Cyclic secondary sulfonamides: Unusually good inhibitors of cancer-related carbonic anhydrase enzymes

Journal of Medicinal Chemistry

Volumn 57, Issue 8, 2014, Pages 3522-3531

  Moeker, Janina ^a   Peat, Thomas S ^b   Bornaghi, Laurent F ^a   Vullo, Daniela ^c   Supuran, Claudiu T ^c   Poulsen, Sally Ann ^a  

^a GRIFFITH UNIVERSITY   (Australia)

^b CSIRO   (Australia)

^c UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

6 (4 PHENYL 1H 1,2,3 TRIAZOL 1 YL) 1,2 BENZISOTHIAZOLE 3 ONE 1,1 DIOXIDE; 6 (4 [3' METHYLPHENYL] 1H 1,2,3 TRIAZOL 1 YL) 1,2 BENZISOTHIAZOLE 3 ONE 1,1 DIOXIDE; 6 AZIDO 1,2 BENZISOTHIAZOLE 3 ONE 1,1 DIOXIDE; 6 [4 [2 TRIFLUOROMETHYL(PHENYL)] 1H 1,2,3 TRIAZOL 1 YL] 1,2 BENZISOTHIAZOLE 3 ONE 1,1 DIOXIDE; 6 [4 [3 SULFONAMIDO(PHENYL)] 1H 1,2,3 TRIAZOL 1 YL) 1,2 BENZISOTHIAZOLE 3 ONE 1,1 DIOXIDE; 6 [4 [4' FLUORO 3' METHYL(PHENYL)] 1H 1,2,3 TRIAZOL 1 YL) 1,2 BENZISOTHIAZOLE 3 ONE 1,1 DIOXIDE; 6 [4 [4' METHOXY 2 METHYL(PHENYL)] 1H 1,2,3 TRIAZOL 1 YL) 1,2 BENZISOTHIAZOLE 3 ONE 1,1 DIOXIDE; 6 [4 [4' METHOXY(PHENYL)] 1H 1,2,3 TRIAZOL 1 YL) 1,2 BENZISOTHIAZOLE 3 ONE 1,1 DIOXIDE; 6 [4 [BETA DEXTRO GLUCOPYRANOSIDE O METHYLENE] 1H 1,2,3 TRIAZOL 1 YL] 1,2 BENZISOTHIAZOLE 3 ONE 1,1 DIOXIDE; ANTINEOPLASTIC AGENT; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE XII; GLYCOCONJUGATE; SACCHARIN DERIVATIVE; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG DESIGN; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROPHILICITY; HYDROPHOBICITY; STRUCTURE ACTIVITY RELATION;

ANTIGENS, NEOPLASM; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; DRUG DISCOVERY; HUMANS; NEOPLASMS; SACCHARIN; SULFONAMIDES;

EID: 84899506318     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm500255y     Document Type: Article

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