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Volumn 13, Issue 4, 2016, Pages 321-342

Brain local and regional neuroglial alterations in alzheimer´s disease: Cell types, responses and implications

Author keywords

Alzheimer s disease; Astrogliosis; Glial eurodegeneration neuroprotection; Glial plasticity; Microgliosis; Neuroglial cells; Reactive neuroglial cells

Indexed keywords

ALZHEIMER DISEASE; ASTHENIA; ASTROCYTE; ASTROCYTOSIS; BRAIN ATROPHY; DEGENERATIVE DISEASE; GLIA; GLIA CELL; GLIOSIS; HISTOPATHOLOGY; HUMAN; IMMUNOCYTOCHEMISTRY; MACROGLIA; MICROGLIA; MORPHOLOGY; NERVE DEGENERATION; NEUROPROTECTION; OLIGODENDROGLIA; OLIGODENDROGLIOSIS; PRIORITY JOURNAL; REVIEW; BRAIN; CLASSIFICATION; COMPLICATION; METABOLISM; NERVOUS SYSTEM DISEASES; PATHOLOGY;

EID: 84964033796     PISSN: 15672050     EISSN: 18755828     Source Type: Journal    
DOI: 10.2174/1567205013666151116141217     Document Type: Review
Times cited : (16)

References (171)
  • 1
    • 17044420319 scopus 로고
    • Madrid: Publicaciones de la Residencia de Estudiantes
    • Ortega y Gasset J. Meditaciones del Quijote. Madrid: Publicaciones de la Residencia de Estudiantes (1914).
    • (1914) Meditaciones Del Quijote
    • Ortegagasset, J.1
  • 4
    • 0001619989 scopus 로고
    • Contribucion al conocimiento de la neuroglia del cerebro humano
    • Ramon, Cajal S. Contribucion al conocimiento de la neuroglia del cerebro humano. Trab Lab Invest Biol 11: 255-315 (1913).
    • (1913) Trab Lab Invest Biol , vol.11 , pp. 255-315
    • Ramon, Cajal, S.1
  • 5
    • 24444476230 scopus 로고
    • Contribution a la connaissance de la nevroglie cerebrale et cerebelleuse dans la paralysie generale progressive
    • Ramon A, Cajal S. Contribution a la connaissance de la nevroglie cerebrale et cerebelleuse dans la paralysie generale progressive. Trav. Lab Recher Biol Univ Madrid 23: 157-216 (1925).
    • (1925) Trav. Lab Recher Biol Univ Madrid , vol.23 , pp. 157-216
    • Ramon, A.1    Cajal, S.2
  • 6
    • 84923090828 scopus 로고
    • Die Neuroglia des Gehirns beim Menschen und bei Saugethieren: Die Neuroglia des Kleinhirns
    • Retzius G. Die Neuroglia des Gehirns beim Menschen und bei Saugethieren: Die Neuroglia des Kleinhirns. Biologische Untersuchungen. Neue Folge 6: 16-20 (1894).
    • (1894) Biologische Untersuchungen. Neue Folge , vol.6 , pp. 16-20
    • Retzius, G.1
  • 7
    • 10644290420 scopus 로고
    • Notiz ubre einige Structurverhaltnisse der Cerebellum und Ruckenmarks
    • Bergmann C. Notiz ubre einige Structurverhaltnisse der Cerebellum und Ruckenmarks. Z Rationelle Med 8: 360-363 (1857).
    • (1857) Z Rationelle Med , vol.8 , pp. 360-363
    • Bergmann, C.1
  • 8
    • 0347135459 scopus 로고    scopus 로고
    • Sulla fina anatomia del cervelletto umano
    • 8, January (1874). (Reprinted 1903, in: Opera Omnia, Istologia normale, 1870-1883. Milan: Ulrico Hoepli
    • Golgi C. Sulla fina anatomia del cervelletto umano. Lecture, Ist. Lomb Sci Lett (Milano) 8, January (1874). (Reprinted 1903, in: Opera Omnia, vol. 1: Istologia normale, 1870-1883. Milan: Ulrico Hoepli pp. 99-111).
    • Lecture, Ist. Lomb Sci Lett (Milano) , vol.1 , pp. 99-111
    • Golgi, C.1
  • 9
    • 0012088271 scopus 로고
    • Notas sobre la neuroglia del cerebelo y el crecimiento de los elementos nerviosos
    • Terrazas R. Notas sobre la neuroglia del cerebelo y el crecimiento de los elementos nerviosos. Rev Trim Micrograf II 49-65 (1897).
    • (1897) Rev Trim Micrograf II , pp. 49-65
    • Terrazas, R.1
  • 10
    • 0003136108 scopus 로고
    • El “tercer elemento” de los centros nerviosos. Poder fagocitario y movilidad de la microglia
    • Del Rio Hortega P. El “tercer elemento” de los centros nerviosos. Poder fagocitario y movilidad de la microglia. Bol Soc Esp Biol 8: 68-82 (1919).
    • (1919) Bol Soc Esp Biol , vol.8 , pp. 68-82
    • Del Rio Hortega, P.1
  • 11
    • 0001811790 scopus 로고
    • La glia de escasas radiaciones (Oligodendroglia)
    • Del Rio Hortega P. La glia de escasas radiaciones (oligodendroglia). Bol Real Soc Esp Hist Nat 21: 63-92 (1921).
    • (1921) Bol Real Soc Esp Hist Nat , vol.21 , pp. 63-92
    • Del Rio Hortega, P.1
  • 12
    • 0012366324 scopus 로고
    • Histogenesis y evolucion normal, exodo y distribucion regional de la microglia
    • Del Rio Hortega P. Histogenesis y evolucion normal, exodo y distribucion regional de la microglia. Mem Real Soci Esp Hist Nat 11: 213-268 (1921).
    • (1921) Mem Real Soci Esp Hist Nat , vol.11 , pp. 213-268
    • Del Rio Hortega, P.1
  • 13
    • 0001952315 scopus 로고
    • Neuroglia: Normal and pathological
    • In: Penfield W, Ed., New York: PB Hoeberr Inc
    • Penfield W. Neuroglia: normal and pathological. In: Penfield W, Ed. Cytology and cellular pathology of the nervous system. Vol 2. New York: PB Hoeberr Inc. pp. 423-479 (1932).
    • (1932) Cytology and Cellular Pathology of the Nervous System , vol.2 , pp. 423-479
    • Penfield, W.1
  • 14
    • 70349579720 scopus 로고    scopus 로고
    • Role of glutamate in neuron-glia metabolic coupling
    • Magistretti PJ. Role of glutamate in neuron-glia metabolic coupling. Am J Clin Nutr 90: 875S-880S (2009).
    • (2009) Am J Clin Nutr , vol.90 , pp. 875S-880S
    • Magistretti, P.J.1
  • 15
    • 84877872994 scopus 로고    scopus 로고
    • Oligodendroglia and neurotrophic factors in neurodegeneration
    • Bankston AN, Mandler MD, Feng Y. Oligodendroglia and neurotrophic factors in neurodegeneration. Neurosci Bull 29: 216-228 (2013).
    • (2013) Neurosci Bull , vol.29 , pp. 216-228
    • Bankston, A.N.1    Mandler, M.D.2    Feng, Y.3
  • 20
    • 0030174947 scopus 로고    scopus 로고
    • Glia-neuron intercommunications and synaptic plasticity
    • Vernadakis A. Glia-neuron intercommunications and synaptic plasticity. Prog Neurobiol 49: 185-214 (1996).
    • (1996) Prog Neurobiol , vol.49 , pp. 185-214
    • Vernadakis, A.1
  • 21
    • 0141533205 scopus 로고    scopus 로고
    • New roles for astrocytes: Redefining the functional architecture of the brain
    • Nedergaard M, Ransom B, Goldman SA. New roles for astrocytes: redefining the functional architecture of the brain. Trends Neurosci 26: 523-530 (2003).
    • (2003) Trends Neurosci , vol.26 , pp. 523-530
    • Nedergaard, M.1    Ransom, B.2    Goldman, S.A.3
  • 22
    • 84904009117 scopus 로고    scopus 로고
    • Sublime microglia: Expanding roles for the guardians of the CNS
    • Salter MW, Beggs S. Sublime microglia: expanding roles for the guardians of the CNS. Cell 158: 15-24 (2014).
    • (2014) Cell , vol.158 , pp. 15-24
    • Salter, M.W.1    Beggs, S.2
  • 24
    • 84884204132 scopus 로고    scopus 로고
    • Microglia: A new frontier for synaptic plasticity, learning and memory, and neurodegenerative disease research
    • Morris GP, Clark IA, Zinn R, Vissel B. Microglia: a new frontier for synaptic plasticity, learning and memory, and neurodegenerative disease research. Neurobiol Learn Mem 105: 40-53 (2013).
    • (2013) Neurobiol Learn Mem , vol.105 , pp. 40-53
    • Morris, G.P.1    Clark, I.A.2    Zinn, R.3    Vissel, B.4
  • 25
    • 84893827000 scopus 로고    scopus 로고
    • The role of astrocytes in the regulation of synaptic plasticity and memory formation
    • Ota Y, Zanetti AT, Hallock RM. The role of astrocytes in the regulation of synaptic plasticity and memory formation. Neural Plast 2013: 185463 (2013).
    • (2013) Neural Plast , pp. 2013
    • Ota, Y.1    Zanetti, A.T.2    Hallock, R.M.3
  • 27
    • 79551591722 scopus 로고    scopus 로고
    • Astrocyte-neuron metabolic relationships: For better and for worse
    • Allaman I, Belanger M, Magistretti PJ. Astrocyte-neuron metabolic relationships: for better and for worse. Trends Neurosci 34: 76-87 (2011).
    • (2011) Trends Neurosci , vol.34 , pp. 76-87
    • Allaman, I.1    Belanger, M.2    Magistretti, P.J.3
  • 28
    • 84897395530 scopus 로고    scopus 로고
    • Dynamic learning and memory, synaptic plasticity and neurogenesis: An update
    • Stuchlik A. Dynamic learning and memory, synaptic plasticity and neurogenesis: an update. Front Behav Neurosci 8: 106 (2014).
    • (2014) Front Behav Neurosci , vol.8
    • Stuchlik, A.1
  • 29
    • 65649124607 scopus 로고    scopus 로고
    • Morphological changes in hippocampal astrocytes induced by environmental enrichment in mice
    • Viola GG, Rodrigues L, Americo JC, Hansel G, Vargas RS, Biasibetti R, et al. Morphological changes in hippocampal astrocytes induced by environmental enrichment in mice. Brain Res 1274: 47-54 (2009).
    • (2009) Brain Res , vol.1274 , pp. 47-54
    • Viola, G.G.1    Rodrigues, L.2    Americo, J.C.3    Hansel, G.4    Vargas, R.S.5    Biasibetti, R.6
  • 31
    • 84907145248 scopus 로고    scopus 로고
    • Structural and functional plasticity of astrocyte processes and dendritic spine interactions
    • Perez-Alvarez A, Navarrete M, Covelo A, Martin ED, Araque A. Structural and functional plasticity of astrocyte processes and dendritic spine interactions. J Neurosci 34: 12738-12744 (2014).
    • (2014) J Neurosci , vol.34 , pp. 12738-12744
    • Perez-Alvarez, A.1    Navarrete, M.2    Covelo, A.3    Martin, E.D.4    Araque, A.5
  • 34
    • 0034608742 scopus 로고    scopus 로고
    • Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival
    • Meucci O, Fatatis A, Simen AA, Miller RJ. Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival. Proc Natl Acad Sci USA 97: 8075-8080 (2000).
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 8075-8080
    • Meucci, O.1    Fatatis, A.2    Simen, A.A.3    Miller, R.J.4
  • 35
    • 84860682848 scopus 로고    scopus 로고
    • Artifact versus reality--how astrocytes contribute to synaptic events
    • Nedergaard M, Verkhratsky A. Artifact versus reality--how astrocytes contribute to synaptic events. Glia 60: 1013-1023 (2012).
    • (2012) Glia , vol.60 , pp. 1013-1023
    • Nedergaard, M.1    Verkhratsky, A.2
  • 36
    • 84897954445 scopus 로고    scopus 로고
    • Microglial dysfunction in brain aging and Alzheimer’s disease
    • Mosher KI, Wyss-Coray T. Microglial dysfunction in brain aging and Alzheimer’s disease. Biochem Pharmacol 88: 594-604 (2014).
    • (2014) Biochem Pharmacol , vol.88 , pp. 594-604
    • Mosher, K.I.1    Wyss-Coray, T.2
  • 38
    • 33644508018 scopus 로고    scopus 로고
    • Diverse microglial responses after intrahippocampal administration of lipopolysaccharide
    • Herber DL, Maloney JL, Roth LM, Freeman MJ, Morgan D, Gordon MN. Diverse microglial responses after intrahippocampal administration of lipopolysaccharide. Glia 53: 382-391 (2006).
    • (2006) Glia , vol.53 , pp. 382-391
    • Herber, D.L.1    Maloney, J.L.2    Roth, L.M.3    Freeman, M.J.4    Morgan, D.5    Gordon, M.N.6
  • 39
    • 84884507439 scopus 로고    scopus 로고
    • Microglia: Multiple roles in surveillance, circuit shaping, and response to injury
    • Benarroch EE. Microglia: Multiple roles in surveillance, circuit shaping, and response to injury. Neurology 81: 1079-1088 (2013).
    • (2013) Neurology , vol.81 , pp. 1079-1088
    • Benarroch, E.E.1
  • 40
    • 84929917147 scopus 로고    scopus 로고
    • Glial asthenia and functional paralysis: A new perspective on neurodegeneration and Alzheimer’s disease
    • Verkhratsky A, Marutle A, Rodriguez-Arellano JJ, Nordberg A. Glial asthenia and functional paralysis: a new perspective on neurodegeneration and Alzheimer’s disease. Neuroscientist pii: 1073858414547132 (2014).
    • (2014) Neuroscientist
    • Verkhratsky, A.1    Marutle, A.2    Rodriguez-Arellano, J.J.3    Nordberg, A.4
  • 44
    • 34948886544 scopus 로고
    • Contribucion al estudio de la neuroglia en la corteza de la demencia senil y su participacion en la alteracion celular de Alzheimer
    • Achucarro N, Gayarre M. Contribucion al estudio de la neuroglia en la corteza de la demencia senil y su participacion en la alteracion celular de Alzheimer. Trab Lab Invest Biol Univ Madrid 12: 68-83 (1914).
    • (1914) Trab Lab Invest Biol Univ Madrid , vol.12 , pp. 68-83
    • Achucarro, N.1    Gayarre, M.2
  • 45
    • 84877806837 scopus 로고
    • La corteza cerebral en la demencia paralitica con el nuevo metodo del oro y sublimado de Cajal
    • Achucarro N, Gayarre M. La corteza cerebral en la demencia paralitica con el nuevo metodo del oro y sublimado de Cajal. Trab Lab Invest Biol Univ Madrid 12: 1-38 (1914).
    • (1914) Trab Lab Invest Biol Univ Madrid , vol.12 , pp. 1-38
    • Achucarro, N.1    Gayarre, M.2
  • 46
    • 84921791889 scopus 로고    scopus 로고
    • Astrocyte reactivity and reactive astrogliosis: Costs and benefits
    • Pekny M, Pekna M. Astrocyte reactivity and reactive astrogliosis: costs and benefits. Physiol Rev 94: 1077-1098 (2014).
    • (2014) Physiol Rev , vol.94 , pp. 1077-1098
    • Pekny, M.1    Pekna, M.2
  • 47
    • 84878755537 scopus 로고    scopus 로고
    • Clinical use of the calcium-binding S100B protein
    • Astrand R, Unden J, Romner B. Clinical use of the calcium-binding S100B protein. Methods Mol Biol 963: 373-384 (2013).
    • (2013) Methods Mol Biol , vol.963 , pp. 373-384
    • Astrand, R.1    Unden, J.2    Romner, B.3
  • 48
    • 84868113465 scopus 로고    scopus 로고
    • The potential role of proinflammatory and antiinflammatory cytokines in Alzheimer disease pathogenesis
    • Azizi G, Mirshafiey A. The potential role of proinflammatory and antiinflammatory cytokines in Alzheimer disease pathogenesis. Immunopharmacol Immunotoxicol 34: 881-895 (2012).
    • (2012) Immunopharmacol Immunotoxicol , vol.34 , pp. 881-895
    • Azizi, G.1    Mirshafiey, A.2
  • 50
    • 78649249224 scopus 로고    scopus 로고
    • Diversity and variability of the nicotine effects on different brain cortical regions. Therapeutic and toxicologic implications
    • Toledano A, Alvarez MI, Toledano-Diaz A. Diversity and variability of the nicotine effects on different brain cortical regions. Therapeutic and toxicologic implications. Central Nervous Syst Agents Med Chem 10: 180-206 (2010)
    • (2010) Central Nervous Syst Agents Med Chem , vol.10 , pp. 180-206
    • Toledano, A.1    Alvarez, M.I.2    Toledano-Diaz, A.3
  • 51
    • 84923117121 scopus 로고    scopus 로고
    • Astroglial cell subtypes in the cerebella of normal adults, elderly adults, and patients with Alzheimer’s disease: A histological and immunohistochemical comparison
    • Alvarez MI, Rivas L, Lacruz C, Toledano A. Astroglial cell subtypes in the cerebella of normal adults, elderly adults, and patients with Alzheimer’s disease: A histological and immunohistochemical comparison. Glia 62: 287-312 (2015).
    • (2015) Glia , vol.62 , pp. 287-312
    • Alvarez, M.I.1    Rivas, L.2    Lacruz, C.3    Toledano, A.4
  • 52
    • 0018679456 scopus 로고
    • The mode of migration of neurons to the hippocampus: A Golgi and electron microscopic analysis in foetal rhesus monkey
    • Nowakowski RS, Rakic P. The mode of migration of neurons to the hippocampus: a Golgi and electron microscopic analysis in foetal rhesus monkey. J Neurocytol 8: 697-718 (1979).
    • (1979) J Neurocytol , vol.8 , pp. 697-718
    • Nowakowski, R.S.1    Rakic, P.2
  • 53
    • 0029146905 scopus 로고
    • The concept of trophic units in the central nervous system
    • Agnati LF, Cortelli P, Pettersson R, Fuxe K. The concept of trophic units in the central nervous system. Prog Neurobiol 46: 561-574 (1995).
    • (1995) Prog Neurobiol , vol.46 , pp. 561-574
    • Agnati, L.F.1    Cortelli, P.2    Pettersson, R.3    Fuxe, K.4
  • 57
    • 0036139877 scopus 로고    scopus 로고
    • Protoplasmic astrocytes in CA1 stratum radiatum occupy separate anatomical domains
    • Bushong EA, Martone ME, Jones YZ, Ellisman MH. Protoplasmic astrocytes in CA1 stratum radiatum occupy separate anatomical domains. J Neurosci 22: 183-192 (2002).
    • (2002) J Neurosci , vol.22 , pp. 183-192
    • Bushong, E.A.1    Martone, M.E.2    Jones, Y.Z.3    Ellisman, M.H.4
  • 58
    • 34250317399 scopus 로고    scopus 로고
    • Synaptic islands defined by the territory of a single astrocyte
    • Halassa MM, Fellin T, Takano H, Dong JH, Haydon PG. Synaptic islands defined by the territory of a single astrocyte. J Neurosci 27: 6473-6477 (2007).
    • (2007) J Neurosci , vol.27 , pp. 6473-6477
    • Halassa, M.M.1    Fellin, T.2    Takano, H.3    Dong, J.H.4    Haydon, P.G.5
  • 60
    • 84930868738 scopus 로고    scopus 로고
    • Modeling cognition and disease using human glial chimeric mice
    • Goldman SA, Nedergaard M, Windrem MS. Modeling cognition and disease using human glial chimeric mice. Glia 63: 1483-1493 (2015).
    • (2015) Glia , vol.63 , pp. 1483-1493
    • Goldman, S.A.1    Nedergaard, M.2    Windrem, M.S.3
  • 62
    • 84911461133 scopus 로고    scopus 로고
    • Calcium-sensing receptors of human astrocyteneuron teams: Amyloid-β-driven mediators and therapeutic targets of Alzheimer’s disease
    • Dal Pra I, Chiarini A, Pacchiana R, Gardenal E, Chakravarthy B, Whitfield JF, et al. Calcium-sensing receptors of human astrocyteneuron teams: amyloid-β-driven mediators and therapeutic targets of Alzheimer’s disease. Curr Neuropharmacol 12: 353-364 (2014).
    • (2014) Curr Neuropharmacol , vol.12 , pp. 353-364
    • Dal Pra, I.1    Chiarini, A.2    Pacchiana, R.3    Gardenal, E.4    Chakravarthy, B.5    Whitfield, J.F.6
  • 63
    • 80051666509 scopus 로고    scopus 로고
    • The neurovascular unit in brain function and disease
    • Lecrux C, Hamel E. The neurovascular unit in brain function and disease. Acta Physiol (Oxf) 203: 47-59 (2011).
    • (2011) Acta Physiol (Oxf) , vol.203 , pp. 47-59
    • Lecrux, C.1    Hamel, E.2
  • 66
    • 84923857715 scopus 로고    scopus 로고
    • Imaging exocytosis and recycling of synapticlike microvesicles in astrocytes
    • Bezzi P, Volterra A. Imaging exocytosis and recycling of synapticlike microvesicles in astrocytes. Cold Spring Harb Protoc 2014(5) pii: pdb.prot081711 (2014).
    • (2014) Cold Spring Harb Protoc , Issue.5
    • Bezzi, P.1    Volterra, A.2
  • 67
    • 84879879175 scopus 로고    scopus 로고
    • Altered synapses and gliotransmission in Alzheimer’s disease and AD model mice
    • Mitew S, Kirkcaldie MT, Dickson TC, Vickers JC. Altered synapses and gliotransmission in Alzheimer’s disease and AD model mice. Neurobiol Aging 34: 2341-2351 (2013).
    • (2013) Neurobiol Aging , vol.34 , pp. 2341-2351
    • Mitew, S.1    Kirkcaldie, M.T.2    Dickson, T.C.3    Vickers, J.C.4
  • 68
    • 84887884739 scopus 로고    scopus 로고
    • Gliotransmission: Focus on exocytotic release of Lglutamate and D-serine from astrocytes
    • Martineau M. Gliotransmission: focus on exocytotic release of Lglutamate and D-serine from astrocytes. Biochem Soc Trans 41: 1557-61 (2013).
    • (2013) Biochem Soc Trans , vol.41 , pp. 1557-1561
    • Martineau, M.1
  • 69
    • 84879671420 scopus 로고    scopus 로고
    • Is there a cerebral lymphatic system?
    • Iliff JJ, Nedergaard M. Is there a cerebral lymphatic system? Stroke 44: S93-S95 (2013).
    • (2013) Stroke , vol.44 , pp. 93-95
    • Iliff, J.J.1    Nedergaard, M.2
  • 71
    • 84878243515 scopus 로고    scopus 로고
    • A phenotypic change but not proliferation underlies glial responses in Alzheimer disease
    • Serrano-Pozo A, Gomez-Isla T, Growdon JH, Frosch MP, Hyman BT. A phenotypic change but not proliferation underlies glial responses in Alzheimer disease. Am J Pathol 182: 2332-2344 (2013).
    • (2013) Am J Pathol , vol.182 , pp. 2332-2344
    • Serrano-Pozo, A.1    Gomez-Isla, T.2    Growdon, J.H.3    Frosch, M.P.4    Hyman, B.T.5
  • 72
    • 84865056621 scopus 로고    scopus 로고
    • GFAP isoforms in adult mouse brain with a focus on neurogenic astrocytes and reactive astrogliosis in mouse models of Alzheimer disease
    • Kamphuis W, Mamber C, Moeton M, Kooijman L, Sluijs JA, Jansen AH, et al. GFAP isoforms in adult mouse brain with a focus on neurogenic astrocytes and reactive astrogliosis in mouse models of Alzheimer disease. PLoS One 7(8): e42823 (2012).
    • (2012) Plos One , vol.7 , Issue.8
    • Kamphuis, W.1    Mamber, C.2    Moeton, M.3    Kooijman, L.4    Sluijs, J.A.5    Jansen, A.H.6
  • 73
    • 84889582306 scopus 로고    scopus 로고
    • Glial fibrillary acidic protein isoform expression in plaque related astrogliosis in Alzheimer’s disease
    • Kamphuis W, Middeldorp J, Kooijman L, Sluijs JA, Kooi EJ, Moeton M, et al. Glial fibrillary acidic protein isoform expression in plaque related astrogliosis in Alzheimer’s disease. Neurobiol Aging 35: 492-510 (2014).
    • (2014) Neurobiol Aging , vol.35 , pp. 492-510
    • Kamphuis, W.1    Middeldorp, J.2    Kooijman, L.3    Sluijs, J.A.4    Kooi, E.J.5    Moeton, M.6
  • 74
    • 84927962117 scopus 로고    scopus 로고
    • GFAP and vimentin eficiency alters gene expression in astrocytes and microglia in wild-type mice and changes the transcriptional response of reactive glia in mouse model for Alzheimer’s disease
    • Kamphuis W, Kooijman L, Orre M, Stassen O, Pekny M, Hol EM. GFAP and vimentin eficiency alters gene expression in astrocytes and microglia in wild-type mice and changes the transcriptional response of reactive glia in mouse model for Alzheimer’s disease. Glia 63: 1036-1056 (2015).
    • (2015) Glia , vol.63 , pp. 1036-1056
    • Kamphuis, W.1    Kooijman, L.2    Orre, M.3    Stassen, O.4    Pekny, M.5    Hol, E.M.6
  • 75
    • 84951077640 scopus 로고    scopus 로고
    • A reduced astrocyte response to β-amyloid plaques in the ageing brain associates with cognitive impairment
    • Mathur R, Ince PG, Minett T, Garwood CJ, Shaw PJ, Matthews FE, et al. A reduced astrocyte response to β-amyloid plaques in the ageing brain associates with cognitive impairment. PLoS One 10(2): e0118463 (2015).
    • (2015) Plos One , vol.10 , Issue.2
    • Mathur, R.1    Ince, P.G.2    Minett, T.3    Garwood, C.J.4    Shaw, P.J.5    Matthews, F.E.6
  • 76
    • 0031446195 scopus 로고    scopus 로고
    • Transgenic mice overexpressing the neurotrophic factor S-100 beta show neuronal cytoskeletal and behavioral signs of altered aging processes: Implications for Alzheimer’s disease and Down’s syndrome
    • Whitaker-Azmitia PM, Wingate M, Borella A, Gerlai R, Roder J, Azmitia EC. Transgenic mice overexpressing the neurotrophic factor S-100 beta show neuronal cytoskeletal and behavioral signs of altered aging processes: implications for Alzheimer’s disease and Down’s syndrome. Brain Res 776: 51-60 (1997).
    • (1997) Brain Res , vol.776 , pp. 51-60
    • Whitaker-Azmitia, P.M.1    Wingate, M.2    Borella, A.3    Gerlai, R.4    Roder, J.5    Azmitia, E.C.6
  • 77
    • 78650248298 scopus 로고    scopus 로고
    • Molecular comparison of GLT1+ and ALDH1L1+ astrocytes in vivo in astroglial reporter mice
    • Yang Y, Vidensky S, Jin L, Jie C, Lorenzini I, Frank M, Rothstein J. Molecular comparison of GLT1+ and ALDH1L1+ astrocytes in vivo in astroglial reporter mice. Glia 59: 200-207 (2011).
    • (2011) Glia , vol.59 , pp. 200-207
    • Yang, Y.1    Vidensky, S.2    Jin, L.3    Jie, C.4    Lorenzini, I.5    Frank, M.6    Rothstein, J.7
  • 78
    • 84925378535 scopus 로고    scopus 로고
    • Partial Loss of the Glutamate Transporter GLT-1. Alters Brain Akt and Insulin Signaling in a Mouse Model of Alzheimer’s Disease
    • Meeker KD, Meabon JS, Cook DG. Partial Loss of the Glutamate Transporter GLT-1. Alters Brain Akt and Insulin Signaling in a Mouse Model of Alzheimer’s Disease. J Alzheimers Dis 45: 509-520 (2015).
    • (2015) J Alzheimers Dis , vol.45 , pp. 509-520
    • Meeker, K.D.1    Meabon, J.S.2    Cook, D.G.3
  • 79
    • 84886311261 scopus 로고    scopus 로고
    • Astrocytes and glutamate homoeostasis in Alzheimer’s disease: A decrease in glutamine synthetase, but not in glutamate transporter-1, in the prefrontal cortex
    • Kulijewicz-Nawrot M, Sykova E, Chvatal A, Verkhratsky A, Rodriguez JJ. Astrocytes and glutamate homoeostasis in Alzheimer’s disease: a decrease in glutamine synthetase, but not in glutamate transporter-1, in the prefrontal cortex. ASN Neuro 5: 273-282 (2013).
    • (2013) ASN Neuro , vol.5 , pp. 273-282
    • Kulijewicz-Nawrot, M.1    Sykova, E.2    Chvatal, A.3    Verkhratsky, A.4    Rodriguez, J.J.5
  • 81
    • 69249222572 scopus 로고    scopus 로고
    • Astrocytes produce the antiinflammatory and neuroprotective agent hydrogen sulfide
    • Lee M, Schwab C, Yu S, McGeer E, McGeer PL. Astrocytes produce the antiinflammatory and neuroprotective agent hydrogen sulfide. Neurobiol Aging 30: 1523-1534 (2009).
    • (2009) Neurobiol Aging , vol.30 , pp. 1523-1534
    • Lee, M.1    Schwab, C.2    Yu, S.3    McGeer, E.4    McGeer, P.L.5
  • 82
    • 0343619405 scopus 로고    scopus 로고
    • Long-term evolution of local, proximal and remote astrocyte responses after diverse nucleus basalis lesioning (An experimental Alzheimer model): GFAP immunocytochemical study
    • Monzon-Mayor M, Alvarez M, Arbelo-Galvan J, Romero-Aleman M, Yanes C, et al. Long-term evolution of local, proximal and remote astrocyte responses after diverse nucleus basalis lesioning (an experimental Alzheimer model): GFAP immunocytochemical study. Brain Res 865: 245-258 (2000).
    • (2000) Brain Res , vol.865 , pp. 245-258
    • Monzon-Mayor, M.1    Alvarez, M.2    Arbelo-Galvan, J.3    Romero-Aleman, M.4    Yanes, C.5
  • 83
    • 0037012205 scopus 로고    scopus 로고
    • GFAP expression withdraws—a trend of glial evolution?
    • Kalman M. GFAP expression withdraws—a trend of glial evolution? Brain Res Bull 57: 509-511 (2002).
    • (2002) Brain Res Bull , vol.57 , pp. 509-511
    • Kalman, M.1
  • 84
    • 84866991708 scopus 로고    scopus 로고
    • Morphological and quantitative analysis of cerebellar cortical cells in Alzheimer’s disease
    • Stepień T, Wierzba-Bobrowicz T, Lewandowska E, Szpak G. Morphological and quantitative analysis of cerebellar cortical cells in Alzheimer’s disease. Folia Neuropathol 50: 250-260 (2012).
    • (2012) Folia Neuropathol , vol.50 , pp. 250-260
    • Stepień, T.1    Wierzba-Bobrowicz, T.2    Lewandowska, E.3    Szpak, G.4
  • 85
    • 0033460181 scopus 로고    scopus 로고
    • Amyloid precursor protein in the cerebellar cortex of Alzheimer’s disease patients devoid of cerebellar s-amyloid deposits. Immunocytochemical study of five cases
    • Toledano A, Alvarez MI, Rivas L, Lacruz C, Martinez-Rodriguez R. Amyloid precursor protein in the cerebellar cortex of Alzheimer’s disease patients devoid of cerebellar s-amyloid deposits. Immunocytochemical study of five cases. J Neural Trans 106: 1151-1169 (1999).
    • (1999) J Neural Trans , vol.106 , pp. 1151-1169
    • Toledano, A.1    Alvarez, M.I.2    Rivas, L.3    Lacruz, C.4    Martinez-Rodriguez, R.5
  • 86
    • 0027431231 scopus 로고
    • Tissue fixation methods alter the immunohistochemical demonstrability of neurofilament proteins, synpatophysin and glial fibrillary acidic protein in human cerebellum
    • Sillevis Smitt PAE, Van der Loos C, Vianney de Jong JMB, Troost D. Tissue fixation methods alter the immunohistochemical demonstrability of neurofilament proteins, synpatophysin and glial fibrillary acidic protein in human cerebellum. Acta Histochem 95: 13-21 (1993).
    • (1993) Acta Histochem , vol.95 , pp. 13-21
    • Sillevis Smitt, P.1    Van Der Loos, C.2    Vianney De Jong, J.3    Troost, D.4
  • 87
    • 33750596410 scopus 로고    scopus 로고
    • The expression of nNOS, iNOS and nitrotyrosine is increased in the rat cerebral cortex in experimental hepatic encephalopathy
    • Suarez I, Bodega G, Arilla E, Felipo V, Fernandez B. The expression of nNOS, iNOS and nitrotyrosine is increased in the rat cerebral cortex in experimental hepatic encephalopathy. Neuropathol Appl Neurobiol 32: 594-604 (2006).
    • (2006) Neuropathol Appl Neurobiol , vol.32 , pp. 594-604
    • Suarez, I.1    Bodega, G.2    Arilla, E.3    Felipo, V.4    Fernandez, B.5
  • 88
    • 0026065843 scopus 로고
    • Altered glial fibrillary acidic protein immunoreactivity in rat brain following chronic hypoxia
    • Zimmer C, Sampaolo S, Sharma HS, Cervos-Navarro J. Altered glial fibrillary acidic protein immunoreactivity in rat brain following chronic hypoxia. Neuroscience 40: 353-361 (1991).
    • (1991) Neuroscience , vol.40 , pp. 353-361
    • Zimmer, C.1    Sampaolo, S.2    Sharma, H.S.3    Cervos-Navarro, J.4
  • 89
    • 0029161762 scopus 로고
    • Age-induced hypertrophy of astrocytes in rat supraoptic nucleus: A cytological, morphometric, and immunocytochemical study
    • Berciano MT, Andres MA, Calle E, Lafarga M. Age-induced hypertrophy of astrocytes in rat supraoptic nucleus: a cytological, morphometric, and immunocytochemical study. Anat Rec 243: 129-144 (1995).
    • (1995) Anat Rec , vol.243 , pp. 129-144
    • Berciano, M.T.1    Res, M.A.2    Calle, E.3    Lafarga, M.4
  • 90
    • 0032103890 scopus 로고    scopus 로고
    • The effect of age and testosterone on the expression of glial fibrillary acidic protein in the rat cerebellum
    • Day RJ, Frank AT, O´Callaghan JP, Jones BC, Anderson JE. The effect of age and testosterone on the expression of glial fibrillary acidic protein in the rat cerebellum. Exp Neurol 151: 343-346 (1998).
    • (1998) Exp Neurol , vol.151 , pp. 343-346
    • Day, R.J.1    Frank, A.T.2    O´Callaghan, J.P.3    Jones, B.C.4    Erson, J.E.5
  • 91
    • 0034810795 scopus 로고    scopus 로고
    • Interleukin-1 beta is required for the early evolution of reactive astrogliosis following CNS lesion
    • Herx LM, Yong VW. Interleukin-1 beta is required for the early evolution of reactive astrogliosis following CNS lesion. J Neuropathol Exp Neurol 60: 961-971 (2001).
    • (2001) J Neuropathol Exp Neurol , vol.60 , pp. 961-971
    • Herx, L.M.1    Yong, V.W.2
  • 92
    • 2142768085 scopus 로고    scopus 로고
    • Effect of methylprednisolone on neuropathic pain and spinal glial activation in rats
    • Takeda K, Sawamura S, Sekiyama H, Tamai H, Hanaoka K. Effect of methylprednisolone on neuropathic pain and spinal glial activation in rats. Anesthesiology 100: 1249-1257 (2004).
    • (2004) Anesthesiology , vol.100 , pp. 1249-1257
    • Takeda, K.1    Sawamura, S.2    Sekiyama, H.3    Tamai, H.4    Hanaoka, K.5
  • 93
    • 0033557386 scopus 로고
    • Occurrence of the diffuse amyloid Abeta-containing glial cells in the cerebral cortex of patients with Alzheimer´s disease
    • Akiyama H, Mori H, Saido T, Kondo H, Ikeda K, Mc Geer PL. Occurrence of the diffuse amyloid Abeta-containing glial cells in the cerebral cortex of patients with Alzheimer´s disease. Glia 25: 324-331 (1991).
    • (1991) Glia , vol.25 , pp. 324-331
    • Akiyama, H.1    Mori, H.2    Saido, T.3    Kondo, H.4    Ikeda, K.5    Mc Geer, P.L.6
  • 94
    • 0027314268 scopus 로고
    • Molecular profile of reactive astrocytes— implications for their role in neurologic disease
    • Eddleston M, Mucke L. Molecular profile of reactive astrocytes— implications for their role in neurologic disease. Neuroscience 54: 15-36 (1993).
    • (1993) Neuroscience , vol.54 , pp. 15-36
    • Eddleston, M.1    Mucke, L.2
  • 95
    • 0035693234 scopus 로고    scopus 로고
    • Similar activation of glial cultures from different rat brain regions by neuroinflammatory stimuli and downregulation of the activation by a new class of small molecule ligands
    • Guo L, Sawkar A, Zasadzki M, Watterson DM, Van Eldik LJ. Similar activation of glial cultures from different rat brain regions by neuroinflammatory stimuli and downregulation of the activation by a new class of small molecule ligands. Neurobiol Aging 22: 975-981 (2001).
    • (2001) Neurobiol Aging , vol.22 , pp. 975-981
    • Guo, L.1    Sawkar, A.2    Zasadzki, M.3    Watterson, D.M.4    Van Eldik, L.J.5
  • 96
    • 0027511579 scopus 로고
    • Microglial and astroglial reactions to ischemic and kainic acid-induced lesions of the adult rat hippocampus
    • Jorgensen MB, Finsen BR, Jensen MB, Castellano B, Diemer NH, Zimmer J. Microglial and astroglial reactions to ischemic and kainic acid-induced lesions of the adult rat hippocampus. Exp Neurol 20: 70-88 (1993).
    • (1993) Exp Neurol , vol.20 , pp. 70-88
    • Jorgensen, M.B.1    Finsen, B.R.2    Jensen, M.B.3    Castellano, B.4    Diemer, N.H.5    Zimmer, J.6
  • 97
    • 84856990170 scopus 로고    scopus 로고
    • Early astrocytic atrophy in the entorhinal cortex of a triple transgenic animal model of Alzheimer’s disease
    • Yeh CY, Vadhwana B, Verkhratsky A, Rodriguez JJ. Early astrocytic atrophy in the entorhinal cortex of a triple transgenic animal model of Alzheimer’s disease. ASN Neuro 3: 271-279 (2011).
    • (2011) ASN Neuro , vol.3 , pp. 271-279
    • Yeh, C.Y.1    Vadhwana, B.2    Verkhratsky, A.3    Rodriguez, J.J.4
  • 98
    • 84864359502 scopus 로고    scopus 로고
    • Astrocytic cytoskeletal atrophy in the medial prefrontal cortex of a triple transgenic mouse model of Alzheimer’s disease
    • Kulijewicz-Nawrot M, Verkhratsky A, Chvatal A, Sykova E, Rodriguez JJ. Astrocytic cytoskeletal atrophy in the medial prefrontal cortex of a triple transgenic mouse model of Alzheimer’s disease. J Anat 221: 252-262 (2012).
    • (2012) J Anat , vol.221 , pp. 252-262
    • Kulijewicz-Nawrot, M.1    Verkhratsky, A.2    Chvatal, A.3    Sykova, E.4    Rodriguez, J.J.5
  • 99
    • 84890556640 scopus 로고    scopus 로고
    • Glutamine synthetase in astrocytes from entorhinal cortex of the triple transgenic animal model of Alzheimer’s disease is not affected by pathological progression
    • Yeh CY, Verkhratsky A, Terzieva S, Rodriguez JJ. Glutamine synthetase in astrocytes from entorhinal cortex of the triple transgenic animal model of Alzheimer’s disease is not affected by pathological progression. Biogerontology 14: 777-787 (2013).
    • (2013) Biogerontology , vol.14 , pp. 777-787
    • Yeh, C.Y.1    Verkhratsky, A.2    Terzieva, S.3    Rodriguez, J.J.4
  • 100
    • 66149116031 scopus 로고    scopus 로고
    • Oligodendrocytes: Susceptibility to injury and involvement in neurologic disease
    • Benarroch EE. Oligodendrocytes: Susceptibility to injury and involvement in neurologic disease. Neurology 72: 1779-1785 (2009).
    • (2009) Neurology , vol.72 , pp. 1779-1785
    • Benarroch, E.E.1
  • 101
    • 0042338688 scopus 로고    scopus 로고
    • Electrophysiologically "complex" glial cells freshly isolated from the hippocampus are immunopositive for the chondroitin sulfate proteoglycan NG2
    • Schools GP, Zhou M, Kimelberg HK. Electrophysiologically "complex" glial cells freshly isolated from the hippocampus are immunopositive for the chondroitin sulfate proteoglycan NG2. J Neurosci Res 73: 765-777 (2003).
    • (2003) J Neurosci Res , vol.73 , pp. 765-777
    • Schools, G.P.1    Zhou, M.2    Kimelberg, H.K.3
  • 102
    • 0023404196 scopus 로고
    • Light and electron microscopic localization of a cell surface antigen (NG2) in the rat cerebellum: Association with smooth protoplasmic astrocytes
    • Levine JM, Card JP. Light and electron microscopic localization of a cell surface antigen (NG2) in the rat cerebellum: association with smooth protoplasmic astrocytes. J Neurosci 7: 2711-2720 (1987).
    • (1987) J Neurosci , vol.7 , pp. 2711-2720
    • Levine, J.M.1    Card, J.P.2
  • 106
    • 84883454794 scopus 로고    scopus 로고
    • M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
    • Miron VE, Boyd A, Zhao JW, Yuen TJ, Ruckh JM, Shadrach JL, et al. M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination. Nat Neurosci 16: 1211-1218 (2013).
    • (2013) Nat Neurosci , vol.16 , pp. 1211-1218
    • Miron, V.E.1    Boyd, A.2    Zhao, J.W.3    Yuen, T.J.4    Ruckh, J.M.5    Shadrach, J.L.6
  • 107
    • 84938972696 scopus 로고    scopus 로고
    • Fibroblast growth factor signaling in oligodendrocyte-lineage cells facilitates recovery of chronically demyelinated lesions but is redundant in acute lesions
    • Furusho M, Roulois AJ, Franklin RJ, Bansal R. Fibroblast growth factor signaling in oligodendrocyte-lineage cells facilitates recovery of chronically demyelinated lesions but is redundant in acute lesions. Glia (in press) doi: 10.1002/glia.22838. (2015).
    • (2015) Glia
    • Furusho, M.1    Roulois, A.J.2    Franklin, R.J.3    Bansal, R.4
  • 108
    • 84904329951 scopus 로고    scopus 로고
    • The translational biology of remyelination: Past, present, and future
    • Franklin RJ, Gallo V. The translational biology of remyelination: past, present, and future. Glia 62: 1905-15 (2014).
    • (2014) Glia , vol.62 , pp. 1905-1915
    • Franklin, R.J.1    Gallo, V.2
  • 110
    • 84875655895 scopus 로고    scopus 로고
    • Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature
    • Wyss-Coray T, Rogers J. Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature. Cold Spring Harb Perspect Med 2(1): a006346 (2012).
    • (2012) Cold Spring Harb Perspect Med , vol.2 , Issue.1
    • Wyss-Coray, T.1    Rogers, J.2
  • 112
    • 80053233055 scopus 로고    scopus 로고
    • Heterogeneity of CNS myeloid cells and their roles in neurodegeneration
    • Prinz M, Priller J, Sisodia SS, Ransohoff RM. Heterogeneity of CNS myeloid cells and their roles in neurodegeneration. Nat Neurosci 14: 1227-1235 (2011).
    • (2011) Nat Neurosci , vol.14 , pp. 1227-1235
    • Prinz, M.1    Priller, J.2    Sisodia, S.S.3    Ransohoff, R.M.4
  • 113
    • 84893515578 scopus 로고    scopus 로고
    • Proliferation of parenchymal microglia is the main source of microgliosis after ischaemic stroke
    • Li T, Pang S, Yu Y, Wu X, Guo J, Zhang S. Proliferation of parenchymal microglia is the main source of microgliosis after ischaemic stroke. Brain 136: 3578-3588 (2013).
    • (2013) Brain , vol.136 , pp. 3578-3588
    • Li, T.1    Pang, S.2    Yu, Y.3    Wu, X.4    Guo, J.5    Zhang, S.6
  • 114
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • Nimmerjahn A, Kirchhoff F, Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308: 1314-1318 (2005).
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 115
    • 38949123792 scopus 로고    scopus 로고
    • Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer’s disease
    • Meyer-Luehmann M, Spires-Jones TL, Prada C, Garcia-Alloza M, de Calignon A et al. Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer’s disease. Nature 451: 720-724 (2008).
    • (2008) Nature , vol.451 , pp. 720-724
    • Meyer-Luehmann, M.1    Spires-Jones, T.L.2    Prada, C.3    Garcia-Alloza, M.4    De Calignon, A.5
  • 119
    • 79251560289 scopus 로고    scopus 로고
    • CD45 deficiency drives amyloid-β peptide oligomers and neuronal loss in Alzheimer’s disease mice
    • Zhu Y, Hou H, Rezai-Zadeh K, Giunta B, Ruscin A, Gemma C, et al. CD45 deficiency drives amyloid-β peptide oligomers and neuronal loss in Alzheimer’s disease mice. J Neurosci 31: 1355-1365 (2011).
    • (2011) J Neurosci , vol.31 , pp. 1355-1365
    • Zhu, Y.1    Hou, H.2    Rezai-Zadeh, K.3    Giunta, B.4    Ruscin, A.5    Gemma, C.6
  • 120
    • 84921476179 scopus 로고    scopus 로고
    • Temporal changes of CD68 and α7 nicotinic acetylcholine receptor expression in microglia in Alzheimer’s diseaselike mouse models
    • Matsumura A, Suzuki S, Iwahara N, Hisahara S, Kawamata J, Suzuki H, et al. Temporal changes of CD68 and α7 nicotinic acetylcholine receptor expression in microglia in Alzheimer’s diseaselike mouse models. J Alzheimers Dis 44: 409-423 (2015).
    • (2015) J Alzheimers Dis , vol.44 , pp. 409-423
    • Matsumura, A.1    Suzuki, S.2    Iwahara, N.3    Hisahara, S.4    Kawamata, J.5    Suzuki, H.6
  • 122
    • 84872706357 scopus 로고    scopus 로고
    • Review: Activation patterns of microglia and their identification in the human brain
    • Boche D, Perry VH, Nicoll JA. Review: activation patterns of microglia and their identification in the human brain. Neuropathol Appl Neurobiol 39: 3-18 (2013).
    • (2013) Neuropathol Appl Neurobiol , vol.39 , pp. 3-18
    • Boche, D.1    Perry, V.H.2    Nicoll, J.A.3
  • 123
    • 27744464859 scopus 로고    scopus 로고
    • The microglial "activation" continuum: From innate to adaptive responses
    • Town T, Nikolic V, Tan J. The microglial "activation" continuum: from innate to adaptive responses. J Neuroinflamm 2: 24 (2005).
    • (2005) J Neuroinflamm , vol.2
    • Town, T.1    Nikolic, V.2    Tan, J.3
  • 124
    • 70449526190 scopus 로고    scopus 로고
    • Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain
    • Colton CA. Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain. J Neuroimmune Pharmacol 4: 399-418 (2009).
    • (2009) J Neuroimmune Pharmacol , vol.4 , pp. 399-418
    • Colton, C.A.1
  • 125
    • 84891373720 scopus 로고    scopus 로고
    • Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro
    • Chhor V, Le Charpentier T, Lebon S, Ore MV, Celador IL, Josserand J, et al. Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro. Brain Behav Immun 32: 70-85 (2013).
    • (2013) Brain Behav Immun , vol.32 , pp. 70-85
    • Chhor, V.1    Le Charpentier, T.2    Lebon, S.3    Ore, M.V.4    Celador, I.L.5    Josserand, J.6
  • 126
    • 30044441094 scopus 로고    scopus 로고
    • Limiting inflammatory responses during activation of innate immunity
    • Han J, Ulevitch RJ. Limiting inflammatory responses during activation of innate immunity. Nat Immunol 6: 1198-1205 (2005).
    • (2005) Nat Immunol , vol.6 , pp. 1198-1205
    • Han, J.1    Ulevitch, R.J.2
  • 127
    • 84907015837 scopus 로고    scopus 로고
    • Opposing effects of membrane-anchored CX3CL1 on amyloid and tau pathologies via the p38 MAPK pathway
    • Lee S, Xu G, Jay TR, Bhatta S, Kim KW, Jung S, Landreth GE, et al. Opposing effects of membrane-anchored CX3CL1 on amyloid and tau pathologies via the p38 MAPK pathway. J Neurosci 34: 12538-12546 (2014).
    • (2014) J Neurosci , vol.34 , pp. 12538-12546
    • Lee, S.1    Xu, G.2    Jay, T.R.3    Bhatta, S.4    Kim, K.W.5    Jung, S.6    Landreth, G.E.7
  • 128
    • 84937113148 scopus 로고    scopus 로고
    • Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques
    • Condello C, Yuan P, Schain A, Grutzendler J. Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques. Nat Commun 6: 6176 (2015).
    • (2015) Nat Commun , vol.6 , pp. 6176
    • Condello, C.1    Yuan, P.2    Schain, A.3    Grutzendler, J.4
  • 129
    • 84861183285 scopus 로고    scopus 로고
    • Intracellular Aβ-oligomers and early inflammation in a model of Alzheimer’s disease
    • Ferretti MT, Bruno MA, Ducatenzeiler A, Klein WL, Cuello AC. Intracellular Aβ-oligomers and early inflammation in a model of Alzheimer’s disease. Neurobiol Aging 33: 1329-1342 (2012).
    • (2012) Neurobiol Aging , vol.33 , pp. 1329-1342
    • Ferretti, M.T.1    Bruno, M.A.2    Ducatenzeiler, A.3    Klein, W.L.4    Cuello, A.C.5
  • 131
    • 0026635173 scopus 로고
    • Phagocytosis and deposition of vascular beta-amyloid in rat brains injected with Alzheimer betaamyloid
    • Frautschy SA, Cole GM, Baird A. Phagocytosis and deposition of vascular beta-amyloid in rat brains injected with Alzheimer betaamyloid. Am J Pathol 140: 1389-1399 (1992).
    • (1992) Am J Pathol , vol.140 , pp. 1389-1399
    • Frautschy, S.A.1    Cole, G.M.2    Baird, A.3
  • 132
    • 84926365784 scopus 로고    scopus 로고
    • The effect of focal brain injury on beta-amyloid plaque deposition, inflammation and synapses in the APP/PS1 mouse model of Alzheimer’s disease
    • Collins JM, King AE, Woodhouse A, Kirkcaldie MT, Vickers J. The effect of focal brain injury on beta-amyloid plaque deposition, inflammation and synapses in the APP/PS1 mouse model of Alzheimer’s disease Exp Neurol 267: 219-229 (2015).
    • (2015) Exp Neurol , vol.267 , pp. 219-229
    • Collins, J.M.1    King, A.E.2    Woodhouse, A.3    Kirkcaldie, M.T.4    Vickers, J.5
  • 133
    • 84884217491 scopus 로고    scopus 로고
    • Increased densities of resting and activated microglia in the dentate gyrus follow senile plaque formation in the CA1 subfield of the hippocampus in the triple transgenic model of Alzheimer’s disease
    • Rodriguez JJ, Noristani HN, Hilditch T, Olabarria M, Yeh CY, Witton J, et al. Increased densities of resting and activated microglia in the dentate gyrus follow senile plaque formation in the CA1 subfield of the hippocampus in the triple transgenic model of Alzheimer’s disease. Neurosci Lett 552: 129-34 (2013).
    • (2013) Neurosci Lett , vol.552 , pp. 129-134
    • Rodriguez, J.J.1    Noristani, H.N.2    Hilditch, T.3    Olabarria, M.4    Yeh, C.Y.5    Witton, J.6
  • 134
    • 34547127632 scopus 로고    scopus 로고
    • Neuroprotective role of the innate immune system by microglia
    • Glezer I, Simard AR, Rivest S. Neuroprotective role of the innate immune system by microglia. Neuroscience 147: 867-883 (2007).
    • (2007) Neuroscience , vol.147 , pp. 867-883
    • Glezer, I.1    Simard, A.R.2    Rivest, S.3
  • 135
    • 0037310024 scopus 로고    scopus 로고
    • The many faces of macrophage activation
    • Mosser D.M. The many faces of macrophage activation. J Leukoc Biol 73: 209-212 (2003).
    • (2003) J Leukoc Biol , vol.73 , pp. 209-212
    • Mosser, D.M.1
  • 136
    • 0037265240 scopus 로고    scopus 로고
    • Alternative activation of macrophages
    • Gordon S. Alternative activation of macrophages. Nat Rev Immunol 3: 23-35 (2003).
    • (2003) Nat Rev Immunol , vol.3 , pp. 23-35
    • Gordon, S.1
  • 138
    • 28544446111 scopus 로고    scopus 로고
    • Monocyte and macrophage heterogeneity
    • Gordon S, Taylor PR. Monocyte and macrophage heterogeneity. Nat Rev Immunol 5: 953-964 (2005).
    • (2005) Nat Rev Immunol , vol.5 , pp. 953-964
    • Gordon, S.1    Taylor, P.R.2
  • 139
    • 33750036957 scopus 로고    scopus 로고
    • Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD
    • Colton CA, Mott RT, Sharpe H, Xu Q, Van Nostrand WE, Vitek MP. Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD. J Neuroinflamm 3: 27-39 (2006).
    • (2006) J Neuroinflamm , vol.3 , pp. 27-39
    • Colton, C.A.1    Mott, R.T.2    Sharpe, H.3    Xu, Q.4    Van Nostrand, W.E.5    Vitek, M.P.6
  • 140
    • 0029033167 scopus 로고
    • Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: Evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation
    • Barger SW, Horster D, Furukawa K, Goodman Y, Krieglstein J, Mattson MP. Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation. Proc Natl Acad Sci USA 92: 9328-9332 (1995).
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 9328-9332
    • Barger, S.W.1    Horster, D.2    Furukawa, K.3    Goodman, Y.4    Krieglstein, J.5    Mattson, M.P.6
  • 142
    • 0035255055 scopus 로고    scopus 로고
    • IL-4, IL-10 and IL-13 modulate A beta(1--42)-induced cytokine and chemokine production in primary murine microglia and a human monocyte cell line
    • Szczepanik AM, Funes S, Petko W, Ringheim GE. IL-4, IL-10 and IL-13 modulate A beta(1--42)-induced cytokine and chemokine production in primary murine microglia and a human monocyte cell line. J Neuroimmunol 113: 49-62 (2001).
    • (2001) J Neuroimmunol , vol.113 , pp. 49-62
    • Szczepanik, A.M.1    Funes, S.2    Petko, W.3    Ringheim, G.E.4
  • 143
    • 0025060307 scopus 로고
    • General and dramatic glial reaction in Alzheimer brains
    • Delacourte A. General and dramatic glial reaction in Alzheimer brains. Neurology 40: 33-37 (1990).
    • (1990) Neurology , vol.40 , pp. 33-37
    • Delacourte, A.1
  • 144
    • 0024824922 scopus 로고
    • Patterns of gliosis in Alzheimer’s disease and aging cerebrum
    • Beach TG, Walker R, McGeer EG. Patterns of gliosis in Alzheimer’s disease and aging cerebrum. Glia 2: 420-436 (1989).
    • (1989) Glia , vol.2 , pp. 420-436
    • Beach, T.G.1    Walker, R.2    McGeer, E.G.3
  • 145
    • 0029006492 scopus 로고
    • Synapse loss and gliosis in the molecular layer of the cerebral cortex in Alzheimer´s disease and in frontal lobe degeneration
    • Brun A, Liu X, Erikson C. Synapse loss and gliosis in the molecular layer of the cerebral cortex in Alzheimer´s disease and in frontal lobe degeneration. Neurodegeneration 4: 171-177 (1995).
    • (1995) Neurodegeneration , vol.4 , pp. 171-177
    • Brun, A.1    Liu, X.2    Erikson, C.3
  • 147
    • 84895067148 scopus 로고    scopus 로고
    • Does Alzheimer’s disease exist in all primates? Alzheimer pathology in non-human primates and its pathophysiological implications (II)
    • Toledano A, Alvarez MI, Lopez-Rodriguez AB, Toledano-Diaz A, Fernandez-Verdecia CI. Does Alzheimer’s disease exist in all primates? Alzheimer pathology in non-human primates and its pathophysiological implications (II). Neurologia 29: 42-55 (2014).
    • (2014) Neurologia , vol.29 , pp. 42-55
    • Toledano, A.1    Alvarez, M.I.2    Lopez-Rodriguez, A.B.3    Toledano-Diaz, A.4    Fernandez-Verdecia, C.I.5
  • 148
    • 84885456046 scopus 로고    scopus 로고
    • The amyloid cascade-inflammatory hypothesis of Alzheimer disease: Implications for therapy
    • McGeer PL, McGeer EG. The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy. Acta Neuropathol 126: 479-497 (2013).
    • (2013) Acta Neuropathol , vol.126 , pp. 479-497
    • McGeer, P.L.1    McGeer, E.G.2
  • 149
    • 84875481274 scopus 로고    scopus 로고
    • The triggering receptor expressed on myeloid cells 2: "TREM-ming" the inflammatory component associated with Alzheimer’s disease
    • Rohn TT. The triggering receptor expressed on myeloid cells 2: "TREM-ming" the inflammatory component associated with Alzheimer’s disease. Oxid Med Cell Longev 2013: 860959 (2013).
    • (2013) Oxid Med Cell Longev , vol.2013
    • Rohn, T.T.1
  • 150
    • 84883315336 scopus 로고    scopus 로고
    • Inflammatory components in human Alzheimer’s disease and after active amyloid-β42 immunization
    • Zotova E, Bharambe V, Cheaveau M, Morgan W, Holmes C, Harris S, et al. Inflammatory components in human Alzheimer’s disease and after active amyloid-β42 immunization. Brain 136: 2677-2696 (2013).
    • (2013) Brain , vol.136 , pp. 2677-2696
    • Zotova, E.1    Bharambe, V.2    Cheaveau, M.3    Morgan, W.4    Holmes, C.5    Harris, S.6
  • 151
    • 0032823758 scopus 로고    scopus 로고
    • Proliferation of microglia and astrocytes in the dentate gyrus following entorhinal cortex lesion: A quantitative bromodeoxyuridine-labelling study
    • Hailer NP, Grampp A, Nitsch R. Proliferation of microglia and astrocytes in the dentate gyrus following entorhinal cortex lesion: a quantitative bromodeoxyuridine-labelling study. Eur J Neurosci 11: 3359-3364 (1999).
    • (1999) Eur J Neurosci , vol.11 , pp. 3359-3364
    • Hailer, N.P.1    Grampp, A.2    Nitsch, R.3
  • 152
    • 36248971777 scopus 로고    scopus 로고
    • Mechanisms of amyloid plaque pathogenesis
    • Fiala JC. Mechanisms of amyloid plaque pathogenesis. Acta Neuropathol 114: 551-571 (2007).
    • (2007) Acta Neuropathol , vol.114 , pp. 551-571
    • Fiala, J.C.1
  • 153
    • 0026783591 scopus 로고
    • Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce beta-amyloid fibrils
    • Frackowiak J, Wisniewski HM, Wegiel J, Merz GS, Iqbal K, Wang KC. Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce beta-amyloid fibrils. Acta Neuropathol 84: 225-233 (1992).
    • (1992) Acta Neuropathol , vol.84 , pp. 225-233
    • Frackowiak, J.1    Wisniewski, H.M.2    Wegiel, J.3    Merz, G.S.4    Iqbal, K.5    Wang, K.C.6
  • 155
    • 84929992130 scopus 로고    scopus 로고
    • Envejecimiento cerebral normal y patologico: Continuum fisiopatologico o dualidad de procesos involutivos
    • Toledano A, Alvarez MI, Toledano-Diaz A. Envejecimiento cerebral normal y patologico: continuum fisiopatologico o dualidad de procesos involutivos. An Real Acad Farm 80: 500-539 (2014).
    • (2014) An Real Acad Farm , vol.80 , pp. 500-539
    • Toledano, A.1    Alvarez, M.I.2    Toledano-Diaz, A.3
  • 156
    • 33644619363 scopus 로고    scopus 로고
    • Soluble amyloid beta-peptide and myelin basic protein strongly stimulate, alone and in synergism with combined proinflammatory cytokines, the expression of functional nitric oxide synthase-2 in normal adult human astrocytes
    • Chiarini A, Dal Pra I, Menapace L, Pacchiana R, Whitfield JF, Armato U. Soluble amyloid beta-peptide and myelin basic protein strongly stimulate, alone and in synergism with combined proinflammatory cytokines, the expression of functional nitric oxide synthase-2 in normal adult human astrocytes. Int J Mol Med 16: 801-807 (2008).
    • (2008) Int J Mol Med , vol.16 , pp. 801-807
    • Chiarini, A.1    Dal Pra, I.2    Menapace, L.3    Pacchiana, R.4    Whitfield, J.F.5    Armato, U.6
  • 158
    • 65949085175 scopus 로고    scopus 로고
    • Calcium-sensing receptor (CaSR) in human brain’s pathophysiology: Roles in late-onset Alzheimer’s disease (LOAD)
    • Chiarini A, Dal Pra I, Marconi M, Chakravarthy B, Whitfield JF, Armato U. Calcium-sensing receptor (CaSR) in human brain’s pathophysiology: roles in late-onset Alzheimer’s disease (LOAD). Curr Pharm Biotechnol 10: 317-326 (2009).
    • (2009) Curr Pharm Biotechnol , vol.10 , pp. 317-326
    • Chiarini, A.1    Dal Pra, I.2    Marconi, M.3    Chakravarthy, B.4    Whitfield, J.F.5    Armato, U.6
  • 159
    • 84945443706 scopus 로고    scopus 로고
    • Models and mechanisms of vascular dementia
    • Venkat P, Chopp M, Chen J. Models and mechanisms of vascular dementia. Exp Neurol 15. pii: S0014-4886(15)00153-3 (2015).
    • (2015) Exp Neurol , vol.15
    • Venkat, P.1    Chopp, M.2    Chen, J.3
  • 161
    • 84935024077 scopus 로고    scopus 로고
    • Cerebral amyloid angiopathy: Emerging concepts
    • Yamada M. Cerebral amyloid angiopathy: emerging concepts. J Stroke 17: 17-30 (2015).
    • (2015) J Stroke , vol.17 , pp. 17-30
    • Yamada, M.1
  • 162
    • 84941935329 scopus 로고    scopus 로고
    • New cardiovascular targets to prevent late onset Alzheimer disease
    • Claassen JA. New cardiovascular targets to prevent late onset Alzheimer disease. Eur J Pharmacol 763(PtA): 131-4 (2015)
    • (2015) Eur J Pharmacol , vol.763 , pp. 131-134
    • Claassen, J.A.1
  • 163
    • 84863471166 scopus 로고    scopus 로고
    • Does Alzheimer’s disease exist in all primates? Alzheimer pathology in non-human primates and its pathophysiological implications (I)
    • Toledano A, Alvarez MI, Lopez-Rodriguez AB, Toledano-Diaz A, Fernandez-Verdecia CI. Does Alzheimer’s disease exist in all primates? Alzheimer pathology in non-human primates and its pathophysiological implications (I). Neurologia 27: 354-369 (2012).
    • (2012) Neurologia , vol.27 , pp. 354-369
    • Toledano, A.1    Alvarez, M.I.2    Lopez-Rodriguez, A.B.3    Toledano-Diaz, A.4    Fernandez-Verdecia, C.I.5
  • 165
    • 2342471420 scopus 로고    scopus 로고
    • The blood-brain barrier, an overview: Structure, regulation, and clinical implications
    • Ballabh P, Braun A, Nedergaard M. The blood-brain barrier, an overview: structure, regulation, and clinical implications. Neurobiol Dis 16: 1-13 (2004).
    • (2004) Neurobiol Dis , vol.16 , pp. 1-13
    • Ballabh, P.1    Braun, A.2    Nedergaard, M.3
  • 167
    • 74949127437 scopus 로고    scopus 로고
    • Formation and maintenance of Alzheimer’s disease beta-amyloid plaques in the absence of microglia
    • Grathwohl SA, Kalin RE, Bolmont T, Prokop S, Winkelmann G, Kaeser SA, et al. Formation and maintenance of Alzheimer’s disease beta-amyloid plaques in the absence of microglia. Nat Neurosci 12: 1361-1363 (2009).
    • (2009) Nat Neurosci , vol.12 , pp. 1361-1363
    • Grathwohl, S.A.1    Kalin, R.E.2    Bolmont, T.3    Prokop, S.4    Winkelmann, G.5    Kaeser, S.A.6
  • 168
    • 84911461133 scopus 로고    scopus 로고
    • Calcium-sensing receptors of human astrocyte-neuron teams: Amyloid-β-driven mediators and therapeutic targets of Alzheimer’s disease
    • Dal Pra I, Chiarini A, Pacchiana R, Gardenal E, Chakravarthy B, Whitfield JF, Armato U. Calcium-sensing receptors of human astrocyte-neuron teams: amyloid-β-driven mediators and therapeutic targets of Alzheimer’s disease. Curr Neuropharmacol 12: 353-364 (2014).
    • (2014) Curr Neuropharmacol , vol.12 , pp. 353-364
    • Dal Pra, I.1    Chiarini, A.2    Pacchiana, R.3    Gardenal, E.4    Chakravarthy, B.5    Whitfield, J.F.6    Armato, U.7
  • 169
    • 84878934982 scopus 로고    scopus 로고
    • Ca(2+) -dependent endoplasmic reticulum stress correlates with astrogliosis in oligomeric amyloid β-treated astrocytes and in a model of Alzheimer’s disease
    • Alberdi E, Wyssenbach A, Alberdi M, Sanchez-Gomez MV, Cavaliere F, Rodriguez JJ, Verkhratsky A, et al. Ca(2+) -dependent endoplasmic reticulum stress correlates with astrogliosis in oligomeric amyloid β-treated astrocytes and in a model of Alzheimer’s disease. Aging Cell 12: 292-302 (2013).
    • (2013) Aging Cell , vol.12 , pp. 292-302
    • Alberdi, E.1    Wyssenbach, A.2    Alberdi, M.3    Sanchez-Gomez, M.V.4    Cavaliere, F.5    Rodriguez, J.J.6    Verkhratsky, A.7
  • 170
    • 79955631182 scopus 로고    scopus 로고
    • The amyloid-β42 proxy, amyloid-β(25-35), induces normal human cerebral astrocytes to produce amyloid-β42
    • Dal Pra I, Whitfileld JF, Pacchiana R, Bonafini C, Talacchi A, Chakravarthy B, et al. The amyloid-β42 proxy, amyloid-β(25-35), induces normal human cerebral astrocytes to produce amyloid-β42. J Alzheimers Dis 24: 335-347 (2011).
    • (2011) J Alzheimers Dis , vol.24 , pp. 335-347
    • Dal Pra, I.1    Whitfileld, J.F.2    Pacchiana, R.3    Bonafini, C.4    Talacchi, A.5    Chakravarthy, B.6
  • 171
    • 77957272288 scopus 로고    scopus 로고
    • Amyloid-β(25-35), an amyloid-β(1-42) surrogate, and proinflammatory cytokines stimulate VEGF-A secretion by cultured, early passage, normoxic adult human cerebral astrocytes
    • Chiarini A, Whitfield J, Bonafini C, Chakravarthy B, Armato U, Dal Pra I. Amyloid-β(25-35), an amyloid-β(1-42) surrogate, and proinflammatory cytokines stimulate VEGF-A secretion by cultured, early passage, normoxic adult human cerebral astrocytes. J Alzheimers Dis 21: 915-926 (2010).
    • (2010) J Alzheimers Dis , vol.21 , pp. 915-926
    • Chiarini, A.1    Whitfield, J.2    Bonafini, C.3    Chakravarthy, B.4    Armato, U.5    Dal Pra, I.6


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