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Volumn 375, Issue 1, 2016, Pages 51-61

Cancer development, chemoresistance, epithelial to mesenchymal transition and stem cells: A snapshot of IL-6 mediated involvement

Author keywords

Cancer stem cell; Chemoresistance and EMT; Cytokine; IL 6

Indexed keywords

ATIPRIMOD; CISPLATIN; GEMCITABINE; GLYCOPROTEIN GP 130; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MULTIDRUG RESISTANCE PROTEIN; NERVE CELL ADHESION MOLECULE; PACLITAXEL; PROTEIN KINASE B; STAT3 PROTEIN; TAMOXIFEN; TOCILIZUMAB; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR TWIST; UVOMORULIN; VIMENTIN; ANTINEOPLASTIC AGENT; IL6 PROTEIN, HUMAN;

EID: 84960172248     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2016.02.048     Document Type: Review
Times cited : (198)

References (142)
  • 1
    • 84887911347 scopus 로고    scopus 로고
    • Platinum-resistance in ovarian cancer cells is mediated by IL-6 secretion via the increased expression of its target cIAP-2
    • Cohen S., Bruchim I., Graiver D., Evron Z., Oron-Karni V., Pasmanik-Chor M., et al. Platinum-resistance in ovarian cancer cells is mediated by IL-6 secretion via the increased expression of its target cIAP-2. J. Mol. Med 2013, 91:357-368.
    • (2013) J. Mol. Med , vol.91 , pp. 357-368
    • Cohen, S.1    Bruchim, I.2    Graiver, D.3    Evron, Z.4    Oron-Karni, V.5    Pasmanik-Chor, M.6
  • 2
    • 28244475975 scopus 로고    scopus 로고
    • Interleukin-6, secreted by human ovarian carcinoma cells, is a potent proangiogenic cytokine
    • Nilsson M.B., Langley R.R., Fidler I.J. Interleukin-6, secreted by human ovarian carcinoma cells, is a potent proangiogenic cytokine. Cancer Res 2005, 65:10794-10800.
    • (2005) Cancer Res , vol.65 , pp. 10794-10800
    • Nilsson, M.B.1    Langley, R.R.2    Fidler, I.J.3
  • 5
    • 0035921689 scopus 로고    scopus 로고
    • Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma
    • Hideshima T., Nakamura N., Chauhan D., Anderson K.C. Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma. Oncogene 2001, 20:5991-6000.
    • (2001) Oncogene , vol.20 , pp. 5991-6000
    • Hideshima, T.1    Nakamura, N.2    Chauhan, D.3    Anderson, K.C.4
  • 6
    • 34548549283 scopus 로고    scopus 로고
    • Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer
    • Berishaj M., Gao S.P., Ahmed S., Leslie K., Al-Ahmadie H., Gerald W.L., et al. Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer. Breast Cancer Res 2007, 9.
    • (2007) Breast Cancer Res , vol.9
    • Berishaj, M.1    Gao, S.P.2    Ahmed, S.3    Leslie, K.4    Al-Ahmadie, H.5    Gerald, W.L.6
  • 7
    • 84979943526 scopus 로고    scopus 로고
    • Diacerein-mediated inhibition of IL-6/IL-6R signaling induces apoptotic effects on breast cancer
    • Bharti R., Dey G., Ojha P.K., Rajput S., Jaganathan S.K., Sen R., et al. Diacerein-mediated inhibition of IL-6/IL-6R signaling induces apoptotic effects on breast cancer. Oncogene 2015.
    • (2015) Oncogene
    • Bharti, R.1    Dey, G.2    Ojha, P.K.3    Rajput, S.4    Jaganathan, S.K.5    Sen, R.6
  • 8
    • 84902168138 scopus 로고    scopus 로고
    • Inflammation and prostate cancer: the role of interleukin 6 (IL-6)
    • Nguyen D.P., Li J.Y., Tewari A.K. Inflammation and prostate cancer: the role of interleukin 6 (IL-6). BJU Int 2014, 113:986-992.
    • (2014) BJU Int , vol.113 , pp. 986-992
    • Nguyen, D.P.1    Li, J.Y.2    Tewari, A.K.3
  • 9
    • 84865422083 scopus 로고    scopus 로고
    • Interleukin-6 signaling pathway in targeted therapy for cancer
    • Guo Y.Q., Xu F., Lu T.H., Duan Z.F., Zhang Z. Interleukin-6 signaling pathway in targeted therapy for cancer. Cancer Treat. Rev 2012, 38:904-910.
    • (2012) Cancer Treat. Rev , vol.38 , pp. 904-910
    • Guo, Y.Q.1    Xu, F.2    Lu, T.H.3    Duan, Z.F.4    Zhang, Z.5
  • 10
    • 22144438698 scopus 로고    scopus 로고
    • IL-6, its receptors and its relationship with bcl-2 and bax proteins in infiltrating and in situ human breast carcinoma
    • Garcia-Tunon I., Ricote M., Ruiz A., Fraile B., Paniagua R., Royuela M. IL-6, its receptors and its relationship with bcl-2 and bax proteins in infiltrating and in situ human breast carcinoma. Histopathology 2005, 47:82-89.
    • (2005) Histopathology , vol.47 , pp. 82-89
    • Garcia-Tunon, I.1    Ricote, M.2    Ruiz, A.3    Fraile, B.4    Paniagua, R.5    Royuela, M.6
  • 11
    • 84922463321 scopus 로고    scopus 로고
    • Microbial amphiphiles: a class of promising new-generation anticancer agents
    • Dey G., Bharti R., Sen R., Mandal M. Microbial amphiphiles: a class of promising new-generation anticancer agents. Drug Discov. Today 2015, 20:136-146.
    • (2015) Drug Discov. Today , vol.20 , pp. 136-146
    • Dey, G.1    Bharti, R.2    Sen, R.3    Mandal, M.4
  • 12
    • 84878552107 scopus 로고    scopus 로고
    • Growth of triple-negative breast cancer cells relies upon coordinate autocrine expression of the proinflammatory cytokines IL-6 and IL-8
    • Hartman Z.C., Poage G.M., den Hollander P., Tsimelzon A., Hill J., Panupinthu N., et al. Growth of triple-negative breast cancer cells relies upon coordinate autocrine expression of the proinflammatory cytokines IL-6 and IL-8. Cancer Res 2013, 73:3470-3480.
    • (2013) Cancer Res , vol.73 , pp. 3470-3480
    • Hartman, Z.C.1    Poage, G.M.2    den Hollander, P.3    Tsimelzon, A.4    Hill, J.5    Panupinthu, N.6
  • 13
    • 77950211267 scopus 로고    scopus 로고
    • Constitutively active stat3 enhances neu-mediated migration and metastasis in mammary tumors via upregulation of cten
    • Barbieri I., Pensa S., Pannellini T., Quaglino E., Maritano D., Demaria M., et al. Constitutively active stat3 enhances neu-mediated migration and metastasis in mammary tumors via upregulation of cten. Cancer Res 2010, 70:2558-2567.
    • (2010) Cancer Res , vol.70 , pp. 2558-2567
    • Barbieri, I.1    Pensa, S.2    Pannellini, T.3    Quaglino, E.4    Maritano, D.5    Demaria, M.6
  • 14
    • 45549093658 scopus 로고    scopus 로고
    • Inflammatory signaling and aryl hydrocarbon receptor mediate synergistic induction of interleukin 6 in MCF-7 cells
    • Hollingshead B.D., Beischlag T.V., DiNatale B.C., Ramadoss P., Perdew G.H. Inflammatory signaling and aryl hydrocarbon receptor mediate synergistic induction of interleukin 6 in MCF-7 cells. Cancer Res 2008, 68:3609-3617.
    • (2008) Cancer Res , vol.68 , pp. 3609-3617
    • Hollingshead, B.D.1    Beischlag, T.V.2    DiNatale, B.C.3    Ramadoss, P.4    Perdew, G.H.5
  • 15
    • 84875974490 scopus 로고    scopus 로고
    • AhR- and NF-kappaB-dependent induction of interleukin-6 by co-exposure to the environmental contaminant benzanthracene and the cytokine tumor necrosis factor-alpha in human mammary MCF-7 cells
    • Kolasa E., Houlbert N., Balaguer P., Fardel O. AhR- and NF-kappaB-dependent induction of interleukin-6 by co-exposure to the environmental contaminant benzanthracene and the cytokine tumor necrosis factor-alpha in human mammary MCF-7 cells. Chem. Biol. Interact 2013, 203:391-400.
    • (2013) Chem. Biol. Interact , vol.203 , pp. 391-400
    • Kolasa, E.1    Houlbert, N.2    Balaguer, P.3    Fardel, O.4
  • 16
    • 70350464482 scopus 로고    scopus 로고
    • Hyperactivated NF-kappa B and AP-1 transcription factors promote highly accessible chromatin and constitutive transcription across the interleukin-6 gene promoter in metastatic breast cancer cells
    • Ndlovu M.N., Van Lint C., Van Wesemael K., Callebert P., Chalbos D., Haegeman G., et al. Hyperactivated NF-kappa B and AP-1 transcription factors promote highly accessible chromatin and constitutive transcription across the interleukin-6 gene promoter in metastatic breast cancer cells. Mol. Cell. Biol 2009, 29:5488-5504.
    • (2009) Mol. Cell. Biol , vol.29 , pp. 5488-5504
    • Ndlovu, M.N.1    Van Lint, C.2    Van Wesemael, K.3    Callebert, P.4    Chalbos, D.5    Haegeman, G.6
  • 18
    • 77957365010 scopus 로고    scopus 로고
    • Differential interleukin-6/Stat3 signaling as a function of cellular context mediates Ras-induced transformation
    • Leslie K., Gao S.P., Berishaj M., Podsypanina K., Ho H., Ivashkiv L., et al. Differential interleukin-6/Stat3 signaling as a function of cellular context mediates Ras-induced transformation. Breast Cancer Res 2010, 12.
    • (2010) Breast Cancer Res , vol.12
    • Leslie, K.1    Gao, S.P.2    Berishaj, M.3    Podsypanina, K.4    Ho, H.5    Ivashkiv, L.6
  • 19
    • 84879731392 scopus 로고    scopus 로고
    • The IL-6/JAK/Stat3 feed-forward loop drives tumorigenesis and metastasis
    • Chang Q., Bournazou E., Sansone P., Berishaj M., Gao S.P., Daly L., et al. The IL-6/JAK/Stat3 feed-forward loop drives tumorigenesis and metastasis. Neoplasia 2013, 15:848-862.
    • (2013) Neoplasia , vol.15 , pp. 848-862
    • Chang, Q.1    Bournazou, E.2    Sansone, P.3    Berishaj, M.4    Gao, S.P.5    Daly, L.6
  • 20
    • 55349104462 scopus 로고    scopus 로고
    • Fibroblasts isolated from common sites of breast cancer metastasis enhance cancer cell growth rates and invasiveness in an interleukin-6-dependent manner
    • Studebaker A.W., Storci G., Werbeck J.L., Sansone P., Sasser A.K., Tavolari S., et al. Fibroblasts isolated from common sites of breast cancer metastasis enhance cancer cell growth rates and invasiveness in an interleukin-6-dependent manner. Cancer Res 2008, 68:9087-9095.
    • (2008) Cancer Res , vol.68 , pp. 9087-9095
    • Studebaker, A.W.1    Storci, G.2    Werbeck, J.L.3    Sansone, P.4    Sasser, A.K.5    Tavolari, S.6
  • 21
    • 84892917277 scopus 로고    scopus 로고
    • Interleukin-6 released by colon cancer-associated fibroblasts is critical for tumour angiogenesis: anti-interleukin-6 receptor antibody suppressed angiogenesis and inhibited tumour-stroma interaction
    • Nagasaki T., Hara M., Nakanishi H., Takahashi H., Sato M., Takeyama H. Interleukin-6 released by colon cancer-associated fibroblasts is critical for tumour angiogenesis: anti-interleukin-6 receptor antibody suppressed angiogenesis and inhibited tumour-stroma interaction. Brit. J. Cancer 2014, 110:469-478.
    • (2014) Brit. J. Cancer , vol.110 , pp. 469-478
    • Nagasaki, T.1    Hara, M.2    Nakanishi, H.3    Takahashi, H.4    Sato, M.5    Takeyama, H.6
  • 22
    • 84866481797 scopus 로고    scopus 로고
    • Mesenchymal stem cell-derived interleukin-6 and vascular endothelial growth factor promote breast cancer cell migration
    • De Luca A., Lamura L., Gallo M., Maffia V., Normanno N. Mesenchymal stem cell-derived interleukin-6 and vascular endothelial growth factor promote breast cancer cell migration. J. Cell. Biochem 2012, 113:3363-3370.
    • (2012) J. Cell. Biochem , vol.113 , pp. 3363-3370
    • De Luca, A.1    Lamura, L.2    Gallo, M.3    Maffia, V.4    Normanno, N.5
  • 23
    • 58249092364 scopus 로고    scopus 로고
    • Mesenchymal stem cell secretion of chemokines during differentiation into osteoblasts, and their potential role in mediating interactions with breast cancer cells
    • Molloy A.P., Martin F.T., Dwyer R.M., Griffin T.P., Murphy M., Barry F.P., et al. Mesenchymal stem cell secretion of chemokines during differentiation into osteoblasts, and their potential role in mediating interactions with breast cancer cells. Int. J. Cancer 2009, 124:326-332.
    • (2009) Int. J. Cancer , vol.124 , pp. 326-332
    • Molloy, A.P.1    Martin, F.T.2    Dwyer, R.M.3    Griffin, T.P.4    Murphy, M.5    Barry, F.P.6
  • 24
    • 84862806829 scopus 로고    scopus 로고
    • IL6-mediated suppression of miR-200c directs constitutive activation of inflammatory signaling circuit driving transformation and tumorigenesis
    • Rokavec M., Wu W.L., Luo J.L. IL6-mediated suppression of miR-200c directs constitutive activation of inflammatory signaling circuit driving transformation and tumorigenesis. Mol. Cell 2012, 45:777-789.
    • (2012) Mol. Cell , vol.45 , pp. 777-789
    • Rokavec, M.1    Wu, W.L.2    Luo, J.L.3
  • 25
    • 79751472667 scopus 로고    scopus 로고
    • Tumor-derived jagged1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells
    • Sethi N., Dai X.D., Winter C.G., Kang Y.B. Tumor-derived jagged1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells. Cancer Cell 2011, 19:192-205.
    • (2011) Cancer Cell , vol.19 , pp. 192-205
    • Sethi, N.1    Dai, X.D.2    Winter, C.G.3    Kang, Y.B.4
  • 26
    • 23844458943 scopus 로고    scopus 로고
    • Interleukin-1 and interleukin-6 gene polymorphisms and the risk of breast cancer in Caucasian women
    • Hefler L.A., Grimm C., Lantzsch T., Lampe D., Leodolter S., Koelbl H., et al. Interleukin-1 and interleukin-6 gene polymorphisms and the risk of breast cancer in Caucasian women. Clin. Cancer Res 2005, 11:5718-5721.
    • (2005) Clin. Cancer Res , vol.11 , pp. 5718-5721
    • Hefler, L.A.1    Grimm, C.2    Lantzsch, T.3    Lampe, D.4    Leodolter, S.5    Koelbl, H.6
  • 27
    • 84883609975 scopus 로고    scopus 로고
    • A mutual activation loop between breast cancer cells and myeloid-derived suppressor cells facilitates spontaneous metastasis through IL-6 trans-signaling in a murine model
    • Oh K., Lee O.Y., Shon S.Y., Nam O., Ryu P.M., Seo M.W., et al. A mutual activation loop between breast cancer cells and myeloid-derived suppressor cells facilitates spontaneous metastasis through IL-6 trans-signaling in a murine model. Breast Cancer Res 2013, 15.
    • (2013) Breast Cancer Res , vol.15
    • Oh, K.1    Lee, O.Y.2    Shon, S.Y.3    Nam, O.4    Ryu, P.M.5    Seo, M.W.6
  • 28
    • 32944477173 scopus 로고    scopus 로고
    • Human immunodeficiency virus-1 Tat protein up-regulates interleukin-6 and interleukin-8 expression in human breast cancer cells
    • Lee Y.W., Hirani A.A., Kyprianou N., Toborek M. Human immunodeficiency virus-1 Tat protein up-regulates interleukin-6 and interleukin-8 expression in human breast cancer cells. Inflamm. Res 2005, 54:380-389.
    • (2005) Inflamm. Res , vol.54 , pp. 380-389
    • Lee, Y.W.1    Hirani, A.A.2    Kyprianou, N.3    Toborek, M.4
  • 29
    • 84872501133 scopus 로고    scopus 로고
    • The clinical significance of inflammatory cytokines in primary cell culture in endometrial carcinoma
    • Smith H.O., Stephens N.D., Qualls C.R., Fligelman T., Wang T., Lin C.Y., et al. The clinical significance of inflammatory cytokines in primary cell culture in endometrial carcinoma. Mol. Oncol 2013, 7:41-54.
    • (2013) Mol. Oncol , vol.7 , pp. 41-54
    • Smith, H.O.1    Stephens, N.D.2    Qualls, C.R.3    Fligelman, T.4    Wang, T.5    Lin, C.Y.6
  • 30
    • 84898005710 scopus 로고    scopus 로고
    • Interleukin 6 promotes endometrial cancer growth through an autocrine feedback loop involving ERK-NF-kappa B signaling pathway
    • Che Q., Liu B.Y., Wang F.Y., He Y.Y., Lu W., Liao Y., et al. Interleukin 6 promotes endometrial cancer growth through an autocrine feedback loop involving ERK-NF-kappa B signaling pathway. Biochem. Bioph. Res. Co 2014, 446:167-172.
    • (2014) Biochem. Bioph. Res. Co , vol.446 , pp. 167-172
    • Che, Q.1    Liu, B.Y.2    Wang, F.Y.3    He, Y.Y.4    Lu, W.5    Liao, Y.6
  • 31
    • 84862304990 scopus 로고    scopus 로고
    • Interleukin-6 signaling regulates anchorage-independent growth, proliferation, adhesion and invasion in human ovarian cancer cells
    • Wang Y., Li L., Guo X., Jin X., Sun W., Zhang X., et al. Interleukin-6 signaling regulates anchorage-independent growth, proliferation, adhesion and invasion in human ovarian cancer cells. Cytokine 2012, 59:228-236.
    • (2012) Cytokine , vol.59 , pp. 228-236
    • Wang, Y.1    Li, L.2    Guo, X.3    Jin, X.4    Sun, W.5    Zhang, X.6
  • 32
    • 84888004137 scopus 로고    scopus 로고
    • Activation of interleukin-6/signal transducer and activator of transcription 3 by human papillomavirus early proteins 6 induces fibroblast senescence to promote cervical tumourigenesis through autocrine and paracrine pathways in tumour microenvironment
    • Ren C.X., Cheng X., Lu B., Yang G. Activation of interleukin-6/signal transducer and activator of transcription 3 by human papillomavirus early proteins 6 induces fibroblast senescence to promote cervical tumourigenesis through autocrine and paracrine pathways in tumour microenvironment. Eur. J. Cancer 2013, 49:3889-3899.
    • (2013) Eur. J. Cancer , vol.49 , pp. 3889-3899
    • Ren, C.X.1    Cheng, X.2    Lu, B.3    Yang, G.4
  • 33
    • 84857931155 scopus 로고    scopus 로고
    • Zerumbone inhibits interleukin-6 and induces apoptosis and cell cycle arrest in ovarian and cervical cancer cells
    • Abdelwahab S.I., Abdul A.B., Zain Z.N., Hadi A.H. Zerumbone inhibits interleukin-6 and induces apoptosis and cell cycle arrest in ovarian and cervical cancer cells. Int. Immunopharmacol 2012, 12:594-602.
    • (2012) Int. Immunopharmacol , vol.12 , pp. 594-602
    • Abdelwahab, S.I.1    Abdul, A.B.2    Zain, Z.N.3    Hadi, A.H.4
  • 35
    • 34247468418 scopus 로고    scopus 로고
    • IL-6 induces AGS gastric cancer cell invasion via activation of the c-Src/RhoA/ROCK signaling pathway
    • Lin M.T., Lin B.R., Chang C.C., Chu C.Y., Su H.J., Chen S.T., et al. IL-6 induces AGS gastric cancer cell invasion via activation of the c-Src/RhoA/ROCK signaling pathway. Int. J. Cancer 2007, 120:2600-2608.
    • (2007) Int. J. Cancer , vol.120 , pp. 2600-2608
    • Lin, M.T.1    Lin, B.R.2    Chang, C.C.3    Chu, C.Y.4    Su, H.J.5    Chen, S.T.6
  • 36
    • 84885671431 scopus 로고    scopus 로고
    • Identification of Liver Cancer Progenitors Whose Malignant Progression Depends on Autocrine IL-6 Signaling
    • He G.B., Dhar D., Nakagawa H., Font-Burgada J., Ogata H., Jiang Y.H., et al. Identification of Liver Cancer Progenitors Whose Malignant Progression Depends on Autocrine IL-6 Signaling. Cell 2013, 155:384-396.
    • (2013) Cell , vol.155 , pp. 384-396
    • He, G.B.1    Dhar, D.2    Nakagawa, H.3    Font-Burgada, J.4    Ogata, H.5    Jiang, Y.H.6
  • 37
    • 84874895627 scopus 로고    scopus 로고
    • Resveratrol downregulates interleukin-6-stimulated sonic hedgehog signaling in human acute myeloid leukemia
    • Su Y.C., Li S.C., Wu Y.C., Wang L.M., Chao K.S., Liao H.F. Resveratrol downregulates interleukin-6-stimulated sonic hedgehog signaling in human acute myeloid leukemia. Evid. Based Complement. Alternat. Med 2013, 2013:547430.
    • (2013) Evid. Based Complement. Alternat. Med , vol.2013 , pp. 547430
    • Su, Y.C.1    Li, S.C.2    Wu, Y.C.3    Wang, L.M.4    Chao, K.S.5    Liao, H.F.6
  • 38
    • 84879301158 scopus 로고    scopus 로고
    • Endothelial cells enhance prostate cancer metastasis via IL-6 -> Androgen Receptor -> TGF-beta -> MMP-9 Signals
    • Wang X.H., Lee S.O., Xia S.J., Jiang Q., Luo J., Li L., et al. Endothelial cells enhance prostate cancer metastasis via IL-6 -> Androgen Receptor -> TGF-beta -> MMP-9 Signals. Mol. Cancer Ther 2013, 12:1026-1037.
    • (2013) Mol. Cancer Ther , vol.12 , pp. 1026-1037
    • Wang, X.H.1    Lee, S.O.2    Xia, S.J.3    Jiang, Q.4    Luo, J.5    Li, L.6
  • 40
    • 74549167737 scopus 로고    scopus 로고
    • Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression
    • Park E.J., Lee J.H., Yu G.Y., He G.B., Ali S.R., Holzer R.G., et al. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 2010, 140:197-208.
    • (2010) Cell , vol.140 , pp. 197-208
    • Park, E.J.1    Lee, J.H.2    Yu, G.Y.3    He, G.B.4    Ali, S.R.5    Holzer, R.G.6
  • 41
    • 84885953929 scopus 로고    scopus 로고
    • Serum interleukin-6 associated with hepatocellular carcinoma risk: a nested case-control study
    • Ohishi W., Cologne J.B., Fujiwara S., Suzuki G., Hayashi T., Niwa Y., et al. Serum interleukin-6 associated with hepatocellular carcinoma risk: a nested case-control study. Int. J. Cancer 2014, 134:154-163.
    • (2014) Int. J. Cancer , vol.134 , pp. 154-163
    • Ohishi, W.1    Cologne, J.B.2    Fujiwara, S.3    Suzuki, G.4    Hayashi, T.5    Niwa, Y.6
  • 42
    • 84900035813 scopus 로고    scopus 로고
    • Activation of a positive feedback loop involving IL-6 and aromatase promotes intratumoral 17 beta-estradiol biosynthesis in endometrial carcinoma microenvironment
    • Che Q., Liu B.Y., Liao Y., Zhang H.J., Yang T.T., He Y.Y., et al. Activation of a positive feedback loop involving IL-6 and aromatase promotes intratumoral 17 beta-estradiol biosynthesis in endometrial carcinoma microenvironment. Int. J. Cancer 2014, 135:282-294.
    • (2014) Int. J. Cancer , vol.135 , pp. 282-294
    • Che, Q.1    Liu, B.Y.2    Liao, Y.3    Zhang, H.J.4    Yang, T.T.5    He, Y.Y.6
  • 43
    • 84887024873 scopus 로고    scopus 로고
    • Interaction between non-small-cell lung cancer cells and fibroblasts via enhancement of TGF-beta signaling by IL-6
    • Abulaiti A., Shintani Y., Funaki S., Nakagiri T., Inoue M., Sawabata N., et al. Interaction between non-small-cell lung cancer cells and fibroblasts via enhancement of TGF-beta signaling by IL-6. Lung Cancer 2013, 82:204-213.
    • (2013) Lung Cancer , vol.82 , pp. 204-213
    • Abulaiti, A.1    Shintani, Y.2    Funaki, S.3    Nakagiri, T.4    Inoue, M.5    Sawabata, N.6
  • 44
    • 84875821295 scopus 로고    scopus 로고
    • IL-6 expression predicts treatment response and outcome in squamous cell carcinoma of the esophagus
    • Chen M.F., Chen P.T., Lu M.S., Lin P.Y., Chen W.C., Lee K.D. IL-6 expression predicts treatment response and outcome in squamous cell carcinoma of the esophagus. Mol. Cancer 2013, 12.
    • (2013) Mol. Cancer , vol.12
    • Chen, M.F.1    Chen, P.T.2    Lu, M.S.3    Lin, P.Y.4    Chen, W.C.5    Lee, K.D.6
  • 45
    • 60649101580 scopus 로고    scopus 로고
    • IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer (vol 15, pg 103, 2009)
    • Grivennikov S., Karin E., Terzic J., Mucida D., Yu G.Y., Vallabhapurapu S., et al. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer (vol 15, pg 103, 2009). Cancer Cell 2009, 15:241.
    • (2009) Cancer Cell , vol.15 , pp. 241
    • Grivennikov, S.1    Karin, E.2    Terzic, J.3    Mucida, D.4    Yu, G.Y.5    Vallabhapurapu, S.6
  • 46
    • 58649101347 scopus 로고    scopus 로고
    • Gp130-mediated stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis
    • Bollrath J., Phesse T.J., von Burstin V.A., Putoczki T., Bennecke M., Bateman T., et al. gp130-mediated stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. Cancer Cell 2009, 15:91-102.
    • (2009) Cancer Cell , vol.15 , pp. 91-102
    • Bollrath, J.1    Phesse, T.J.2    von Burstin, V.A.3    Putoczki, T.4    Bennecke, M.5    Bateman, T.6
  • 47
    • 84865295971 scopus 로고    scopus 로고
    • STAT3 activation by IL-6 from mesenchymal stem cells promotes the proliferation and metastasis of osteosarcoma
    • Tu B., Du L., Fan Q.M., Tang Z., Tang T.T. STAT3 activation by IL-6 from mesenchymal stem cells promotes the proliferation and metastasis of osteosarcoma. Cancer Lett 2012, 325:80-88.
    • (2012) Cancer Lett , vol.325 , pp. 80-88
    • Tu, B.1    Du, L.2    Fan, Q.M.3    Tang, Z.4    Tang, T.T.5
  • 48
    • 84885069504 scopus 로고    scopus 로고
    • Activation of STAT3 in human gastric cancer cells via interleukin (IL)-6-Type cytokine signaling correlates with clinical implications
    • Wang Z.G., Si X.L., Xu A., Meng X.N., Gao S.L., Qi Y.J., et al. Activation of STAT3 in human gastric cancer cells via interleukin (IL)-6-Type cytokine signaling correlates with clinical implications. PLoS ONE 2013, 8.
    • (2013) PLoS ONE , vol.8
    • Wang, Z.G.1    Si, X.L.2    Xu, A.3    Meng, X.N.4    Gao, S.L.5    Qi, Y.J.6
  • 49
    • 84892914226 scopus 로고    scopus 로고
    • NF-kappa B-Induced IL-6 Ensures STAT3 activation and tumor aggressiveness in glioblastoma
    • McFarland B.C., Hong S.W., Rajbhandari R., Twitty G.B., Gray G.K., Yu H., et al. NF-kappa B-Induced IL-6 Ensures STAT3 activation and tumor aggressiveness in glioblastoma. PLoS ONE 2013, 8.
    • (2013) PLoS ONE , vol.8
    • McFarland, B.C.1    Hong, S.W.2    Rajbhandari, R.3    Twitty, G.B.4    Gray, G.K.5    Yu, H.6
  • 50
    • 84872598543 scopus 로고    scopus 로고
    • Role of MMP-2 in the regulation of IL-6/Stat3 survival signaling via interaction with alpha 5 beta 1 integrin in glioma
    • Kesanakurti D., Chetty C., Dinh D.H., Gujrati M., Rao J.S. Role of MMP-2 in the regulation of IL-6/Stat3 survival signaling via interaction with alpha 5 beta 1 integrin in glioma. Oncogene 2013, 32:327-340.
    • (2013) Oncogene , vol.32 , pp. 327-340
    • Kesanakurti, D.1    Chetty, C.2    Dinh, D.H.3    Gujrati, M.4    Rao, J.S.5
  • 51
    • 79953756112 scopus 로고    scopus 로고
    • Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer
    • Lesina M., Kurkowski M.U., Ludes K., Rose-John S., Treiber M., Kloppel G., et al. Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer. Cancer Cell 2011, 19:456-469.
    • (2011) Cancer Cell , vol.19 , pp. 456-469
    • Lesina, M.1    Kurkowski, M.U.2    Ludes, K.3    Rose-John, S.4    Treiber, M.5    Kloppel, G.6
  • 52
    • 79952278711 scopus 로고    scopus 로고
    • Elevated expression of APE1/Ref-1 and its regulation on IL-6 and IL-8 in bone marrow stromal cells of multiple myeloma
    • Xie J.Y., Li M.X., Xiang D.B., Mou J.H., Qing Y., Zeng L.L., et al. Elevated expression of APE1/Ref-1 and its regulation on IL-6 and IL-8 in bone marrow stromal cells of multiple myeloma. Clin. Lymphoma Myeloma Leuk 2010, 10:385-393.
    • (2010) Clin. Lymphoma Myeloma Leuk , vol.10 , pp. 385-393
    • Xie, J.Y.1    Li, M.X.2    Xiang, D.B.3    Mou, J.H.4    Qing, Y.5    Zeng, L.L.6
  • 53
    • 79958789624 scopus 로고    scopus 로고
    • Integrin-linked kinase regulates melanoma angiogenesis by activating NF-kappa B/interleukin-6 signaling pathway
    • Wani A.A., Jafarnejad S.M., Zhou J., Li G. Integrin-linked kinase regulates melanoma angiogenesis by activating NF-kappa B/interleukin-6 signaling pathway. Oncogene 2011, 30:2778-2788.
    • (2011) Oncogene , vol.30 , pp. 2778-2788
    • Wani, A.A.1    Jafarnejad, S.M.2    Zhou, J.3    Li, G.4
  • 54
    • 81255189474 scopus 로고    scopus 로고
    • IL-6 controls leukemic multipotent progenitor cell fate and contributes to chronic myelogenous leukemia development
    • Reynaud D., Pietras E., Barry-Holson K., Mir A., Binnewies M., Jeanne M., et al. IL-6 controls leukemic multipotent progenitor cell fate and contributes to chronic myelogenous leukemia development. Cancer Cell 2011, 20:661-673.
    • (2011) Cancer Cell , vol.20 , pp. 661-673
    • Reynaud, D.1    Pietras, E.2    Barry-Holson, K.3    Mir, A.4    Binnewies, M.5    Jeanne, M.6
  • 55
    • 84885183807 scopus 로고    scopus 로고
    • Early role for IL-6 signalling during generation of induced pluripotent stem cells revealed by heterokaryon RNA-Seq
    • Brady J.J., Li M., Suthram S., Jiang H., Wong W.H., Blau H.M. Early role for IL-6 signalling during generation of induced pluripotent stem cells revealed by heterokaryon RNA-Seq. Nat. Cell Biol 2013, 15:U1244-U1272.
    • (2013) Nat. Cell Biol , vol.15 , pp. U1244-U1272
    • Brady, J.J.1    Li, M.2    Suthram, S.3    Jiang, H.4    Wong, W.H.5    Blau, H.M.6
  • 56
    • 70350223977 scopus 로고    scopus 로고
    • Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth
    • Wang H., Lathia J.D., Wu Q.L., Wang J.L., Li Z.Z., Heddleston J.M., et al. Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth. Stem Cells 2009, 27:2393-2404.
    • (2009) Stem Cells , vol.27 , pp. 2393-2404
    • Wang, H.1    Lathia, J.D.2    Wu, Q.L.3    Wang, J.L.4    Li, Z.Z.5    Heddleston, J.M.6
  • 57
    • 84892870266 scopus 로고    scopus 로고
    • Interleukin-6 induces malignant transformation of rat mesenchymal stem cells in association with enhanced signaling of signal transducer and activator of transcription 3
    • Cui X.R., Liu J.P., Bai L., Tian J., Zhu J. Interleukin-6 induces malignant transformation of rat mesenchymal stem cells in association with enhanced signaling of signal transducer and activator of transcription 3. Cancer Sci 2014, 105:64-71.
    • (2014) Cancer Sci , vol.105 , pp. 64-71
    • Cui, X.R.1    Liu, J.P.2    Bai, L.3    Tian, J.4    Zhu, J.5
  • 58
    • 84895756231 scopus 로고    scopus 로고
    • RhoC regulates cancer stem cells in head and neck squamous cell carcinoma by overexpressing IL-6 and phosphorylation of STAT3
    • Islam M., Sharma S., Teknos T.N. RhoC regulates cancer stem cells in head and neck squamous cell carcinoma by overexpressing IL-6 and phosphorylation of STAT3. PLoS ONE 2014, 9.
    • (2014) PLoS ONE , vol.9
    • Islam, M.1    Sharma, S.2    Teknos, T.N.3
  • 59
    • 84907887777 scopus 로고    scopus 로고
    • Endothelial interleukin-6 defines the tumorigenic potential of primary human cancer stem cells
    • Krishnamurthy S., Warner K.A., Dong Z.H., Imai A., Nor C., Ward B.B., et al. Endothelial interleukin-6 defines the tumorigenic potential of primary human cancer stem cells. Stem Cells 2014, 32:2845-2857.
    • (2014) Stem Cells , vol.32 , pp. 2845-2857
    • Krishnamurthy, S.1    Warner, K.A.2    Dong, Z.H.3    Imai, A.4    Nor, C.5    Ward, B.B.6
  • 60
    • 84891885126 scopus 로고    scopus 로고
    • Loss of let-7 MicroRNA Upregulates IL-6 in bone marrow-derived mesenchymal stem cells triggering a reactive stromal response to prostate cancer
    • Sung S.Y., Liao C.H., Wu H.P., Hsiao W.C., Wu I.H., Yu J.P., et al. Loss of let-7 MicroRNA Upregulates IL-6 in bone marrow-derived mesenchymal stem cells triggering a reactive stromal response to prostate cancer. PLoS ONE 2013, 8.
    • (2013) PLoS ONE , vol.8
    • Sung, S.Y.1    Liao, C.H.2    Wu, H.P.3    Hsiao, W.C.4    Wu, I.H.5    Yu, J.P.6
  • 61
    • 84903781265 scopus 로고    scopus 로고
    • The IL-6-STAT3 axis mediates a reciprocal crosstalk between cancer-derived mesenchymal stem cells and neutrophils to synergistically prompt gastric cancer progression
    • Zhu Q., Zhang X., Zhang L., Li W., Wu H., Yuan X., et al. The IL-6-STAT3 axis mediates a reciprocal crosstalk between cancer-derived mesenchymal stem cells and neutrophils to synergistically prompt gastric cancer progression. Cell Death Dis 2014, 5:e1295.
    • (2014) Cell Death Dis , vol.5 , pp. e1295
    • Zhu, Q.1    Zhang, X.2    Zhang, L.3    Li, W.4    Wu, H.5    Yuan, X.6
  • 62
    • 78149413180 scopus 로고    scopus 로고
    • Interleukin 6 mediated recruitment of mesenchymal stem cells to the hypoxic tumor milieu
    • Rattigan Y., Hsu J.M., Mishra P.J., Glod J., Banerjee D. Interleukin 6 mediated recruitment of mesenchymal stem cells to the hypoxic tumor milieu. Exp. Cell Res 2010, 316:3417-3424.
    • (2010) Exp. Cell Res , vol.316 , pp. 3417-3424
    • Rattigan, Y.1    Hsu, J.M.2    Mishra, P.J.3    Glod, J.4    Banerjee, D.5
  • 63
    • 78449297256 scopus 로고    scopus 로고
    • Human mesenchymal stem cells promote growth of osteosarcoma: involvement of interleukin-6 in the interaction between human mesenchymal stem cells and Saos-2
    • Bian Z.Y., Fan Q.M., Li G., Xu W.T., Tang T.T. Human mesenchymal stem cells promote growth of osteosarcoma: involvement of interleukin-6 in the interaction between human mesenchymal stem cells and Saos-2. Cancer Sci 2010, 101:2554-2560.
    • (2010) Cancer Sci , vol.101 , pp. 2554-2560
    • Bian, Z.Y.1    Fan, Q.M.2    Li, G.3    Xu, W.T.4    Tang, T.T.5
  • 64
    • 84873537569 scopus 로고    scopus 로고
    • Role of the IL-6-JAK1-STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells
    • Kim S.Y., Kang J.W., Song X.X., Kim B.K., Yoo Y.D., Kwon Y.T., et al. Role of the IL-6-JAK1-STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells. Cell. Signal 2013, 25:961-969.
    • (2013) Cell. Signal , vol.25 , pp. 961-969
    • Kim, S.Y.1    Kang, J.W.2    Song, X.X.3    Kim, B.K.4    Yoo, Y.D.5    Kwon, Y.T.6
  • 65
    • 79952121979 scopus 로고    scopus 로고
    • Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion
    • Iliopoulos D., Hirsch H.A., Wang G.N., Struhl K. Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion. Proc. Natl. Acad. Sci. USA 2011, 108:1397-1402.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 1397-1402
    • Iliopoulos, D.1    Hirsch, H.A.2    Wang, G.N.3    Struhl, K.4
  • 66
    • 84893522248 scopus 로고    scopus 로고
    • Syndecan-1 (CD138) modulates triple-negative breast cancer stem cell properties via regulation of LRP-6 and IL-6-mediated STAT3 signaling
    • Ibrahim S.A., Hassan H., Vilardo L., Kumar S.K., Kumar A.V., Kelsch R., et al. Syndecan-1 (CD138) modulates triple-negative breast cancer stem cell properties via regulation of LRP-6 and IL-6-mediated STAT3 signaling. PLoS ONE 2013, 8:e85737.
    • (2013) PLoS ONE , vol.8 , pp. e85737
    • Ibrahim, S.A.1    Hassan, H.2    Vilardo, L.3    Kumar, S.K.4    Kumar, A.V.5    Kelsch, R.6
  • 67
    • 36849039660 scopus 로고    scopus 로고
    • IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland
    • Sansone P., Storci G., Tavolari S., Guarnieri T., Giovannini C., Taffurelli M., et al. IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland. J. Clin. Invest 2007, 117:3988-4002.
    • (2007) J. Clin. Invest , vol.117 , pp. 3988-4002
    • Sansone, P.1    Storci, G.2    Tavolari, S.3    Guarnieri, T.4    Giovannini, C.5    Taffurelli, M.6
  • 68
    • 79959956046 scopus 로고    scopus 로고
    • The JAK2/STAT3 signaling pathway is required for growth of CD44(+)CD24(-) stem cell-like breast cancer cells in human tumors
    • Marotta L.L.C., Almendro V., Marusyk A., Shipitsin M., Schemme J., Walker S.R., et al. The JAK2/STAT3 signaling pathway is required for growth of CD44(+)CD24(-) stem cell-like breast cancer cells in human tumors. J. Clin. Invest 2011, 121:2723-2735.
    • (2011) J. Clin. Invest , vol.121 , pp. 2723-2735
    • Marotta, L.L.C.1    Almendro, V.2    Marusyk, A.3    Shipitsin, M.4    Schemme, J.5    Walker, S.R.6
  • 69
    • 84911002427 scopus 로고    scopus 로고
    • IL-6 enriched lung cancer stem-like cell population by inhibition of cell cycle regulators via DNMT1 upregulation
    • Liu C.C., Lin J.H., Hsu T.W., Su K., Li A.F., Hsu H.S., et al. IL-6 enriched lung cancer stem-like cell population by inhibition of cell cycle regulators via DNMT1 upregulation. Int. J. Cancer 2014.
    • (2014) Int. J. Cancer
    • Liu, C.C.1    Lin, J.H.2    Hsu, T.W.3    Su, K.4    Li, A.F.5    Hsu, H.S.6
  • 70
    • 85019184138 scopus 로고    scopus 로고
    • RMP promotes venous metastases of hepatocellular carcinoma through promoting IL-6 transcription
    • Zhang J., Pan Y.F., Ding Z.W., Yang G.Z., Tan Y.X., Yang C., et al. RMP promotes venous metastases of hepatocellular carcinoma through promoting IL-6 transcription. Oncogene 2014, 0.
    • (2014) Oncogene
    • Zhang, J.1    Pan, Y.F.2    Ding, Z.W.3    Yang, G.Z.4    Tan, Y.X.5    Yang, C.6
  • 71
    • 84890859206 scopus 로고    scopus 로고
    • Bone marrow-derived myofibroblasts promote colon tumorigenesis through the IL-6/JAK2/STAT3 pathway
    • Zhu L.M., Cheng X.J., Ding Y.F., Shi J.D., Jin H.Y., Wang H., et al. Bone marrow-derived myofibroblasts promote colon tumorigenesis through the IL-6/JAK2/STAT3 pathway. Cancer Lett 2014, 343:80-89.
    • (2014) Cancer Lett , vol.343 , pp. 80-89
    • Zhu, L.M.1    Cheng, X.J.2    Ding, Y.F.3    Shi, J.D.4    Jin, H.Y.5    Wang, H.6
  • 72
    • 79952766231 scopus 로고    scopus 로고
    • Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks (vol 71, pg 614, 2011)
    • Liu S., Ginestier C., Ou S.J., Clouthier S.G., Patel S.H., Monville F. Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks (vol 71, pg 614, 2011). Cancer Res 2011, 71:2407.
    • (2011) Cancer Res , vol.71 , pp. 2407
    • Liu, S.1    Ginestier, C.2    Ou, S.J.3    Clouthier, S.G.4    Patel, S.H.5    Monville, F.6
  • 73
    • 84863349461 scopus 로고    scopus 로고
    • IL-6-induced epithelial-mesenchymal transition promotes the generation of breast cancer stem-like cells analogous to mammosphere cultures
    • Xie G.Z., Yao Q.W., Liu Y., Du S.S., Liu A.H., Guo Z.Z., et al. IL-6-induced epithelial-mesenchymal transition promotes the generation of breast cancer stem-like cells analogous to mammosphere cultures. Int. J. Oncol 2012, 40:1171-1179.
    • (2012) Int. J. Oncol , vol.40 , pp. 1171-1179
    • Xie, G.Z.1    Yao, Q.W.2    Liu, Y.3    Du, S.S.4    Liu, A.H.5    Guo, Z.Z.6
  • 74
    • 70350778443 scopus 로고    scopus 로고
    • An epigenetic switch involving NF-kappa B, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation
    • Iliopoulos D., Hirsch H.A., Struhl K. An epigenetic switch involving NF-kappa B, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation. Cell 2009, 139:693-706.
    • (2009) Cell , vol.139 , pp. 693-706
    • Iliopoulos, D.1    Hirsch, H.A.2    Struhl, K.3
  • 75
    • 78549283836 scopus 로고    scopus 로고
    • Epigenetic control of the basal-like gene expression profile via Interleukin-6 in breast cancer cells
    • Anello L.D., Sansone P., Storci G., Mitrugno V., Uva G.D., Chieco P., et al. Epigenetic control of the basal-like gene expression profile via Interleukin-6 in breast cancer cells. Mol. Cancer 2010, 9.
    • (2010) Mol. Cancer , vol.9
    • Anello, L.D.1    Sansone, P.2    Storci, G.3    Mitrugno, V.4    Uva, G.D.5    Chieco, P.6
  • 76
    • 84055207487 scopus 로고    scopus 로고
    • IL-6 promotes head and neck tumor metastasis by inducing epithelial-mesenchymal transition via the JAK-STAT3-SNAIL signaling pathway
    • Yadav A., Kumar B., Datta J., Teknos T.N., Kumar P. IL-6 promotes head and neck tumor metastasis by inducing epithelial-mesenchymal transition via the JAK-STAT3-SNAIL signaling pathway. Mol. Cancer Res 2011, 9:1658-1667.
    • (2011) Mol. Cancer Res , vol.9 , pp. 1658-1667
    • Yadav, A.1    Kumar, B.2    Datta, J.3    Teknos, T.N.4    Kumar, P.5
  • 77
    • 84921641318 scopus 로고    scopus 로고
    • EMT in cervical cancer: its role in tumour progression and response to therapy
    • Qureshi R., Arora H., Rizvi M.A. EMT in cervical cancer: its role in tumour progression and response to therapy. Cancer Lett 2014.
    • (2014) Cancer Lett
    • Qureshi, R.1    Arora, H.2    Rizvi, M.A.3
  • 78
    • 84897561550 scopus 로고    scopus 로고
    • IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis
    • Rokavec M., Oner M.G., Li H.H., Jackstadt R., Jiang L.C., Lodygin D., et al. IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. J. Clin. Invest 2014, 124:1853-1867.
    • (2014) J. Clin. Invest , vol.124 , pp. 1853-1867
    • Rokavec, M.1    Oner, M.G.2    Li, H.H.3    Jackstadt, R.4    Jiang, L.C.5    Lodygin, D.6
  • 79
    • 58149218143 scopus 로고    scopus 로고
    • Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial-mesenchymal transition in ovarian carcinomas
    • Colomiere M., Ward A.C., Riley C., Trenerry M.K., Cameron-Smith D., Findlay J., et al. Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial-mesenchymal transition in ovarian carcinomas. Br. J. Cancer 2009, 100:134-144.
    • (2009) Br. J. Cancer , vol.100 , pp. 134-144
    • Colomiere, M.1    Ward, A.C.2    Riley, C.3    Trenerry, M.K.4    Cameron-Smith, D.5    Findlay, J.6
  • 80
    • 84944525336 scopus 로고    scopus 로고
    • The CCL2/CCR2 axis enhances IL-6-induced epithelial-mesenchymal transition by cooperatively activating STAT3-Twist signaling
    • Chen W., Gao Q., Han S., Pan F., Fan W. The CCL2/CCR2 axis enhances IL-6-induced epithelial-mesenchymal transition by cooperatively activating STAT3-Twist signaling. Tumour Biol 2014.
    • (2014) Tumour Biol
    • Chen, W.1    Gao, Q.2    Han, S.3    Pan, F.4    Fan, W.5
  • 81
    • 84899733576 scopus 로고    scopus 로고
    • Metformin inhibits the IL-6-Induced epithelial-mesenchymal transition and lung adenocarcinoma growth and metastasis
    • Zhao Z.Q., Cheng X.M., Wang Y.B., Han R., Li L., Xiang T., et al. Metformin inhibits the IL-6-Induced epithelial-mesenchymal transition and lung adenocarcinoma growth and metastasis. PLoS ONE 2014, 9.
    • (2014) PLoS ONE , vol.9
    • Zhao, Z.Q.1    Cheng, X.M.2    Wang, Y.B.3    Han, R.4    Li, L.5    Xiang, T.6
  • 82
    • 69249221254 scopus 로고    scopus 로고
    • Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells
    • Sullivan N.J., Sasser A.K., Axel A.E., Vesuna F., Raman V., Ramirez N., et al. Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells. Oncogene 2009, 28:2940-2947.
    • (2009) Oncogene , vol.28 , pp. 2940-2947
    • Sullivan, N.J.1    Sasser, A.K.2    Axel, A.E.3    Vesuna, F.4    Raman, V.5    Ramirez, N.6
  • 83
    • 84902301802 scopus 로고    scopus 로고
    • Breast cancer cell invasion mediated by Galpha12 signaling involves expression of interleukins-6 and -8, and matrix metalloproteinase-2
    • Chia C.Y., Kumari U., Casey P.J. Breast cancer cell invasion mediated by Galpha12 signaling involves expression of interleukins-6 and -8, and matrix metalloproteinase-2. J. Mol. Signal 2014, 9:6.
    • (2014) J. Mol. Signal , vol.9 , pp. 6
    • Chia, C.Y.1    Kumari, U.2    Casey, P.J.3
  • 84
    • 79956126860 scopus 로고    scopus 로고
    • IL-6 promotes prostate tumorigenesis and progression through autocrine cross-activation of IGF-IR
    • Rojas A., Liu G., Coleman I., Nelson P.S., Zhang M., Dash R., et al. IL-6 promotes prostate tumorigenesis and progression through autocrine cross-activation of IGF-IR. Oncogene 2011, 30:2345-2355.
    • (2011) Oncogene , vol.30 , pp. 2345-2355
    • Rojas, A.1    Liu, G.2    Coleman, I.3    Nelson, P.S.4    Zhang, M.5    Dash, R.6
  • 85
    • 84922273516 scopus 로고    scopus 로고
    • Enhanced invasion of lung adenocarcinoma cells after co-culture with THP-1-derived macrophages via the induction of EMT by IL-6
    • Che D.H., Pan B., Tian Q., Shang L.H., Liu F., Jin S., et al. Enhanced invasion of lung adenocarcinoma cells after co-culture with THP-1-derived macrophages via the induction of EMT by IL-6. Immunol. Lett 2014, 160:1-10.
    • (2014) Immunol. Lett , vol.160 , pp. 1-10
    • Che, D.H.1    Pan, B.2    Tian, Q.3    Shang, L.H.4    Liu, F.5    Jin, S.6
  • 87
    • 84902580297 scopus 로고    scopus 로고
    • Interleukin-6-induced epithelial-mesenchymal transition through signal transducer and activator of transcription 3 in human cervical carcinoma
    • Miao J.W., Liu L.J., Huang J. Interleukin-6-induced epithelial-mesenchymal transition through signal transducer and activator of transcription 3 in human cervical carcinoma. Int. J. Oncol 2014, 45:165-176.
    • (2014) Int. J. Oncol , vol.45 , pp. 165-176
    • Miao, J.W.1    Liu, L.J.2    Huang, J.3
  • 88
    • 84893736743 scopus 로고    scopus 로고
    • Retinoic acid inhibits pancreatic cancer cell migration and EMT through the downregulation of IL-6 in cancer associated fibroblast cells
    • Guan J., Zhang H., Wen Z., Gu Y.M., Cheng Y., Sun Y., et al. Retinoic acid inhibits pancreatic cancer cell migration and EMT through the downregulation of IL-6 in cancer associated fibroblast cells. Cancer Lett 2014, 345:132-139.
    • (2014) Cancer Lett , vol.345 , pp. 132-139
    • Guan, J.1    Zhang, H.2    Wen, Z.3    Gu, Y.M.4    Cheng, Y.5    Sun, Y.6
  • 89
    • 85027946414 scopus 로고    scopus 로고
    • Interleukin 6 downregulates p53 expression and activity by stimulating ribosome biogenesis: a new pathway connecting inflammation to cancer
    • Brighenti E., Calabrese C., Liguori G., Giannone F.A., Trere D., Montanaro L., et al. Interleukin 6 downregulates p53 expression and activity by stimulating ribosome biogenesis: a new pathway connecting inflammation to cancer. Oncogene 2014, 33:4396-4406.
    • (2014) Oncogene , vol.33 , pp. 4396-4406
    • Brighenti, E.1    Calabrese, C.2    Liguori, G.3    Giannone, F.A.4    Trere, D.5    Montanaro, L.6
  • 90
    • 84884730112 scopus 로고    scopus 로고
    • Arsenite evokes IL-6 secretion, autocrine regulation of STAT3 signaling, and miR-21 expression, processes involved in the EMT and malignant transformation of human bronchial epithelial cells
    • Luo F., Xu Y., Ling M., Zhao Y., Xu W.C., Liang X., et al. Arsenite evokes IL-6 secretion, autocrine regulation of STAT3 signaling, and miR-21 expression, processes involved in the EMT and malignant transformation of human bronchial epithelial cells. Toxicol. Appl. Pharm 2013, 273:27-34.
    • (2013) Toxicol. Appl. Pharm , vol.273 , pp. 27-34
    • Luo, F.1    Xu, Y.2    Ling, M.3    Zhao, Y.4    Xu, W.C.5    Liang, X.6
  • 92
    • 84877855030 scopus 로고    scopus 로고
    • Hsp27 regulates epithelial mesenchymal transition, metastasis, and circulating tumor cells in prostate cancer
    • Shiota M., Bishop J.L., Nip K.M., Zardan A., Takeuchi A., Cordonnier T., et al. Hsp27 regulates epithelial mesenchymal transition, metastasis, and circulating tumor cells in prostate cancer. Cancer Res 2013, 73:3109-3119.
    • (2013) Cancer Res , vol.73 , pp. 3109-3119
    • Shiota, M.1    Bishop, J.L.2    Nip, K.M.3    Zardan, A.4    Takeuchi, A.5    Cordonnier, T.6
  • 93
    • 43249107158 scopus 로고    scopus 로고
    • Tumor-derived tumor necrosis factor-alpha promotes progression and epithelial-mesenchymal transition in renal cell carcinoma cells
    • Chuang M.J., Sun K.H., Tang S.J., Deng M.W., Wu Y.H., Sung J.S., et al. Tumor-derived tumor necrosis factor-alpha promotes progression and epithelial-mesenchymal transition in renal cell carcinoma cells. Cancer Sci 2008, 99:905-913.
    • (2008) Cancer Sci , vol.99 , pp. 905-913
    • Chuang, M.J.1    Sun, K.H.2    Tang, S.J.3    Deng, M.W.4    Wu, Y.H.5    Sung, J.S.6
  • 94
    • 84909592613 scopus 로고    scopus 로고
    • SCCA1/SERPINB3 promotes oncogenesis and epithelial-mesenchymal transition via the unfolded protein response and IL6 signaling
    • Sheshadri N., Catanzaro J.M., Bott A.J., Sun Y., Ullman E., Chen E.I., et al. SCCA1/SERPINB3 promotes oncogenesis and epithelial-mesenchymal transition via the unfolded protein response and IL6 signaling. Cancer Res 2014, 74:6318-6329.
    • (2014) Cancer Res , vol.74 , pp. 6318-6329
    • Sheshadri, N.1    Catanzaro, J.M.2    Bott, A.J.3    Sun, Y.4    Ullman, E.5    Chen, E.I.6
  • 95
    • 84901036169 scopus 로고    scopus 로고
    • Metformin sensitizes EGFR-TKI-resistant human lung cancer cells in vitro and in vivo through inhibition of IL-6 signaling and EMT reversal
    • Li L., Han R., Xiao H., Lin C., Wang Y., Liu H., et al. Metformin sensitizes EGFR-TKI-resistant human lung cancer cells in vitro and in vivo through inhibition of IL-6 signaling and EMT reversal. Clin. Cancer Res 2014, 20:2714-2726.
    • (2014) Clin. Cancer Res , vol.20 , pp. 2714-2726
    • Li, L.1    Han, R.2    Xiao, H.3    Lin, C.4    Wang, Y.5    Liu, H.6
  • 96
    • 0035893768 scopus 로고    scopus 로고
    • Autocrine production of interleukin 6 causes multidrug resistance in breast cancer cells
    • Conze D., Weiss L., Regen P.S., Bhushan A., Weaver D., Johnson P., et al. Autocrine production of interleukin 6 causes multidrug resistance in breast cancer cells. Cancer Res 2001, 61:8851-8858.
    • (2001) Cancer Res , vol.61 , pp. 8851-8858
    • Conze, D.1    Weiss, L.2    Regen, P.S.3    Bhushan, A.4    Weaver, D.5    Johnson, P.6
  • 97
    • 84906814857 scopus 로고    scopus 로고
    • IL-6 secreted by cancer-associated fibroblasts induces tamoxifen resistance in luminal breast cancer
    • Sun X., Mao Y., Wang J., Zu L., Hao M., Cheng G., et al. IL-6 secreted by cancer-associated fibroblasts induces tamoxifen resistance in luminal breast cancer. Oncogene 2014, 33:4450.
    • (2014) Oncogene , vol.33 , pp. 4450
    • Sun, X.1    Mao, Y.2    Wang, J.3    Zu, L.4    Hao, M.5    Cheng, G.6
  • 98
    • 84865401715 scopus 로고    scopus 로고
    • Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+breast cancer by expanding the cancer stem cell population
    • Korkaya H., Kim G.I., Davis A., Malik F., Henry N.L., Ithimakin S., et al. Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+breast cancer by expanding the cancer stem cell population. Mol. Cell 2012, 47:570-584.
    • (2012) Mol. Cell , vol.47 , pp. 570-584
    • Korkaya, H.1    Kim, G.I.2    Davis, A.3    Malik, F.4    Henry, N.L.5    Ithimakin, S.6
  • 99
    • 84876117639 scopus 로고    scopus 로고
    • Role of crosstalk between interleukin-6 and transforming growth factor-beta 1 in epithelial-mesenchymal transition and chemoresistance in biliary tract cancer
    • Yamada D., Kobayashi S., Wada H., Kawamoto K., Marubashi S., Eguchi H., et al. Role of crosstalk between interleukin-6 and transforming growth factor-beta 1 in epithelial-mesenchymal transition and chemoresistance in biliary tract cancer. Eur. J. Cancer 2013, 49:1725-1740.
    • (2013) Eur. J. Cancer , vol.49 , pp. 1725-1740
    • Yamada, D.1    Kobayashi, S.2    Wada, H.3    Kawamoto, K.4    Marubashi, S.5    Eguchi, H.6
  • 100
    • 84888393766 scopus 로고    scopus 로고
    • Autocrine production of interleukin-6 confers ovarian cancer cells resistance to tamoxifen via ER isoforms and SRC-1
    • Wang Y., Qu Y., Zhang X.L., Xing J., Niu X.L., Chen X., et al. Autocrine production of interleukin-6 confers ovarian cancer cells resistance to tamoxifen via ER isoforms and SRC-1. Mol. Cell. Endocrinol 2014, 382:791-803.
    • (2014) Mol. Cell. Endocrinol , vol.382 , pp. 791-803
    • Wang, Y.1    Qu, Y.2    Zhang, X.L.3    Xing, J.4    Niu, X.L.5    Chen, X.6
  • 101
    • 77953611991 scopus 로고    scopus 로고
    • Autocrine production of interleukin-6 confers cisplatin and paclitaxel resistance in ovarian cancer cells
    • Wang Y., Niu X.L., Qu Y., Wu J., Zhu Y.Q., Sun W.J., et al. Autocrine production of interleukin-6 confers cisplatin and paclitaxel resistance in ovarian cancer cells. Cancer Lett 2010, 295:110-123.
    • (2010) Cancer Lett , vol.295 , pp. 110-123
    • Wang, Y.1    Niu, X.L.2    Qu, Y.3    Wu, J.4    Zhu, Y.Q.5    Sun, W.J.6
  • 102
    • 49649127657 scopus 로고    scopus 로고
    • Mechanisms of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer
    • Engelman J.A., Janne P.A. Mechanisms of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer. Clin. Cancer Res 2008, 14:2895-2899.
    • (2008) Clin. Cancer Res , vol.14 , pp. 2895-2899
    • Engelman, J.A.1    Janne, P.A.2
  • 103
    • 77957273623 scopus 로고    scopus 로고
    • TGF-beta IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer
    • Yao Z., Fenoglio S., Gao D.C., Camiolo M., Stiles B., Lindsted T., et al. TGF-beta IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:15535-15540.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 15535-15540
    • Yao, Z.1    Fenoglio, S.2    Gao, D.C.3    Camiolo, M.4    Stiles, B.5    Lindsted, T.6
  • 104
    • 84867405669 scopus 로고    scopus 로고
    • Activation of IL-6R/JAK1/STAT3 signaling induces de novo resistance to irreversible EGFR Inhibitors in non-small cell lung cancer with T790M resistance mutation
    • Kim S.M., Kwon O.J., Hong Y.K., Kim J.H., Solca F., Ha S.J., et al. Activation of IL-6R/JAK1/STAT3 signaling induces de novo resistance to irreversible EGFR Inhibitors in non-small cell lung cancer with T790M resistance mutation. Mol. Cancer Ther 2012, 11:2254-2264.
    • (2012) Mol. Cancer Ther , vol.11 , pp. 2254-2264
    • Kim, S.M.1    Kwon, O.J.2    Hong, Y.K.3    Kim, J.H.4    Solca, F.5    Ha, S.J.6
  • 105
    • 84909987265 scopus 로고    scopus 로고
    • Interleukin 6 augments lung cancer chemotherapeutic resistance via ataxia-telangiectasia mutated/NF-kappaB pathway activation
    • Yan H.Q., Huang X.B., Ke S.Z., Jiang Y.N., Zhang Y.H., Wang Y.N., et al. Interleukin 6 augments lung cancer chemotherapeutic resistance via ataxia-telangiectasia mutated/NF-kappaB pathway activation. Cancer Sci 2014, 105:1220-1227.
    • (2014) Cancer Sci , vol.105 , pp. 1220-1227
    • Yan, H.Q.1    Huang, X.B.2    Ke, S.Z.3    Jiang, Y.N.4    Zhang, Y.H.5    Wang, Y.N.6
  • 106
    • 84855472067 scopus 로고    scopus 로고
    • Mesenchymal stem cells enhance lung cancer initiation through activation of IL-6/JAK2/STAT3 pathway
    • Hsu H.S., Lin J.H., Hsu T.W., Su K., Wang C.W., Yang K.Y., et al. Mesenchymal stem cells enhance lung cancer initiation through activation of IL-6/JAK2/STAT3 pathway. Lung Cancer 2012, 75:167-177.
    • (2012) Lung Cancer , vol.75 , pp. 167-177
    • Hsu, H.S.1    Lin, J.H.2    Hsu, T.W.3    Su, K.4    Wang, C.W.5    Yang, K.Y.6
  • 107
    • 66449085018 scopus 로고    scopus 로고
    • Interleukin-6 increases prostate cancer cells resistance to bicalutamide via TIF2
    • Feng S., Tang Q., Sun M., Chun J.Y., Evans C.P., Gao A.C. Interleukin-6 increases prostate cancer cells resistance to bicalutamide via TIF2. Mol. Cancer Ther 2009, 8:665-671.
    • (2009) Mol. Cancer Ther , vol.8 , pp. 665-671
    • Feng, S.1    Tang, Q.2    Sun, M.3    Chun, J.Y.4    Evans, C.P.5    Gao, A.C.6
  • 108
    • 80053927147 scopus 로고    scopus 로고
    • Interleukin-6: a potential biomarker of resistance to multitargeted receptor tyrosine kinase inhibitors in castration-resistant prostate cancer
    • Kutikov A., Makhov P., Golovine K., Canter D.J., Sirohi M., Street R., et al. Interleukin-6: a potential biomarker of resistance to multitargeted receptor tyrosine kinase inhibitors in castration-resistant prostate cancer. Urology 2011, 78.
    • (2011) Urology , vol.78
    • Kutikov, A.1    Makhov, P.2    Golovine, K.3    Canter, D.J.4    Sirohi, M.5    Street, R.6
  • 109
    • 84880697448 scopus 로고    scopus 로고
    • The role of IL-6 in the radiation response of prostate cancer
    • Wu C.T., Chen M.F., Chen W.C., Hsieh C.C. The role of IL-6 in the radiation response of prostate cancer. Radiat. Oncol 2013, 8.
    • (2013) Radiat. Oncol , vol.8
    • Wu, C.T.1    Chen, M.F.2    Chen, W.C.3    Hsieh, C.C.4
  • 110
    • 84895832199 scopus 로고    scopus 로고
    • Autophagy Pathway Is Required for IL-6 Induced Neuroendocrine Differentiation and Chemoresistance of Prostate Cancer LNCaP Cells
    • Chang P.C., Wang T.Y., Chang Y.T., Chu C.Y., Lee C.L., Hsu H.W., et al. Autophagy Pathway Is Required for IL-6 Induced Neuroendocrine Differentiation and Chemoresistance of Prostate Cancer LNCaP Cells. PLoS ONE 2014, 9.
    • (2014) PLoS ONE , vol.9
    • Chang, P.C.1    Wang, T.Y.2    Chang, Y.T.3    Chu, C.Y.4    Lee, C.L.5    Hsu, H.W.6
  • 111
    • 77956238512 scopus 로고    scopus 로고
    • Inhibition of STAT3 signaling blocks the anti-apoptotic activity of IL-6 in human liver cancer cells
    • Liu Y., Li P.K., Li C.L., Lin J.Y. Inhibition of STAT3 signaling blocks the anti-apoptotic activity of IL-6 in human liver cancer cells. J. Biol. Chem 2010, 285:27429-27439.
    • (2010) J. Biol. Chem , vol.285 , pp. 27429-27439
    • Liu, Y.1    Li, P.K.2    Li, C.L.3    Lin, J.Y.4
  • 112
    • 20444467988 scopus 로고    scopus 로고
    • High serum levels of interleukin-6 in endometrial carcinoma are associated with uterine serous papillary histology, a highly aggressive and chemotherapy-resistant variant of endometrial cancer
    • Bellone S., Watts K., Cane S., Palmieri M., Cannon M.J., Burnett A., et al. High serum levels of interleukin-6 in endometrial carcinoma are associated with uterine serous papillary histology, a highly aggressive and chemotherapy-resistant variant of endometrial cancer. Gynecol. Oncol 2005, 98:92-98.
    • (2005) Gynecol. Oncol , vol.98 , pp. 92-98
    • Bellone, S.1    Watts, K.2    Cane, S.3    Palmieri, M.4    Cannon, M.J.5    Burnett, A.6
  • 113
    • 77951196379 scopus 로고    scopus 로고
    • Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance
    • Cherfils-Vicini J., Platonova S., Gillard M., Laurans L., Validire P., Caliandro R., et al. Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance. J. Clin. Invest 2010, 120:1285-1297.
    • (2010) J. Clin. Invest , vol.120 , pp. 1285-1297
    • Cherfils-Vicini, J.1    Platonova, S.2    Gillard, M.3    Laurans, L.4    Validire, P.5    Caliandro, R.6
  • 114
    • 84897557011 scopus 로고    scopus 로고
    • TLR5 activation by flagellin induces doxorubicin resistance via interleukin-6 (IL-6) expression in two multiple myeloma cells
    • Cho H.Y., Lee S.W. TLR5 activation by flagellin induces doxorubicin resistance via interleukin-6 (IL-6) expression in two multiple myeloma cells. Cell. Immunol 2014, 289:27-35.
    • (2014) Cell. Immunol , vol.289 , pp. 27-35
    • Cho, H.Y.1    Lee, S.W.2
  • 115
    • 0035986837 scopus 로고    scopus 로고
    • Overexpression of IL-6 but not IL-8 increases paclitaxel resistance of U-20S human osteosarcoma cells
    • Duan Z., Lamendola D.E., Penson R.T., Kronish K.M., Seide M.V. Overexpression of IL-6 but not IL-8 increases paclitaxel resistance of U-20S human osteosarcoma cells. Cytokine 2002, 17:234-242.
    • (2002) Cytokine , vol.17 , pp. 234-242
    • Duan, Z.1    Lamendola, D.E.2    Penson, R.T.3    Kronish, K.M.4    Seide, M.V.5
  • 116
    • 84929940184 scopus 로고    scopus 로고
    • FTY720 inhibits proliferation and epithelial-mesenchymal transition in cholangiocarcinoma by inactivating STAT3 signaling
    • Lu Z.Y., Wang J.B., Zheng T.S., Liang Y.J., Yin D.L., Song R.P., et al. FTY720 inhibits proliferation and epithelial-mesenchymal transition in cholangiocarcinoma by inactivating STAT3 signaling. BMC Cancer 2014, 14.
    • (2014) BMC Cancer , vol.14
    • Lu, Z.Y.1    Wang, J.B.2    Zheng, T.S.3    Liang, Y.J.4    Yin, D.L.5    Song, R.P.6
  • 117
    • 84866396210 scopus 로고    scopus 로고
    • Let-7 expression is a significant determinant of response to chemotherapy through the regulation of IL-6/STAT3 pathway in esophageal squamous cell carcinoma
    • Sugimura K., Miyata H., Tanaka K., Hamano R., Takahashi T., Kurokawa Y., et al. Let-7 expression is a significant determinant of response to chemotherapy through the regulation of IL-6/STAT3 pathway in esophageal squamous cell carcinoma. Clin. Cancer Res 2012, 18:5144-5153.
    • (2012) Clin. Cancer Res , vol.18 , pp. 5144-5153
    • Sugimura, K.1    Miyata, H.2    Tanaka, K.3    Hamano, R.4    Takahashi, T.5    Kurokawa, Y.6
  • 118
    • 84866534198 scopus 로고    scopus 로고
    • Enhanced chemosensitization in multidrug-resistant human breast cancer cells by inhibition of IL-6 and IL-8 production
    • Shi Z., Yang W.M., Chen L.P., Yang D.H., Zhou Q., Zhu J., et al. Enhanced chemosensitization in multidrug-resistant human breast cancer cells by inhibition of IL-6 and IL-8 production. Breast Cancer Res. Treat 2012, 135:737-747.
    • (2012) Breast Cancer Res. Treat , vol.135 , pp. 737-747
    • Shi, Z.1    Yang, W.M.2    Chen, L.P.3    Yang, D.H.4    Zhou, Q.5    Zhu, J.6
  • 119
    • 1642539107 scopus 로고    scopus 로고
    • Enhanced radiosensitization and chemosensitization in NF-kappa B-suppressed human oral cancer cells via the inhibition of gamma-irradiation- and 5-Fu-induced production,of Il-6 and Il-8
    • Tamatani T., Azuma M., Ashida Y., Motegi K., Takashima R., Harada K., et al. Enhanced radiosensitization and chemosensitization in NF-kappa B-suppressed human oral cancer cells via the inhibition of gamma-irradiation- and 5-Fu-induced production,of Il-6 and Il-8. Int. J. Cancer 2004, 108:912-921.
    • (2004) Int. J. Cancer , vol.108 , pp. 912-921
    • Tamatani, T.1    Azuma, M.2    Ashida, Y.3    Motegi, K.4    Takashima, R.5    Harada, K.6
  • 120
    • 84894495362 scopus 로고    scopus 로고
    • STAT3 induction of miR-146b forms a feedback loop to inhibit the NF-kappa B to IL-6 signaling axis and STAT3-Driven cancer phenotypes
    • Xiang M., Birkbak N.J., Vafaizadeh V., Walker S.R., Yeh J.E., Liu S.H., et al. STAT3 induction of miR-146b forms a feedback loop to inhibit the NF-kappa B to IL-6 signaling axis and STAT3-Driven cancer phenotypes. Sci. Signal 2014, 7.
    • (2014) Sci. Signal , vol.7
    • Xiang, M.1    Birkbak, N.J.2    Vafaizadeh, V.3    Walker, S.R.4    Yeh, J.E.5    Liu, S.H.6
  • 121
    • 84868000009 scopus 로고    scopus 로고
    • MicroRNA control of epithelial-mesenchymal transition and metastasis
    • Zhang J.S., Ma L. MicroRNA control of epithelial-mesenchymal transition and metastasis. Cancer Metast. Rev 2012, 31:653-662.
    • (2012) Cancer Metast. Rev , vol.31 , pp. 653-662
    • Zhang, J.S.1    Ma, L.2
  • 122
    • 84944279660 scopus 로고    scopus 로고
    • MicroRNA-142-3p inhibits cell proliferation and invasion of cervical cancer cells by targeting FZD7
    • Deng B., Zhang Y., Zhang S., Wen F., Miao Y., Guo K. MicroRNA-142-3p inhibits cell proliferation and invasion of cervical cancer cells by targeting FZD7. Tumour Biol 2015, 36:8065-8073.
    • (2015) Tumour Biol , vol.36 , pp. 8065-8073
    • Deng, B.1    Zhang, Y.2    Zhang, S.3    Wen, F.4    Miao, Y.5    Guo, K.6
  • 123
    • 84906062671 scopus 로고    scopus 로고
    • MicroRNA-9 is associated with epithelial-mesenchymal transition, breast cancer stem cell phenotype, and tumor progression in breast cancer
    • Gwak J.M., Kim H.J., Kim E.J., Chung Y.R., Yun S., Seo A.N., et al. MicroRNA-9 is associated with epithelial-mesenchymal transition, breast cancer stem cell phenotype, and tumor progression in breast cancer. Breast Cancer Res. Treat 2014, 147:39-49.
    • (2014) Breast Cancer Res. Treat , vol.147 , pp. 39-49
    • Gwak, J.M.1    Kim, H.J.2    Kim, E.J.3    Chung, Y.R.4    Yun, S.5    Seo, A.N.6
  • 124
    • 84973572388 scopus 로고    scopus 로고
    • Down-regulation of microRNA-9 leads to activation of IL-6/Jak/STAT3 pathway through directly targeting IL-6 in HeLa cell
    • Zhang J., Jia J., Zhao L., Li X., Xie Q., Chen X., et al. Down-regulation of microRNA-9 leads to activation of IL-6/Jak/STAT3 pathway through directly targeting IL-6 in HeLa cell. Mol. Carcinog 2015.
    • (2015) Mol. Carcinog
    • Zhang, J.1    Jia, J.2    Zhao, L.3    Li, X.4    Xie, Q.5    Chen, X.6
  • 125
    • 84927578539 scopus 로고    scopus 로고
    • Interleukin-6 mediated upregulation of CYP1B1 and CYP2E1 in colorectal cancer involves DNA methylation, miR27b and STAT3
    • Patel S.A., Bhambra U., Charalambous M.P., David R.M., Edwards R.J., Lightfoot T., et al. Interleukin-6 mediated upregulation of CYP1B1 and CYP2E1 in colorectal cancer involves DNA methylation, miR27b and STAT3. Br. J. Cancer 2014, 111:2287-2296.
    • (2014) Br. J. Cancer , vol.111 , pp. 2287-2296
    • Patel, S.A.1    Bhambra, U.2    Charalambous, M.P.3    David, R.M.4    Edwards, R.J.5    Lightfoot, T.6
  • 126
    • 84928139467 scopus 로고    scopus 로고
    • MiR-34a inhibits oral cancer progression partially by repression of interleukin-6-receptor
    • Li T., Li L., Li D., Wang S., Sun J. MiR-34a inhibits oral cancer progression partially by repression of interleukin-6-receptor. Int. J. Clin. Exp. Pathol 2015, 8:1364-1373.
    • (2015) Int. J. Clin. Exp. Pathol , vol.8 , pp. 1364-1373
    • Li, T.1    Li, L.2    Li, D.3    Wang, S.4    Sun, J.5
  • 127
    • 84890226018 scopus 로고    scopus 로고
    • Epigenetic regulation of the miR142-3p/interleukin-6 circuit in glioblastoma
    • Chiou G.Y., Chien C.S., Wang M.L., Chen M.T., Yang Y.P., Yu Y.L., et al. Epigenetic regulation of the miR142-3p/interleukin-6 circuit in glioblastoma. Mol. Cell 2013, 52:693-706.
    • (2013) Mol. Cell , vol.52 , pp. 693-706
    • Chiou, G.Y.1    Chien, C.S.2    Wang, M.L.3    Chen, M.T.4    Yang, Y.P.5    Yu, Y.L.6
  • 128
    • 84861686487 scopus 로고    scopus 로고
    • MiR-21 regulates epithelial-mesenchymal transition phenotype and hypoxia-inducible factor-1a expression in third-sphere forming breast cancer stem cell-like cells
    • Han M.L., Wang Y.M., Liu M.R., Bi X.K., Bao J.J., Zeng N., et al. MiR-21 regulates epithelial-mesenchymal transition phenotype and hypoxia-inducible factor-1a expression in third-sphere forming breast cancer stem cell-like cells. Cancer Sci 2012, 103:1058-1064.
    • (2012) Cancer Sci , vol.103 , pp. 1058-1064
    • Han, M.L.1    Wang, Y.M.2    Liu, M.R.3    Bi, X.K.4    Bao, J.J.5    Zeng, N.6
  • 129
    • 34548039517 scopus 로고    scopus 로고
    • Interleukin-6-dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer
    • Loffler D., Brocke-Heidrich K., Pfeifer G., Stocsits C., Hackermuller J., Kretzschmar A.K., et al. Interleukin-6-dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer. Blood 2007, 110:1330-1333.
    • (2007) Blood , vol.110 , pp. 1330-1333
    • Loffler, D.1    Brocke-Heidrich, K.2    Pfeifer, G.3    Stocsits, C.4    Hackermuller, J.5    Kretzschmar, A.K.6
  • 130
    • 84907917653 scopus 로고    scopus 로고
    • Hepatitis B virus X protein promotes hepatocellular carcinoma transformation through interleukin-6 activation of microRNA-21 expression
    • Li C.H., Xu F.Y., Chow S., Feng L., Yin D.L., Ng T.B., et al. Hepatitis B virus X protein promotes hepatocellular carcinoma transformation through interleukin-6 activation of microRNA-21 expression. Eur. J. Cancer 2014, 50:2560-2569.
    • (2014) Eur. J. Cancer , vol.50 , pp. 2560-2569
    • Li, C.H.1    Xu, F.Y.2    Chow, S.3    Feng, L.4    Yin, D.L.5    Ng, T.B.6
  • 131
    • 84861828232 scopus 로고    scopus 로고
    • The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness
    • Bao B., Azmi A.S., Ali S., Ahmad A., Li Y.W., Banerjee S., et al. The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness. Bba-Rev. Cancer 2012, 1826:272-296.
    • (2012) Bba-Rev. Cancer , vol.1826 , pp. 272-296
    • Bao, B.1    Azmi, A.S.2    Ali, S.3    Ahmad, A.4    Li, Y.W.5    Banerjee, S.6
  • 133
    • 84871261049 scopus 로고    scopus 로고
    • Hypoxia-induced aggressiveness of pancreatic cancer cells is due to increased expression of VEGF, IL-6 and miR-21, Which can be attenuated by CDF treatment
    • Bao B., Ali S., Ahmad A., Azmi A.S., Li Y.W., Banerjee S., et al. Hypoxia-induced aggressiveness of pancreatic cancer cells is due to increased expression of VEGF, IL-6 and miR-21, Which can be attenuated by CDF treatment. PLoS ONE 2012, 7.
    • (2012) PLoS ONE , vol.7
    • Bao, B.1    Ali, S.2    Ahmad, A.3    Azmi, A.S.4    Li, Y.W.5    Banerjee, S.6
  • 134
    • 84928927906 scopus 로고    scopus 로고
    • Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment
    • Li P., Shan J.X., Chen X.H., Zhang D., Su L.P., Huang X.Y., et al. Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment. Cell Res 2015, 25:588-603.
    • (2015) Cell Res , vol.25 , pp. 588-603
    • Li, P.1    Shan, J.X.2    Chen, X.H.3    Zhang, D.4    Su, L.P.5    Huang, X.Y.6
  • 135
    • 77954818666 scopus 로고    scopus 로고
    • MicroRNA and drug resistance
    • Ma J., Dong C., Ji C. MicroRNA and drug resistance. Cancer Gene Ther 2010, 17:523-531.
    • (2010) Cancer Gene Ther , vol.17 , pp. 523-531
    • Ma, J.1    Dong, C.2    Ji, C.3
  • 136
    • 84949458087 scopus 로고    scopus 로고
    • Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: a review of the past decade
    • Chen Z.L., Shi T.L., Zhang L., Zhu P.L., Deng M.Y., Huang C., et al. Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: a review of the past decade. Cancer Lett 2016, 370:153-164.
    • (2016) Cancer Lett , vol.370 , pp. 153-164
    • Chen, Z.L.1    Shi, T.L.2    Zhang, L.3    Zhu, P.L.4    Deng, M.Y.5    Huang, C.6
  • 137
    • 77957969261 scopus 로고    scopus 로고
    • Targeting miRNAs involved in cancer stem cell and EMT regulation: an emerging concept in overcoming drug resistance
    • Wang Z.W., Li Y.W., Ahmad A., Azmi A.S., Kong D.J., Banerjee S., et al. Targeting miRNAs involved in cancer stem cell and EMT regulation: an emerging concept in overcoming drug resistance. Drug Resist. Update 2010, 13:109-118.
    • (2010) Drug Resist. Update , vol.13 , pp. 109-118
    • Wang, Z.W.1    Li, Y.W.2    Ahmad, A.3    Azmi, A.S.4    Kong, D.J.5    Banerjee, S.6
  • 138
    • 84908161000 scopus 로고    scopus 로고
    • Revisiting STAT3 signalling in cancer: new and unexpected biological functions
    • Yu H., Lee H., Herrmann A., Buettner R., Jove R. Revisiting STAT3 signalling in cancer: new and unexpected biological functions. Nat. Rev. Cancer 2014, 14:736-746.
    • (2014) Nat. Rev. Cancer , vol.14 , pp. 736-746
    • Yu, H.1    Lee, H.2    Herrmann, A.3    Buettner, R.4    Jove, R.5
  • 139
    • 84960796938 scopus 로고    scopus 로고
    • Induction of miRNA-181a by genotoxic treatments promotes chemotherapeutic resistance and metastasis in breast cancer
    • Niu J., Xue A., Chi Y., Xue J., Wang W., Zhao Z., et al. Induction of miRNA-181a by genotoxic treatments promotes chemotherapeutic resistance and metastasis in breast cancer. Oncogene 2015.
    • (2015) Oncogene
    • Niu, J.1    Xue, A.2    Chi, Y.3    Xue, J.4    Wang, W.5    Zhao, Z.6
  • 140
    • 84887438346 scopus 로고    scopus 로고
    • Axl mediates acquired resistance of head and neck cancer cells to the epidermal growth factor receptor inhibitor erlotinib
    • Giles K.M., Kalinowski F.C., Candy P.A., Epis M.R., Zhang P.M., Redfern A.D., et al. Axl mediates acquired resistance of head and neck cancer cells to the epidermal growth factor receptor inhibitor erlotinib. Mol. Cancer Ther 2013, 12:2541-2558.
    • (2013) Mol. Cancer Ther , vol.12 , pp. 2541-2558
    • Giles, K.M.1    Kalinowski, F.C.2    Candy, P.A.3    Epis, M.R.4    Zhang, P.M.5    Redfern, A.D.6
  • 141
    • 84929104125 scopus 로고    scopus 로고
    • The Effects and molecular mechanisms of MiR-106a in multidrug resistance reversal in human glioma U87/DDP and U251/G cell lines
    • Wang Q., Wang Z., Chu L., Li X., Kan P., Xin X., et al. The Effects and molecular mechanisms of MiR-106a in multidrug resistance reversal in human glioma U87/DDP and U251/G cell lines. PLoS ONE 2015, 10:e0125473.
    • (2015) PLoS ONE , vol.10 , pp. e0125473
    • Wang, Q.1    Wang, Z.2    Chu, L.3    Li, X.4    Kan, P.5    Xin, X.6
  • 142
    • 77950690023 scopus 로고    scopus 로고
    • Interleukin-6 in bone metastasis and cancer progression
    • Ara T., Declerck Y.A. Interleukin-6 in bone metastasis and cancer progression. Eur. J. Cancer 2010, 46:1223-1231.
    • (2010) Eur. J. Cancer , vol.46 , pp. 1223-1231
    • Ara, T.1    Declerck, Y.A.2


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