Elevated expression of APE1/Ref-1 and its regulation on IL-6 and IL-8 in bone marrow stromal cells of multiple myeloma

Clinical Lymphoma, Myeloma and Leukemia

Volumn 10, Issue 5, 2010, Pages 385-393

  Xie, Jia Yin ^a   Li, Meng Xia ^a   Xiang, De Bing ^a   Mou, Jiang Hong ^a   Qing, Yi ^a   Zeng, Lin Li ^a   Yang, Zhen Zhou ^a   Guan, Wei ^a   Wang, Dong ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

BMSC; Interleukin; NF B

Indexed keywords

ADENOVIRUS VECTOR; APYRIMIDINIC ENDONUCLEASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; REDOX EFFECTOR FACTOR 1; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; APEX1 PROTEIN, HUMAN; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE;

ADULT; AGED; ARTICLE; BONE MARROW CELL; CANCER CELL; CANCER GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; COCULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DNA BINDING; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MULTIPLE MYELOMA; PROTEIN ANALYSIS; PROTEIN EXPRESSION; STROMA CELL; TUMOR MICROENVIRONMENT; BIOSYNTHESIS; FEMALE; GENETICS; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY;

ADULT; AGED; BONE MARROW CELLS; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; FEMALE; HUMANS; INTERLEUKIN-6; INTERLEUKIN-8; MALE; MIDDLE AGED; MULTIPLE MYELOMA; RNA, SMALL INTERFERING; STROMAL CELLS;

EID: 79952278711     PISSN: 21522650     EISSN: 21522669     Source Type: Journal    
DOI: 10.3816/CLML.2010.n.072     Document Type: Article

References (35)

1. Kastritis E, Palumbo A, Dimopoulos MA. Treatment of relapsed/refractory multiple myeloma. Semin Hematol 2009; 46:143-57.
2. Li ZW, Dalton WS. Tumor microenvironment and drug resistance in hematologic malignancies. Blood Rev 2006; 20:333-42. (Pubitemid 44691998)
3. Wallace SR, Oken MM, Lunetta KL, et al. Abnormalities of bone marrow mesenchymal cells in multiple myeloma patients. Cancer 2001; 91:1219-30. (Pubitemid 32267031)
4. Zdzisinska B, Bojarska-Junak A, Dmoszynska A, et al. Abnormal cytokine production by bone marrow stromal cells of multiple myeloma patients in response to RPMI8226 myeloma cells. Arch Immunol Ther Exp (Warsz) 2008; 56:207-21.
5. Kline M, Donovan K, Wellik L, et al. Cytokine and chemokine profiles in multiple myeloma; significance of stromal interaction and correlation of IL-8 production with disease progression. Leuk Res 2007; 31:591-8. (Pubitemid 46559994)
6. Garderet L, Mazurier C, Chapel A, et al. Mesenchymal stem cell abnormalities in patients with multiple myeloma. Leuk Lymphoma 2007; 48:2032-41. (Pubitemid 47542991)
7. Aggarwal R, Ghobrial IM, Roodman GD. Chemokines in multiple myeloma. Exp Hematol 2006; 34:1289-95. (Pubitemid 44376817)
8. Ndlovu N, Van Lint C, Van Wesemael K, et al. Hyperactivated NF-{kappa}B and AP-1 transcription factors promote highly accessible chromatin and constitutive transcription across the interleukin-6 gene promoter in metastatic breast cancer cells. Mol Cell Biol 2009; 29:5488-504
9. Zhu YM, Bradbury DA, Pang L, et al. Transcriptional regulation of interleukin (IL)-8 by bradykinin in human airway smooth muscle cells involves prostanoid-dependent activation of AP-1 and nuclear factor (NF)-IL-6 and prostanoid-independent activation of NF-kappaB. J Biol Chem 2003; 278:29366-75. (Pubitemid 36935854)
10. Podar K, Richardson PG, Hideshima T, et al. The malignant clone and the bone-marrow environment. Best Pract Res Clin Haematol 2007; 20:597-612. (Pubitemid 350215375)
11. Kastritis E, Charidimou A, Varkaris A, et al. Targeted therapies in multiple myeloma. Target Oncol 2009; 4:23-36.
12. Anton K, Glod J. Targeting the tumor stroma in cancer therapy. Curr Pharm Biotechnol 2009; 10:185-91.
13. Evans AR, Limp-Foster M, Kelley MR. Going APE over ref-1. Mutat Res 2000; 461:83-108.
14. Bhakat KK, Mantha AK, Mitra S. Transcriptional Regulatory Functions of Mammalian AP-endonuclease (APE1/Ref-1), an Essential Multifunctional Protein. Antioxid Redox Signal 2009; 11:621-38.
15. Xanthoudakis S, Smeyne RJ, Wallace JD, et al. The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice. Proc Natl Acad Sci USA 1996; 93:8919-23. (Pubitemid 26281992)
16. Zou GM, Luo MH, Reed A, et al. Ape1 regulates hematopoietic differentiation of embryonic stem cells through its redox functional domain. Blood 2007; 109:1917-22. (Pubitemid 46348187)
17. Tell G, Quadrifoglio F, Tiribelli C, et al. The many functions of APE1/Ref-1: not only a DNA repair enzyme. Antioxid Redox Signal 2009; 11:601-20.
18. Schindl M, Oberhuber G, Pichlbauer EG, et al. DNA repair-redox enzyme apurinic endonuclease in cervical cancer: evaluation of redox control of HIF-1alpha and prognostic significance. Int J Oncol 2001; 19:799-802.
19. Yoo DG, Song YJ, Cho EJ, et al. Alteration of APE1/ref-1 expression in non-small cell lung cancer: the implications of impaired extracellular superoxide dismutase and catalase antioxidant systems. Lung Cancer 2008; 60:277-84. (Pubitemid 351622081)
20. Thomson B, Tritt R, Davis M, et al. Histology-specific expression of a DNA repair protein in pediatric rhabdomyosarcomas. J Pediatr Hematol Oncol 2001; 23:234-9. (Pubitemid 32524928)
21. Tudek B. Base excision repair modulation as a risk factor for human cancers. Mol Aspects Med 2007; 28:258-75. (Pubitemid 47331613)
22. Yang ZZ, Chen XH, Wang D. Experimental study enhancing the chemosensitivity of multiple myeloma to melphalan by using a tissue-specific APE1-silencing RNA expression vector. Clin Lymphoma Myeloma 2007; 7:296-304. (Pubitemid 46408195)
23. Tell G, Damante G, Caldwell D, et al. The intracellular localization of APE1/Ref-1: more than a passive phenomenon? Antioxid Redox Signal 2005; 7:367-84. (Pubitemid 40279805)
24. O'Hara AM, Bhattacharyya A, Mifflin RC, et al. Interleukin-8 induction by Helicobacter pylori in gastric epithelial cells is dependent on apurinic/apyrimidinic endonuclease-1/redox factor-1. J Immunol 2006; 177:7990-9. (Pubitemid 44846316)
25. Frossi B, De Carli M, Daniel KC, et al. Oxidative stress stimulates IL-4 and IL-6 production in mast cells by an APE/Ref-1-dependent pathway. Eur J Immunol 2003; 33:2168-77. (Pubitemid 37010034)
26. Li MX, Wang D, Zhong ZY, et al. Targeting truncated APE1 in mitochondria enhances cell survival after oxidative stress. Free Radic Biol Med 2008; 45:592-601.
27. Wang D, Xiang DB, Yang XQ, et al. APE1 overexpression is associated with cisplatin resistance in non-small cell lung cancer and targeted inhibition of APE1 enhances the activity of cisplatin in A549 cells. Lung Cancer 2009; 66:298-304.
28. Yang ZZ, Li MX, Zhang YS, et al. Knock down of the dual functional protein apurinic/apyrimidinic endonuclease 1 enhances the killing effect of hematoporphrphyrin derivative-mediated photodynamic therapy on non-small cell lung cancer cells in vitro and in a xenograft model. Cancer Sci 2010; 101:180-7.
29. Xiang DB, Chen ZT, Wang D, et al. Chimeric adenoviral vector Ad5/F35-mediated APE1 siRNA enhances sensitivity of human colorectal cancer cells to radiotherapy in vitro and in vivo. Cancer Gene Ther 2008; 15:625-35.
30. Corre J, Mahtouk K, Attal M, et al. Bone marrow mesenchymal stem cells are abnormal in multiple myeloma. Leukemia 2007; 21:1079-88. (Pubitemid 46672085)
31. Seo Y, Kinsella TJ. Essential role of DNA base excision repair on survival in an acidic tumor microenvironment. Cancer Res 2009; 69:7285-93.
32. Chen DS, Olkowski ZL. Biological responses of human apurinic endonuclease to radiation-induced DNA damage. Ann N Y Acad Sci 1994; 726:306-8. (Pubitemid 24290989)
33. Vascotto C, Fantini D, Romanello M, et al. APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process. Mol Cell Biol 2009; 29:1834-54.
34. Barnes T, Kim WC, Mantha AK, et al. Identification of Apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNA. Nucleic Acids Res 2009; 37:3946-58.
35. Tell G, Wilson DM 3rd, Lee CH. Intrusion of a DNA repair protein in the RNome world: is this the beginning of a new era? Mol Cell Biol 2010; 30:366-71.