메뉴 건너뛰기




Volumn 17, Issue 8, 2006, Pages 1074-1080

Direct Screening of a Dynamic Combinatorial Library Using Mass Spectrometry

Author keywords

[No Author keywords available]

Indexed keywords

DYNAMIC COMBINATORIAL LIBRARY (DCL); PROTEIN-LIGAND COMPLEXES; STATIC LIBRARY; SUSTAINED OFF-RESONANCE IRRADIATION COLLISION ACTIVATED DISSOCIATION (SORI-CAD);

EID: 33746268183     PISSN: 10440305     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jasms.2006.03.017     Document Type: Article
Times cited : (66)

References (45)
  • 1
    • 0032820242 scopus 로고    scopus 로고
    • Dynamic Combinatorial Chemistry and Virtual Combinatorial Libraries
    • Lehn J.-M. Dynamic Combinatorial Chemistry and Virtual Combinatorial Libraries. Chem. Eur. J 5 (1999) 2455-2463
    • (1999) Chem. Eur. J , vol.5 , pp. 2455-2463
    • Lehn, J.-M.1
  • 2
    • 33746211457 scopus 로고    scopus 로고
    • (a) Rowan, S. J.; Cantrill, S. J.; Cousins, G. R. L.; Sanders, J. K. M.; Stoddart, J. F. Dynamic Covalent Chemistry. Angew. Chem. 2002, 114, 938-993; (b)Angew. Chem. Int. Ed. 2002, 41, 898-952.
  • 3
    • 0034032553 scopus 로고    scopus 로고
    • Molecular Evolution. Dynamic Combinatorial Libraries, Autocatalytic Networks, and the Quest for Molecular Function
    • Cousins G.R.L., Poulsen S.-A., and Sanders J.K.M. Molecular Evolution. Dynamic Combinatorial Libraries, Autocatalytic Networks, and the Quest for Molecular Function. Curr. Opin. Chem. Biol 4 (2000) 270-279
    • (2000) Curr. Opin. Chem. Biol , vol.4 , pp. 270-279
    • Cousins, G.R.L.1    Poulsen, S.-A.2    Sanders, J.K.M.3
  • 4
    • 18544388577 scopus 로고    scopus 로고
    • In Situ Generation and Screening of a Dynamic Combinatorial Carbohydrate Library against Concanavalin A
    • Ramström O., and Lehn J.-M. In Situ Generation and Screening of a Dynamic Combinatorial Carbohydrate Library against Concanavalin A. Chem. BioChem 1 (2000) 41-48
    • (2000) Chem. BioChem , vol.1 , pp. 41-48
    • Ramström, O.1    Lehn, J.-M.2
  • 5
    • 1842784768 scopus 로고    scopus 로고
    • Dynamic Combinatorial Carbohydrate Libraries. Probing the Binding Site of the Concanavalin A Lectin
    • Ramström O., Lohmann S., Bunyapaiboonsri T., and Lehn J.-M. Dynamic Combinatorial Carbohydrate Libraries. Probing the Binding Site of the Concanavalin A Lectin. Chem. Eur. J 10 (2004) 1711-1715
    • (2004) Chem. Eur. J , vol.10 , pp. 1711-1715
    • Ramström, O.1    Lohmann, S.2    Bunyapaiboonsri, T.3    Lehn, J.-M.4
  • 6
    • 0035382539 scopus 로고    scopus 로고
    • Dynamic Deconvolution of a Pre-equilibrated Dynamic Combinatorial Library of Acetylcholinesterase Inhibitors
    • Bunyapaiboonsri T., Ramström O., Lohmann S., Lehn J.-M., Peng L., and Goeldner M. Dynamic Deconvolution of a Pre-equilibrated Dynamic Combinatorial Library of Acetylcholinesterase Inhibitors. Chem. BioChem 2 (2001) 438-444
    • (2001) Chem. BioChem , vol.2 , pp. 438-444
    • Bunyapaiboonsri, T.1    Ramström, O.2    Lohmann, S.3    Lehn, J.-M.4    Peng, L.5    Goeldner, M.6
  • 8
    • 0037472768 scopus 로고    scopus 로고
    • Ketones as Building Blocks for Dynamic Combinatorial Libraries. Highly Active Neuraminidase Inhibitors Generated via Selection Pressure of the Biological Target
    • Hochgürtel M., Biesinger R., Kroth H., Piecha D., Hofmann M.W., Krause S., Schaaf O., Nicolau C., and Eliseev A.V. Ketones as Building Blocks for Dynamic Combinatorial Libraries. Highly Active Neuraminidase Inhibitors Generated via Selection Pressure of the Biological Target. J. Med. Chem 46 (2003) 356-358
    • (2003) J. Med. Chem , vol.46 , pp. 356-358
    • Hochgürtel, M.1    Biesinger, R.2    Kroth, H.3    Piecha, D.4    Hofmann, M.W.5    Krause, S.6    Schaaf, O.7    Nicolau, C.8    Eliseev, A.V.9
  • 9
    • 0030898702 scopus 로고    scopus 로고
    • Virtual Combinatorial Libraries. Dynamic Generation of Molecular and Supramolecular Diversity by Self-Assembly
    • Huc I., and Lehn J.-M. Virtual Combinatorial Libraries. Dynamic Generation of Molecular and Supramolecular Diversity by Self-Assembly. Proc. Natl. Acad. Sci. U.S.A 94 (1997) 2106-2110
    • (1997) Proc. Natl. Acad. Sci. U.S.A , vol.94 , pp. 2106-2110
    • Huc, I.1    Lehn, J.-M.2
  • 10
    • 33746216513 scopus 로고    scopus 로고
    • Nguyen, R.; Huc, I. Using an Enzyme's Active Site to Template Inhibitors. Angew. Chem. 2001, 113, 1824-1826; (b) Angew. Chem. Int. Ed. 2001, 40, 1774-1776.
  • 11
    • 0037157092 scopus 로고    scopus 로고
    • Amplification of Screening Sensitivity Through Selective Destruction. Theory and Screening of a Library of Carbonic Anhydrase Inhibitors
    • Cheeseman J.D., Corbett A.D., Shu R., Croteau J., Gleason J.L., and Kazlauskas R.J. Amplification of Screening Sensitivity Through Selective Destruction. Theory and Screening of a Library of Carbonic Anhydrase Inhibitors. J. Am. Chem. Soc 124 (2002) 5692-5701
    • (2002) J. Am. Chem. Soc , vol.124 , pp. 5692-5701
    • Cheeseman, J.D.1    Corbett, A.D.2    Shu, R.3    Croteau, J.4    Gleason, J.L.5    Kazlauskas, R.J.6
  • 12
    • 33746255558 scopus 로고    scopus 로고
    • Corbett, A. D.; Cheeseman, J. D.; Kazlauskas, R. J.; Gleason, J. L. Pseudodynamic Combinatorial Libraries: A Receptor-Assisted Approach for Drug Discovery. Angew. Chem. 2004, 116, 2486-2490; (b) Angew. Chem. Int. Ed. 2004, 43, 2432-2436.
  • 13
    • 0346996358 scopus 로고    scopus 로고
    • Generation of Bis-Cationic Heterocyclic Inhibitors of Bacillus subtilis HPr Kinase/Phosphatase from a Ditopic Dynamic Combinatorial Library
    • Bunyapaiboonsri T., Ramström H., Ramström O., Haiech J., and Lehn J.-M. Generation of Bis-Cationic Heterocyclic Inhibitors of Bacillus subtilis HPr Kinase/Phosphatase from a Ditopic Dynamic Combinatorial Library. J. Med. Chem 46 (2003) 5803-5811
    • (2003) J. Med. Chem , vol.46 , pp. 5803-5811
    • Bunyapaiboonsri, T.1    Ramström, H.2    Ramström, O.3    Haiech, J.4    Lehn, J.-M.5
  • 14
    • 33746216509 scopus 로고    scopus 로고
    • Zameo, S.; Vauzeilles, B.; Beau, J.-M. Dynamic Combinatorial Chemistry: Lysozyme Selects an Aromatic Motif That Mimics a Carbohydrate Residue. Angew. Chem. 2005, 117, 987-991; (b) Angew. Chem. Int. Ed. 2005, 44, 965-969.
  • 16
    • 33746211531 scopus 로고    scopus 로고
    • Larsson, R.; Pei, Z.; Ramström, O. Catalytic Self-Screening of Cholinesterase Substrates from a Dynamic Combinatorial Thioester Library. Angew. Chem. 2004, 116, 3802-3804; (b) Angew. Chem. Int. Ed. 2004, 43, 3716-3718.
  • 17
    • 25144520090 scopus 로고    scopus 로고
    • Hotchkiss, T.; Kramer, H. B.; Doores, K. J.; Gamblin, D. P.; Oldham, N. J.; Davis, B. G. Ligand Amplification in a Dynamic Combinatorial Glycopeptide Library. Chem. Commun. 2005, 4262-4266.
  • 18
    • 29044441527 scopus 로고    scopus 로고
    • Uracil-Directed Ligand Tethering. An Efficient Strategy for Uracil DNA Glycosylase (UNG) Inhibitor Development
    • Jiang Y.L., Krosky D.J., Seiple L., and Stivers J.T. Uracil-Directed Ligand Tethering. An Efficient Strategy for Uracil DNA Glycosylase (UNG) Inhibitor Development. J. Am. Chem. Soc 127 (2005) 17412-17420
    • (2005) J. Am. Chem. Soc , vol.127 , pp. 17412-17420
    • Jiang, Y.L.1    Krosky, D.J.2    Seiple, L.3    Stivers, J.T.4
  • 19
    • 33746192039 scopus 로고    scopus 로고
    • Congreve, M. S.; Davis, D. J.; Devine, L.; Granata, C.; O'Reilly, M.; Wyatt, P. G.; Jhoti, H. Detection of Ligands from a Dynamic Combinatorial Library by X-ray Crystallography. Angew. Chem. 2004, 115, 4617-4620; (b)Angew. Chem. Int. Ed. 2003, 42, 4479-4482.
  • 20
    • 33746211532 scopus 로고    scopus 로고
    • Poulsen, S.-A.; Bornaghi, L. F. Fragment-Based Drug Discovery of Carbonic Anhydrase II Inhibitors by Dynamic Combinatorial Chemistry Utilizing Alkene Cross Metathesis. Bioorg. Med. Chem., in press.
  • 21
    • 13344268905 scopus 로고    scopus 로고
    • In Vitro Combinatorial Chemistry to Create Drug Candidates
    • Weber L. In Vitro Combinatorial Chemistry to Create Drug Candidates. Drug. Discov. Today. Technologies 1 (2004) 261-267
    • (2004) Drug. Discov. Today. Technologies , vol.1 , pp. 261-267
    • Weber, L.1
  • 23
    • 0030621966 scopus 로고    scopus 로고
    • Studying Noncovalent Protein Complexes by Electrospray Ionization Mass Spectrometry
    • and references therein.
    • Loo J.A. Studying Noncovalent Protein Complexes by Electrospray Ionization Mass Spectrometry. Mass Spectrom. Rev 16 (1997) 1-23, and references therein.
    • (1997) Mass Spectrom. Rev , vol.16 , pp. 1-23
    • Loo, J.A.1
  • 24
    • 33846278908 scopus 로고    scopus 로고
    • New Mass Spectrometric Methods for the Study of Noncovalent Associations of Biopolymers
    • and references therein.
    • Smith R.D., Bruce J.E., Wu Q., and Lei P. New Mass Spectrometric Methods for the Study of Noncovalent Associations of Biopolymers. Chem. Soc. Rev 26 (1997) 191-202, and references therein.
    • (1997) Chem. Soc. Rev , vol.26 , pp. 191-202
    • Smith, R.D.1    Bruce, J.E.2    Wu, Q.3    Lei, P.4
  • 25
  • 26
    • 15844410706 scopus 로고    scopus 로고
    • Bruce, JE. Schwartz, B. L.; Hofstadler, S. A.; Anderson, G. A.; Smith, R. D.; Whitesides, G. M. Screening Derivatized Peptide Libraries for Tight Binding Inhibitors to Carbonic Anhydrase II by Electrospray Ionization-Mass Spectrometry
    • Gao J., Cheng X., Chen R., and Sigal G.B. Bruce, JE. Schwartz, B. L.; Hofstadler, S. A.; Anderson, G. A.; Smith, R. D.; Whitesides, G. M. Screening Derivatized Peptide Libraries for Tight Binding Inhibitors to Carbonic Anhydrase II by Electrospray Ionization-Mass Spectrometry. J. Med. Chem 39 (1996) 1949-1955
    • (1996) J. Med. Chem , vol.39 , pp. 1949-1955
    • Gao, J.1    Cheng, X.2    Chen, R.3    Sigal, G.B.4
  • 28
    • 0034684262 scopus 로고    scopus 로고
    • Characterization of Low-Affinity Complexes Between RNA and Small Molecules Using Electrospray Ionization Mass Spectrometry
    • Griffey R.H., Sannes-Lowery K.A., Drader J.J., Mohan V., Swayze E.E., and Hofstadler S.A. Characterization of Low-Affinity Complexes Between RNA and Small Molecules Using Electrospray Ionization Mass Spectrometry. J. Am. Chem. Soc 122 (2000) 9933-9938
    • (2000) J. Am. Chem. Soc , vol.122 , pp. 9933-9938
    • Griffey, R.H.1    Sannes-Lowery, K.A.2    Drader, J.J.3    Mohan, V.4    Swayze, E.E.5    Hofstadler, S.A.6
  • 30
    • 0036780842 scopus 로고    scopus 로고
    • Fourier Transform-Ion Cyclotron Resonance Mass Spectrometric Resolution, Identification, and Screening of Noncovalent Complexes of Hck Src Homology 2 Domain Receptor and Ligands from a 324-Member Peptide Combinatorial Library
    • Wigger M., Eyler J.R., Benner S.A., Li W., and Marshall A.G. Fourier Transform-Ion Cyclotron Resonance Mass Spectrometric Resolution, Identification, and Screening of Noncovalent Complexes of Hck Src Homology 2 Domain Receptor and Ligands from a 324-Member Peptide Combinatorial Library. J. Am. Soc. Mass Spectrom 13 (2002) 1162-1169
    • (2002) J. Am. Soc. Mass Spectrom , vol.13 , pp. 1162-1169
    • Wigger, M.1    Eyler, J.R.2    Benner, S.A.3    Li, W.4    Marshall, A.G.5
  • 31
    • 0141958921 scopus 로고    scopus 로고
    • Influence of Solution and Gas Phase Processes on Protein-Carbohydrate Binding Affinities Determined by Nanoelectrospray Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
    • Wang W., Kitova E.N., and Klassen J.S. Influence of Solution and Gas Phase Processes on Protein-Carbohydrate Binding Affinities Determined by Nanoelectrospray Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. Anal. Chem 75 (2003) 4945-4955
    • (2003) Anal. Chem , vol.75 , pp. 4945-4955
    • Wang, W.1    Kitova, E.N.2    Klassen, J.S.3
  • 32
    • 10844233968 scopus 로고    scopus 로고
    • Evaluation of Automated Nano-Electrospray Mass Spectrometry in the Determination of Noncovalent Protein-Ligand Complexes
    • De Vriendt K., Sandra K., Desmet T., Nerinckx W., Van Beeumen J., and Devreese B. Evaluation of Automated Nano-Electrospray Mass Spectrometry in the Determination of Noncovalent Protein-Ligand Complexes. Rapid Commun. Mass Spectrom 18 (2004) 3061-3067
    • (2004) Rapid Commun. Mass Spectrom , vol.18 , pp. 3061-3067
    • De Vriendt, K.1    Sandra, K.2    Desmet, T.3    Nerinckx, W.4    Van Beeumen, J.5    Devreese, B.6
  • 33
    • 3543008337 scopus 로고    scopus 로고
    • Determination of Dissociation Constants for Protein-Ligand Complexes by Electrospray Ionization Mass Spectrometry
    • Tjernberg A., Carnö S., Oliv F., Benkestock K., Edlund P.-O., Griffiths W.J., and Hallén D. Determination of Dissociation Constants for Protein-Ligand Complexes by Electrospray Ionization Mass Spectrometry. Anal. Chem 76 (2004) 4325-4331
    • (2004) Anal. Chem , vol.76 , pp. 4325-4331
    • Tjernberg, A.1    Carnö, S.2    Oliv, F.3    Benkestock, K.4    Edlund, P.-O.5    Griffiths, W.J.6    Hallén, D.7
  • 35
    • 28844481944 scopus 로고    scopus 로고
    • Screening a Natural Product-Based Combinatorial Library using FTICR Mass Spectrometry
    • Poulsen S.-A., Davis R.A., and Keys T.G. Screening a Natural Product-Based Combinatorial Library using FTICR Mass Spectrometry. Bioorg. Med. Chem 14 (2006) 510-515
    • (2006) Bioorg. Med. Chem , vol.14 , pp. 510-515
    • Poulsen, S.-A.1    Davis, R.A.2    Keys, T.G.3
  • 37
    • 0842281270 scopus 로고    scopus 로고
    • Carbonic Anhydrase Inhibitors. The First Selective, Membrane-Impermeant Inhibitors Targeting the Tumor-Associated Isozyme IX
    • Pastorekova S., Casini A., Scozzafava A., Vullo D., Pastorek J., and Supuran C.T. Carbonic Anhydrase Inhibitors. The First Selective, Membrane-Impermeant Inhibitors Targeting the Tumor-Associated Isozyme IX. Bioorg. Med. Chem. Lett 14 (2004) 869-873
    • (2004) Bioorg. Med. Chem. Lett , vol.14 , pp. 869-873
    • Pastorekova, S.1    Casini, A.2    Scozzafava, A.3    Vullo, D.4    Pastorek, J.5    Supuran, C.T.6
  • 38
    • 0033592059 scopus 로고    scopus 로고
    • Dynamic Combinatorial Libraries of Pseudo-Peptide Hydrazone Macrocycles
    • Cousins G.R.L., Poulsen S.-A., and Sanders J.K.M. Dynamic Combinatorial Libraries of Pseudo-Peptide Hydrazone Macrocycles. Chem. Commun (1999) 1575-1576
    • (1999) Chem. Commun , pp. 1575-1576
    • Cousins, G.R.L.1    Poulsen, S.-A.2    Sanders, J.K.M.3
  • 39
    • 0037460008 scopus 로고    scopus 로고
    • Optimizing the Reversibility of Hydrazone Formation for Dynamic Combinatorial Chemistry
    • Nguyen R., and Huc I. Optimizing the Reversibility of Hydrazone Formation for Dynamic Combinatorial Chemistry. Chem. Commun (2003) 942-943
    • (2003) Chem. Commun , pp. 942-943
    • Nguyen, R.1    Huc, I.2
  • 41
    • 16544390541 scopus 로고    scopus 로고
    • Carbonic Anhydrases. Current State of the Art Therapeutic Applications and Future Prospects
    • Pastorekova S., Parkkila S., Pastorek J., and Supuran C.T. Carbonic Anhydrases. Current State of the Art Therapeutic Applications and Future Prospects. J. Enz. Inhib. Med. Chem 19 (2004) 199-229
    • (2004) J. Enz. Inhib. Med. Chem , vol.19 , pp. 199-229
    • Pastorekova, S.1    Parkkila, S.2    Pastorek, J.3    Supuran, C.T.4
  • 42
    • 15444377021 scopus 로고    scopus 로고
    • Carbonic Anhydrase Inhibitors. Synthesis and Inhibition of Cytosolic/Membrane-Associated Carbonic Anhydrase Isozymes I, II, and IX with Sulfonamides Incorporating Hydrazino Moieties
    • Winum J.-Y., Dogne J.-M., Casini A., de Leval X., Montero J.-L., Scozzafava A., Vullo D., Innocenti A., and Supuran C.T. Carbonic Anhydrase Inhibitors. Synthesis and Inhibition of Cytosolic/Membrane-Associated Carbonic Anhydrase Isozymes I, II, and IX with Sulfonamides Incorporating Hydrazino Moieties. J. Med. Chem 48 (2005) 2121-2125
    • (2005) J. Med. Chem , vol.48 , pp. 2121-2125
    • Winum, J.-Y.1    Dogne, J.-M.2    Casini, A.3    de Leval, X.4    Montero, J.-L.5    Scozzafava, A.6    Vullo, D.7    Innocenti, A.8    Supuran, C.T.9
  • 43
    • 0014217558 scopus 로고
    • Combination of Bovine Carbonic Anhydrase with a Fluorescent Sulfonamide
    • Chen R.F., and Kernohan J.C. Combination of Bovine Carbonic Anhydrase with a Fluorescent Sulfonamide. J. Biol. Chem 242 (1967) 5813-5823
    • (1967) J. Biol. Chem , vol.242 , pp. 5813-5823
    • Chen, R.F.1    Kernohan, J.C.2
  • 44
    • 0029925009 scopus 로고    scopus 로고
    • Benzenesulfonamide-Peptide Conjugates as Probes for Secondary Binding Sites Near the Active Site of Carbonic Anhydrase
    • Sigal G.B., and Whitesides G.M. Benzenesulfonamide-Peptide Conjugates as Probes for Secondary Binding Sites Near the Active Site of Carbonic Anhydrase. Bioorg. Med. Chem. Lett 6 (1996) 559-564
    • (1996) Bioorg. Med. Chem. Lett , vol.6 , pp. 559-564
    • Sigal, G.B.1    Whitesides, G.M.2
  • 45
    • 27644495243 scopus 로고    scopus 로고
    • Synthesis and Structure-Activity Relationships of Novel Benzene Sulfonamides with Potent Binding Affinity for Bovine Carbonic Anhydrase II
    • Poulsen S.-A., Bornaghi L.F., and Healy P.C. Synthesis and Structure-Activity Relationships of Novel Benzene Sulfonamides with Potent Binding Affinity for Bovine Carbonic Anhydrase II. Bioorg. Med. Chem. Lett 24 (2005) 5429-5433
    • (2005) Bioorg. Med. Chem. Lett , vol.24 , pp. 5429-5433
    • Poulsen, S.-A.1    Bornaghi, L.F.2    Healy, P.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.