The emergence of geroscience as an interdisciplinary approach to the enhancement of health span and life span

Cold Spring Harbor Perspectives in Medicine

Volumn 6, Issue 4, 2016, Pages

  Sierra, Felipe ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; DNA; FREE RADICAL; PROTEIN;

ADAPTATION; AGING; APOPTOSIS; ARTICLE; CELL AGING; CELL REGENERATION; CHRONIC DISEASE; COMORBIDITY; DISEASE PREDISPOSITION; DNA DAMAGE; DNA REPAIR; ENVIRONMENTAL FACTOR; EPIGENETICS; GERIATRIC DISORDER; GERIATRICS; GERONTOLOGICAL RESEARCH; GEROSCIENCE; HEALTH; HEALTH SPAN; HUMAN; INFLAMMATION; LIFESPAN; METABOLISM; NONHUMAN; PROTEIN HOMEOSTASIS; QUALITY OF LIFE; STEM CELL; STRESS; TELOMERE SHORTENING; AGED; LIFE EXPECTANCY; MEDICAL RESEARCH; PHYSIOLOGY; VERY ELDERLY;

AGED; AGED, 80 AND OVER; AGING; BIOMEDICAL RESEARCH; CHRONIC DISEASE; GERIATRICS; HUMANS; LIFE EXPECTANCY; QUALITY OF LIFE;

EID: 84962376897     PISSN: None     EISSN: 21571422     Source Type: Journal    
DOI: 10.1101/cshperspect.a025163     Document Type: Article

References (103)

1. Aydinonat D, Penn DJ, Smith S, Moodley Y, Hoelzl F, Knauer F, Schwarzenberger F. 2014. Social isolation shortens telomeres in African grey parrots (Psittacus erithacus erithacus). PLoS ONE 9: e93839.
2. Baker DJ, Wijshake T, Tchkonia T, LeBrasseur NK, Childs BG, van de Sluis B, Kirkland JL, van Deursen JM. 2011. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 479: 232-236.
3. Balch WE, Morimoto RI, Dillin A, Kelly JW. 2008. Adapting proteostasis for disease intervention. Science 319: 916-919.
4. Barzilai N, Huffman DM, Muzumdar RH, Bartke A. 2012. The critical role of metabolic pathways in aging. Diabetes 61: 1315-1322.
5. Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, et al. 2006.Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444: 337-342.
6. Bhattacharya J, Cutler DM, Goldman DP, Hurd MD, Joyce GF, Lakdawalla DN, Panis CWA, Shang B. 2004. Disability forecasts and futureMedicare costs. In Frontiers in health policy research (ed. Cutler DM, Garber AM), Vol 7, 75-94. National Bureau of Economic Research, Cambridge, MA.
7. Blasco MA. 2007. Telomere length, stem cells and aging. Nat Chem Biol 3: 640-649.
8. Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, Harley CB, Shay JW, Lichtsteiner S, Wright WE. 1998. Extension of life-span by introduction of telomerase into normal human cells. Science 279: 349-352.
9. Breusing N, Grune T. 2008. Regulation of proteasome-mediated protein degradation during oxidative stress and aging. Biol Chem 389: 203-209.
10. Brunet A, Berger SL. 2014. Epigenetics of aging and agingrelated disease. J Gerontol A Biol Sci Med Sci 69: S17-S20.
11. Bruunsgaard H, Pedersen BK. 2003. Age-related inflammatory cytokines and disease. Immunol Allergy Clin North Am 23: 15-39.
12. Bruunsgaard H, Andersen-Ranberg K, Hjelmborg JB, Pedersen BK, Jeune B. 2003. Elevated levels of tumor necrosis factor alpha and mortality in centenarians. Am J Med 115: 278-283.
13. Burch J, Augustine AD, Frieden LA, Hadley E, Howcroft TK, Johnson R, Khalsa PS, Kohanski RA, Li XL, Macchiarini F, et al. 2014. Advances in geroscience: Impact on healthspan and chronic disease. J Gerontol A Biol Sci Med Sci 69: S1-S3.
14. Calabrese EJ, Iavicoli I, Calabrese V. 2012. Hormesis:Why it is important to biogerontologists. Biogerontology 13: 215-235.
15. Cawthon RM, Smith KR, O’Brien E, Sivatchenko A, Kerber RA. 2003. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 361: 393-395.
16. Conboy IM, Conboy MJ, Wagers AJ, Girma ER, Weissman IL, Rando TA. 2005. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 433: 760-764.
17. Corona G, Vignozzi L, Sforza A, Maggi M. 2013. Risks and benefits of late onset hypogonadism treatment: An expert opinion. World J Mens Health 31: 103-125.
18. Cuervo AM. 2008. Autophagy and aging: Keeping that old broom working. Trends Genet 24: 604-612.
19. De Cabo R, Carmona-Gutierrez D, Bernier M, Hall MN, Madeo F. 2014. The search for antiaging interventions: From elixirs to fasting regimens. Cell 157: 1515-1526.
20. De Martinis M, Franceschi C, Monti D, Ginaldi L. 2005. Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity. FEBS Lett 579: 2035-2039.
21. Dillin A, Gottschling DE, Nyström T. 2014. The good and the bad of being connected: The integrons of aging. Curr Opin Cell Biol 26: 107-112.
22. Durieux J, Wolff S, Dillin A. 2011. The cell-non-autonomous nature of electron transport chain-mediated longevity. Cell 114: 79-91.
23. Epel ES, Lithgow GJ. 2014. Stress biology and aging mechanisms: Toward understanding the deep connection between adaptation to stress and longevity. J Gerontol A Biol Sci Med Sci 69: S10-S16.
24. Epel ES, Blackburn EH, Lin J, Dhabhar FS, Adler NE, Morrow JD, Cawthon RM. 2004. Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci 101: 17312-17315.
25. Epel ES, Merkin SS, Cawthon R, Blackburn EH, Adler NE, Pletcher MJ, Seeman TE. 2009. The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men. Aging (Albany) 1: 81-88.
26. Fernández AF, Fraga MF. 2011. The effects of the dietary polyphenol resveratrol on human healthy aging. Epigenetics 6: 870-874.
27. Ferrucci L, Harris TB, Guralnik JM, Tracy RP, Corti MC, Cohen HJ, Penninx B, Pahor M, Wallace R, Havlik RJ. 1999. Serum IL-6 level and the development of disability in older persons. J Am Geriatr Soc 47: 639-646.
28. Flurkey K, Currer JM, Harrison DE. 2007. The mouse in aging research. In The mouse in biomedical research (ed. Fox JG, et al.), 2nd ed., Vol. 3, 637-672.
29. Fontana L, Partridge L, Longo VD. 2010. Extending healthy life span—From yeast to humans. Science 328: 321-326.
30. Franceschi C. 2007. Inflammaging as a major characteristic f old people: Can it be prevented or cured? Nutr Rev 65: S173-S176.
31. Franceschi C, Campisi J. 2014. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci 69: S4-S9.
32. Franceschi C, Capri M, Monti D, Giunta S, Olivieri F, Sevini F, Panourgia MP, Invidia L, Celani L, Scurti M, et al. 2007. Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev 128: 92-105.
33. Goldman DP, Cutler D, Rowe JW, Michaud PC, Sullivan J, Peneva D, Olshansky SJ. 2013. Substantial health and economic returns from delayed aging may warrant a new focus for medical research. Health Aff (Millwood) 32: 1698-1705.
34. Gorbunova V, Seluanov A, Mao Z, Hine C. 2007. Changes in DNA repair during aging. Nucleic Acids Res 35: 7466-7474.
35. Gorbunova V, Seluanov A, Zhang Z, Gladyshev VN, Vijg J. 2014. Comparative genetics of longevity and cancer: Insights from long-lived rodents. Nat Rev Genet 15: 531-540.
36. Greer EL, Maures TJ, Ucar D, Hauswirth AG, Mancini E, Lim JP, Benayoun BA, Shi Y, Brunet A. 2011. Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans. Nature 479: 365-371.
37. Harris TB, Ferrucci L, Tracy RP, Corti MC, Wacholder S, Ettinger WH Jr, Heimovitz H, Cohen HJ, Wallace R. 1999. Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am JMed 106: 506-512.
38. Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS, et al. 2009. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460: 392-395.
39. Harrison DE, Strong R, Allison DB, Ames BN, Astle CM, Atamna H, Fernandez E, Flurkey K, Javors MA, Nadon NL, et al. 2014. Acarbose, 17-a-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males. Aging Cell 13: 273-282.
40. Herrera E, Samper E, Martìn-Caballero J, Flores JM, Lee HW, Blasco MA. 1999. Disease states associated with telomerase deficiency appear earlier in micewith short telomeres. EMBO J 18: 2950-2960.
41. Hoeijmakers JH. 2009. DNA damage, aging, and cancer. New Engl J Med 361: 1475-1485.
42. Howcroft TK, Campisi J, Louis GB, Smith MT, Wise B, Wyss-Coray T, Augustine AD, McElhaney JE, Kohanski R, Sierra F. 2013. The role of inflammation in age-related disease. Aging 5: 84-93.
43. Imai SI, Guarente L. 2014. NADþ and sirtuins in aging and disease. Trends Cell Biol 24: 464-471.
44. Isobe KI, Cheng Z, Nishio N, Suganya T, Tanaka Y, Ito S. 2014. iPSCs, aging and age-related diseases. N Biotechnol 31: 411-421.
45. Jensen-Seaman MI, Furey TS, Payseur BA, Lu Y, Roskin KM, Chen CF, Thomas MA, Haussler D, Jacob HJ. 2004. Comparative recombination rates in the rat, mouse, and human genomes. Genome Res 14: 528-538.
46. Johnson TE. 2008. Caenorhabditis elegans 2007: Th e premier model for the study of aging. Exp Gerontol 43: 1-4.
47. Johnson SC, Rabinovitch PS, Kaeberlein M. 2013. mTOR is a key modulator of ageing and age-related disease. Nature 493: 338-345.
48. Kato M, Chen X, Inukai S, Zhao H, Slack FJ. 2011. Ageassociated changes in expression of small, noncoding RNAs, including microRNAs, in C. elegans. RNA 17: 1804-1820.
49. Katsimpardi L, Litterman NK, Schein PA, Miller CM, Loffredo FS, Wojtkiewicz GR, Chen JW, Lee RT, Wagers AJ, Rubin LL. 2014. Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors. Science 344: 630-634.
50. Kennedy BK, Berger SL, Brunet A, Campisi J, Cuervo AM, Epel ES, Franceschi C, Lithgow GJ, Morimoto RI, Pessin JE, et al. 2014. Geroscience: Linking aging to chronic disease. Cell 159: 709-713.
51. Kenyon C. 2010. The genetics of aging. Nature 464: 504-512.
52. Krtolica A, Campisi J. 2003. Integrating epithelial cancer, aging stroma and cellular senescence. Adv Gerontol 11: 109-116.
53. Kumar S, Subramanian S. 2002.Mutation rates in mammalian genomes. Proc Natl Acad Sci 99: 803-808.
54. Liu GH, Ding Z, Izpisua-Belmonte JC. 2012. iPSC technology to study human aging and aging-related disorders. Curr Opin Cell Biol 24: 765-774.
55. Loffredo FS, Steinhauser ML, Jay SM, Gannon J, Pancoast JR, Yalamanchi P, Sinha M, Dall’Osso C, Khong D, Shadrach JL, et al. 2013. Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell 153: 828-839.
56. López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. 2013. The hallmarks of aging. Cell 153: 1194-1217.
57. Mahmoudi S, Brunet A. 2012. Aging and reprogramming: A two-way street. Curr Opin Cell Biol 24: 744-756.
58. Martin-Montalvo A, Mercken EM, Mitchell SJ, Palacios HH, Mote PL, Scheibye-Knudsen M, Gomes AP, Ward TM, Minor RK, Blouin MJ, et al. 2013. Metformin improves healthspan and lifespan in mice. Nat Commun 4: 2192.
59. Matsumoto AM. 2013. Testosterone administration in older men. Endocrinol Metab Clin North Am 42: 271-286.
60. McCay CM, Crowell MF. 1934. Prolonging the life span. Sci Mon 39: 405-414.
61. McCay CM, Crowell MF, Maynard LA. 1935. The effect of retarded growth upon the length of life span and upon the ultimate body size. J Nutr 10: 63-79.
62. McEwen BS. 2013. Brain on stress: How the social environment gets under the skin. Proc Natl Acad Sci 109: 17180-17185.
63. Mendelson DN, Schwartz WB. 1993. The effects of aging and population growth on health care costs. Health Aff 12: 119-125.
64. Miller RA. 2002. Extending life: Scientific prospects and political obstacles. Milbank Q 80: 155-174.
65. Miller RA, Harrison DE, Astle CM, Fernandez E, Flurkey K, Han M, Javors MA, Li X, Nadon NL, Nelson JF, et al. 2014. Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction. Aging Cell 13: 468-477.
66. Milman S, Atzmon G, Huffman DM, Wan J, Crandall JP, Cohen P, Barzilai N. 2014. Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity. Aging Cell 13: 769-771.
67. Morimoto RI, Cuervo AM. 2014. Proteostasis and the aging proteome in health and disease. J Gerontol A Biol Sci Med Sci 69: S33-S38.
68. Munkácsy E, Rea SL. 2014. The paradox of mitochondrial dysfunction and extended longevity. Exp Gerontol 56: 221-233.
69. Neugarten BL, Havighurst RJ. 1977. Extending the human life span: Social policy and social ethics. National Science Foundation, Arlington, VA.
70. Niccoli T, Partridge L. 2012. Ageing as a risk factor for disease. Curr Biol 22: R741-R752.
71. Olshansky SJ, Perry D, Miller RA, Butler RN. 2006. In pursuit of the longevity dividend. The Scientist 20: 28-36.
72. Olshansky SJ, Perry D, Miller RA, Butler RN. 2007. Pursuing the longevity dividend. Scientific goals for an aging world. Ann NY Acad Sci 1114: 11-13.
73. Pala FS, Gürkan H. 2008. The role of free radicals in ethiopathogenesis of diseases. Adv Molec Biol 1: 1-9.
74. Parks CG, Miller DB, McCanlies EC, Cawthon RM, Andrew ME, DeRoo LA, Sandler DP. 2009. Telomere length, current perceived stress, and urinary stress hormones in women. Cancer Epidemiol Biomarkers Prev 18: 551-560.
75. Pawelec G, Goldeck D, Derhovanessian E. 2014. Inflammation, ageing and chronic disease. Curr Opin Immunol 29: 23-28.
76. Pawlikowska L, Hu D, Huntsman S, Sung A, Chu C, Chen J, Joyner AH, Schork NJ, Hsueh WC, Reiner AP, et al. 2009. Association of common genetic variation in the insulin/IGF-1 signaling pathway with human longevity. Aging Cell 8: 460-472.
77. Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N, Swindell WR, Kamara D, Minor RK, Perez E, et al. 2008. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab 8: 157-168.
78. Pérez VI, Van Remmen H, Bokov A, Epstein CJ, Vijg J, Richardson A. 2009. The overexpression of major antioxidant enzymes does not extend the lifespan of mice. Aging Cell 8: 73-75.
79. Promislow DEL. 1994. DNA repair and the evolution of longevity: Acritical analysis. J Theoret Biol 170: 291-300.
80. Rando TA, Chang HY. 2008. Aging, rejuvenation, and epigenetic reprogramming: Resetting the aging clock. Ann Rev Biochem 77: 727-754.
81. Rea SL. 2005.Metabolism in the Caenorhabditis elegans Mit mutants. Exp Gerontol 40: 841-849.
82. Rehan L, Laszki-Szcząchor K, Sobieszczań ska M, Polak-Jonkisz D. 2014. SIRT1 andNAD as regulators of ageing. Life Sci 105: 1-6.
83. Rincon M, Rudin E, Barzilai N. 2005. The insulin/IGF-1 signaling in mammals and its relevance to human longevity. Exp Gerontol 40: 873-877.
84. Ristow M, Schmeisser S. 2011. Extending life span by increasing oxidative stress. Free Radic Biol Med 51: 327-336.
85. Rodrıguez S, Eriksson M. 2010. Evidence for the involvement of lamins in aging. Curr Aging Sci 3: 81-89.
86. Schriner SE, Linford NJ, Martin GM, Treuting P, Ogburn CE, Emond M, Coskun PE, Ladiges W, Wolf N, Van Remmen H, et al. 2005. Extension of murine life span by overexpression of catalase targeted to mitochondria. Science 308: 1909-1911.
87. Sierra F. 2006. Is (your cellular response to) stress killing you? J Gerontol A Biol Sci Med Sci 61: 557-561.
88. Slagboom PE, Beekman M, Passtoors WM, Deelen J, Vaarhorst AA, Boer JM, van den Akker EB, van Heemst D, de Craen AJ, Maier AB, et al. 2011. Genomics of human longevity. Philos Trans R Soc Lond B Biol Sci 366: 35-42.
89. Tchkonia T, Zhu Y, van Deursen J, Campisi J, Kirkland J. 2013. Cellular senescence and the senescent secretory phenotype: Therapeutic opportunities. J Clin Invest 123: 966-972.
90. Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder CE, Bohlooly Y M, Gidlöf S, Oldfors A, Wibom R, et al. 2004. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429: 417-423.
91. Vaidya A, Mao Z, Tian X, Spencer B, Seluanov A, Gorbunova V. 2014. Knock-in reporter mice demonstrate that DNA repair by non-homologous end joining declines with age. PLoS Genet 10: e1004511.
92. Van Remmen H, Ikeno Y, Hamilton M, Pahlavani M, Wolf N, Thorpe SR, Alderson NL, Baynes JW, Epstein CJ, Huang TT, et al. 2003. Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol Genomics 16: 29-37.
93. Villeda SA, Luo J, Mosher KI, Zou B, Britschgi M, Bieri G, Stan TM, Fainberg N, Ding Z, Eggel A, et al. 2011. The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature 477: 90-94.
94. Villeda SA, Plambeck KE, Middeldorp J, Castellano JM, Mosher KI, Luo J, Smith LK, Bieri G, Lin K, Berdnik D, et al. 2014. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nat Med 20: 659-663.
95. Wallace DC. 2005. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: A dawn for evolutionary medicine. Ann Rev Genet 39: 359-407.
96. Warner HR. 2005. Developing a research agenda in biogerontology: Basic mechanisms. Sci Aging Knowl Environ 44: pe33.
97. Wheeler HE, Kim SK. 2011. Genetics and genomics of human aging. Philos Trans R Soc Lond B Biol Sci 366: 43-50.
98. Wilkinson JE, Burmeister L, Brooks SV, Chan CC, Friedline S, Harrison DE, Hejtmancik JF, Nadon N, Strong R, Wood LK, et al. 2012. Rapamycin slows aging in mice. Aging Cell 11: 675-682.
99. Wong E, Cuervo AM. 2010. Integration of clearance mechanisms: The proteasome and autophagy. Cold Spring Harb Perspect Biol 2: a006734.
100. Wood JG, Hillenmeyer S, Lawrence C, Chang C, Hosier S, Lightfoot W, Mukherjee E, Jiang N, Schorl C, Brodsky AS, et al. 2010. Chromatin remodeling in the aging genome of Drosophila. Aging Cell 9: 971-978.
101. Worman HJ. 2012. Nuclear lamins and laminopathies. J Pathol 226: 316-325.
102. Wu D, Ren Z, Pae M, Guo W, Cui X, Merrill AH, Meydani SN. 2007. Aging up-regulates expression of inflammatory mediators in mouse adipose tissue. J Immunol 179: 4829-4839.
103. Zalli A, Carvalho LA, Lin J, Hamer M, Erusalimsky JD, Blackburn EH, Steptoe A. 2014. Shorter telomeres with high telomerase activity are associated with raised allostatic load and impoverished psychosocial resources. Proc Natl Acad Sci 111: 4519-4524.