-
1
-
-
77049308856
-
Aging: A theory based on free radical and radiation chemistry
-
Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol. 1956;11:298-300.
-
(1956)
J Gerontol
, vol.11
, pp. 298-300
-
-
Harman, D.1
-
2
-
-
36949073539
-
A theory of ageing
-
Maynard Smith J. A theory of ageing. Nature. 1959;184:956-957.
-
(1959)
Nature
, vol.184
, pp. 956-957
-
-
Maynard Smith, J.1
-
3
-
-
8344285638
-
Impact of genome instability on transcription regulation of aging and senescence
-
Vijg J. Impact of genome instability on transcription regulation of aging and senescence. Mech Ageing Dev. 2004;125:747-753.
-
(2004)
Mech Ageing Dev
, vol.125
, pp. 747-753
-
-
Vijg, J.1
-
4
-
-
13944270339
-
Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors
-
Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell. 2005;120:513-522.
-
(2005)
Cell
, vol.120
, pp. 513-522
-
-
Campisi, J.1
-
5
-
-
0035818520
-
Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals
-
Moskovitz J, Bar-Noy S, Williams WM, Requena J, Berlett BS, Stadtman ER. Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals. Proc Natl Acad Sci U S A. 2001;98:12920-12925.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 12920-12925
-
-
Moskovitz, J.1
Bar-Noy, S.2
Williams, W.M.3
Requena, J.4
Berlett, B.S.5
Stadtman, E.R.6
-
6
-
-
7744232493
-
Misfolded proteins, endoplasmic reticulum stress and neurodegeneration
-
Rao RV, Bredesen D. Misfolded proteins, endoplasmic reticulum stress and neurodegeneration. Curr Opin Cell Biol. 2004;16:653-662.
-
(2004)
Curr Opin Cell Biol
, vol.16
, pp. 653-662
-
-
Rao, R.V.1
Bredesen, D.2
-
7
-
-
0027278557
-
Instability and decay of the primary structure of DNA
-
Lindahl T. Instability and decay of the primary structure of DNA. Nature. 1993;362:709-715.
-
(1993)
Nature
, vol.362
, pp. 709-715
-
-
Lindahl, T.1
-
9
-
-
0030932869
-
Cancer susceptibility genes: Gatekeepers and caretakers
-
Kinzler KW, Vogelstein B. Cancer susceptibility genes: gatekeepers and caretakers. Nature. 1997;386:761-763.
-
(1997)
Nature
, vol.386
, pp. 761-763
-
-
Kinzler, K.W.1
Vogelstein, B.2
-
10
-
-
0036860224
-
Mutation theory of aging, assessed in transgenic mice and knockout mice
-
Ono T, Uehara Y, Saito Y, Ikehata H. Mutation theory of aging, assessed in transgenic mice and knockout mice. Mech Ageing Dev. 2002;123:1543-1552.
-
(2002)
Mech Ageing Dev
, vol.123
, pp. 1543-1552
-
-
Ono, T.1
Uehara, Y.2
Saito, Y.3
Ikehata, H.4
-
11
-
-
0034641886
-
Age-dependent spontaneous mutagenesis in Xpc mice defective in nucleotide excision repair
-
Wijnhoven SWP, Kool HJM, Mullenders LHF, et al. Age-dependent spontaneous mutagenesis in Xpc mice defective in nucleotide excision repair. Oncogene. 2000;19:5034-5037.
-
(2000)
Oncogene
, vol.19
, pp. 5034-5037
-
-
Wijnhoven, S.W.P.1
Kool, H.J.M.2
Mullenders, L.H.F.3
-
12
-
-
2942556985
-
Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress
-
Van Remmen H, Qi W, Sabia M, et al. Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress. Free Radic Biol Med. 2004;36:1625-1634.
-
(2004)
Free Radic Biol Med
, vol.36
, pp. 1625-1634
-
-
Van Remmen, H.1
Qi, W.2
Sabia, M.3
-
13
-
-
0032827888
-
Deletion of Ku86 causes early onset of senescence in mice
-
Vogel H, Lim DS, Karsenty G, Finegold M, Hasty P. Deletion of Ku86 causes early onset of senescence in mice. Proc Natl Acad Sci U S A. 1999;96:10770-10775.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 10770-10775
-
-
Vogel, H.1
Lim, D.S.2
Karsenty, G.3
Finegold, M.4
Hasty, P.5
-
14
-
-
0037123638
-
Premature aging in mice deficient in DNA repair and transcription
-
De Boer J, Andressoo JO, de Wit J, et al. Premature aging in mice deficient in DNA repair and transcription. Science. 2002;296:1276-1279.
-
(2002)
Science
, vol.296
, pp. 1276-1279
-
-
De Boer, J.1
Andressoo, J.O.2
De Wit, J.3
-
15
-
-
21144434217
-
Extension of murine life span by overexpression of catalase targeted to mitochondria
-
Schriner SE, Linford NJ, Martin GM, et al. Extension of murine life span by overexpression of catalase targeted to mitochondria. Science. 2005;308:1909-1911.
-
(2005)
Science
, vol.308
, pp. 1909-1911
-
-
Schriner, S.E.1
Linford, N.J.2
Martin, G.M.3
-
16
-
-
0030931491
-
Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
-
Blasco MA, Lee HW, Hande MP, et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell. 1997;91:25-34.
-
(1997)
Cell
, vol.91
, pp. 25-34
-
-
Blasco, M.A.1
Lee, H.W.2
Hande, M.P.3
-
17
-
-
4544301617
-
Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes
-
Du X, Shen J, Kugan N, et al. Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes. Mol Cell Biol. 2004;24:8437-8446.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 8437-8446
-
-
Du, X.1
Shen, J.2
Kugan, N.3
-
18
-
-
14644432483
-
A mouse model of Werner syndrome: What can it tell us about aging and cancer?
-
Chang S. A mouse model of Werner syndrome: what can it tell us about aging and cancer? Int J Biochem Cell Biol. 2005;37:991-999.
-
(2005)
Int J Biochem Cell Biol
, vol.37
, pp. 991-999
-
-
Chang, S.1
-
19
-
-
0037421896
-
Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing
-
Wong KK, Maser RS, Bachoo RM, et al. Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature. 2003;421:643-648.
-
(2003)
Nature
, vol.421
, pp. 643-648
-
-
Wong, K.K.1
Maser, R.S.2
Bachoo, R.M.3
-
20
-
-
0037011958
-
P53 mutant mice that display early ageing-associated phenotypes
-
Tyner SD, Venkatachalam S, Choi J, et al. p53 mutant mice that display early ageing-associated phenotypes. Nature. 2002;415:45-53.
-
(2002)
Nature
, vol.415
, pp. 45-53
-
-
Tyner, S.D.1
Venkatachalam, S.2
Choi, J.3
-
21
-
-
0034578389
-
Aggresomes, inclusion bodies and protein aggregation
-
Kopito RR. Aggresomes, inclusion bodies and protein aggregation. Trends Cell Biol. 2000;10:524-530.
-
(2000)
Trends Cell Biol
, vol.10
, pp. 524-530
-
-
Kopito, R.R.1
-
22
-
-
0026843954
-
Mammalian stress response: Induction of the glucose-regulated protein family
-
Lee AS. Mammalian stress response: induction of the glucose-regulated protein family. Curr Opin Cell Biol. 1992;4:267-273.
-
(1992)
Curr Opin Cell Biol
, vol.4
, pp. 267-273
-
-
Lee, A.S.1
-
23
-
-
0036856008
-
Translational control in the endoplasmic reticulum stress response
-
Ron D. Translational control in the endoplasmic reticulum stress response. J Clin Invest. 2002;110:1383-1388.
-
(2002)
J Clin Invest
, vol.110
, pp. 1383-1388
-
-
Ron, D.1
-
25
-
-
4344618623
-
Autophagy, proteasomes, lipofuscin, and oxidative stress in the aging brain
-
Keller JN, Dimayuga E, Chen Q, Thorpe J, Gee J, Ding Q. Autophagy, proteasomes, lipofuscin, and oxidative stress in the aging brain. Int J Biochem Cell Biol. 2004;36:2376-2391.
-
(2004)
Int J Biochem Cell Biol
, vol.36
, pp. 2376-2391
-
-
Keller, J.N.1
Dimayuga, E.2
Chen, Q.3
Thorpe, J.4
Gee, J.5
Ding, Q.6
-
26
-
-
0025672628
-
Dietary energy restriction in mice reduces hepatic expression of glucose-regulated protein 78 (BiP) and 94 mRNA
-
Spindler SR, Crew MD, Mote PL, Grizzle JM, Walford RL. Dietary energy restriction in mice reduces hepatic expression of glucose-regulated protein 78 (BiP) and 94 mRNA. J Nutr. 1990;120:1412-1417.
-
(1990)
J Nutr
, vol.120
, pp. 1412-1417
-
-
Spindler, S.R.1
Crew, M.D.2
Mote, P.L.3
Grizzle, J.M.4
Walford, R.L.5
-
27
-
-
25844494542
-
Sick chaperones, cellular stress, and disease
-
Macario AJL, Conway de Macario E. Sick chaperones, cellular stress, and disease. N Engl J Med. 2005;353:1489-1501.
-
(2005)
N Engl J Med
, vol.353
, pp. 1489-1501
-
-
Macario, A.J.L.1
Conway De Macario, E.2
-
28
-
-
0037051942
-
Extended longevity of Caenorhabditis elegans by knocking in extra copies of hsp70F, a homolog of mot-2 (mortalin)/mthsp70/Grp75
-
Yokoyama K, Fukumoto K, Murakanii T, et al. Extended longevity of Caenorhabditis elegans by knocking in extra copies of hsp70F, a homolog of mot-2 (mortalin)/mthsp70/Grp75. FEBS Lett. 2002;516:53-57.
-
(2002)
FEBS Lett
, vol.516
, pp. 53-57
-
-
Yokoyama, K.1
Fukumoto, K.2
Murakanii, T.3
-
29
-
-
0041507039
-
Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin-like signals
-
Walker GA, Lithgow GJ. Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin-like signals. Aging Cell. 2003;2:131-139.
-
(2003)
Aging Cell
, vol.2
, pp. 131-139
-
-
Walker, G.A.1
Lithgow, G.J.2
-
30
-
-
0034626747
-
Genetic pathways that regulate ageing in model organisms
-
Guarente L, Kenyon C. Genetic pathways that regulate ageing in model organisms. Nature. 2000;408:255-262.
-
(2000)
Nature
, vol.408
, pp. 255-262
-
-
Guarente, L.1
Kenyon, C.2
-
31
-
-
2342510386
-
Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation
-
Dor Y, Brown J, Martinez OI, Melton DA. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature. 2004;429:41-46.
-
(2004)
Nature
, vol.429
, pp. 41-46
-
-
Dor, Y.1
Brown, J.2
Martinez, O.I.3
Melton, D.A.4
-
32
-
-
5444271778
-
Stem cells, aging, and cancer: Inevitabilities and outcomes
-
Bell DR, Van Zant G. Stem cells, aging, and cancer: inevitabilities and outcomes. Oncogene. 2004;23:7290-7296.
-
(2004)
Oncogene
, vol.23
, pp. 7290-7296
-
-
Bell, D.R.1
Van Zant, G.2
-
33
-
-
13244287677
-
Mechanisms of hair graying: Incomplete melanocyte stem cell maintenance in the niche
-
Nishimura EK, Granter SR, Fisher DE. Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche. Science. 2005;307:720-724.
-
(2005)
Science
, vol.307
, pp. 720-724
-
-
Nishimura, E.K.1
Granter, S.R.2
Fisher, D.E.3
-
34
-
-
13444256201
-
Aging bone and cartilage: Cross-cutting issues
-
Carrington JL. Aging bone and cartilage: cross-cutting issues. Biochem Biophys Res Commun. 2005;328:700-708.
-
(2005)
Biochem Biophys Res Commun
, vol.328
, pp. 700-708
-
-
Carrington, J.L.1
-
35
-
-
0242585476
-
Asymmetric inheritance of oxidatively damaged proteins during cytokinesis
-
Aguilaniu H, Gustafsson L, Rigoulet M, Nystrom T. Asymmetric inheritance of oxidatively damaged proteins during cytokinesis. Science. 2003;299:1752-1753.
-
(2003)
Science
, vol.299
, pp. 1752-1753
-
-
Aguilaniu, H.1
Gustafsson, L.2
Rigoulet, M.3
Nystrom, T.4
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