J. 16:3219-3232.
29. Luger, K., A. W. Mader, R. K. Richmond, D. F. Sarget, and T. J. Richmond. 1997. Crystal structure of the nucleosome core particle at 2.8 Å resolution. Nature 389:251-260.
30. Luo, R. X., A. A. Postigo, and D. C. Dean. 1998. Rb interacts with histone deacetylase to repress transcription. Cell 92:463-473.
31. Lusser, A., G. Brosch, A. Loidl, H. Haas, and P. Loidl. 1997. Identification of maize histone deacetylase HD2 as an acidic nucleolar phosphoprotein. Science 277:88-91.
32. Magnaghi-Jaulin, L., R. Groisman, I. Naguibneva, P. Robin, S. Lorain, J. P. Le Villain, F. Troalen, D. Tronche, and A. Harel-Bellan. 1998. Retinoblastoma protein represses transcription by recruiting a histone deacetylase. Nature 391:601-605.
33. Magnani, I., L. Larizza, L. Doneda, L. Weitnauer, R. Rizzi, and R. Di Lernia. 1989. Malformation syndrome with t(2;22) in a cancer family with chromosome instability. Cancer Genet. Cytogenet. 38:223-227.
34. Martinez-Balbas, M. A., A. J. Bannister, K. Martin, P. Haus-Seuffert, M. Meisterernst, and T. Kouzarudes. 1998. The acetyltransferase activity of CBP stimulates transcription. EMBO J. 17:2886-2893.
35. Miska, E., C. Karlsson, E. Langley, S. Neilsen, J. Pines, and T. Kouzarides. HDAC4 deacetylase associates with and represses the MEF2 transcription factor. EMBO J., in press.
36. Molkentin, J. D., and E. N. Olson. 1996. Combinatorial control of muscle development by basic helix-loop-helix and MADS-box transcription factors. Proc. Natl. Acad. Sci. USA 93:9366-9373.
37. Nagase, T., K. Ishikawa, N. Miyajima, A. Tanaka, H. Kotani, N. Nomura, and O. Ohara. 1998. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 5:31-39.
38. Ohara, O., T. Nagase, K. Ishikawa, D. Nakajima, M. Ohira, N. Seki, and N. Nomura. 1997. Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. DNA Res. 4:53-59.
39. O'Neill, L. P., and B. M. Turner. 1995. Histone H4 acetylation distinguishes coding regions of the human genome from heterochromatin in a differentiation-dependent but transcription-independent manner. EMBO J. 14:3946-3957.
40. Omatskv, O. I., and J. C. McDermott. 1996. MEF2 protein expression, DNA binding specificity and complex formation, and transcriptional activity in muscle and non-muscle cells. J. Biol. Chem. 271:24927-24933.
41. Pazin, M. J., and J. T. Kadonaga. 1997. What's up and down with histone deacetylation and transcription? Cell 89:325-328.
42. Pollock, R., and R. Treisman. 1991. Human SRF-related proteins: DNA-binding properties and potential regulatory targets. Genes Dev. 5:2327-2341.
43. Rundlett, S. E., A. A. Carmen, R. Kobayashi, S. Bavykin, B. M. Turner, and M. Grunstein. 1996. HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. Proc. Natl. Acad. Sci. USA 93:14503-14508.
44. Satyaraj, E., and U. Storb. 1998. MEF2 proteins, required for muscle differentiation, bind an essential site in the 1g lambda enhancer. J. Immunol. 161:4795-4802.
45. Scanlan, M. J., Y. T. Chen, B. Williamson, A. O. Gure, E. Stockert, J. D. Gordan, O. Tureci, U. Sahin, M. Pfreundschuh, and L. J. Old. 1998. Characterization of human colon cancer antigens recognized by autologous antibodies. Int. J. Cancer 76:652-658.
46. Schreiber, M., A. Kolbus, F. Piu, A. Szabowski, U. Mohle-Steinlein, J. Tian, M. Karin, P. Angel, and E. F. Wagner. 1999. Control of cell cycle progression by c-Jun is p53 dependent. Genes Dev. 13:607-619.
47. Sparrow, D. B., E. A. Miska, E. Langley, S. Reynaud-Deonauth, S. Kotecha, N. Towers, G. Spohr, T. Kouzarides, and T. J. Mohun. MEF-2 function is modified by a novel co-repressor, MITR. EMBO J., in press.
48. Stifani, S., C. M. Blaumueller, N. J. Redhead, R. E. Hill, and S. Artavanis-Tsakonas. 1992. Human homologs of a Drosophila Enhancer of Split gene product define a novel family of nuclear proteins. Nat. Genet. 2:119-127.
49. Struhl, K. 1998. Histone acetylation and transcriptional regulatory mechanisms. Genes Dev. 12:599-606.
50. Taunton, J., C. A. Hassig, and S. L. Schreiber. 1996. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272:408-411.
51. Th'ng, J. P. H., X.-W. Guo, R. A. Swank, H. A. Crissman, and E. M. Bradbury. 1994. Inhibition of mitotic histone phosphorylation by staurosporine leads to chromosome decondensation. J. Biol. Chem. 269:9568-9573.
52. Uejima, H., T. Shinohara, Y. Nakayama, H. Kugoh, and M. Oshimura. 1998. Mapping a novel cellular-senescence gene to human chromosome 2q37 by irradiation microcell-mediated chromosome transfer. Mol. Carcinog. 22:34-45.
53. van Holde, K. E. 1989. Chromatin. Springer-Verlag, Berlin, Germany.
54. Verdel, A. and S. Khochbin. 1999. Identification of a new family of higher eukaryotic histone deacetylases. J. Biol. Chem. 274:2440-2445.
55. Wolfe, A. 1995. Chromatin: structure and function, 2nd ed. Academic Press, Harcourt Brace & Company, New York, N.Y.
56. Wolle, A. P. 1997. Transcriptional control: sinful repression. Nature 387:16-17.
57. Workman, J. L., and R. E. Kingston. 1998. Alteration of nucleosome structure as a mechanism of transcriptional regulation. Annu. Rev. Biochem. 67:545-579.
58. Yang, W. M., C. Inouye, Y. Zeng, D. Bearss, and E. Seto. 1996. Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3. Proc. Natl. Acad. Sci. USA 93: 12845-12850.
59. Yang, W. M., Y. L. Yao, J. M. Sun, J. R. Davie, and E. Seto. 1997. Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family. J. Biol. Chem. 272:28001-28007.
60. Yang, X. J., V. V. Ogryzko, J. Nishikawa, B. H. Howard, and Y. Nakatani. 1996. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature 382:319-324.
61. Yew, P. R., X. Liu, and A. J. Berk. 1994. Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53. Genes Dev. 8:190-202.
62. Zhang, Y., R. Iratni, H. Erdjument-Bromage, P. Tempst, and D. Reinberg. 1997. Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex. Cell 89:357-64.
63. Zhao, M., L. New, V. V. Kravchenko, Y. Kato, H. Gram, F. D. Padova, E. N. Olson, R. J. Ulevitch, and J. Han. 1998. Regulation of the MEF2 family of transcription factors by p38. Mol. Cell. Biol. 19:21-30.