Library Screening by Means of Mass Spectrometry (MS) Binding Assays-Exemplarily Demonstrated for a Pseudostatic Library Addressing γ-Aminobutyric Acid (GABA) Transporter1 (GAT1)

ChemMedChem

Volumn 7, Issue 9, 2012, Pages 1678-1690

  Sindelar, Miriam ^a   Wanner, Klaus T ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Binding assays; Dynamic combinatorial chemistry; Hydrazones; Mass spectrometry; Membrane proteins

Indexed keywords

1 (4,4 DIPHENYL 3 BUTENYL)NIPECOTIC ACID; 1 [2 (BENZHYDRYLIDENEAMINOOXY)ETHYL] 1,2,5,6 TETRAHYDRO 3 PYRIDINECARBOXYLIC ACID; 1 [2 [2' (1,1' BIPHENYL 2 YLMETHYLIDENE)HYDRAZINE]ETHYL]PIPERIDINE 3 CARBOXYLIC ACID; 1 [2 [2' [1 (2 THIOPHENYLPHENYL)METHYLIDENE]HYDRAZINE]ETHYL]PIPERIDINE 3 CARBOXYLIC ACID; 4 AMINOBUTYRIC ACID CARRIER; 4 AMINOBUTYRIC ACID TRANSPORTER 1; GUVACINE; NIPECOTIC ACID; NIPECOTIC ACID DERIVATIVE; TIAGABINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING ASSAY; COMBINATORIAL CHEMISTRY; DRUG SCREENING; DRUG STRUCTURE; FEASIBILITY STUDY; LIGAND BINDING; MASS SPECTROMETRY; MOLECULAR LIBRARY; PRIORITY JOURNAL;

ANIMALS; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DISCOVERY; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; GABA UPTAKE INHIBITORS; HEK293 CELLS; HUMANS; HYDRAZONES; MASS SPECTROMETRY; MICE; PROTEIN BINDING; SMALL MOLECULE LIBRARIES;

EID: 84865574659     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201200201     Document Type: Article

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