Native State Mass Spectrometry, Surface Plasmon Resonance, and X-ray Crystallography Correlate Strongly as a Fragment Screening Combination

Journal of Medicinal Chemistry

Volumn 59, Issue 5, 2016, Pages 2192-2204

  Woods, Lucy A ^a   Dolezal, Olan ^b   Ren, Bin ^b   Ryan, John H ^b   Peat, Thomas S ^b   Poulsen, Sally Ann ^a  

^a GRIFFITH UNIVERSITY   (Australia)

^b CSIRO   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONATE DEHYDRATASE II; CINNAMIC ACID; PHENYLACETIC ACID; SULFONAMIDE; TETRAZOLE DERIVATIVE; CARBONATE DEHYDRATASE INHIBITOR; MOLECULAR LIBRARY;

ANALYTIC METHOD; ARTICLE; CONTROLLED STUDY; CORRELATIONAL STUDY; DRUG SCREENING; ENZYME BINDING; FRAGMENT BASED DRUG DISCOVERY; HUMAN; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN STABILITY; SURFACE PLASMON RESONANCE; SURFACE PROPERTY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; X RAY CRYSTALLOGRAPHY; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; METABOLISM; MOLECULAR LIBRARY; PHARMACOLOGY; PRECLINICAL STUDY; PROCEDURES; STRUCTURE ACTIVITY RELATION;

CARBONIC ANHYDRASE II; CARBONIC ANHYDRASE INHIBITORS; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; HUMANS; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PLASMON RESONANCE;

EID: 84961175129     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b01940     Document Type: Article

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