Lipid accumulation stimulates the cap-independent translation of SREBP-1a mRNA by promoting hnRNP A1 binding to its 5′-UTR in a cellular model of hepatic steatosis

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1861, Issue 5, 2016, Pages 471-481

  Siculella, Luisa ^a   Tocci, Romina ^a   Rochira, Alessio ^a   Testini, Mariangela ^a   Gnoni, Antonio ^b   Damiano, Fabrizio ^a  

^a UNIVERSITY OF SALENTO   (Italy)

^b UNIVERSITY OF BARI   (Italy)

Author keywords

Acetyl CoA carboxylase; Cap independent translation; Fatty acid synthase; Lipid droplets; Non alcoholic fatty liver disease; Sterol Regulatory Element Binding Protein 1

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; CITRATE CARRIER PROTEIN; FAT DROPLET; FATTY ACID SYNTHASE; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1; LIPID; MESSENGER RNA; MITOCHONDRIAL PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; OLEIC ACID; PALMITIC ACID; PROTEIN KINASE B; SMALL INTERFERING RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1A; UNCLASSIFIED DRUG; 5' UNTRANSLATED REGION; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN GROUP A B; HNRNP A1; INTERNAL RIBOSOME ENTRY SITE; SREBF1 PROTEIN, HUMAN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

5' UNTRANSLATED REGION; ARTICLE; CAP INDEPENDENT TRANSLATION; CELL NUCLEUS; CONTROLLED STUDY; CYTOSOL; EXPERIMENTAL FATTY LIVER; GENE EXPRESSION; GENETIC TRANSCRIPTION AND TRANSLATION; HEPG2 CELL LINE; HUMAN; HUMAN CELL; INTERNAL RIBOSOME ENTRY SITE; LIPID STORAGE; LIPOGENESIS; MOLECULAR PATHOLOGY; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE; RNA TRANSLATION; SIGNAL TRANSDUCTION; BINDING SITE; BIOSYNTHESIS; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; LIVER; LIVER CELL; METABOLISM; NONALCOHOLIC FATTY LIVER; PATHOLOGY; PROTEIN TRANSPORT; TIME FACTOR;

5' UNTRANSLATED REGIONS; BINDING SITES; GENE EXPRESSION REGULATION; HEP G2 CELLS; HEPATOCYTES; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEIN GROUP A-B; HUMANS; INTERNAL RIBOSOME ENTRY SITES; LIPOGENESIS; LIVER; NON-ALCOHOLIC FATTY LIVER DISEASE; OLEIC ACID; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PALMITIC ACID; PROTEIN TRANSPORT; RNA INTERFERENCE; RNA, MESSENGER; SIGNAL TRANSDUCTION; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TIME FACTORS; TRANSFECTION;

EID: 84961673912     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2016.02.003     Document Type: Article

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