Saccharin: A lead compound for structure-based drug design of carbonic anhydrase IX inhibitors

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 4, 2015, Pages 849-854

  Mahon, Brian P ^a   Hendon, Alex M ^a   Driscoll, Jenna M ^a   Rankin, Gregory M ^b   Poulsen, Sally Ann ^b   Supuran, Claudiu T ^c   McKenna, Robert ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b GRIFFITH UNIVERSITY   (Australia)

^c UNIVERSITY OF FLORENCE   (Italy)

Author keywords

CA IX mimic; Carbonic anhydrase IX; Metalloenzyme; Saccharin; Structure based drug design

Indexed keywords

ACETAZOLAMIDE; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE IX INHIBITOR; SACCHARIN; UNCLASSIFIED DRUG; CA9 PROTEIN, HUMAN; CARBONATE DEHYDRATASE; TUMOR ANTIGEN;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROPHOBICITY; X RAY CRYSTALLOGRAPHY; CHEMISTRY; ENZYMOLOGY; METABOLISM; MOLECULAR DOCKING; NEOPLASMS;

ANTIGENS, NEOPLASM; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; MOLECULAR DOCKING SIMULATION; NEOPLASMS; SACCHARIN;

EID: 84922326262     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.12.030     Document Type: Article

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