MicroRNA-34α-mediated down-regulation of the microglial-enriched triggering receptor and phagocytosis-sensor TREM2 in age-related macular degeneration

PLoS ONE

Volumn 11, Issue 3, 2016, Pages

  Bhattacharjee, Surjyadipta ^a   Zhao, Yuhai ^a,b   Dua, Prerna ^c   Rogaev, Evgeny I ^d,e,f   Lukiw, Walter J ^a,b,e  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c LOUISIANA TECH UNIVERSITY   (United States)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^e VAVILOV INSTITUTE OF GENERAL GENETICS   (Russian Federation)

^f MOSCOW STATE UNIVERSITY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; ANTISENSE OLIGONUCLEOTIDE; CAFFEIC ACID PHENETHYL ESTER; CAY 10512; CURCUMIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MICRORNA 34A; NITRONE DERIVATIVE; PHENYL BUTYL NITRONE; REACTIVE OXYGEN METABOLITE; RESVERATROL; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 3' UNTRANSLATED REGION; HYDROGEN PEROXIDE; IMMUNOGLOBULIN RECEPTOR; INTERLEUKIN 1BETA; MEMBRANE PROTEIN; MICRORNA; MIRN34 MICRORNA, HUMAN; TREM2 PROTEIN, HUMAN; TUMOR NECROSIS FACTOR;

3' UNTRANSLATED REGION; AGE RELATED MACULAR DEGENERATION; AGED; ANTIOXIDANT ACTIVITY; ARTICLE; BIOINFORMATICS; CONTROLLED STUDY; FEMALE; GENE EXPRESSION REGULATION; GENETIC CODE; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN TISSUE; LUCIFERASE ASSAY; MICROGLIA; NORTHERN BLOTTING; OXIDATIVE STRESS; PHAGOCYTOSIS; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; TREM2 GENE; WESTERN BLOTTING; ANIMAL; BIOLOGY; CASE CONTROL STUDY; CELL LINE; DOWN REGULATION; DRUG EFFECTS; GENETICS; MACULAR DEGENERATION; METABOLISM; MOLECULAR GENETICS; MOUSE; NUCLEOTIDE SEQUENCE; PATHOLOGY; RETINA;

3' UNTRANSLATED REGIONS; AGED; ANIMALS; BASE SEQUENCE; CASE-CONTROL STUDIES; CELL LINE; COMPUTATIONAL BIOLOGY; DOWN-REGULATION; FEMALE; HUMANS; HYDROGEN PEROXIDE; INTERLEUKIN-1BETA; MACULAR DEGENERATION; MEMBRANE GLYCOPROTEINS; MICE; MICROGLIA; MICRORNAS; MOLECULAR SEQUENCE DATA; OXIDATIVE STRESS; PHAGOCYTOSIS; RECEPTORS, IMMUNOLOGIC; RETINA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84961842133     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0150211     Document Type: Article

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