-
1
-
-
79957871035
-
Beta-amyloid activates PARP causing astrocytic metabolic failure and neuronal death
-
Abeti R, Abramov AY, Duchen MR (2011) Beta-amyloid activates PARP causing astrocytic metabolic failure and neuronal death. Brain 134, 1658-1672.
-
(2011)
Brain
, vol.134
, pp. 1658-1672
-
-
Abeti, R.1
Abramov, A.Y.2
Duchen, M.R.3
-
2
-
-
0038452658
-
Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity
-
Abramov AY, Canevari L, Duchen MR (2003) Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity. J. Neurosci. 23, 5088-5095.
-
(2003)
J. Neurosci.
, vol.23
, pp. 5088-5095
-
-
Abramov, A.Y.1
Canevari, L.2
Duchen, M.R.3
-
3
-
-
1642499152
-
β-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase
-
Abramov AY, Canevari L, Duchen MR (2004) β-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase. J. Neurosci. 24, 565-575.
-
(2004)
J. Neurosci.
, vol.24
, pp. 565-575
-
-
Abramov, A.Y.1
Canevari, L.2
Duchen, M.R.3
-
4
-
-
77949267093
-
2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors
-
2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors. Cell Calcium 47, 264-272.
-
(2010)
Cell Calcium
, vol.47
, pp. 264-272
-
-
Alberdi, E.1
Sánchez-Gómez, M.V.2
Cavaliere, F.3
Pérez-Samartín, A.4
Zugaza, J.L.5
Trullas, R.6
Domercq, M.7
Matute, C.8
-
5
-
-
64549126867
-
Astrocytes process synaptic information
-
Araque A (2008) Astrocytes process synaptic information. Neuron Glia Biol. 4, 3-10.
-
(2008)
Neuron Glia Biol
, vol.4
, pp. 3-10
-
-
Araque, A.1
-
6
-
-
84856971964
-
Different bamyloid oligomer assemblies in Alzheimer brains correlate with age of disease onset and impaired cholinergic activity
-
Bao F, Wicklund L, Lacor PN, Klein WL, Nordberg A, Marutle A (2012) Different bamyloid oligomer assemblies in Alzheimer brains correlate with age of disease onset and impaired cholinergic activity. Neurobiol. Aging 33, e1-e13.
-
(2012)
Neurobiol. Aging
, vol.33
-
-
Bao, F.1
Wicklund, L.2
Lacor, P.N.3
Klein, W.L.4
Nordberg, A.5
Marutle, A.6
-
7
-
-
52249115856
-
Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease
-
Busche MA, Eichhoff G, Adelsberger H, Abramowski D, Wiederhold KH, Haass C, Staufenbiel M, Konnerth A, Garaschuk O (2008) Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease. Science 321, 1686-1689.
-
(2008)
Science
, vol.321
, pp. 1686-1689
-
-
Busche, M.A.1
Eichhoff, G.2
Adelsberger, H.3
Abramowski, D.4
Wiederhold, K.H.5
Haass, C.6
Staufenbiel, M.7
Konnerth, A.8
Garaschuk, O.9
-
8
-
-
35848951621
-
Aβ 1-42 induces mild endoplasmic reticulum stress in an aggregation state-dependent manner
-
Chafekar SM, Hoozemans JJ, Zwart R, Baas F, Scheper W (2007) Aβ 1-42 induces mild endoplasmic reticulum stress in an aggregation state-dependent manner. Antioxid. Redox Signal. 9, 2245-2254.
-
(2007)
Antioxid. Redox Signal.
, vol.9
, pp. 2245-2254
-
-
Chafekar, S.M.1
Hoozemans, J.J.2
Zwart, R.3
Baas, F.4
Scheper, W.5
-
9
-
-
77953428883
-
Amyloid β-peptide directly induces spontaneous calcium transients, delayed intercellular calcium waves and gliosis in rat cortical astrocytes
-
Chow SK, Yu D, Macdonald CL, Buibas M, Silva GA (2010) Amyloid β-peptide directly induces spontaneous calcium transients, delayed intercellular calcium waves and gliosis in rat cortical astrocytes. ASN Neuro 2, e00026.
-
(2010)
ASN Neuro
, vol.2
-
-
Chow, S.K.1
Yu, D.2
Macdonald, C.L.3
Buibas, M.4
Silva, G.A.5
-
10
-
-
0037200117
-
Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability
-
Dahlgren KN, Manelli AM, Stine WB Jr, Baker LK, Krafft GA, LaDu MJ (2002) Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability. J. Biol. Chem. 277, 32046-32053.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 32046-32053
-
-
Dahlgren, K.N.1
Manelli, A.M.2
Stine Jr, W.B.3
Baker, L.K.4
Krafft, G.A.5
LaDu, M.J.6
-
11
-
-
34249672242
-
Aβ oligomers induce neuronal oxidative stress through an N-methyl-Daspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine
-
De Felice FG, Velasco PT, Lambert MP, Viola K, Fernandez SJ, Ferreira ST, Klein WL (2007) Aβ oligomers induce neuronal oxidative stress through an N-methyl-Daspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine. J. Biol. Chem. 282, 11590-11601.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 11590-11601
-
-
De Felice, F.G.1
Velasco, P.T.2
Lambert, M.P.3
Viola, K.4
Fernandez, S.J.5
Ferreira, S.T.6
Klein, W.L.7
-
12
-
-
20444496481
-
Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers
-
Demuro A, Mina E, Kayed R, Milton SC, Parker I, Glabe CG (2005) Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers. J. Biol. Chem. 280, 17294-17300.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 17294-17300
-
-
Demuro, A.1
Mina, E.2
Kayed, R.3
Milton, S.C.4
Parker, I.5
Glabe, C.G.6
-
13
-
-
77951251848
-
Calcium signaling and amyloid toxicity in Alzheimer disease
-
Demuro A, Parker I, Stutzmann GE (2010) Calcium signaling and amyloid toxicity in Alzheimer disease. J. Biol. Chem. 285, 12463-12468.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 12463-12468
-
-
Demuro, A.1
Parker, I.2
Stutzmann, G.E.3
-
14
-
-
33750338533
-
Astrocyte calcium elevations: properties, propagation, and effects on brain signaling
-
Fiacco TA, McCarthy KD (2006) Astrocyte calcium elevations: properties, propagation, and effects on brain signaling. Glia 54, 676-690.
-
(2006)
Glia
, vol.54
, pp. 676-690
-
-
Fiacco, T.A.1
McCarthy, K.D.2
-
15
-
-
79959945013
-
Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary cultures
-
Garwood CJ, Pooler AM, Atherton J, Hanger DP, Noble W (2011) Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary cultures. Cell Death Dis. 2, e167.
-
(2011)
Cell Death Dis
, vol.2
-
-
Garwood, C.J.1
Pooler, A.M.2
Atherton, J.3
Hanger, D.P.4
Noble, W.5
-
16
-
-
33746088374
-
Neuroprotection by two polyphenols following excitotoxicity and experimental ischemia
-
Gottlieb M, Leal-Campanario R, Campos-Esparza MR, Sánchez-Gomez MV, Alberdi E, Arranz A, Delgado-García JM, Gruart A, Matute C (2006) Neuroprotection by two polyphenols following excitotoxicity and experimental ischemia. Neurobiol. Dis. 23, 374-386.
-
(2006)
Neurobiol. Dis.
, vol.23
, pp. 374-386
-
-
Gottlieb, M.1
Leal-Campanario, R.2
Campos-Esparza, M.R.3
Sánchez-Ǵmez, M.V.4
Alberdi, E.5
Arranz, A.6
Delgado-García, J.M.7
Gruart, A.8
Matute, C.9
-
17
-
-
54049089921
-
Amyloid-beta peptide induces temporal membrane biphasic changes in astrocytes through cytosolic phospholipase A2
-
Hicks JB, Lai Y, Sheng W, Yang X, Zhu D, Sun GY, Lee JC (2008) Amyloid-beta peptide induces temporal membrane biphasic changes in astrocytes through cytosolic phospholipase A2. Biochim. Biophys. Acta 1778, 2512-2519.
-
(2008)
Biochim. Biophys. Acta
, vol.1778
, pp. 2512-2519
-
-
Hicks, J.B.1
Lai, Y.2
Sheng, W.3
Yang, X.4
Zhu, D.5
Sun, G.Y.6
Lee, J.C.7
-
18
-
-
65349093893
-
The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus
-
Hoozemans JJ, van Haastert ES, Nijholt DA, Rozemuller AJ, Eikelenboom P, Scheper W (2009) The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus. Am. J. Pathol. 174, 1241-1251.
-
(2009)
Am. J. Pathol.
, vol.174
, pp. 1241-1251
-
-
Hoozemans, J.J.1
van Haastert, E.S.2
Nijholt, D.A.3
Rozemuller, A.J.4
Eikelenboom, P.5
Scheper, W.6
-
19
-
-
47749113650
-
Aβ plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks
-
Kuchibhotla KV, Goldman ST, Lattarulo CR, Wu HY, Hyman BT, Bacskai BJ (2008) Aβ plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks. Neuron 59, 214- 225.
-
(2008)
Neuron
, vol.59
, pp. 214-225
-
-
Kuchibhotla, K.V.1
Goldman, S.T.2
Lattarulo, C.R.3
Wu, H.Y.4
Hyman, B.T.5
Bacskai, B.J.6
-
20
-
-
61349096009
-
Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice
-
Kuchibhotla KV, Lattarulo CR, Hyman BT, Bacskai BJ (2009) Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice. Science 323, 1211-1215.
-
(2009)
Science
, vol.323
, pp. 1211-1215
-
-
Kuchibhotla, K.V.1
Lattarulo, C.R.2
Hyman, B.T.3
Bacskai, B.J.4
-
21
-
-
0019313317
-
Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue
-
McCarthy KD, de Vellis J (1980) Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J. Cell Biol. 85, 890-902.
-
(1980)
J. Cell Biol.
, vol.85
, pp. 890-902
-
-
McCarthy, K.D.1
de Vellis, J.2
-
22
-
-
0032144457
-
The effects of β/A4-amyloid and its fragments on calcium homeostasis, glial fibrillary acidic protein and S100b staining, morphology and survival of cultured hippocampal astrocytes
-
Meske V, Hamker U, Albert F, Ohm TG (1998) The effects of β/A4-amyloid and its fragments on calcium homeostasis, glial fibrillary acidic protein and S100b staining, morphology and survival of cultured hippocampal astrocytes. Neuroscience 85, 1151-1160.
-
(1998)
Neuroscience
, vol.85
, pp. 1151-1160
-
-
Meske, V.1
Hamker, U.2
Albert, F.3
Ohm, T.G.4
-
24
-
-
0042697305
-
Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction
-
Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM (2003) Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 39, 409-421.
-
(2003)
Neuron
, vol.39
, pp. 409-421
-
-
Oddo, S.1
Caccamo, A.2
Shepherd, J.D.3
Murphy, M.P.4
Golde, T.E.5
Kayed, R.6
Metherate, R.7
Mattson, M.P.8
Akbari, Y.9
LaFerla, F.M.10
-
25
-
-
33144487701
-
Temporal profile of amyloid-β (Aβ) oligomerization in an in vivo model of Alzheimer disease: a link between Aβ and tau pathology
-
Oddo S, Caccamo A, Tran L, Lambert MP, Glabe CG, Klein WL, LaFerla FM (2006) Temporal profile of amyloid-β (Aβ) oligomerization in an in vivo model of Alzheimer disease: a link between Aβ and tau pathology. J. Biol. Chem. 281, 1599-1604.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 1599-1604
-
-
Oddo, S.1
Caccamo, A.2
Tran, L.3
Lambert, M.P.4
Glabe, C.G.5
Klein, W.L.6
LaFerla, F.M.7
-
26
-
-
77952573750
-
Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer's disease
-
Olabarria M, Noristani HN, Verkhratsky A, Rodríguez JJ (2010) Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer's disease. Glia 58, 831-838.
-
(2010)
Glia
, vol.58
, pp. 831-838
-
-
Olabarria, M.1
Noristani, H.N.2
Verkhratsky, A.3
Rodríguez, J.J.4
-
27
-
-
77951667651
-
Selective induction of astrocytic gliosis generates deficits in neuronal inhibition
-
Ortinski PI, Dong J, Mungenast A, Yue C, Takano H, Watson DJ, Haydon PG, Coulter DA (2010) Selective induction of astrocytic gliosis generates deficits in neuronal inhibition. Nat. Neurosci. 13, 584-591.
-
(2010)
Nat. Neurosci.
, vol.13
, pp. 584-591
-
-
Ortinski, P.I.1
Dong, J.2
Mungenast, A.3
Yue, C.4
Takano, H.5
Watson, D.J.6
Haydon, P.G.7
Coulter, D.A.8
-
28
-
-
0030028486
-
Mechanisms of intracellular calcium regulation in adult astrocytes
-
Peuchen S, Clark JB, Duchen MR (1996) Mechanisms of intracellular calcium regulation in adult astrocytes. Neuroscience 71, 871-883.
-
(1996)
Neuroscience
, vol.71
, pp. 871-883
-
-
Peuchen, S.1
Clark, J.B.2
Duchen, M.R.3
-
29
-
-
49249118742
-
Neurotoxic effect of oligomeric and fibrillar species of amyloid-β peptide 1-42: involvement of endoplasmic reticulum calcium release in oligomer-induced cell death
-
Resende R, Ferreiro E, Pereira C, Resende de Oliveira C (2008) Neurotoxic effect of oligomeric and fibrillar species of amyloid-β peptide 1-42: involvement of endoplasmic reticulum calcium release in oligomer-induced cell death. Neuroscience 155, 725-737.
-
(2008)
Neuroscience
, vol.155
, pp. 725-737
-
-
Resende, R.1
Ferreiro, E.2
Pereira, C.3
Resende de Oliveira, C.4
-
30
-
-
70349829186
-
Endoplasmic reticulum calcium release through ryanodine and IP3 receptors contributes to neuronal excitotoxicity
-
Ruiz A, Matute C, Alberdi E (2009) Endoplasmic reticulum calcium release through ryanodine and IP3 receptors contributes to neuronal excitotoxicity. Cell Calcium 46, 273-281.
-
(2009)
Cell Calcium
, vol.46
, pp. 273-281
-
-
Ruiz, A.1
Matute, C.2
Alberdi, E.3
-
31
-
-
79958745516
-
2+ release through ryanodine receptors contributes to AMPA receptor-mediated mitochondrial dysfunction and ER stress in oligodendrocytes
-
2+ release through ryanodine receptors contributes to AMPA receptor-mediated mitochondrial dysfunction and ER stress in oligodendrocytes. Cell Death Dis. 1, e54.
-
(2010)
Cell Death Dis
, vol.1
-
-
Ruiz, A.1
Matute, C.2
Alberdi, E.3
-
32
-
-
84858120121
-
Amyloid-β oligomers in cerebrospinal fluid are associated with cognitive decline in patients with Alzheimer's disease
-
Santos AN, Ewers M, Minthon L, Simm A, Silber RE, Blennow K, Prvulovic D, Hansson O, Hampel H (2012) Amyloid-β oligomers in cerebrospinal fluid are associated with cognitive decline in patients with Alzheimer's disease. J. Alzheimers Dis. 29, 171-176.
-
(2012)
J. Alzheimers Dis.
, vol.29
, pp. 171-176
-
-
Santos, A.N.1
Ewers, M.2
Minthon, L.3
Simm, A.4
Silber, R.E.5
Blennow, K.6
Prvulovic, D.7
Hansson, O.8
Hampel, H.9
-
33
-
-
79961124071
-
The unfolded protein response and proteostasis in Alzheimer disease: preferential activation of autophagy by endoplasmic reticulum stress
-
Scheper W, Nijholt DA, Hoozemans JJ (2011) The unfolded protein response and proteostasis in Alzheimer disease: preferential activation of autophagy by endoplasmic reticulum stress. Autophagy 7, 910-911.
-
(2011)
Autophagy
, vol.7
, pp. 910-911
-
-
Scheper, W.1
Nijholt, D.A.2
Hoozemans, J.J.3
-
34
-
-
0035066332
-
Alzheimer's disease: genes, proteins and therapy
-
Selkoe DJ (2001) Alzheimer's disease: genes, proteins and therapy. Physiol. Rev. 81, 741-766.
-
(2001)
Physiol. Rev.
, vol.81
, pp. 741-766
-
-
Selkoe, D.J.1
-
35
-
-
33947314641
-
Natural oligomers of the Alzheimer amyloid-β protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signalling pathway
-
Shankar GM, Bloodgood BL, Townsend M, Walsh DM, Selkoe DJ, Sabatini BL (2007) Natural oligomers of the Alzheimer amyloid-β protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signalling pathway. J. Neurosci. 27, 2866-2875.
-
(2007)
J. Neurosci.
, vol.27
, pp. 2866-2875
-
-
Shankar, G.M.1
Bloodgood, B.L.2
Townsend, M.3
Walsh, D.M.4
Selkoe, D.J.5
Sabatini, B.L.6
-
36
-
-
0031887764
-
2+ levels in cultured rat astrocytes
-
2+ levels in cultured rat astrocytes. Neurosci. Lett. 243, 121-124.
-
(1998)
Neurosci. Lett.
, vol.243
, pp. 121-124
-
-
Stix, B.1
Reiser, G.2
-
37
-
-
77950617631
-
A mouse model of amyloid β oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo
-
Tomiyama T, Matsuyama S, Iso H, Umeda T, Takuma H, Ohnishi K, Ishibashi K, Teraoka R, Sakama N, Yamashita T, Nishitsuji K, Ito K, Shimada H, Lambert MP, Klein WL, Mori HA (2010) A mouse model of amyloid β oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo. J. Neurosci. 30, 4845-4856.
-
(2010)
J. Neurosci.
, vol.30
, pp. 4845-4856
-
-
Tomiyama, T.1
Matsuyama, S.2
Iso, H.3
Umeda, T.4
Takuma, H.5
Ohnishi, K.6
Ishibashi, K.7
Teraoka, R.8
Sakama, N.9
Yamashita, T.10
Nishitsuji, K.11
Ito, K.12
Shimada, H.13
Lambert, M.P.14
Klein, W.L.15
Mori, H.A.16
-
38
-
-
12944314765
-
Physiology and pathophysiology of the calcium store in the endoplasmic reticulum of neurons
-
Verkhratsky A (2005) Physiology and pathophysiology of the calcium store in the endoplasmic reticulum of neurons. Physiol. Rev. 85, 201-279.
-
(2005)
Physiol. Rev.
, vol.85
, pp. 201-279
-
-
Verkhratsky, A.1
-
40
-
-
0037025272
-
The endoplasmic reticulum as an integrating signalling organelle: from neuronal signalling to neuronal death
-
Verkhratsky A, Petersen OH (2002) The endoplasmic reticulum as an integrating signalling organelle: from neuronal signalling to neuronal death. Eur. J. Pharmacol. 447, 141-154.
-
(2002)
Eur. J. Pharmacol.
, vol.447
, pp. 141-154
-
-
Verkhratsky, A.1
Petersen, O.H.2
-
41
-
-
84860555370
-
Neurological diseases as primary gliopathies: a reassessment of neurocentrism
-
Verkhratsky A, Sofroniew MV, Messing A, deLanerolle NC, Rempe D, Rodriguez JJ, Nedergaard M (2012) Neurological diseases as primary gliopathies: a reassessment of neurocentrism. ASN Neuro 4, e00082.
-
(2012)
ASN Neuro
, vol.4
-
-
Verkhratsky, A.1
Sofroniew, M.V.2
Messing, A.3
deLanerolle, N.C.4
Rempe, D.5
Rodriguez, J.J.6
Nedergaard, M.7
-
42
-
-
78650647193
-
Astrocytes in Alzheimer disease: emerging roles in calcium dysregulation and synaptic plasticity
-
Vincent AJ, Gasperini R, Foa L, Small DH (2010) Astrocytes in Alzheimer disease: emerging roles in calcium dysregulation and synaptic plasticity. J. Alzheimers Dis. 22, 699-714.
-
(2010)
J. Alzheimers Dis.
, vol.22
, pp. 699-714
-
-
Vincent, A.J.1
Gasperini, R.2
Foa, L.3
Small, D.H.4
|