Protein folding and misfolding in the neurodegenerative disorders: A review

Revue Neurologique

Volumn 170, Issue 3, 2014, Pages 151-161

  Bolshette, N B ^a   Thakur, K K ^a   Bidkar, A P ^a   Trandafir, C ^b   Kumar, P ^a   Gogoi, R ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

^b IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

Author keywords

Alzheimer; Amyloid ; Molecular chaperone; Protein folding; synuclein

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID PRECURSOR PROTEIN; CHAPERONE; ESTRADIOL; ESTROGEN; HEAT SHOCK PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT; AMYLOID BETA PROTEIN; NERVE PROTEIN; PROTEASOME; SECRETASE;

ALZHEIMER DISEASE; ARTICLE; HORMONE SUBSTITUTION; HUMAN; NONHUMAN; PARKINSON DISEASE; PATHOGENESIS; PROTEIN AGGREGATION; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; AMYLOID PLAQUE; AUTOPHAGY; DEGENERATIVE DISEASE; METABOLISM; NEUROFIBRILLARY TANGLE; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN PROCESSING; UBIQUITINATION; UNFOLDED PROTEIN RESPONSE;

ALPHA-SYNUCLEIN; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; AUTOPHAGY; HEAT-SHOCK PROTEINS; HUMANS; MOLECULAR CHAPERONES; NERVE TISSUE PROTEINS; NEURODEGENERATIVE DISEASES; NEUROFIBRILLARY TANGLES; PARKINSON DISEASE; PHOSPHORYLATION; PLAQUE, AMYLOID; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN FOLDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; UBIQUITINATION; UNFOLDED PROTEIN RESPONSE;

EID: 84897575716     PISSN: 00353787     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurol.2013.11.002     Document Type: Review

References (83)

1. C. Qiu, M. Kivipelto, and von Strauss E: Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention Dialogues Clin Neurosci 11 2009 111 128
2. G. Levy The relationship of Parkinson disease with aging Arch Neurol 64 2007 1242 1246
3. C. Pimentel, L. Batista-Nascimento, C. Rodrigues-Pousada, and R.A. Menezes Oxidative stress in Alzheimer's and Parkinson's diseases: insights from the yeast Saccharomyces cerevisiae Oxid Med Cell Longev 2012 2012 132146
4. F.U. Hartl, and M. Hayer-Hartl Converging concepts of protein folding in vitro and in vivo Nat Struct Mol Biol 16 2009 574 581
5. E. Herczenik, and M.F. Gebbink Molecular and cellular aspects of protein misfolding and disease FASEB J 22 2008 2115 2133
6. B. Chen, M. Retzlaff, T. Roos, and J. Frydman Cellular strategies of protein quality control Cold Spring Harb Perspect Biol 3 2011 a004374
7. M.R. Rogel, A. Jaitovich, and K.M. Ridge The role of the ubiquitin-proteasome pathway in keratin intermediate filament protein degradation Proc Am Thorac Soc 7 2010 71 76
8. A.N. Hegde, and S.C. Upadhya The ubiquitin-proteasome pathway in health and disease of the nervous system Trends Neurosci 30 2007 587 595
9. M. Takalo, A. Salminen, H. Soininen, M. Hiltunen, and A. Haapasalo Protein aggregation and degradation mechanisms in neurodegenerative diseases Am J Neurodegener Dis 2 2013 1 14
10. D.J. Klionsky, P. Codogno, A.M. Cuervo, V. Deretic, and Z. Elazar et al. A comprehensive glossary of autophagy-related molecules and processes Autophagy 6 2010 438 448
11. J.P. Taylor, F. Tanaka, J. Robitschek, C.M. Sandoval, and A. Taye et al. Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein Hum Mol Genet 12 2003 749 757
12. C.B. Anfinsen Principles that govern the folding of protein chains Science 181 1973 223 230
13. R.M. Koffie, B.T. Hyman, and T.L. Spires-Jones Alzheimer's disease: synapses gone cold Mol Neurodegener 6 2011 63
14. J. Kirstein-Miles, and R.I. Morimoto Caenorhabditis elegans as a model system to study intercompartmental proteostasis: Interrelation of mitochondrial function, longevity, and neurodegenerative diseases Dev Dyn 239 2010 1529 1538
15. S. Petrakis, T. Rasko, J. Russ, R.P. Friedrich, and M. Stroedicke et al. Identification of human proteins that modify misfolding and proteotoxicity of pathogenic ataxin-1 PLoS Genet 8 2012 e1002897
16. M.B. Liddell, S. Lovestone, and M.J. Owen Genetic risk of Alzheimer's disease: advising relatives Br J Psychiatry 178 2001 7 11
17. D. Avramopoulos Genetics of Alzheimer's disease: recent advances Genome Med 1 2009 34
18. M. Caleo, L. Restani, E. Vannini, Z. Siskova, and H. Al-Malki et al. The role of activity in synaptic degeneration in a protein misfolding disease, prion disease PLoS One 7 2012 e41182
19. I. Baskakov, and D.W. Bolen Forcing thermodynamically unfolded proteins to fold J Biol Chem 273 1998 4831 4834
20. C. Voisine, J.S. Pedersen, and R.I. Morimoto Chaperone networks: tipping the balance in protein folding diseases Neurobiol Dis 40 2010 12 20
21. M.C. Haigis, and B.A. Yankner The aging stress response Mol Cell 40 2010 333 344
22. J.A. Schellman Temperature, stability, and the hydrophobic interaction Biophys J 73 1997 2960 2964
23. C. Scharnagl, M. Reif, and J. Friedrich Stability of proteins: temperature, pressure and the role of the solvent Biochim Biophys Acta 1749 2005 187 213
24. T.E. Creighton Protein folding Biochem J 270 1990 1 16
25. F. Chiti, and C.M. Dobson Protein misfolding, functional amyloid, and human disease Annu Rev Biochem 75 2006 333 366
26. M. Gruebele How to mark off paths on the protein energy landscape Proc Natl Acad Sci U S A 106 2009 18879 18880
27. L.J. Lapidus Understanding protein aggregation from the view of monomer dynamics Mol Biosyst 9 2013 29 35
28. M. Hinczewski, J.C. Gebhardt, M. Rief, and D. Thirumalai From mechanical folding trajectories to intrinsic energy landscapes of biopolymers Proc Natl Acad Sci U S A 110 2013 4500 4505
29. R. Noiva, and W.J. Lennarz Protein disulfide isomerase. A multifunctional protein resident in the lumen of the endoplasmic reticulum J Biol Chem 267 1992 3553 3556
30. D.J. Selkoe Folding proteins in fatal ways Nature 426 2003 900 904
31. F.E. Cohen, M.J. Sternberg, D.C. Phillips, I.D. Kuntz, and P.A. Kollman A diffusion - collision - adhesion model for the kinetics of myoglobin refolding Nature 286 1980 632 634
32. S.J. Hagen Solvent viscosity and friction in protein folding dynamics Curr Protein Pept Sci 11 2010 385 395
33. H.R. Brignull, J.F. Morley, and R.I. Morimoto The stress of misfolded proteins: C. elegans models for neurodegenerative disease and aging Adv Exp Med Biol 594 2007 167 189
34. S. Walter, and J. Buchner Molecular chaperones - cellular machines for protein folding Angew Chem Int Ed Engl 41 2002 1098 1113
35. F.U. Hartle Mechanisms and pathways of chaperone-mediated protein folding Cold Spring Harb Symp Quant Biol 60 1995 429 434
36. K.A. Dill Dominant forces in protein folding Biochemistry 29 1990 7133 7155
37. T. Nakamura, and S.A. Lipton Cell death: protein misfolding and neurodegenerative diseases Apoptosis 14 2009 455 468
38. A. Mogk, M.P. Mayer, and E. Deuerling Mechanisms of protein folding: molecular chaperones and their application in biotechnology Chembiochem 3 2002 807 814
39. Q. Zhang, E.T. Powers, J. Nieva, M.E. Huff, and M.A. Dendle et al. Metabolite-initiated protein misfolding may trigger Alzheimer's disease Proc Natl Acad Sci U S A 101 2004 4752 4757
40. R. Morales, L.D. Estrada, R. Diaz-Espinoza, D. Morales-Scheihing, and M.C. Jara et al. Molecular cross talk between misfolded proteins in animal models of Alzheimer's and prion diseases J Neurosci 30 2010 4528 4535
41. T.K. Chaudhuri, and S. Paul Protein-misfolding diseases and chaperone-based therapeutic approaches FEBS J 273 2006 1331 1349
42. D.J. Selkoe Alzheimer's disease Cold Spring Harb Perspect Biol 2011 3
43. F.M. Menzies, K. Moreau, and D.C. Rubinsztein Protein misfolding disorders and macroautophagy Curr Opin Cell Biol 23 2011 190 197
44. D. Galimberti, and E. Scarpini Genetics and biology of Alzheimer's disease and frontotemporal lobar degeneration Int J Clin Exp Med 3 2010 129 143
45. K. Takata, and Y. Kitamura Molecular approaches to the treatment, prophylaxis, and diagnosis of Alzheimer's disease: tangle formation, amyloid-beta, and microglia in Alzheimer's disease J Pharmacol Sci 118 2012 331 337
46. V. Nimmrich, and A. Eckert Calcium channel blockers and dementia Br J Pharmacol 169 2013 1203 1210
47. E.G. McGeer, and P.L. McGeer Neuroinflammation in Alzheimer's disease and mild cognitive impairment: a field in its infancy J Alzheimers Dis 19 2010 355 361
48. V. Rhein, G. Baysang, S. Rao, F. Meier, and A. Bonert et al. Amyloid-beta leads to impaired cellular respiration, energy production and mitochondrial electron chain complex activities in human neuroblastoma cells Cell Mol Neurobiol 29 2009 1063 1071
49. B. DuBoff, M. Feany, and J. Gotz Why size matters - balancing mitochondrial dynamics in Alzheimer's disease Trends Neurosci 36 2013 325 335
50. C.J. Garwood, A.M. Pooler, J. Atherton, D.P. Hanger, and W. Noble Astrocytes are important mediators of Abeta-induced neurotoxicity and tau phosphorylation in primary culture Cell Death Dis 2 2011 e167
51. D. Ozawa, T. Nakamura, M. Koike, K. Hirano, and Y. Miki et al. Shuttling protein nucleolin is a microglia receptor for Amyloid Beta Peptide 1-42 Biol Pharm Bull 36 2013 1587 1593
52. A. Recchia, P. Debetto, A. Negro, D. Guidolin, and S.D. Skaper et al. Alpha-synuclein and Parkinson's disease FASEB J 18 2004 617 626
53. S.B. Prusiner, M.R. Scott, S.J. DeArmond, and F.E. Cohen Prion protein biology Cell 93 1998 337 348
54. O.W. Wan, and K.K. Chung The role of alpha-synuclein oligomerization and aggregation in cellular and animal models of Parkinson's disease PLoS One 7 2012 e38545
55. J.M. George The synucleins Genome Biol 3 2002 [REVIEWS3002]
56. A. Negro, A.M. Brunati, A. Donella-Deana, M.L. Massimino, and L.A. Pinna Multiple phosphorylation of alpha-synuclein by protein tyrosine kinase Syk prevents eosin-induced aggregation FASEB J 16 2002 210 212
57. C. Lavedan The synuclein family Genome Res 8 1998 871 880
58. D.F. Clayton, and J.M. George The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease Trends Neurosci 21 1998 249 254
59. M. Deleidi, and W. Maetzler Protein clearance mechanisms of alpha-synuclein and amyloid-Beta in lewy body disorders Int J Alzheimers Dis 2012 2012 391438
60. L.A. Volpicelli-Daley, K.C. Luk, T.P. Patel, S.A. Tanik, and D.M. Riddle et al. Exogenous alpha-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death Neuron 72 2012 57 71
61. G. Hamilton, S.E. Harris, G. Davies, D.C. Liewald, and A. Tenesa et al. Alzheimer's disease genes are associated with measures of cognitive ageing in the lothian birth cohorts of 1921 and 1936 Int J Alzheimers Dis 2011 2011 505984
62. D.W. Miller, S.M. Hague, J. Clarimon, M. Baptista, and K. Gwinn-Hardy et al. Alpha-synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication Neurology 62 2004 1835 1838
63. K.A. Conway, J.C. Rochet, R.M. Bieganski, and P.T. Lansbury Jr. Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct Science 294 2001 1346 1349
64. M. Periquet, T. Fulga, L. Myllykangas, M.G. Schlossmacher, and M.B. Feany Aggregated alpha-synuclein mediates dopaminergic neurotoxicity in vivo J Neurosci 27 2007 3338 3346
65. J.C. Rochet, K.A. Conway, and P.T. Lansbury Jr. Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synuclein Biochemistry 39 2000 10619 10626
66. M. Baba, S. Nakajo, P.H. Tu, T. Tomita, and K. Nakaya et al. Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies Am J Pathol 152 1998 879 884
67. D.J. Selkoe Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases Nat Cell Biol 6 2004 1054 1061
68. R. Jones The roles of PINK1 and Parkin in Parkinson's disease PLoS Biol 8 2010 e1000299
69. A. Ciechanover Linking ubiquitin, parkin and synphilin-1 Nat Med 7 2001 1108 1109
70. D. Voges, P. Zwickl, and W. Baumeister The 26S proteasome: a molecular machine designed for controlled proteolysis Annu Rev Biochem 68 1999 1015 1068
71. A. Roostaee, S. Beaudoin, A. Staskevicius, and X. Roucou Aggregation and neurotoxicity of recombinant alpha-synuclein aggregates initiated by dimerization Mol Neurodegener 8 2013 5
72. Y. Mizuno, N. Hattori, H. Mori, T. Suzuki, and K. Tanaka Parkin and Parkinson's disease Curr Opin Neurol 14 2001 477 482
73. S. Shimizu, and Y. Ohno Improving the treatment of Parkinson's disease: a novel approach by modulating 5-HT (1A) receptors Aging Dis 4 2012 1 13
74. M.R. Cookson alpha-Synuclein and neuronal cell death Mol Neurodegener 4 2009 9
75. S. Massone, I. Vassallo, G. Fiorino, M. Castelnuovo, and F. Barbieri et al. 17A, a novel non-coding RNA, regulates GABA B alternative splicing and signaling in response to inflammatory stimuli and in Alzheimer disease Neurobiol Dis 41 2011 308 317
76. C. Zhang, A. Browne, D. Child, J.R. Divito, and J.A. Stevenson et al. Loss of function of ATXN1 increases amyloid beta-protein levels by potentiating beta-secretase processing of beta-amyloid precursor protein J Biol Chem 285 2010 8515 8526
77. C.L. Masters, J.J. Kril, G.M. Halliday, R. Pamphlett, and S. Collins et al. Overview and recent advances in neuropathology Part 2: Neurodegeneration. Pathology 43 2011 93 102
78. T. Nakamura, and S.A. Lipton Redox regulation of mitochondrial fission, protein misfolding, synaptic damage, and neuronal cell death: potential implications for Alzheimer's and Parkinson's diseases Apoptosis 15 2009 1354 1363
79. H. Zhao, U. Dreses-Werringloer, P. Davies, and P. Marambaud Amyloid-beta peptide degradation in cell cultures by mycoplasma contaminants BMC Res Notes 1 2008 38
80. N. Todorova, L. Yeung, A. Hung, and I. Yarovsky Janus cyclic peptides: a new approach to amyloid fibril inhibition? PLoS One 8 2013 e57437
81. X. Yang, Y. Yang, J. Wu, and J. Zhu Stable expression of a novel fusion peptide of thioredoxin-1 and ABAD-inhibiting peptide protects PC12 cells from intracellular amyloid-beta J Mol Neurosci 33 2007 180 188
82. S.D. Yan, and D.M. Stern Mitochondrial dysfunction and Alzheimer's disease: role of amyloid-beta peptide alcohol dehydrogenase (ABAD) Int J Exp Pathol 86 2005 161 171
83. P.G. Coune, B.L. Schneider, and P. Aebischer Parkinson's disease: gene therapies Cold Spring Harb Perspect Med 2 2012 a009431