-
1
-
-
84867758122
-
BET bromodomain inhibition as a novel strategy for reactivation of HIV-1
-
C. Banerjee, N. Archin, D. Michaels, A.C. Belkina, G.V. Denis, J. Bradner, P. Sebastiani, D.M. Margolis, and M. Montano BET bromodomain inhibition as a novel strategy for reactivation of HIV-1 J. Leukoc. Biol. 92 2012 1147 1154
-
(2012)
J. Leukoc. Biol.
, vol.92
, pp. 1147-1154
-
-
Banerjee, C.1
Archin, N.2
Michaels, D.3
Belkina, A.C.4
Denis, G.V.5
Bradner, J.6
Sebastiani, P.7
Margolis, D.M.8
Montano, M.9
-
3
-
-
78649866399
-
Constitutively active calcineurin induces cardiac endoplasmic reticulum stress and protects against apoptosis that is mediated by alpha-crystallin-B
-
N. Bousette, S. Chugh, V. Fong, R. Isserlin, K.H. Kim, A. Volchuk, P.H. Backx, P. Liu, T. Kislinger, and D.H. MacLennan Constitutively active calcineurin induces cardiac endoplasmic reticulum stress and protects against apoptosis that is mediated by alpha-crystallin-B Proc. Natl. Acad. Sci. USA 107 2010 18481 18486
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 18481-18486
-
-
Bousette, N.1
Chugh, S.2
Fong, V.3
Isserlin, R.4
Kim, K.H.5
Volchuk, A.6
Backx, P.H.7
Liu, P.8
Kislinger, T.9
Maclennan, D.H.10
-
5
-
-
80052955256
-
BET bromodomain inhibition as a therapeutic strategy to target c-Myc
-
J.E. Delmore, G.C. Issa, M.E. Lemieux, P.B. Rahl, J. Shi, H.M. Jacobs, E. Kastritis, T. Gilpatrick, R.M. Paranal, and J. Qi BET bromodomain inhibition as a therapeutic strategy to target c-Myc Cell 146 2011 904 917
-
(2011)
Cell
, vol.146
, pp. 904-917
-
-
Delmore, J.E.1
Issa, G.C.2
Lemieux, M.E.3
Rahl, P.B.4
Shi, J.5
Jacobs, H.M.6
Kastritis, E.7
Gilpatrick, T.8
Paranal, R.M.9
Qi, J.10
-
6
-
-
0344464733
-
Gene Expression Dynamics Inspector (GEDI): For integrative analysis of expression profiles
-
G.S. Eichler, S. Huang, and D.E. Ingber Gene Expression Dynamics Inspector (GEDI): for integrative analysis of expression profiles Bioinformatics 19 2003 2321 2322
-
(2003)
Bioinformatics
, vol.19
, pp. 2321-2322
-
-
Eichler, G.S.1
Huang, S.2
Ingber, D.E.3
-
7
-
-
67650227687
-
Positive transcription elongation factor b activity in compensatory myocardial hypertrophy is regulated by cardiac lineage protein-1
-
J. Espinoza-Derout, M. Wagner, L. Salciccioli, J.M. Lazar, S. Bhaduri, E. Mascareno, B. Chaqour, and M.A. Siddiqui Positive transcription elongation factor b activity in compensatory myocardial hypertrophy is regulated by cardiac lineage protein-1 Circ. Res. 104 2009 1347 1354
-
(2009)
Circ. Res.
, vol.104
, pp. 1347-1354
-
-
Espinoza-Derout, J.1
Wagner, M.2
Salciccioli, L.3
Lazar, J.M.4
Bhaduri, S.5
Mascareno, E.6
Chaqour, B.7
Siddiqui, M.A.8
-
8
-
-
78650847770
-
Selective inhibition of BET bromodomains
-
P. Filippakopoulos, J. Qi, S. Picaud, Y. Shen, W.B. Smith, O. Fedorov, E.M. Morse, T. Keates, T.T. Hickman, and I. Felletar Selective inhibition of BET bromodomains Nature 468 2010 1067 1073
-
(2010)
Nature
, vol.468
, pp. 1067-1073
-
-
Filippakopoulos, P.1
Qi, J.2
Picaud, S.3
Shen, Y.4
Smith, W.B.5
Fedorov, O.6
Morse, E.M.7
Keates, T.8
Hickman, T.T.9
Felletar, I.10
-
9
-
-
84859181036
-
Histone recognition and large-scale structural analysis of the human bromodomain family
-
P. Filippakopoulos, S. Picaud, M. Mangos, T. Keates, J.P. Lambert, D. Barsyte-Lovejoy, I. Felletar, R. Volkmer, S. Müller, and T. Pawson Histone recognition and large-scale structural analysis of the human bromodomain family Cell 149 2012 214 231
-
(2012)
Cell
, vol.149
, pp. 214-231
-
-
Filippakopoulos, P.1
Picaud, S.2
Mangos, M.3
Keates, T.4
Lambert, J.P.5
Barsyte-Lovejoy, D.6
Felletar, I.7
Volkmer, R.8
Müller, S.9
Pawson, T.10
-
10
-
-
33748745399
-
Transcriptional genomics associates FOX transcription factors with human heart failure
-
S. Hannenhalli, M.E. Putt, J.M. Gilmore, J. Wang, M.S. Parmacek, J.A. Epstein, E.E. Morrisey, K.B. Margulies, and T.P. Cappola Transcriptional genomics associates FOX transcription factors with human heart failure Circulation 114 2006 1269 1276
-
(2006)
Circulation
, vol.114
, pp. 1269-1276
-
-
Hannenhalli, S.1
Putt, M.E.2
Gilmore, J.M.3
Wang, J.4
Parmacek, M.S.5
Epstein, J.A.6
Morrisey, E.E.7
Margulies, K.B.8
Cappola, T.P.9
-
11
-
-
67649648237
-
Control of inducible gene expression by signal-dependent transcriptional elongation
-
D.C. Hargreaves, T. Horng, and R. Medzhitov Control of inducible gene expression by signal-dependent transcriptional elongation Cell 138 2009 129 145
-
(2009)
Cell
, vol.138
, pp. 129-145
-
-
Hargreaves, D.C.1
Horng, T.2
Medzhitov, R.3
-
12
-
-
36049037185
-
Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart
-
J. Heineke, M. Auger-Messier, J. Xu, T. Oka, M.A. Sargent, A. York, R. Klevitsky, S. Vaikunth, S.A. Duncan, and B.J. Aronow Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart J. Clin. Invest. 117 2007 3198 3210
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 3198-3210
-
-
Heineke, J.1
Auger-Messier, M.2
Xu, J.3
Oka, T.4
Sargent, M.A.5
York, A.6
Klevitsky, R.7
Vaikunth, S.8
Duncan, S.A.9
Aronow, B.J.10
-
14
-
-
23744514308
-
The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription
-
M.K. Jang, K. Mochizuki, M. Zhou, H.S. Jeong, J.N. Brady, and K. Ozato The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription Mol. Cell 19 2005 523 534
-
(2005)
Mol. Cell
, vol.19
, pp. 523-534
-
-
Jang, M.K.1
Mochizuki, K.2
Zhou, M.3
Jeong, H.S.4
Brady, J.N.5
Ozato, K.6
-
15
-
-
0004788326
-
Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways
-
Y.W. Jiang, P. Veschambre, H. Erdjument-Bromage, P. Tempst, J.W. Conaway, R.C. Conaway, and R.D. Kornberg Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways Proc. Natl. Acad. Sci. USA 95 1998 8538 8543
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 8538-8543
-
-
Jiang, Y.W.1
Veschambre, P.2
Erdjument-Bromage, H.3
Tempst, P.4
Conaway, J.W.5
Conaway, R.C.6
Kornberg, R.D.7
-
16
-
-
84875198920
-
Transcriptional regulation and its misregulation in disease
-
T.I. Lee, and R.A. Young Transcriptional regulation and its misregulation in disease Cell 152 2013 1237 1251
-
(2013)
Cell
, vol.152
, pp. 1237-1251
-
-
Lee, T.I.1
Young, R.A.2
-
17
-
-
0025280867
-
Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study
-
D. Levy, R.J. Garrison, D.D. Savage, W.B. Kannel, and W.P. Castelli Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study N. Engl. J. Med. 322 1990 1561 1566
-
(1990)
N. Engl. J. Med.
, vol.322
, pp. 1561-1566
-
-
Levy, D.1
Garrison, R.J.2
Savage, D.D.3
Kannel, W.B.4
Castelli, W.P.5
-
18
-
-
84867021989
-
Transcriptional amplification in tumor cells with elevated c-Myc
-
C.Y. Lin, J. Lovén, P.B. Rahl, R.M. Paranal, C.B. Burge, J.E. Bradner, T.I. Lee, and R.A. Young Transcriptional amplification in tumor cells with elevated c-Myc Cell 151 2012 56 67
-
(2012)
Cell
, vol.151
, pp. 56-67
-
-
Lin, C.Y.1
Lovén, J.2
Rahl, P.B.3
Paranal, R.M.4
Burge, C.B.5
Bradner, J.E.6
Lee, T.I.7
Young, R.A.8
-
19
-
-
84876222028
-
Selective inhibition of tumor oncogenes by disruption of super-enhancers
-
J. Lovén, H.A. Hoke, C.Y. Lin, A. Lau, D.A. Orlando, C.R. Vakoc, J.E. Bradner, T.I. Lee, and R.A. Young Selective inhibition of tumor oncogenes by disruption of super-enhancers Cell 153 2013 320 334
-
(2013)
Cell
, vol.153
, pp. 320-334
-
-
Lovén, J.1
Hoke, H.A.2
Lin, C.Y.3
Lau, A.4
Orlando, D.A.5
Vakoc, C.R.6
Bradner, J.E.7
Lee, T.I.8
Young, R.A.9
-
20
-
-
84863946664
-
Cardiomyocyte-specific IκB kinase (IKK)/NF-κB activation induces reversible inflammatory cardiomyopathy and heart failure
-
H.J. Maier, T.G. Schips, A. Wietelmann, M. Krüger, C. Brunner, M. Sauter, K. Klingel, T. Böttger, T. Braun, and T. Wirth Cardiomyocyte- specific IκB kinase (IKK)/NF-κB activation induces reversible inflammatory cardiomyopathy and heart failure Proc. Natl. Acad. Sci. USA 109 2012 11794 11799
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 11794-11799
-
-
Maier, H.J.1
Schips, T.G.2
Wietelmann, A.3
Krüger, M.4
Brunner, C.5
Sauter, M.6
Klingel, K.7
Böttger, T.8
Braun, T.9
Wirth, T.10
-
21
-
-
16244378559
-
Mixed messages: Transcription patterns in failing and recovering human myocardium
-
K.B. Margulies, S. Matiwala, C. Cornejo, H. Olsen, W.A. Craven, and D. Bednarik Mixed messages: transcription patterns in failing and recovering human myocardium Circ. Res. 96 2005 592 599
-
(2005)
Circ. Res.
, vol.96
, pp. 592-599
-
-
Margulies, K.B.1
Matiwala, S.2
Cornejo, C.3
Olsen, H.4
Craven, W.A.5
Bednarik, D.6
-
22
-
-
84865229469
-
Small-molecule inhibition of BRDT for male contraception
-
M.M. Matzuk, M.R. McKeown, P. Filippakopoulos, Q. Li, L. Ma, J.E. Agno, M.E. Lemieux, S. Picaud, R.N. Yu, and J. Qi Small-molecule inhibition of BRDT for male contraception Cell 150 2012 673 684
-
(2012)
Cell
, vol.150
, pp. 673-684
-
-
Matzuk, M.M.1
McKeown, M.R.2
Filippakopoulos, P.3
Li, Q.4
Ma, L.5
Agno, J.E.6
Lemieux, M.E.7
Picaud, S.8
Yu, R.N.9
Qi, J.10
-
23
-
-
14644431730
-
Toward transcriptional therapies for the failing heart: Chemical screens to modulate genes
-
T.A. McKinsey, and E.N. Olson Toward transcriptional therapies for the failing heart: chemical screens to modulate genes J. Clin. Invest. 115 2005 538 546
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 538-546
-
-
McKinsey, T.A.1
Olson, E.N.2
-
24
-
-
34447511648
-
Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility
-
R.L. Montgomery, C.A. Davis, M.J. Potthoff, M. Haberland, J. Fielitz, X. Qi, J.A. Hill, J.A. Richardson, and E.N. Olson Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility Genes Dev. 21 2007 1790 1802
-
(2007)
Genes Dev.
, vol.21
, pp. 1790-1802
-
-
Montgomery, R.L.1
Davis, C.A.2
Potthoff, M.J.3
Haberland, M.4
Fielitz, J.5
Qi, X.6
Hill, J.A.7
Richardson, J.A.8
Olson, E.N.9
-
25
-
-
78650806593
-
Suppression of inflammation by a synthetic histone mimic
-
E. Nicodeme, K.L. Jeffrey, U. Schaefer, S. Beinke, S. Dewell, C.W. Chung, R. Chandwani, I. Marazzi, P. Wilson, and H. Coste Suppression of inflammation by a synthetic histone mimic Nature 468 2010 1119 1123
-
(2010)
Nature
, vol.468
, pp. 1119-1123
-
-
Nicodeme, E.1
Jeffrey, K.L.2
Schaefer, U.3
Beinke, S.4
Dewell, S.5
Chung, C.W.6
Chandwani, R.7
Marazzi, I.8
Wilson, P.9
Coste, H.10
-
26
-
-
84878966650
-
BRD4 coordinates recruitment of pause release factor P-TEFb and the pausing complex NELF/DSIF to regulate transcription elongation of interferon-stimulated genes
-
10.1128/MCB.01180-12
-
M.C. Patel, M. Debrosse, M. Smith, A. Dey, W. Huynh, N. Sarai, T.D. Heightman, T. Tamura, and K. Ozato BRD4 coordinates recruitment of pause release factor P-TEFb and the pausing complex NELF/DSIF to regulate transcription elongation of interferon-stimulated genes Mol. Cell. Biol. 33 2013 2497 2507 10.1128/MCB.01180-12
-
(2013)
Mol. Cell. Biol.
, vol.33
, pp. 2497-2507
-
-
Patel, M.C.1
Debrosse, M.2
Smith, M.3
Dey, A.4
Huynh, W.5
Sarai, N.6
Heightman, T.D.7
Tamura, T.8
Ozato, K.9
-
27
-
-
33746403681
-
Controlling the elongation phase of transcription with P-TEFb
-
B.M. Peterlin, and D.H. Price Controlling the elongation phase of transcription with P-TEFb Mol. Cell 23 2006 297 305
-
(2006)
Mol. Cell
, vol.23
, pp. 297-305
-
-
Peterlin, B.M.1
Price, D.H.2
-
28
-
-
77951920690
-
C-Myc regulates transcriptional pause release
-
P.B. Rahl, C.Y. Lin, A.C. Seila, R.A. Flynn, S. McCuine, C.B. Burge, P.A. Sharp, and R.A. Young c-Myc regulates transcriptional pause release Cell 141 2010 432 445
-
(2010)
Cell
, vol.141
, pp. 432-445
-
-
Rahl, P.B.1
Lin, C.Y.2
Seila, A.C.3
Flynn, R.A.4
McCuine, S.5
Burge, C.B.6
Sharp, P.A.7
Young, R.A.8
-
29
-
-
0025873338
-
Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy
-
H.A. Rockman, R.S. Ross, A.N. Harris, K.U. Knowlton, M.E. Steinhelper, L.J. Field, J. Ross Jr., and K.R. Chien Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy Proc. Natl. Acad. Sci. USA 88 1991 8277 8281
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 8277-8281
-
-
Rockman, H.A.1
Ross, R.S.2
Harris, A.N.3
Knowlton, K.U.4
Steinhelper, M.E.5
Field, L.J.6
Ross, Jr.J.7
Chien, K.R.8
-
30
-
-
84855396777
-
Executive summary: Heart disease and stroke statistics - 2012 update: A report from the American Heart Association
-
American Heart Association Statistics Committee and Stroke Statistics Subcommittee
-
V.L. Roger, A.S. Go, D.M. Lloyd-Jones, E.J. Benjamin, J.D. Berry, W.B. Borden, D.M. Bravata, S. Dai, E.S. Ford, C.S. Fox American Heart Association Statistics Committee and Stroke Statistics Subcommittee Executive summary: heart disease and stroke statistics - 2012 update: a report from the American Heart Association Circulation 125 2012 188 197
-
(2012)
Circulation
, vol.125
, pp. 188-197
-
-
Roger, V.L.1
Go, A.S.2
Lloyd-Jones, D.M.3
Benjamin, E.J.4
Berry, J.D.5
Borden, W.B.6
Bravata, D.M.7
Dai, S.8
Ford, E.S.9
Fox, C.S.10
-
31
-
-
0036851825
-
Activation and function of cyclin T-Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy
-
M. Sano, M. Abdellatif, H. Oh, M. Xie, L. Bagella, A. Giordano, L.H. Michael, F.J. DeMayo, and M.D. Schneider Activation and function of cyclin T-Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy Nat. Med. 8 2002 1310 1317
-
(2002)
Nat. Med.
, vol.8
, pp. 1310-1317
-
-
Sano, M.1
Abdellatif, M.2
Oh, H.3
Xie, M.4
Bagella, L.5
Giordano, A.6
Michael, L.H.7
Demayo, F.J.8
Schneider, M.D.9
-
32
-
-
33947520124
-
P53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload
-
M. Sano, T. Minamino, H. Toko, H. Miyauchi, M. Orimo, Y. Qin, H. Akazawa, K. Tateno, Y. Kayama, and M. Harada p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload Nature 446 2007 444 448
-
(2007)
Nature
, vol.446
, pp. 444-448
-
-
Sano, M.1
Minamino, T.2
Toko, H.3
Miyauchi, H.4
Orimo, M.5
Qin, Y.6
Akazawa, H.7
Tateno, K.8
Kayama, Y.9
Harada, M.10
-
33
-
-
84873863863
-
Transcriptional regulation patterns revealed by high resolution chromatin immunoprecipitation during cardiac hypertrophy
-
D. Sayed, M. He, Z. Yang, L. Lin, and M. Abdellatif Transcriptional regulation patterns revealed by high resolution chromatin immunoprecipitation during cardiac hypertrophy J. Biol. Chem. 288 2013 2546 2558
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 2546-2558
-
-
Sayed, D.1
He, M.2
Yang, Z.3
Lin, L.4
Abdellatif, M.5
-
34
-
-
0037074010
-
Signaling network model of chromatin
-
S.L. Schreiber, and B.E. Bernstein Signaling network model of chromatin Cell 111 2002 771 778
-
(2002)
Cell
, vol.111
, pp. 771-778
-
-
Schreiber, S.L.1
Bernstein, B.E.2
-
35
-
-
84864462544
-
A map of the cis-regulatory sequences in the mouse genome
-
Y. Shen, F. Yue, D.F. McCleary, Z. Ye, L. Edsall, S. Kuan, U. Wagner, J. Dixon, L. Lee, V.V. Lobanenkov, and B. Ren A map of the cis-regulatory sequences in the mouse genome Nature 488 2012 116 120
-
(2012)
Nature
, vol.488
, pp. 116-120
-
-
Shen, Y.1
Yue, F.2
McCleary, D.F.3
Ye, Z.4
Edsall, L.5
Kuan, S.6
Wagner, U.7
Dixon, J.8
Lee, L.9
Lobanenkov, V.V.10
Ren, B.11
-
36
-
-
0020411183
-
Myocyte hypertrophy in neonatal rat heart cultures and its regulation by serum and by catecholamines
-
P. Simpson, A. McGrath, and S. Savion Myocyte hypertrophy in neonatal rat heart cultures and its regulation by serum and by catecholamines Circ. Res. 51 1982 787 801
-
(1982)
Circ. Res.
, vol.51
, pp. 787-801
-
-
Simpson, P.1
McGrath, A.2
Savion, S.3
-
37
-
-
78649668307
-
MTOR attenuates the inflammatory response in cardiomyocytes and prevents cardiac dysfunction in pathological hypertrophy
-
X. Song, Y. Kusakari, C.Y. Xiao, S.D. Kinsella, M.A. Rosenberg, M. Scherrer-Crosbie, K. Hara, A. Rosenzweig, and T. Matsui mTOR attenuates the inflammatory response in cardiomyocytes and prevents cardiac dysfunction in pathological hypertrophy Am. J. Physiol. Cell Physiol. 299 2010 C1256 C1266
-
(2010)
Am. J. Physiol. Cell Physiol.
, vol.299
-
-
Song, X.1
Kusakari, Y.2
Xiao, C.Y.3
Kinsella, S.D.4
Rosenberg, M.A.5
Scherrer-Crosbie, M.6
Hara, K.7
Rosenzweig, A.8
Matsui, T.9
-
38
-
-
84859879034
-
Deep RNA sequencing reveals novel cardiac transcriptomic signatures for physiological and pathological hypertrophy
-
H.K. Song, S.E. Hong, T. Kim, and H. Kim Deep RNA sequencing reveals novel cardiac transcriptomic signatures for physiological and pathological hypertrophy PLoS ONE 7 2012 e35552
-
(2012)
PLoS ONE
, vol.7
, pp. 35552
-
-
Song, H.K.1
Hong, S.E.2
Kim, T.3
Kim, H.4
-
39
-
-
27344435774
-
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
-
A. Subramanian, P. Tamayo, V.K. Mootha, S. Mukherjee, B.L. Ebert, M.A. Gillette, A. Paulovich, S.L. Pomeroy, T.R. Golub, E.S. Lander, and J.P. Mesirov Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles Proc. Natl. Acad. Sci. USA 102 2005 15545 15550
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 15545-15550
-
-
Subramanian, A.1
Tamayo, P.2
Mootha, V.K.3
Mukherjee, S.4
Ebert, B.L.5
Gillette, M.A.6
Paulovich, A.7
Pomeroy, S.L.8
Golub, T.R.9
Lander, E.S.10
Mesirov, J.P.11
-
40
-
-
33847695362
-
Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity
-
C.M. Trivedi, Y. Luo, Z. Yin, M. Zhang, W. Zhu, T. Wang, T. Floss, M. Goettlicher, P.R. Noppinger, and W. Wurst Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity Nat. Med. 13 2007 324 331
-
(2007)
Nat. Med.
, vol.13
, pp. 324-331
-
-
Trivedi, C.M.1
Luo, Y.2
Yin, Z.3
Zhang, M.4
Zhu, W.5
Wang, T.6
Floss, T.7
Goettlicher, M.8
Noppinger, P.R.9
Wurst, W.10
-
41
-
-
79961091829
-
Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo
-
J.H. van Berlo, J.W. Elrod, B.J. Aronow, W.T. Pu, and J.D. Molkentin Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo Proc. Natl. Acad. Sci. USA 108 2011 12331 12336
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 12331-12336
-
-
Van Berlo, J.H.1
Elrod, J.W.2
Aronow, B.J.3
Pu, W.T.4
Molkentin, J.D.5
-
42
-
-
84873868258
-
Signaling effectors underlying pathologic growth and remodeling of the heart
-
J.H. van Berlo, M. Maillet, and J.D. Molkentin Signaling effectors underlying pathologic growth and remodeling of the heart J. Clin. Invest. 123 2013 37 45
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 37-45
-
-
Van Berlo, J.H.1
Maillet, M.2
Molkentin, J.D.3
-
43
-
-
44349116852
-
The transition from transcriptional initiation to elongation
-
J.T. Wade, and K. Struhl The transition from transcriptional initiation to elongation Curr. Opin. Genet. Dev. 18 2008 130 136
-
(2008)
Curr. Opin. Genet. Dev.
, vol.18
, pp. 130-136
-
-
Wade, J.T.1
Struhl, K.2
-
44
-
-
52049099175
-
Quantitative control of adaptive cardiac hypertrophy by acetyltransferase p300
-
J.Q. Wei, L.A. Shehadeh, J.M. Mitrani, M. Pessanha, T.I. Slepak, K.A. Webster, and N.H. Bishopric Quantitative control of adaptive cardiac hypertrophy by acetyltransferase p300 Circulation 118 2008 934 946
-
(2008)
Circulation
, vol.118
, pp. 934-946
-
-
Wei, J.Q.1
Shehadeh, L.A.2
Mitrani, J.M.3
Pessanha, M.4
Slepak, T.I.5
Webster, K.A.6
Bishopric, N.H.7
-
45
-
-
15244358503
-
Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals
-
X. Xie, J. Lu, E.J. Kulbokas, T.R. Golub, V. Mootha, K. Lindblad-Toh, E.S. Lander, and M. Kellis Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals Nature 434 2005 338 345
-
(2005)
Nature
, vol.434
, pp. 338-345
-
-
Xie, X.1
Lu, J.2
Kulbokas, E.J.3
Golub, T.R.4
Mootha, V.5
Lindblad-Toh, K.6
Lander, E.S.7
Kellis, M.8
-
46
-
-
23744467035
-
Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4
-
Z. Yang, J.H. Yik, R. Chen, N. He, M.K. Jang, K. Ozato, and Q. Zhou Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4 Mol. Cell 19 2005 535 545
-
(2005)
Mol. Cell
, vol.19
, pp. 535-545
-
-
Yang, Z.1
Yik, J.H.2
Chen, R.3
He, N.4
Jang, M.K.5
Ozato, K.6
Zhou, Q.7
-
47
-
-
84871775620
-
Cardiomyocyte-specific overexpression of HEXIM1 prevents right ventricular hypertrophy in hypoxia-induced pulmonary hypertension in mice
-
N. Yoshikawa, N. Shimizu, T. Maruyama, M. Sano, T. Matsuhashi, K. Fukuda, M. Kataoka, T. Satoh, H. Ojima, and T. Sawai Cardiomyocyte-specific overexpression of HEXIM1 prevents right ventricular hypertrophy in hypoxia-induced pulmonary hypertension in mice PLoS ONE 7 2012 e52522
-
(2012)
PLoS ONE
, vol.7
, pp. 52522
-
-
Yoshikawa, N.1
Shimizu, N.2
Maruyama, T.3
Sano, M.4
Matsuhashi, T.5
Fukuda, K.6
Kataoka, M.7
Satoh, T.8
Ojima, H.9
Sawai, T.10
-
48
-
-
0037162697
-
Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy
-
C.L. Zhang, T.A. McKinsey, S. Chang, C.L. Antos, J.A. Hill, and E.N. Olson Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy Cell 110 2002 479 488
-
(2002)
Cell
, vol.110
, pp. 479-488
-
-
Zhang, C.L.1
McKinsey, T.A.2
Chang, S.3
Antos, C.L.4
Hill, J.A.5
Olson, E.N.6
-
49
-
-
84871160931
-
Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells
-
W. Zhang, C. Prakash, C. Sum, Y. Gong, Y. Li, J.J. Kwok, N. Thiessen, S. Pettersson, S.J. Jones, and S. Knapp Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells J. Biol. Chem. 287 2012 43137 43155
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 43137-43155
-
-
Zhang, W.1
Prakash, C.2
Sum, C.3
Gong, Y.4
Li, Y.5
Kwok, J.J.6
Thiessen, N.7
Pettersson, S.8
Jones, S.J.9
Knapp, S.10
-
50
-
-
11144320715
-
Microarray analysis of gene expression after transverse aortic constriction in mice
-
M. Zhao, A. Chow, J. Powers, G. Fajardo, and D. Bernstein Microarray analysis of gene expression after transverse aortic constriction in mice Physiol. Genomics 19 2004 93 105
-
(2004)
Physiol. Genomics
, vol.19
, pp. 93-105
-
-
Zhao, M.1
Chow, A.2
Powers, J.3
Fajardo, G.4
Bernstein, D.5
-
51
-
-
33748062350
-
Hypertrophic growth in cardiac myocytes is mediated by Myc through a Cyclin D2-dependent pathway
-
W. Zhong, S. Mao, S. Tobis, E. Angelis, M.C. Jordan, K.P. Roos, M.C. Fishbein, I.M. de Alborán, and W.R. MacLellan Hypertrophic growth in cardiac myocytes is mediated by Myc through a Cyclin D2-dependent pathway EMBO J. 25 2006 3869 3879
-
(2006)
EMBO J.
, vol.25
, pp. 3869-3879
-
-
Zhong, W.1
Mao, S.2
Tobis, S.3
Angelis, E.4
Jordan, M.C.5
Roos, K.P.6
Fishbein, M.C.7
De Alborán, I.M.8
Maclellan, W.R.9
-
52
-
-
80055000824
-
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
-
J. Zuber, J. Shi, E. Wang, A.R. Rappaport, H. Herrmann, E.A. Sison, D. Magoon, J. Qi, K. Blatt, and M. Wunderlich RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia Nature 478 2011 524 528
-
(2011)
Nature
, vol.478
, pp. 524-528
-
-
Zuber, J.1
Shi, J.2
Wang, E.3
Rappaport, A.R.4
Herrmann, H.5
Sison, E.A.6
Magoon, D.7
Qi, J.8
Blatt, K.9
Wunderlich, M.10
-
53
-
-
77952713824
-
RVX-208: A small molecule that increases apolipoprotein A-I and high-density lipoprotein cholesterol in vitro and in vivo
-
D. Bailey, R. Jahagirdar, A. Gordon, A. Hafiane, S. Campbell, S. Chatur, G.S. Wagner, H.C. Hansen, F.S. Chiacchia, and J. Johansson RVX-208: a small molecule that increases apolipoprotein A-I and high-density lipoprotein cholesterol in vitro and in vivo J Am Coll Cardiol 55 2010 2580 2589
-
(2010)
J Am Coll Cardiol
, vol.55
, pp. 2580-2589
-
-
Bailey, D.1
Jahagirdar, R.2
Gordon, A.3
Hafiane, A.4
Campbell, S.5
Chatur, S.6
Wagner, G.S.7
Hansen, H.C.8
Chiacchia, F.S.9
Johansson, J.10
-
54
-
-
79953137084
-
GATA6 promotes angiogenic function and survival in endothelial cells by suppression of autocrine transforming growth factor beta/activin receptor-like kinase 5 signaling
-
N. Froese, B. Kattih, A. Breitbart, A. Grund, R. Geffers, J.D. Molkentin, A. Kispert, K.C. Wollert, H. Drexler, and J. Heineke GATA6 promotes angiogenic function and survival in endothelial cells by suppression of autocrine transforming growth factor beta/activin receptor-like kinase 5 signaling J. Biol. Chem. 286 2011 5680 5690
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 5680-5690
-
-
Froese, N.1
Kattih, B.2
Breitbart, A.3
Grund, A.4
Geffers, R.5
Molkentin, J.D.6
Kispert, A.7
Wollert, K.C.8
Drexler, H.9
Heineke, J.10
-
55
-
-
77953015031
-
Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation
-
26ra26
-
S.M. Haldar, Y. Lu, D. Jeyaraj, D. Kawanami, Y. Cui, S.J. Eapen, C. Hao, Y. Li, Y.Q. Doughman, and M. Watanabe Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation Sci. Transl. Med. 2 2010 26ra26
-
(2010)
Sci. Transl. Med.
, vol.2
-
-
Haldar, S.M.1
Lu, Y.2
Jeyaraj, D.3
Kawanami, D.4
Cui, Y.5
Eapen, S.J.6
Hao, C.7
Li, Y.8
Doughman, Y.Q.9
Watanabe, M.10
-
56
-
-
84860168859
-
Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation
-
S.M. Haldar, D. Jeyaraj, P. Anand, H. Zhu, Y. Lu, D.A. Prosdocimo, B. Eapen, D. Kawanami, M. Okutsu, and L. Brotto Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation Proc. Natl. Acad. Sci. USA 109 2012 6739 6744
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 6739-6744
-
-
Haldar, S.M.1
Jeyaraj, D.2
Anand, P.3
Zhu, H.4
Lu, Y.5
Prosdocimo, D.A.6
Eapen, B.7
Kawanami, D.8
Okutsu, M.9
Brotto, L.10
-
57
-
-
0041357130
-
Minimally invasive aortic banding in mice: Effects of altered cardiomyocyte insulin signaling during pressure overload
-
P. Hu, D. Zhang, L. Swenson, G. Chakrabarti, E.D. Abel, and S.E. Litwin Minimally invasive aortic banding in mice: effects of altered cardiomyocyte insulin signaling during pressure overload Am. J. Physiol. Heart Circ. Physiol. 285 2003 H1261 H1269
-
(2003)
Am. J. Physiol. Heart Circ. Physiol.
, vol.285
-
-
Hu, P.1
Zhang, D.2
Swenson, L.3
Chakrabarti, G.4
Abel, E.D.5
Litwin, S.E.6
-
58
-
-
62349130698
-
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
-
B. Langmead, C. Trapnell, M. Pop, and S.L. Salzberg Ultrafast and memory-efficient alignment of short DNA sequences to the human genome Genome Biol. 10 2009 R25
-
(2009)
Genome Biol.
, vol.10
, pp. 25
-
-
Langmead, B.1
Trapnell, C.2
Pop, M.3
Salzberg, S.L.4
-
59
-
-
0035839475
-
The transcription factors GATA4 and GATA6 regulate cardiomyocyte hypertrophy in vitro and in vivo
-
Q. Liang, L.J. De Windt, S.A. Witt, T.R. Kimball, B.E. Markham, and J.D. Molkentin The transcription factors GATA4 and GATA6 regulate cardiomyocyte hypertrophy in vitro and in vivo J. Biol. Chem. 276 2001 30245 30253
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 30245-30253
-
-
Liang, Q.1
De Windt, L.J.2
Witt, S.A.3
Kimball, T.R.4
Markham, B.E.5
Molkentin, J.D.6
-
60
-
-
84862809492
-
Interaction between NFκB and NFAT coordinates cardiac hypertrophy and pathological remodeling
-
Q. Liu, Y. Chen, M. Auger-Messier, and J.D. Molkentin Interaction between NFκB and NFAT coordinates cardiac hypertrophy and pathological remodeling Circ. Res. 110 2012 1077 1086
-
(2012)
Circ. Res.
, vol.110
, pp. 1077-1086
-
-
Liu, Q.1
Chen, Y.2
Auger-Messier, M.3
Molkentin, J.D.4
-
61
-
-
84867316537
-
BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia
-
C.J. Ott, N. Kopp, L. Bird, R.M. Paranal, J. Qi, T. Bowman, S.J. Rodig, A.L. Kung, J.E. Bradner, and D.M. Weinstock BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia Blood 120 2012 2843 2852
-
(2012)
Blood
, vol.120
, pp. 2843-2852
-
-
Ott, C.J.1
Kopp, N.2
Bird, L.3
Paranal, R.M.4
Qi, J.5
Bowman, T.6
Rodig, S.J.7
Kung, A.L.8
Bradner, J.E.9
Weinstock, D.M.10
-
62
-
-
84878565710
-
PFI-1, a Highly Selective Protein Interaction Inhibitor, Targeting BET Bromodomains
-
S. Picaud, D. Da Costa, A. Thanasopoulou, P. Filippakopoulos, P.V. Fish, M. Philpott, O. Fedorov, P. Brennan, M.E. Bunnage, and D.R. Owen PFI-1, a Highly Selective Protein Interaction Inhibitor, Targeting BET Bromodomains Cancer Res 73 2013 3336 3346
-
(2013)
Cancer Res
, vol.73
, pp. 3336-3346
-
-
Picaud, S.1
Da Costa, D.2
Thanasopoulou, A.3
Filippakopoulos, P.4
Fish, P.V.5
Philpott, M.6
Fedorov, O.7
Brennan, P.8
Bunnage, M.E.9
Owen, D.R.10
-
63
-
-
53849146020
-
Model-based analysis of ChIP-Seq (MACS)
-
Y. Zhang, T. Liu, C.A. Meyer, J. Eeckhoute, D.S. Johnson, B.E. Bernstein, C. Nusbaum, R.M. Myers, M. Brown, W. Li, and X.S. Liu Model-based analysis of ChIP-Seq (MACS) Genome Biol. 9 2008 R137
-
(2008)
Genome Biol.
, vol.9
, pp. 137
-
-
Zhang, Y.1
Liu, T.2
Meyer, C.A.3
Eeckhoute, J.4
Johnson, D.S.5
Bernstein, B.E.6
Nusbaum, C.7
Myers, R.M.8
Brown, M.9
Li, W.10
Liu, X.S.11
|