The effect of age and testosterone on the expression of glial fibrillary acidic protein in the rat cerebellum

Experimental Neurology

Volumn 151, Issue 2, 1998, Pages 343-346

  Day, J R ^a   Frank, A T ^a   O'Callaghan, J P ^a   Jones, B C ^b   Anderson, J E ^c  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

^c NONE

Author keywords

Aging; Astrocytes; Cerebellum; GFAP; Rat; Testosterone

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; TESTOSTERONE;

AGE; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN SLICE; CEREBELLUM; CONTROLLED STUDY; GENE EXPRESSION; HORMONE SUBSTITUTION; MALE; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TESTOSTERONE BLOOD LEVEL;

EID: 0032103890     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1998.6801     Document Type: Article

References (40)

1. Barnes C. Normal aging: Regionally specific changes in hippocampal synaptic transmission. Trends Neurosci. 17:1994;13-18.
2. Beck K., Lamballe F., Klein R., Barbacid M., Schauwecker P., McNeill T., Finch C., Hefti F., Day J. Function of non-catalyticTrk. J. Neurosci. 13:1993;4001-4014.
3. Collier T., Coleman P. Divergence of biological and chronological aging: Evidence from rodent studies. Neurobiol. Aging. 12:1991;685-693.
4. Coleman P., Flood D. Net dendritic stability of layer II pyramidal neurons in F344 rat entorhinal cortex from 12 to 37 months. Neurobiol. Aging. 12:1991;535-541.
5. Day J., Laping N., Lambert-Etchells M., Brown S., O'Callaghan J., McNeill T., Finch C. Gonadal steroids regulate the expression of glial fibrillary acidic protein in the adult male rat hippocampus. Neuroscience. 55:1993;435-443.
6. Day J., Laping N., McNeill T., Schreiber S., Pasinetti G., Finch C. Castration enhances the expression of glial fibrillary acidic protein and sulfated glycoprotein-2 in the intact and lesion-altered hippocampus of the adult male rat. Mol. Endocrinol. 4:1990;1995-2002.
7. Finch C., Day J. Molecular biology of aging in the nervous system: A synopsis of the levels of mechanisms. Neurodegenerative Diseases. 1994;Saunders, Philadelphia. p. 33-50.
8. Garcia-Estrada J., Del Rio J., Luquin S., Soriano E., Garcia-Segura L. Gonadal hormones down-regulate reactive gliosis and astrocyte proliferation after a penetrating brain injury. Brain Res. 628:1995;271-278.
9. Geinisman Y., Bondareff W., Dodge J. Hypertrophy of astroglial processes in the dentate gyrus of the senescent rat. Am. J. Anat. 153:1978;537-545.
10. Goss J., Finch C., Morgan D. Age-related changes in glial fibrillary acidic protein mRNA in the mouse brain. Neurobiol. Aging. 12:1991;165-170.
11. Goss J., Morgan D. Enhanced glial fibrillary acidic protein mRNA in response to fornix transection in aged mice. J. Neurochem. 64:1995;1351-1360.
12. Gould E., Woolley C., Frankfurt M., McEwen B. Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood. J. Neurosci. 10:1990;1286-1291.
13. Jalenques I., Burette A., Albuisson E., Romand R. Age-related changes in GFAP-immunoreactive astrocytes in the rat ventral cochlear nucleus. Hear. Res. 107:1997;114-124.
14. Kohama S., Goss J., Finch C., McNeill T. Increases of glial fibrillary acidic protein in the aging female mouse brain. Neurobiol. Aging. 16:1995;59-67.
15. Laping N., Nichols N., Day J., Johnson S., Finch C. Corticosterone differentially regulates the bilateral response of astrocyte mRNAs in the hippocampus to entorhinal cortex lesions in male rats. Mol. Brain Res. 10:1991;291-297.
16. Laping N., Teter B., Anderson C., Osterburg H., O'Callaghan J., Johnson S., Finch C. Age-related increases in glial fibrillary acidic protein do not show proportionate changes in transcription rates or DNA methylation in the cerebral cortex and hippocampus of male rats. J. Neurosci. Res. 39:1994;710-717.
17. Laping N., Teter B., Nichols N., Rozovsky I., Finch C. Glial fibrillary acidic protein: regulation by hormones, cytokines, and growth factors. Brain Pathol. 4:1994;259-275.
18. Linneman D., Skarsfeit T. Regional changes in expression of NCAM, GFAP, and S100 in aging rat brain. Neurobiol. Aging. 15:1994;651-655.
19. Major D., Kesslak J., Cotman C., Finch C., Day J. Life-long restriction attenuates age-related increases in hippocampal glial acidic protein mRNA. Neurobiol. Aging. 18:1997;523-526.
20. Mathewson A., Berry M. Observations on the astrocyte response to a cerebral stab wound in adult rats. Brain Res. 327:1985;61-69.
21. Matthews D., Cotman C., Lynch G. An electron microscopic study of lesion-induced synaptogenesis in the dentate gyrus of the adult rat. II. Reappearance of morphologically normal synaptic contacts. Brain Res. 115:1976;23-41.
22. Nichols N., Day J., Laping N., Johnson S., Finch C. GFAP mRNA increases with age in rat and human brain. Neurobiol. Aging. 14:1993;421-429.
23. Nichols N., Finch C., Nelson J. Food restriction delays the age-related increase in GFAP mRNA in rat hypothalamus. Neurobiol. Aging. 16:1995;1-5.
24. Norton W., Aquino D., Hozumi I., Chiu F., Bronson C. Quantitative aspects of reactive gliosis: A review. Neurochem. Res. 17:1992;877-885.
25. O'Callaghan J. Quantification of glial fibrillary acidic protein: Comparison of slot-immunobinding assays with a novel sandwich ELISA. Neurotoxicol. Teratol. 13:1991;275-281.
26. O'Callaghan J., Brinton R., McEwen B. Glucocorticoids regulate the concentration of glial fibrillary acidic protein throughout the brain. Brain Res. 494:1989;159-161.
27. O'Callaghan J., Brinton R., McEwen B. Glucocorticoids regulate the synthesis of glial fibrillary acidic protein in intact and adrenalectomized rats do not affect its expression following brain injury. J. Neurochem. 57:1991;860-869.
28. O'Callaghan J., Miller D. The concentration of glial fibrillary acidic protein increases with age in the mouse and rat brain. Neurobiol. Aging. 12:1991;171-174.
29. Ordy J., Wengenack T., Bialobok P., Coleman P., Rodier P., Baggs R., Dunlap W., Kates B. Selective vulnerability and early progression of hippocampal CA1 pyramidal cell degeneration and GFAP-positive astrocyte reactivity in the rat four-vessel occlusion model of transient global ischemia. Exp. Neurol. 119:1993;128-139.
30. Pfaff D., Keiner M. Atlas of estradiol-concentrating cells in the central nervous system of the female rat. J. Comp. Neurol. 151:1973;121-158.
31. Pilegaard K., Ladefoged O. Total number of astrocytes in the molecular layer of the dentate gyrus of rats at different ages. Anal. Quant. Cytol. Histol. 18:1996;279-285.
32. Schauwecker P., McNeill T. Enhanced but delayed axonal sprouting in the commissural/associational pathway following a combined entorhinal cortex/fimbria fornix lesion. J. Comp. Neurol. 351:1995;453-464.
33. Scheff S., Bernardo L., Cotman C. Decline in reactive fiber outgrowth in the dentate gyrus of aged rats following entorhinal cortex removal. Brain Res. 199:1980;21-38.
34. Scheff S., Morse J., Dekosky S. Neurotrophic effects of steroids on lesion-induced growth in the hippocampus. I. The asteroidal condition. Brain Res. 457:1988;246-255.
35. Simerly R., Chang C., Muramatsu M., Swanson L. Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: Anin situ. J. Comp. Neurol. 294:1990;76-95.
36. Wagner A., Beck G., Platt D. Evidence that V+ fibronectin, GFAP and S100 beta mRNAs are increased in the hippocampus of aged rats. Exp. Gerontol. 28:1993;135-143.
37. West M., Coleman P., Flood D., Troncoso J. Differential neuronal loss in the hippocampus in normal aging and in patients with Alzheimer's disease. Ugeskr Laeger. 157:1995;3190-3193.
38. Woolley C., Gould E., Frankfurt M., McEwen B. Naturally occurring fluctuation in dendritic spine density on adult hippocampal pyramidal neurons. J. Neurosci. 10:1990;4035-4039.
39. Woolley C., McEwen B. Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. J. Neurosci. 12:1992;2549-2554.
40. Yoshida T., Goldsmith S., Morgan T., Stone D., Finch C. Transcription supports age-related increases of GFAP gene expression in the male rat brain. Neurosci. Lett. 215:1996;107-110.