메뉴 건너뛰기




Volumn 80, Issue 3, 2014, Pages 500-539

Normal and pathological brain aging: A physiopathological continuum or an involutive duality;Envejecimiento cerebral normal y patológico: Continuum fisiopatológico o dualidad de procesos involutivos

Author keywords

Alzheimer's Disease; Continuum; Normal brain senility; Pathological brain senility

Indexed keywords

AGING; ALZHEIMER DISEASE; ARTICLE; HUMAN; NEUROIMAGING; PATHOPHYSIOLOGY; SENILITY;

EID: 84929992130     PISSN: 00340634     EISSN: 1697428X     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (4)

References (120)
  • 8
    • 84922020621 scopus 로고    scopus 로고
    • Variation in variables that predict progression from MCI to AD dementia over duration of follow-up
    • Li, S.; Okonkwo, O.; Albert, M.; Wang, M. C. Variation in variables that predict progression from MCI to AD dementia over duration of follow-up. Am J Alzheimers Dis 2, 12-28 (2013).
    • (2013) Am J Alzheimers Dis , vol.2 , pp. 12-28
    • Li, S.1    Okonkwo, O.2    Albert, M.3    Wang, M.C.4
  • 10
    • 84897954670 scopus 로고    scopus 로고
    • The complexities of the pathology-pathogenesis relationship in Alzheimer disease
    • en Prensa
    • Castellani, R.J.; Perry, G. The complexities of the pathology-pathogenesis relationship in Alzheimer disease. Biochem Pharmacol (en prensa). doi: 10.1016/j.bcp.2014.01.009 (2014).
    • (2014) Biochem Pharmacol
    • Castellani, R.J.1    Perry, G.2
  • 11
    • 84880759156 scopus 로고    scopus 로고
    • Neurotoxicity of amyloid β-protein: Synaptic and network Dysfunction
    • Mucke, L.; Selkoe, D. J. Neurotoxicity of amyloid β-protein: synaptic and network Dysfunction; Cold Spring Harb Perspect Med; 2(7):a006338. doi: 10.1101/cshperspect.a006338 (2012).
    • (2012) Cold Spring Harb Perspect Med , vol.2 , Issue.7
    • Mucke, L.1    Selkoe, D.J.2
  • 12
    • 84865418523 scopus 로고    scopus 로고
    • Alzheimer's disease pathologic cascades: Who comes first, what drives what
    • Swerdlow, R. H. Alzheimer's disease pathologic cascades: who comes first, what drives what. Neurotox Res 22, 182-194 (2012).
    • (2012) Neurotox Res , vol.22 , pp. 182-194
    • Swerdlow, R.H.1
  • 15
    • 84892561652 scopus 로고    scopus 로고
    • The mammalian neocortex new pyramidal neuron: A new conception
    • Marín-Padilla, M. The mammalian neocortex new pyramidal neuron: a new conception. Front Neuroanat, 7, 51-63 (doi: 10.3389/fnana.2013.00051) (2014).
    • (2014) Front Neuroanat , vol.7 , pp. 51-63
    • Marín-Padilla, M.1
  • 17
    • 62449302387 scopus 로고    scopus 로고
    • Stem cells of the adult mammalian brain and their niche
    • Basak, O., Taylor, V. Stem cells of the adult mammalian brain and their niche. Cell. Mol Life Sci 66, 1057-1072 (2009).
    • (2009) Cell. Mol Life Sci , vol.66 , pp. 1057-1072
    • Basak, O.1    Taylor, V.2
  • 18
    • 84891553207 scopus 로고    scopus 로고
    • Dendritic spines: The locus of structural and functional plasticity
    • Sala, C.; Segal, M. Dendritic spines: the locus of structural and functional plasticity. Physiol Rev 94(1), 141-88 (2014).
    • (2014) Physiol Rev , vol.94 , Issue.1 , pp. 141-188
    • Sala, C.1    Segal, M.2
  • 19
    • 84887545227 scopus 로고    scopus 로고
    • Cell biology in neuroscience: The interplay between Hebbian and homeostatic synaptic plasticity
    • Vitureira, N.; Goda, Y. Cell biology in neuroscience: the interplay between Hebbian and homeostatic synaptic plasticity. J Cell Biol 203, 175-186 (2013)
    • (2013) J Cell Biol , vol.203 , pp. 175-186
    • Vitureira, N.1    Goda, Y.2
  • 20
    • 84896718286 scopus 로고    scopus 로고
    • Multiscale modeling and synaptic plasticity
    • Bhalla, U. S. Multiscale Modeling and Synaptic Plasticity. Prog Mol Biol Trans Sci 123, 351-386 (2014).
    • (2014) Prog Mol Biol Trans Sci , vol.123 , pp. 351-386
    • Bhalla, U.S.1
  • 21
    • 6744268028 scopus 로고    scopus 로고
    • Mecanismos de adaptación en el Sistema Nervioso. Su importancia en la patología y la terapéutica
    • Toledano, A. Mecanismos de adaptación en el Sistema Nervioso. Su importancia en la patología y la terapéutica. Anal Real Acad Farm 65, 693-767 (1999).
    • (1999) Anal Real Acad Farm , vol.65 , pp. 693-767
    • Toledano, A.1
  • 22
    • 0018056044 scopus 로고
    • Aging of the central nervous system
    • Frol'kis, V.V.; Bezrukov, V.V. Aging of the central nervous system. Hum Physiol 4, 478-499 (1979).
    • (1979) Hum Physiol , vol.4 , pp. 478-499
    • Frol'Kis, V.V.1    Bezrukov, V.V.2
  • 23
    • 0018967123 scopus 로고
    • Aging and environmental influences on two types of dendritic spines in the rat occipital cortex
    • Connor, J.R. jr.; Diamond, M.C.; Johnson A.R.E. Aging and Environmental Influences on two types of dendritic Spines in the rat occipital cortex. Experimental Neurology 70, 371-379 (1980)
    • (1980) Experimental Neurology , vol.70 , pp. 371-379
    • Connor, J.R.1    Diamond, M.C.2    Johnson, A.R.E.3
  • 24
    • 0018726532 scopus 로고
    • Dendritic growth in the aged human brain and failure of growth in senile dementia
    • Buell, S.; Coleman, P. Dendritic growth in the aged human brain and failure of growth in senile dementia. Science 206, 854-856 (1979).
    • (1979) Science , vol.206 , pp. 854-856
    • Buell, S.1    Coleman, P.2
  • 26
    • 0000293742 scopus 로고
    • Über eine eigenartige erkrankung der hirnrinde
    • Alzheimer, A. Über eine eigenartige erkrankung der hirnrinde. Allg Z Psychiat 64, 146-148 (1907).
    • (1907) Allg Z Psychiat , vol.64 , pp. 146-148
    • Alzheimer, A.1
  • 30
    • 0022414054 scopus 로고
    • Diagnosis of Alzheimer's disease
    • Khachaturian; ZS. Diagnosis of Alzheimer's Disease. Arch Neurol 42, 1097-1105 (1985).
    • (1985) Arch Neurol , vol.42 , pp. 1097-1105
    • Khachaturian, Z.S.1
  • 31
    • 0025908356 scopus 로고
    • The consortium to establish a registry for Alzheimer's disease (CERAD); Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
    • Mirra, S. S.; Heyman, A.; Mckeel, D.; Sumi, S. M.; Crain, B. J.; Brownlee, L. M.; Vogel, F. S.; Hughes, J. P.; Van Belle, G.; Berg, L. The Consortium to establish a registry for Alzheimer's disease (CERAD); Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 41, 479-486 (1991).
    • (1991) Neurology , vol.41 , pp. 479-486
    • Mirra, S.S.1    Heyman, A.2    Mckeel, D.3    Sumi, S.M.4    Crain, B.J.5    Brownlee, L.M.6    Vogel, F.S.7    Hughes, J.P.8    Van Belle, G.9    Berg, L.10
  • 34
    • 0032587612 scopus 로고    scopus 로고
    • Probst. A Low amyloid (Abeta) plaque load and relative predominance of diffuse plaques distinguish argyrophilic grain disease from Alzheimer's disease
    • Tolnay, M.; Calhoun, M.; Pham, H. C.; Egensperger, R.; Probst. A Low amyloid (Abeta) plaque load and relative predominance of diffuse plaques distinguish argyrophilic grain disease from Alzheimer's disease. Neuropathol Appl Neurobiol 25, 295-305 (1999).
    • (1999) Neuropathol Appl Neurobiol , vol.25 , pp. 295-305
    • Tolnay, M.1    Calhoun, M.2    Pham, H.C.3    Egensperger, R.4
  • 35
    • 0026347220 scopus 로고
    • Quantitative neuropathological study of Alzheimer-type pathology in the hippocampus: Comparison of senile dementia of Alzheimer type, senile dementia of Lewy body type, Parkinson's disease and non-demented elderly control patients
    • Ince, P.; Irving, D.; MacArthur, F.; Perry, R. H. Quantitative neuropathological study of Alzheimer-type pathology in the hippocampus: comparison of senile dementia of Alzheimer type, senile dementia of Lewy body type, Parkinson's disease and non-demented elderly control patients. J Neurol Sci. 106,142-152 (1991).
    • (1991) J Neurol Sci. , vol.106 , pp. 142-152
    • Ince, P.1    Irving, D.2    MacArthur, F.3    Perry, R.H.4
  • 36
    • 84897827105 scopus 로고    scopus 로고
    • Asymmetry and heterogeneity of Alzheimer's and frontotemporal pathology in primaryprogressive aphasia
    • en prensa
    • Mesulam, M. M.; Weintraub, S.; Rogalski, E. J.; Wieneke, C.; Geula, C.; Bigio, E. H. Asymmetry and heterogeneity of Alzheimer's and frontotemporal pathology in primaryprogressive aphasia. Brain (en prensa) (2014).
    • (2014) Brain
    • Mesulam, M.M.1    Weintraub, S.2    Rogalski, E.J.3    Wieneke, C.4    Geula, C.5    Bigio, E.H.6
  • 39
    • 84876347675 scopus 로고    scopus 로고
    • Prevalence of neuropsychiatric symptoms across the declining memory continuum: An observational study in a memory clinic setting
    • Zhang, M.; Wang, H.; Li, T.; Yu, X. Prevalence of neuropsychiatric symptoms across the declining memory continuum: an observational study in a memory clinic setting. Dement Geriatr Cogn Dis Extra 2, 200-208 (2012).
    • (2012) Dement Geriatr Cogn Dis Extra , vol.2 , pp. 200-208
    • Zhang, M.1    Wang, H.2    Li, T.3    Yu, X.4
  • 40
    • 79951568317 scopus 로고    scopus 로고
    • Cerebrospinal fluid biomarkers and memory present distinct associations along the continuum from healthy subjects to AD patients
    • Rami, L.; Fortea, J.; Bosch, B.; Solé-Padullés, C.; Lladó, A.; Iranzo, A.; Sánchez-Valle, R.; Molinuevo, J. L. Cerebrospinal fluid biomarkers and memory present distinct associations along the continuum from healthy subjects to AD patients. J Alz Dis 23, 319-26 (2011).
    • (2011) J Alz Dis , vol.23 , pp. 319-326
    • Rami, L.1    Fortea, J.2    Bosch, B.3    Solé-Padullés, C.4    Lladó, A.5    Iranzo, A.6    Sánchez-Valle, R.7    Molinuevo, J.L.8
  • 42
    • 27744464859 scopus 로고    scopus 로고
    • The microglial "activation" continuum: From innate to adaptive responses
    • Town, T.; Nikolic, V.; Tan, J. The microglial "activation" continuum: from innate to adaptive responses. J Neuroinflammation 31, 2-24 (2005).
    • (2005) J Neuroinflammation , vol.31 , pp. 2-24
    • Town, T.1    Nikolic, V.2    Tan, J.3
  • 43
    • 0037172826 scopus 로고    scopus 로고
    • Phases of Abeta deposition in the human brain and its relevance for the development of AD
    • Thal, D. R.; Rüb, U.; Orantes, M.; Braak, H. Phases of Abeta deposition in the human brain and its relevance for the development of AD. Neurology 58, 1791-1800 (2002).
    • (2002) Neurology , vol.58 , pp. 1791-1800
    • Thal, D.R.1    Rüb, U.2    Orantes, M.3    Braak, H.4
  • 44
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • Braak, H.; Braak, E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82, 239-259 (1991).
    • (1991) Acta Neuropathol , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 47
    • 84856295588 scopus 로고    scopus 로고
    • The clinical value of large neuroimaging data sets in Alzheimer's disease
    • Toga, A. W. The clinical value of large neuroimaging data sets in Alzheimer's disease. Neuroimaging Clin N Am 22, 107-118 (2012).
    • (2012) Neuroimaging Clin N Am , vol.22 , pp. 107-118
    • Toga, A.W.1
  • 48
    • 84890423856 scopus 로고    scopus 로고
    • Associations between Alzheimer disease biomarkers, neurodegeneration, and cognition in cognitively normal older people
    • Wirth, M.; Villeneuve, S.; Haase, C. M.; Madison, C. M.; Oh, H.; Landau, S. M.; Rabinovici, G. D.; Jagust, W. J. Associations between Alzheimer disease biomarkers, neurodegeneration, and cognition in cognitively normal older people. JAMA Neurol. 70,1512-1519 (2013)
    • (2013) JAMA Neurol , vol.70 , pp. 1512-1519
    • Wirth, M.1    Villeneuve, S.2    Haase, C.M.3    Madison, C.M.4    Oh, H.5    Landau, S.M.6    Rabinovici, G.D.7    Jagust, W.J.8
  • 50
    • 0035323250 scopus 로고    scopus 로고
    • Continuum of care for Alzheimer's disease: A nurse education and counseling program
    • Wright, L. K.; Litaker, M.; Laraia, M. T.; DeAndrade, S. Continuum of care for Alzheimer's disease: a nurse education and counseling program. Issues Ment Health Nurs 22, 231-252 (2001).
    • (2001) Issues Ment Health Nurs , vol.22 , pp. 231-252
    • Wright, L.K.1    Litaker, M.2    Laraia, M.T.3    DeAndrade, S.4
  • 52
    • 70349980863 scopus 로고    scopus 로고
    • The interface between Alzheimer's disease, normal aging, and related disorders
    • Armstrong, R. A. The interface between Alzheimer's disease, normal aging, and related disorders. Curr Aging Sci 1, 122-132 (2008).
    • (2008) Curr Aging Sci , vol.1 , pp. 122-132
    • Armstrong, R.A.1
  • 54
    • 84876383766 scopus 로고    scopus 로고
    • New genes and new insights from old genes: Update on Alzheimer disease
    • Ringman, J. M.; Coppola, G. New genes and new insights from old genes: update on Alzheimer disease. Continuum (Minneap Minn) 19, 358-71 (2013).
    • (2013) Continuum (Minneap Minn) , vol.19 , pp. 358-371
    • Ringman, J.M.1    Coppola, G.2
  • 55
    • 84889090645 scopus 로고    scopus 로고
    • Examination of the clinicopathologic continuum of Alzheimer disease in the autopsy cohort of the National Alzheimer Coordinating Center
    • Serrano-Pozo, A.; Qian, J.; Monsell, S. E.; Frosch, M. P.; Betensky, R.A.; Hyman, B. T. Examination of the clinicopathologic continuum of Alzheimer disease in the autopsy cohort of the National Alzheimer Coordinating Center. J Neuropathol Exp Neurol. 72,1182-1192 (2013).
    • (2013) J Neuropathol Exp Neurol. , vol.72 , pp. 1182-1192
    • Serrano-Pozo, A.1    Qian, J.2    Monsell, S.E.3    Frosch, M.P.4    Betensky, R.A.5    Hyman, B.T.6
  • 56
    • 84930005714 scopus 로고    scopus 로고
    • La neuropatología y la biología molecular de la enfermedad de Alzheimer
    • Cruz-Sánchez F.F., Ed.; Edimsa, Barcelona
    • Pappolla, M. A. La Neuropatología y la Biología Molecular de la Enfermedad de Alzheimer. En:. Neuropathología. Diagnóstico y Clínica. Cruz-Sánchez F.F., Ed.; Edimsa, Barcelona, 2000; p 543.
    • (2000) Neuropathología. Diagnóstico y Clínica , pp. 543
    • Pappolla, M.A.1
  • 57
    • 84871400877 scopus 로고    scopus 로고
    • Intraneuronal β-amyloid and its interactions with proteins and subcellular organelles
    • Penke, B.; Tóth, A. M.; Földi, I.; Szu'cs, M.; Janáky, T. Intraneuronal β-amyloid and its interactions with proteins and subcellular organelles. Electrophoresis 33, 3608-3616 (2012).
    • (2012) Electrophoresis , vol.33 , pp. 3608-3616
    • Penke, B.1    Tóth, A.M.2    Földi, I.3    Szu'cs, M.4    Janáky, T.5
  • 58
    • 0025060307 scopus 로고
    • General and dramatic glial reaction in Alzheimer brains
    • Delacourte, A. General and dramatic glial reaction in Alzheimer brains. Neurology 40, 33-37 (1990)
    • (1990) Neurology , vol.40 , pp. 33-37
    • Delacourte, A.1
  • 59
    • 0035898257 scopus 로고    scopus 로고
    • The morphological phenotype of b-amyloid plaques and associated neuritic changes in Alzheimer's
    • Dickson; C., Vickers, J. C. The morphological phenotype of b-amyloid plaques and associated neuritic changes in Alzheimer's. Neuroscience 105, 99-107 (2001).
    • (2001) Neuroscience , vol.105 , pp. 99-107
    • Dickson, C.1    Vickers, J.C.2
  • 60
    • 0034295217 scopus 로고    scopus 로고
    • Microglia cells are the driving force in fibrillar plaque formation, whereas astrocytes are a leading factor in plague degradation
    • Wegiel, J.; Wang, K. C.; Tarnawski, M.; Lach, B. Microglia cells are the driving force in fibrillar plaque formation, whereas astrocytes are a leading factor in plague degradation. Acta Neuropathol 100, 356-364 (2000).
    • (2000) Acta Neuropathol , vol.100 , pp. 356-364
    • Wegiel, J.1    Wang, K.C.2    Tarnawski, M.3    Lach, B.4
  • 61
    • 0019972810 scopus 로고
    • The cholinergic hypothesis of geriatric memory dysfunction
    • 217
    • Bartus, R. T.; Dean, R. L.; 3rd, Beer, B. Lippa AS The cholinergic hypothesis of geriatric memory dysfunction. Science 30, 217(4558):408-14 (1982).
    • (1982) Science , vol.30 , Issue.4558 , pp. 408-414
    • Bartus, R.T.1    Dean, R.L.2    Beer, B.3    Lippa, A.S.4
  • 62
    • 0021264594 scopus 로고
    • Alzheimer's presenile dementia, senile dementia of Alzheimer type and Down's syndrome in middle age form an age related continuum of pathological changes
    • Mann, D. M.; Yates, P. O.; Marcyniuk, B. Alzheimer's presenile dementia, senile dementia of Alzheimer type and Down's syndrome in middle age form an age related continuum of pathological changes. Neuropathol Appl Neurobiol 10, 185-207 (1984).
    • (1984) Neuropathol Appl Neurobiol , vol.10 , pp. 185-207
    • Mann, D.M.1    Yates, P.O.2    Marcyniuk, B.3
  • 63
    • 2342429093 scopus 로고    scopus 로고
    • Oxidative stress in mild cognitive impairment and Alzheimer disease: A continuum
    • Apr
    • Mecocci, P. Oxidative stress in mild cognitive impairment and Alzheimer disease: a continuum. J Alzheimers Dis. 2004 Apr;6(2):159-63.
    • (2004) J Alzheimers Dis , vol.6 , Issue.2 , pp. 159-163
    • Mecocci, P.1
  • 64
    • 48249103491 scopus 로고    scopus 로고
    • Neurodegenerative lysosomal disorders: A continuum from development to late age
    • Nixon, R. A.; Yang, D. S.; Lee, J. H. Neurodegenerative lysosomal disorders: a continuum from development to late age. Autophagy 4, 590-9 (2008).
    • (2008) Autophagy , vol.4 , pp. 590-599
    • Nixon, R.A.1    Yang, D.S.2    Lee, J.H.3
  • 65
    • 0033460181 scopus 로고    scopus 로고
    • Amyloid precursor protein in the cerebellar cortex of Alzheimer 's disease patients devoid of cerebellar β-amyloid deposits. Immunocytochemical study of five cases
    • Toledano, A.; Álvarez, MI.; Rivas, L.; Lacruz, C.; Martínez-Rodríguez, R. Amyloid precursor protein in the cerebellar cortex of Alzheimer 's disease patients devoid of cerebellar β-amyloid deposits. Immunocytochemical study of five cases. J Neural Trans 106, 1151-1169 (1999).
    • (1999) J Neural Trans , vol.106 , pp. 1151-1169
    • Toledano, A.1    Álvarez, M.I.2    Rivas, L.3    Lacruz, C.4    Martínez-Rodríguez, R.5
  • 66
    • 0023767217 scopus 로고
    • Hypotheses concerning the aetiology of the Alzheimer's disease
    • Toledano, A. Hypotheses concerning the aetiology of the Alzheimer's disease. Pharmacopsychiat 21, 17-25 (1988).
    • (1988) Pharmacopsychiat , vol.21 , pp. 17-25
    • Toledano, A.1
  • 67
    • 0028170027 scopus 로고
    • Pyritinol facilitates the recovery of cortical cholinergic deficits caused by nucleus basalis lesions
    • P-D Section
    • Toledano, A.; Bentura, M. Pyritinol facilitates the recovery of cortical cholinergic deficits caused by nucleus basalis lesions J Neural Transm [P-D Section] 7, 195-209 (1994).
    • (1994) J Neural Transm , vol.7 , pp. 195-209
    • Toledano, A.1    Bentura, M.2
  • 68
    • 0015965912 scopus 로고
    • Human memory and the cholinergic system: Relationship to aging?
    • Drachman, D. A.; Leavitt, J. Human memory and the cholinergic system: relationship to aging? Arch Neurol 30, 113-121 (1974).
    • (1974) Arch Neurol , vol.30 , pp. 113-121
    • Drachman, D.A.1    Leavitt, J.2
  • 69
    • 0020686674 scopus 로고
    • Alzheimer's disease: A disorder of cortical cholinergic innervation
    • Coyle, J. T.; Price, D. L.; De Long, M. R. Alzheimer's disease: a disorder of cortical cholinergic innervation. Science 219, 1184-1190 (1983).
    • (1983) Science , vol.219 , pp. 1184-1190
    • Coyle, J.T.1    Price, D.L.2    De Long, M.R.3
  • 70
    • 84876375022 scopus 로고    scopus 로고
    • Alzheimer disease pharmacologic treatment and treatment research
    • Schneider, L. S. Alzheimer disease pharmacologic treatment and treatment research. Continuum (Minneap Minn). 19, 339-357 (2013).
    • (2013) Continuum (Minneap Minn) , vol.19 , pp. 339-357
    • Schneider, L.S.1
  • 71
    • 0033913711 scopus 로고    scopus 로고
    • The parahippocampal gyrus in Alzheimer's disease. Clinical and preclinical neuroanatomical correlates
    • Van Hoesen, G. W.; Augustinack, J. C.; Dierking, J.; Redman, S. J.; Thangavel, R. The parahippocampal gyrus in Alzheimer's disease. Clinical and preclinical neuroanatomical correlates. Ann N Y Acad Sci 911, 254-274 (2000).
    • (2000) Ann N y Acad Sci , vol.911 , pp. 254-274
    • Van Hoesen, G.W.1    Augustinack, J.C.2    Dierking, J.3    Redman, S.J.4    Thangavel, R.5
  • 72
    • 0033943447 scopus 로고    scopus 로고
    • From healthy aging to early Alzheimer's disease: In vivo detection of entorhinal cortex atrophy
    • de Toledo-Morrell, L.; Goncharova, I.; Dickerson, B.; Wilson, R. S.; Bennett, D. A. From healthy aging to early Alzheimer's disease: in vivo detection of entorhinal cortex atrophy. Ann N Y Acad Sci 911, 240-53 (2000).
    • (2000) Ann N y Acad Sci , vol.911 , pp. 240-253
    • De Toledo-Morrell, L.1    Goncharova, I.2    Dickerson, B.3    Wilson, R.S.4    Bennett, D.A.5
  • 76
    • 84863471166 scopus 로고    scopus 로고
    • Does Alzheimer's disease exist in all primates? Alzheimer pathology in non-human primates and its pathophysiological implications (I)
    • también versión en español
    • Toledano, A.; Álvarez, M. I.; López-Rodríguez, A. B.; Toledano-Díaz, A.; Fernández-Verdecia, C. I. Does Alzheimer's disease exist in all primates? Alzheimer pathology in non-human primates and its pathophysiological implications (I). Neurologia 27, 354-69 (2012) [también versión en español]
    • (2012) Neurologia , vol.27 , pp. 354-369
    • Toledano, A.1    Álvarez, M.I.2    López-Rodríguez, A.B.3    Toledano-Díaz, A.4    Fernández-Verdecia, C.I.5
  • 77
    • 84895067148 scopus 로고    scopus 로고
    • Does Alzheimer's disease exist in all primates? Alzheimer pathology in non-human primates and its pathophysiological implications (II)
    • también versión en español
    • Toledano, A.; Álvarez, M. I.; López-Rodríguez, A. B.; Toledano-Díaz, A.; Fernández-Verdecia, C. I. Does Alzheimer's disease exist in all primates? Alzheimer pathology in non-human primates and its pathophysiological implications (II) Neurologia. 29, 42-55 (2014) [también versión en español]
    • (2014) Neurologia , vol.29 , pp. 42-55
    • Toledano, A.1    Álvarez, M.I.2    López-Rodríguez, A.B.3    Toledano-Díaz, A.4    Fernández-Verdecia, C.I.5
  • 78
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy, J.; Selkoe, D. J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 19, 353-356 (2002).
    • (2002) Science , vol.19 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 80
    • 33644761191 scopus 로고    scopus 로고
    • Microcebus murinus: A useful primate model for human cerebral aging and Alzheimer's disease?
    • Bons, N.; Rieger, F.; Prudhomme, D.; Fisher, A.; Krause, K. H. Microcebus murinus: a useful primate model for human cerebral aging and Alzheimer's disease? Genes Brain Behav 5, 120-130 (2006).
    • (2006) Genes Brain Behav , vol.5 , pp. 120-130
    • Bons, N.1    Rieger, F.2    Prudhomme, D.3    Fisher, A.4    Krause, K.H.5
  • 81
    • 2442676889 scopus 로고    scopus 로고
    • Cognitive function and its neural mechanism in nonhuman primate models of aging Alzheimer's diseases, and menopause
    • Voytko, M. L.; Tinker, G. P. Cognitive function and its neural mechanism in nonhuman primate models of aging Alzheimer's diseases, and menopause. Front Biosci 9, 1899-1914 (2004).
    • (2004) Front Biosci , vol.9 , pp. 1899-1914
    • Voytko, M.L.1    Tinker, G.P.2
  • 82
    • 0016266189 scopus 로고
    • The St Kitts vervet (Cercopithecus aethiops)
    • McGuire, M. T. The St Kitts vervet (Cercopithecus aethiops). J Med Primatol 3, 285-297 (1974).
    • (1974) J Med Primatol , vol.3 , pp. 285-297
    • McGuire, M.T.1
  • 83
    • 3042692322 scopus 로고    scopus 로고
    • Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a nonhuman primate, the Caribbean vervet
    • Lemere, C. A.; Beierschmitt, A.; Iglesias, M.; Spooner, E. T.; Bloom, J.K.; Leverone, J. F. Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a nonhuman primate, the Caribbean vervet. Am J Pathol 165, 83-97 (2004).
    • (2004) Am J Pathol , vol.165 , pp. 83-97
    • Lemere, C.A.1    Beierschmitt, A.2    Iglesias, M.3    Spooner, E.T.4    Bloom, J.K.5    Leverone, J.F.6
  • 85
    • 84886678332 scopus 로고    scopus 로고
    • Animal models of Alzheimer disease
    • LaFerla, F. M.; Green, K. N. Animal models of Alzheimer disease. Cold Spring Harb Perspect Med, 2 (11), a006320. doi: 10.1101/cshperspect.a006320 (2012).
    • (2012) Cold Spring Harb Perspect Med , vol.2 , Issue.11
    • LaFerla, F.M.1    Green, K.N.2
  • 86
    • 80054088628 scopus 로고    scopus 로고
    • Determination of spatial and temporal distribution of microglia by 230nm-high-resolution, high-throughput automated analysis reveals different amyloid plaque populations in an APP/PS1 mouse model of Alzheimer's disease
    • Scheffler, K.; Stenzel, J.; Krohn, M.; Lange, C.; Hofrichter, J.; Schumacher, T.; Brüning, T.; Plath, A. S.; Walker, L.; Pahnke, J. Determination of spatial and temporal distribution of microglia by 230nm-high-resolution, high-throughput automated analysis reveals different amyloid plaque populations in an APP/PS1 mouse model of Alzheimer's disease. Curr Alzheimer Res 8,781-788 (2011).
    • (2011) Curr Alzheimer Res , vol.8 , pp. 781-788
    • Scheffler, K.1    Stenzel, J.2    Krohn, M.3    Lange, C.4    Hofrichter, J.5    Schumacher, T.6    Brüning, T.7    Plath, A.S.8    Walker, L.9    Pahnke, J.10
  • 87
    • 84859298550 scopus 로고    scopus 로고
    • The value and limitations of transgenic mouse models used in drug discovery for Alzheimer's disease: An update
    • Bales, K.R. The value and limitations of transgenic mouse models used in drug discovery for Alzheimer's disease: an update. Expert Opin Drug Discov. 7, 281-297 (2012).
    • (2012) Expert Opin Drug Discov , vol.7 , pp. 281-297
    • Bales, K.R.1
  • 88
    • 80053987137 scopus 로고    scopus 로고
    • APP transgenic mice and their application to drug discovery
    • Howlett, D. R. APP transgenic mice and their application to drug discovery. Histol Histopathol 26, 1611-1632 (2011).
    • (2011) Histol Histopathol , vol.26 , pp. 1611-1632
    • Howlett, D.R.1
  • 89
    • 77956229704 scopus 로고    scopus 로고
    • Neuropathology after active Abeta42 immunotherapy: Implications for Alzheimer's disease pathogenesis
    • Boche, D.; Denham, N.; Holmes, C.; Nicoll, J. A. Neuropathology after active Abeta42 immunotherapy: implications for Alzheimer's disease pathogenesis. Acta Neuropathol 120, 369-384 (2010).
    • (2010) Acta Neuropathol , vol.120 , pp. 369-384
    • Boche, D.1    Denham, N.2    Holmes, C.3    Nicoll, J.A.4
  • 90
    • 84900485727 scopus 로고    scopus 로고
    • What is normal in normal aging? Effects of aging, amyloid and Alzheimer's disease on the cerebral cortex and the hippocampus
    • en prensa
    • Fjell, A.; McEvoy, M.; Holland, L.; D.; Dale, A. M.; Walhovda, K. B. The Alzheimer's disease Neuroimaging Initiative. What is normal in normal aging? Effects of aging, amyloid and Alzheimer's disease on the cerebral cortex and the hippocampus. Prog Neurobiol (en prensa) (2014). http://dx.doi.org/10.1016/j.pneurobio.2014.02.004.
    • (2014) Prog Neurobiol
    • The Alzheimer's disease Neuroimaging Initiative1    Fjell, A.2    McEvoy, M.3    Holland, L.D.4    Dale, A.M.5    Walhovda, K.B.6
  • 91
    • 84899821091 scopus 로고    scopus 로고
    • Association of structural global brain network properties with intelligence in normal aging
    • Fischer, F. U.; Wolf, D.; Scheurich, A.; Fellgiebel, A. Association of structural global brain network properties with intelligence in normal aging. PLoS One 22, 9 (2014). doi: 10.1371/journal.pone.0086258.
    • (2014) PLoS One , vol.22 , pp. 9
    • Fischer, F.U.1    Wolf, D.2    Scheurich, A.3    Fellgiebel, A.4
  • 93
    • 84901712583 scopus 로고    scopus 로고
    • Glucose metabolism in normal aging and Alzheimer's disease: Methodological and physiological considerations for PET studies
    • Mosconi, L. Glucose metabolism in normal aging and Alzheimer's disease: Methodological and physiological considerations for PET studies. Clin Trans Imaging 1, doi: 10.1007/s40336-013-0026-y (2013).
    • (2013) Clin Trans Imaging , vol.1
    • Mosconi, L.1
  • 95
    • 84895746988 scopus 로고    scopus 로고
    • Amyloid deposition is decreasing in aging brains: An autopsy study of 1,599 older people
    • Kövari, E.; Herrmann, F. R.; Bouras, C.; Gold, G. Amyloid deposition is decreasing in aging brains: an autopsy study of 1,599 older people. Neurology 28, 326-331 (2014)
    • (2014) Neurology , vol.28 , pp. 326-331
    • Kövari, E.1    Herrmann, F.R.2    Bouras, C.3    Gold, G.4
  • 97
    • 84922394004 scopus 로고    scopus 로고
    • Age-related differences in the dynamic architecture of intrinsic networks
    • en prensa
    • Madhyastha, T. M.; Grabowski, T. J. Age-related differences in the dynamic architecture of intrinsic networks. Brain Connect 30, (en prensa) (2014).
    • (2014) Brain Connect , vol.30
    • Madhyastha, T.M.1    Grabowski, T.J.2
  • 98
    • 84929995282 scopus 로고    scopus 로고
    • Multiple neuronal and glial mechanisms can be involved in the response to the activation of nicotinic receptors. A
    • Neural Transmissions: Characteristics, Mechanisms and Malfunctioning, Costa, A. Villalba, E. (Eds). Nova Science Publishers, Inc.; Hauppauge, NY
    • Toledano, A.; Álvarez M. I.; Toledano-Díaz, A. Multiple neuronal and glial mechanisms can be involved in the response to the activation of nicotinic receptors. A. In: Horizons in Neuroscience Research. Volume 3 Neural Transmissions: Characteristics, Mechanisms and Malfunctioning, Costa, A. Villalba, E. (Eds). Nova Science Publishers, Inc.; Hauppauge, NY, pp 1-34 (2011).
    • (2011) Horizons in Neuroscience Research , vol.3 , pp. 1-34
    • Toledano, A.1    Álvarez, M.I.2    Toledano-Díaz, A.3
  • 100
    • 84890423856 scopus 로고    scopus 로고
    • Associations between Alzheimer disease biomarkers, neurodegeneration, and cognition in cognitively normal older people
    • Wirth, M.; Villeneuve, S.; Haase, C. M.; Madison, C. M.; Oh, H.; Landau, S. M.; Rabinovici, G. D.; Jagust, W. J. Associations between Alzheimer disease biomarkers, neurodegeneration, and cognition in cognitively normal older people. JAMA Neurol 70, 1512-1519 (2013).
    • (2013) JAMA Neurol , vol.70 , pp. 1512-1519
    • Wirth, M.1    Villeneuve, S.2    Haase, C.M.3    Madison, C.M.4    Oh, H.5    Landau, S.M.6    Rabinovici, G.D.7    Jagust, W.J.8
  • 102
    • 84886489793 scopus 로고    scopus 로고
    • Modulation of multiple memory systems: From neurotransmitters to metabolic substrates
    • Gold, P. E.; Newman, L. A.; Scavuzzo, C. J,; Korol, D. L. Modulation of multiple memory systems: from neurotransmitters to metabolic substrates. Hippocampus 23, 1053-1065 (2013).
    • (2013) Hippocampus , vol.23 , pp. 1053-1065
    • Gold, P.E.1    Newman, L.A.2    Scavuzzo, C.J.3    Korol, D.L.4
  • 105
    • 84879240834 scopus 로고    scopus 로고
    • Functional alteration patterns of default mode networks: Comparisons of normal aging, amnestic mild cognitive impairment and Alzheimer's disease
    • Cha, J.; Jo, H. J.; Kim, H. J.; Seo, S. W.; Kim, H. S.; Yoon, U., Park, H:, Na, D. L.; Lee, J. M. Functional alteration patterns of default mode networks: comparisons of normal aging, amnestic mild cognitive impairment and Alzheimer's disease. Eur J Neurosci 37, 1916-1924 (2013).
    • (2013) Eur J Neurosci , vol.37 , pp. 1916-1924
    • Cha, J.1    Jo, H.J.2    Kim, H.J.3    Seo, S.W.4    Kim, H.S.5    Yoon, U.6    Park, H.7    Na, D.L.8    Lee, J.M.9
  • 109
    • 84897954510 scopus 로고    scopus 로고
    • Is synaptic loss a unique hallmark of Alzheimer's disease?
    • en prensa
    • Scheff, S. W.; Neltner, J. H.; Nelson, P. T. Is synaptic loss a unique hallmark of Alzheimer's disease? Biochem Pharmacol. 9 (en prensa) (2014). doi: 10.1016/j.bcp.2013.12.028.
    • (2014) Biochem Pharmacol , vol.9
    • Scheff, S.W.1    Neltner, J.H.2    Nelson, P.T.3
  • 110
    • 84891818678 scopus 로고    scopus 로고
    • Cerebrovascular pathology and amyloid plaque formation in Alzheimer's disease
    • Lee, C. W.; Shih, Y. H.; Kuo, Y. M. Cerebrovascular pathology and amyloid plaque formation in Alzheimer's disease. Curr Alzheimer Res 11, 4-10 (2014).
    • (2014) Curr Alzheimer Res , vol.11 , pp. 4-10
    • Lee, C.W.1    Shih, Y.H.2    Kuo, Y.M.3
  • 112
    • 84903304059 scopus 로고    scopus 로고
    • Oxidative stress and mitochondrial dysfunction in Alzheimer's disease
    • en prensa
    • Wang, X.; Wang, W.; Li, L.; Perry, G.; Lee, H. G.; Zhu, X. Oxidative stress and mitochondrial dysfunction in Alzheimer's disease. Biochim Biophys Acta. (en prensa) (2013) doi: 10.1016/j.bbadis.2013.10.015.
    • (2013) Biochim Biophys Acta
    • Wang, X.1    Wang, W.2    Li, L.3    Perry, G.4    Lee, H.G.5    Zhu, X.6
  • 113
    • 84876829216 scopus 로고    scopus 로고
    • Neuropathological approaches to cerebral aging and neuroplasticity
    • Jellinger, K. A.; Attems, J. Neuropathological approaches to cerebral aging and neuroplasticity. Dialogues Clin Neurosci 15, 29-43 (2013).
    • (2013) Dialogues Clin Neurosci , vol.15 , pp. 29-43
    • Jellinger, K.A.1    Attems, J.2
  • 114
    • 84864464317 scopus 로고    scopus 로고
    • Cross-linking of cell surface amyloid precursor protein leads to increased β-amyloid peptide production in hippocampal neurons: Implications for Alzheimer's disease
    • Lefort, R.; Pozueta, J.; Shelanski, M. Cross-linking of cell surface amyloid precursor protein leads to increased β-amyloid peptide production in hippocampal neurons: implications for Alzheimer's disease. J Neurosci 32, 10674-10685 (2012).
    • (2012) J Neurosci , vol.32 , pp. 10674-10685
    • Lefort, R.1    Pozueta, J.2    Shelanski, M.3
  • 115
    • 77955288165 scopus 로고    scopus 로고
    • Intermediate phenotypes identify divergent pathways to Alzheimer's disease
    • Shulman, J. M.; Chibnik, L. B.; Aubin, C.; Schneider, J. A.; Bennett, D.A.; De Jager, P. L. Intermediate phenotypes identify divergent pathways to Alzheimer's disease. PLoS One 5(6), e11244 (2010). doi: 10.1371/journal.pone.0011244.
    • (2010) PLoS One , vol.5 , Issue.6
    • Shulman, J.M.1    Chibnik, L.B.2    Aubin, C.3    Schneider, J.A.4    Bennett, D.A.5    De Jager, P.L.6
  • 116
    • 75349095224 scopus 로고    scopus 로고
    • Alzheimer-type tau pathology in advanced aged nonhuman primate brains harboring substantial amyloid deposition
    • Oikawa, N.; Kimura, N.; Yanagisawa, K. Alzheimer-type tau pathology in advanced aged nonhuman primate brains harboring substantial amyloid deposition. Brain Res 1315, 137-149 (2010).
    • (2010) Brain Res , vol.1315 , pp. 137-149
    • Oikawa, N.1    Kimura, N.2    Yanagisawa, K.3
  • 119
    • 84858999754 scopus 로고    scopus 로고
    • Lesion-induced vertebrate models of Alzheimer Dementia
    • Deyn, P.P.; Van Dam, D. (Eds). Humana Press; Amsterdam
    • Toledano, A.; Álvarez M. I. Lesion-induced vertebrate models of Alzheimer Dementia. En Animal models of Dementia; Deyn, P.P.; Van Dam, D. (Eds). Humana Press; Amsterdam, 210; pp 295-345.
    • Animal Models of Dementia , vol.210 , pp. 295-345
    • Toledano, A.1    Álvarez, M.I.2
  • 120
    • 78649249224 scopus 로고    scopus 로고
    • Diversity and variability of the nicotine effects on different brain cortical regions. Therapeutic and toxicologic implications
    • Toledano, A.; Álvarez M. I.; Toledano-Díaz, A. Diversity and variability of the nicotine effects on different brain cortical regions. Therapeutic and toxicologic implications. CNS Agents Med Chem 10, 180-206 (2010).
    • (2010) CNS Agents Med Chem , vol.10 , pp. 180-206
    • Toledano, A.1    Álvarez, M.I.2    Toledano-Díaz, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.