Activation of interleukin-6/signal transducer and activator of transcription 3 by human papillomavirus early proteins 6 induces fibroblast senescence to promote cervical tumourigenesis through autocrine and paracrine pathways in tumour microenvironment

European Journal of Cancer

Volumn 49, Issue 18, 2013, Pages 3889-3899

  Ren, Chunxia ^a,b,c   Cheng, Xi ^a,b   Lu, Bei ^c   Yang, Gong ^a,b  

^a FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

^b FUDAN UNIVERSITY   (China)

^c WUXI PEOPLE S HOSPITAL AFFILIATED TO NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Cervical cancer; Fibroblast senescence; HPV E6; IL 6; STAT3

Indexed keywords

EARLY PROTEIN 6; INTERLEUKIN 6; RECOMBINANT INTERLEUKIN 6; SHORT HAIRPIN RNA; STAT3 PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOCRINE EFFECT; CANCER GROWTH; CANCER TISSUE; CARCINOGENESIS; CELL AGING; CONTROLLED STUDY; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN PAPILLOMAVIRUS TYPE 18; HUMAN TISSUE; INFECTION RISK; MOUSE; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR VOLUME; UPREGULATION; UTERINE CERVIX CANCER; WART VIRUS;

CERVICAL CANCER; FIBROBLAST SENESCENCE; HPV E6; IL-6; STAT3;

ANIMALS; AUTOCRINE COMMUNICATION; CELL AGING; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; DNA-BINDING PROTEINS; FEMALE; FIBROBLASTS; HELA CELLS; HOST-PATHOGEN INTERACTIONS; HUMAN PAPILLOMAVIRUS 16; HUMAN PAPILLOMAVIRUS 18; HUMANS; INTERLEUKIN-6; MICE; MICE, INBRED BALB C; MICE, NUDE; ONCOGENE PROTEINS, VIRAL; PARACRINE COMMUNICATION; REPRESSOR PROTEINS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRANSPLANTATION, HETEROLOGOUS; TUMOR MICROENVIRONMENT; UTERINE CERVICAL NEOPLASMS;

EID: 84888004137     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2013.07.140     Document Type: Article

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