-
1
-
-
79251469043
-
Development of molecularly targeted therapies in biliary tract cancers: Reassessing the challenges and opportunities
-
A.X. Zhu, and A.F. Hezel Development of molecularly targeted therapies in biliary tract cancers: reassessing the challenges and opportunities Hepatology 53 2 2011 695 704
-
(2011)
Hepatology
, vol.53
, Issue.2
, pp. 695-704
-
-
Zhu, A.X.1
Hezel, A.F.2
-
2
-
-
80052429730
-
Treatment of borderline cases for curative resection of biliary tract cancer
-
S. Kobayashi, H. Nagano, and S. Marubashi Treatment of borderline cases for curative resection of biliary tract cancer J Surg Oncol 104 5 2011 499 503
-
(2011)
J Surg Oncol
, vol.104
, Issue.5
, pp. 499-503
-
-
Kobayashi, S.1
Nagano, H.2
Marubashi, S.3
-
3
-
-
77950822827
-
Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer
-
J. Valle, H. Wasan, and D.H. Palmer Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer N Engl J Med 362 14 2010 1273 1281
-
(2010)
N Engl J Med
, vol.362
, Issue.14
, pp. 1273-1281
-
-
Valle, J.1
Wasan, H.2
Palmer, D.H.3
-
4
-
-
78649385782
-
Advances in the treatment of metastatic or unresectable biliary tract cancer
-
J.W. Valle Advances in the treatment of metastatic or unresectable biliary tract cancer Ann Oncol 21 Suppl. 7 2010 vii345 vii348
-
(2010)
Ann Oncol
, vol.21
, Issue.SUPPL. 7
-
-
Valle, J.W.1
-
5
-
-
79952022819
-
Diagnostic value of FDG-PET for lymph node metastasis and outcome of surgery for biliary cancer
-
S. Kobayashi, H. Nagano, and H. Hoshino Diagnostic value of FDG-PET for lymph node metastasis and outcome of surgery for biliary cancer J Surg Oncol 103 3 2011 223 229
-
(2011)
J Surg Oncol
, vol.103
, Issue.3
, pp. 223-229
-
-
Kobayashi, S.1
Nagano, H.2
Hoshino, H.3
-
6
-
-
0036595629
-
Epithelial-mesenchymal transitions in tumour progression
-
J.P. Thiery Epithelial-mesenchymal transitions in tumour progression Nat Rev Cancer 2 6 2002 442 454
-
(2002)
Nat Rev Cancer
, vol.2
, Issue.6
, pp. 442-454
-
-
Thiery, J.P.1
-
7
-
-
70450198396
-
Epithelial-mesenchymal transitions in development and disease
-
J.P. Thiery, H. Acloque, R.Y. Huang, and M.A. Nieto Epithelial- mesenchymal transitions in development and disease Cell 139 5 2009 871 890
-
(2009)
Cell
, vol.139
, Issue.5
, pp. 871-890
-
-
Thiery, J.P.1
Acloque, H.2
Huang, R.Y.3
Nieto, M.A.4
-
8
-
-
68049115773
-
SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer
-
A. Blackford, O.K. Serrano, and C.L. Wolfgang SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer Clin Cancer Res 15 14 2009 4674 4679
-
(2009)
Clin Cancer Res
, vol.15
, Issue.14
, pp. 4674-4679
-
-
Blackford, A.1
Serrano, O.K.2
Wolfgang, C.L.3
-
9
-
-
72949120827
-
Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma
-
M.H. Yang, C.L. Chen, and G.Y. Chau Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma Hepatology 50 5 2009 1464 1474
-
(2009)
Hepatology
, vol.50
, Issue.5
, pp. 1464-1474
-
-
Yang, M.H.1
Chen, C.L.2
Chau, G.Y.3
-
10
-
-
84855999650
-
E/N-cadherin switch mediates cancer progression via TGF-beta-induced epithelial-to-mesenchymal transition in extrahepatic cholangiocarcinoma
-
K. Araki, T. Shimura, and H. Suzuki E/N-cadherin switch mediates cancer progression via TGF-beta-induced epithelial-to-mesenchymal transition in extrahepatic cholangiocarcinoma Br J Cancer 105 12 2011 1885 1893
-
(2011)
Br J Cancer
, vol.105
, Issue.12
, pp. 1885-1893
-
-
Araki, K.1
Shimura, T.2
Suzuki, H.3
-
11
-
-
84865000582
-
Role of the hypoxia-related gene, JMJD1A, in hepatocellular carcinoma: Clinical impact on recurrence after hepatic resection
-
D. Yamada, S. Kobayashi, and H. Yamamoto Role of the hypoxia-related gene, JMJD1A, in hepatocellular carcinoma: clinical impact on recurrence after hepatic resection Ann Surg Oncol 19 Suppl. 3 2012 355 364
-
(2012)
Ann Surg Oncol
, vol.19
, Issue.SUPPL. 3
, pp. 355-364
-
-
Yamada, D.1
Kobayashi, S.2
Yamamoto, H.3
-
12
-
-
20444452357
-
Interleukin-6 contributes to Mcl-1 up-regulation and TRAIL resistance via an Akt-signaling pathway in cholangiocarcinoma cells
-
DOI 10.1053/j.gastro.2005.03.010, PII S0016508505003835
-
S. Kobayashi, N.W. Werneburg, S.F. Bronk, S.H. Kaufmann, and G.J. Gores Interleukin-6 contributes to Mcl-1 up-regulation and TRAIL resistance via an Akt-signaling pathway in cholangiocarcinoma cells Gastroenterology 128 7 2005 2054 2065 (Pubitemid 40824713)
-
(2005)
Gastroenterology
, vol.128
, Issue.7
, pp. 2054-2065
-
-
Kobayashi, S.1
Werneburg, N.W.2
Bronk, S.F.3
Kaufmann, S.H.4
Gores, G.J.5
-
13
-
-
79951558136
-
Tyrosine kinase inhibitor PTK/ZK enhances the antitumor effects of interferon-alpha/5-fluorouracil therapy for hepatocellular carcinoma cells
-
M. Murakami, S. Kobayashi, and S. Marubashi Tyrosine kinase inhibitor PTK/ZK enhances the antitumor effects of interferon-alpha/5-fluorouracil therapy for hepatocellular carcinoma cells Ann Surg Oncol 18 2 2011 589 596
-
(2011)
Ann Surg Oncol
, vol.18
, Issue.2
, pp. 589-596
-
-
Murakami, M.1
Kobayashi, S.2
Marubashi, S.3
-
14
-
-
0037698899
-
Cholangiocarcinoma: Current concepts and insights
-
DOI 10.1053/jhep.2003.50200
-
G.J. Gores Cholangiocarcinoma: current concepts and insights Hepatology 37 5 2003 961 969 (Pubitemid 36538671)
-
(2003)
Hepatology
, vol.37
, Issue.5
, pp. 961-969
-
-
Gores, G.J.1
-
15
-
-
0029583937
-
Role of transforming growth factor β1 on hepatic regeneration and apoptosis in liver diseases
-
S. Takiya, T. Tagaya, and K. Takahashi Role of transforming growth factor beta 1 on hepatic regeneration and apoptosis in liver diseases J Clin Pathol 48 12 1995 1093 1097 (Pubitemid 26014847)
-
(1995)
Journal of Clinical Pathology
, vol.48
, Issue.12
, pp. 1093-1097
-
-
Takiya, S.1
Tagaya, T.2
Takahashi, K.3
Kawashima, H.4
Kamiya, M.5
Fukuzawa, Y.6
Kobayashi, S.7
Fukatsu, A.8
Kakumu, S.9
-
16
-
-
0031031016
-
The pathobiology of biliary epithelia
-
S.K. Roberts, J. Ludwig, and N.F. Larusso The pathobiology of biliary epithelia Gastroenterology 112 1 1997 269 279 (Pubitemid 27009011)
-
(1997)
Gastroenterology
, vol.112
, Issue.1
, pp. 269-279
-
-
Roberts, S.K.1
Ludwig, J.2
LaRusso, N.F.3
-
17
-
-
0031912084
-
Marked elevation of serum interleukin-6 in patients with cholangiocarcinoma: Validation of utility as a clinical marker
-
DOI 10.1097/00000658-199803000-00012
-
J.S. Goydos, A.M. Brumfield, E. Frezza, A. Booth, M.T. Lotze, and S.E. Carty Marked elevation of serum interleukin-6 in patients with cholangiocarcinoma: validation of utility as a clinical marker Ann Surg 227 3 1998 398 404 (Pubitemid 28131021)
-
(1998)
Annals of Surgery
, vol.227
, Issue.3
, pp. 398-404
-
-
Goydos, J.S.1
Brumfield, A.M.2
Frezza, E.3
Booth, A.4
Lotze, M.T.5
Carty, S.E.6
-
18
-
-
33745104992
-
Local balance of transforming growth factor-β1 secreted from cholangiocarcinoma cells and stromal-derived factor-1 secreted from stromal fibroblasts is a factor involved in invasion of cholangiocarcinoma
-
DOI 10.1111/j.1440-1827.2006.01982.x
-
S. Ohira, K. Itatsu, and M. Sasaki Local balance of transforming growth factor-beta1 secreted from cholangiocarcinoma cells and stromal-derived factor-1 secreted from stromal fibroblasts is a factor involved in invasion of cholangiocarcinoma Pathol Int 56 7 2006 381 389 (Pubitemid 43886802)
-
(2006)
Pathology International
, vol.56
, Issue.7
, pp. 381-389
-
-
Ohira, S.1
Itatsu, K.2
Sasaki, M.3
Harada, K.4
Sato, Y.5
Zen, Y.6
Ishikawa, A.7
Oda, K.8
Nagasaka, T.9
Nimura, Y.10
Nakanuma, Y.11
-
19
-
-
77950346282
-
Immunity, inflammation, and cancer
-
S.I. Grivennikov, F.R. Greten, and M. Karin Immunity, inflammation, and cancer Cell 140 6 2010 883 899
-
(2010)
Cell
, vol.140
, Issue.6
, pp. 883-899
-
-
Grivennikov, S.I.1
Greten, F.R.2
Karin, M.3
-
20
-
-
0028098065
-
Transforming growth factor-β1 and mannose 6-phosphate/insulin-like growth factor-II receptor expression during intrahepatic bile duct hyperplasia and biliary fibrosis in the rat
-
DOI 10.1016/0270-9139(94)90019-1
-
L.A. Saperstein, R.L. Jirtle, M. Farouk, H.J. Thompson, K.S. Chung, and W.C. Meyers Transforming growth factor-beta 1 and mannose 6-phosphate/insulin- like growth factor-II receptor expression during intrahepatic bile duct hyperplasia and biliary fibrosis in the rat Hepatology 19 2 1994 412 417 (Pubitemid 24046786)
-
(1994)
Hepatology
, vol.19
, Issue.2
, pp. 412-417
-
-
Saperstein, L.A.1
Jirtle, R.L.2
Farouk, M.3
Thompson, H.J.4
Chung, K.S.5
Meyers, W.C.6
-
21
-
-
84858231133
-
Acetylation: A novel link between double-strand break repair and autophagy
-
G. Shubassi, T. Robert, F. Vanoli, S. Minucci, and M. Foiani Acetylation: a novel link between double-strand break repair and autophagy Cancer Res 72 6 2012 1332 1335
-
(2012)
Cancer Res
, vol.72
, Issue.6
, pp. 1332-1335
-
-
Shubassi, G.1
Robert, T.2
Vanoli, F.3
Minucci, S.4
Foiani, M.5
-
22
-
-
0032714310
-
Inhibition of interleukin 6-mediated mitogen-activated protein kinase activation attenuates growth of a cholangiocarcinoma cell line
-
DOI 10.1002/hep.510300522
-
J. Park, L. Tadlock, G.J. Gores, and T. Patel Inhibition of interleukin 6-mediated mitogen-activated protein kinase activation attenuates growth of a cholangiocarcinoma cell line Hepatology 30 5 1999 1128 1133 (Pubitemid 29510848)
-
(1999)
Hepatology
, vol.30
, Issue.5
, pp. 1128-1133
-
-
Park, J.1
Tadlock, L.2
Gores, G.J.3
Patel, T.4
-
23
-
-
0034234736
-
Growth control of human biliary epithelial cells by interleukin 6, hepatocyte growth factor, transforming growth factor β1, and activin A: Comparison of a cholangiocarcinoma cell line with primary cultures of non- neoplastic biliary epithelial cells
-
S. Yokomuro, H. Tsuji, and J.G. Lunz 3rd Growth control of human biliary epithelial cells by interleukin 6, hepatocyte growth factor, transforming growth factor beta1, and activin A: comparison of a cholangiocarcinoma cell line with primary cultures of non-neoplastic biliary epithelial cells Hepatology 32 1 2000 26 35 (Pubitemid 30432362)
-
(2000)
Hepatology
, vol.32
, Issue.1
, pp. 26-35
-
-
Yokomuro, S.1
Tsuji, H.2
Lunz III, J.G.3
Sakamoto, T.4
Ezure, T.5
Murase, N.6
Demetris, A.J.7
-
24
-
-
0033948810
-
The effect of interleukin-6 (IL-6)/gp130 signalling on biliary epithelial cell growth, in vitro
-
DOI 10.1006/cyto.1999.0612
-
S. Yokomuro, J.G. Lunz 3rd, T. Sakamoto, T. Ezure, N. Murase, and A.J. Demetris The effect of interleukin-6 (IL-6)/gp130 signalling on biliary epithelial cell growth, in vitro Cytokine 12 6 2000 727 730 (Pubitemid 30453506)
-
(2000)
Cytokine
, vol.12
, Issue.6
, pp. 727-730
-
-
Yokomuro, S.1
Lunz III, J.G.2
Sakamoto, T.3
Ezure, T.4
Murase, N.5
Demetris, A.J.6
-
25
-
-
0037373855
-
Transforming growth factor β1 stimulates vascular endothelial growth factor gene transcription in human cholangiocellular carcinoma cells
-
C. Benckert, S. Jonas, and T. Cramer Transforming growth factor beta 1 stimulates vascular endothelial growth factor gene transcription in human cholangiocellular carcinoma cells Cancer Res 63 5 2003 1083 1092 (Pubitemid 36278442)
-
(2003)
Cancer Research
, vol.63
, Issue.5
, pp. 1083-1092
-
-
Benckert, C.1
Jonas, S.2
Cramer, T.3
Von Marschall, Z.4
Schafer, G.5
Peters, M.6
Wagner, K.7
Radke, C.8
Wiedenmann, B.9
Neuhaus, P.10
Hocker, M.11
Rosewicz, S.12
-
26
-
-
33746902024
-
Over-expression of interleukin-6 enhances cell survival and transformed cell growth in human malignant cholangiocytes
-
DOI 10.1016/j.jhep.2005.10.030, PII S0168827805007701
-
F. Meng, Y. Yamagiwa, Y. Ueno, and T. Patel Over-expression of interleukin-6 enhances cell survival and transformed cell growth in human malignant cholangiocytes J Hepatol 44 6 2006 1055 1065 (Pubitemid 44308229)
-
(2006)
Journal of Hepatology
, vol.44
, Issue.6
, pp. 1055-1065
-
-
Meng, F.1
Yamagiwa, Y.2
Ueno, Y.3
Patel, T.4
-
27
-
-
60849091056
-
Cross-talk between TGF-beta1 and IL-6 in human trabecular meshwork cells
-
P.B. Liton, G. Li, C. Luna, P. Gonzalez, and D.L. Epstein Cross-talk between TGF-beta1 and IL-6 in human trabecular meshwork cells Mol Vis 15 2009 326 334
-
(2009)
Mol Vis
, vol.15
, pp. 326-334
-
-
Liton, P.B.1
Li, G.2
Luna, C.3
Gonzalez, P.4
Epstein, D.L.5
-
28
-
-
33748039410
-
1 in activated rat pancreatic stellate cells
-
DOI 10.1002/jcb.20906
-
H. Aoki, H. Ohnishi, and K. Hama Existence of autocrine loop between interleukin-6 and transforming growth factor-beta1 in activated rat pancreatic stellate cells J Cell Biochem 99 1 2006 221 228 (Pubitemid 44297966)
-
(2006)
Journal of Cellular Biochemistry
, vol.99
, Issue.1
, pp. 221-228
-
-
Aoki, H.1
Ohnishi, H.2
Hama, K.3
Shinozaki, S.4
Kita, H.5
Yamamoto, H.6
Osawa, H.7
Sato, K.8
Tamada, K.9
Sugano, K.10
-
29
-
-
0033527448
-
The nuclear factor-kappaB engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter
-
W. Vanden Berghe, K. De Bosscher, E. Boone, S. Plaisance, and G. Haegeman The nuclear factor-kappaB engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter J Biol Chem 274 45 1999 32091 32098
-
(1999)
J Biol Chem
, vol.274
, Issue.45
, pp. 32091-32098
-
-
Vanden Berghe, W.1
De Bosscher, K.2
Boone, E.3
Plaisance, S.4
Haegeman, G.5
-
30
-
-
2442665037
-
Activation of the interleukin-6 promoter by a dominant negative mutant of c-Jun
-
DOI 10.1016/S0167-4889(04)00041-2, PII S0167488904000412
-
L. Faggioli, C. Costanzo, M. Donadelli, and M. Palmieri Activation of the interleukin-6 promoter by a dominant negative mutant of c-Jun Biochim Biophys Acta 1692 1 2004 17 24 (Pubitemid 38670257)
-
(2004)
Biochimica et Biophysica Acta - Molecular Cell Research
, vol.1692
, Issue.1
, pp. 17-24
-
-
Faggioli, L.1
Costanzo, C.2
Donadelli, M.3
Palmieri, M.4
-
31
-
-
73349121322
-
Interleukin (IL)-6 modulates transforming growth factor-beta expression in skin and dermal fibroblasts from IL-6-deficient mice
-
L.R. Luckett-Chastain, and R.M. Gallucci Interleukin (IL)-6 modulates transforming growth factor-beta expression in skin and dermal fibroblasts from IL-6-deficient mice Br J Dermatol 161 2 2009 237 248
-
(2009)
Br J Dermatol
, vol.161
, Issue.2
, pp. 237-248
-
-
Luckett-Chastain, L.R.1
Gallucci, R.M.2
-
32
-
-
0030445799
-
Transforming growth factor-β1 and -β2 positively regulate TGF-β1 mRNA expression in trabecular cells
-
J. Li, B.J. Tripathi, K.V. Chalam, and R.C. Tripathi Transforming growth factor-beta 1 and -beta 2 positively regulate TGF-beta 1 mRNA expression in trabecular cells Invest Ophthalmol Vis Sci 37 13 1996 2778 2782 (Pubitemid 27026566)
-
(1996)
Investigative Ophthalmology and Visual Science
, vol.37
, Issue.13
, pp. 2778-2782
-
-
Li, J.1
Tripathi, B.J.2
Chalam, K.V.3
Tripathi, R.C.4
-
33
-
-
77956629545
-
Histone deacetylase inhibition suppresses the transforming growth factor beta1-induced epithelial-to-mesenchymal transition in hepatocytes
-
A. Kaimori, J.J. Potter, M. Choti, Z. Ding, E. Mezey, and A.A. Koteish Histone deacetylase inhibition suppresses the transforming growth factor beta1-induced epithelial-to-mesenchymal transition in hepatocytes Hepatology 52 3 2010 1033 1045
-
(2010)
Hepatology
, vol.52
, Issue.3
, pp. 1033-1045
-
-
Kaimori, A.1
Potter, J.J.2
Choti, M.3
Ding, Z.4
Mezey, E.5
Koteish, A.A.6
-
34
-
-
70350381535
-
Strong Smad4 expression correlates with poor prognosis after surgery in patients with hepatocellular carcinoma
-
K. Hiwatashi, S. Ueno, and M. Sakoda Strong Smad4 expression correlates with poor prognosis after surgery in patients with hepatocellular carcinoma Ann Surg Oncol 16 11 2009 3176 3182
-
(2009)
Ann Surg Oncol
, vol.16
, Issue.11
, pp. 3176-3182
-
-
Hiwatashi, K.1
Ueno, S.2
Sakoda, M.3
-
35
-
-
0029066689
-
Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability
-
S. Markowitz, J. Wang, and L. Myeroff Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability Science 268 5215 1995 1336 1338
-
(1995)
Science
, vol.268
, Issue.5215
, pp. 1336-1338
-
-
Markowitz, S.1
Wang, J.2
Myeroff, L.3
-
36
-
-
0030848192
-
Frequency of Smad gene mutations in human cancers
-
G.J. Riggins, K.W. Kinzler, B. Vogelstein, and S. Thiagalingam Frequency of Smad gene mutations in human cancers Cancer Res 57 13 1997 2578 2580 (Pubitemid 27283760)
-
(1997)
Cancer Research
, vol.57
, Issue.13
, pp. 2578-2580
-
-
Riggins, G.J.1
Kinzler, K.W.2
Vogelstein, B.3
Thiagalingam, S.4
-
37
-
-
33745856213
-
Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice
-
DOI 10.1172/JCI27282
-
X. Xu, S. Kobayashi, and W. Qiao Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice J Clin Invest 116 7 2006 1843 1852 (Pubitemid 44033309)
-
(2006)
Journal of Clinical Investigation
, vol.116
, Issue.7
, pp. 1843-1852
-
-
Xu, X.1
Kobayashi, S.2
Qiao, W.3
Li, C.4
Xiao, C.5
Radaeva, S.6
Stiles, B.7
Wang, R.-H.8
Ohara, N.9
Yoshino, T.10
LeRoith, D.11
Torbenson, M.S.12
Gores, G.J.13
Wu, H.14
Gao, B.15
Deng, C.-X.16
-
38
-
-
0042303832
-
Transforming growth factor-β1 activates interleukin-6 expression in prostate cancer cells through the synergistic collaboration of the Smad2, p38-NF-κB, JNK, and Ras signaling pathways
-
DOI 10.1038/sj.onc.1206478
-
J.I. Park, M.G. Lee, and K. Cho Transforming growth factor-beta1 activates interleukin-6 expression in prostate cancer cells through the synergistic collaboration of the Smad2, p38-NF-kappaB, JNK, and Ras signaling pathways Oncogene 22 28 2003 4314 4332 (Pubitemid 36897963)
-
(2003)
Oncogene
, vol.22
, Issue.28
, pp. 4314-4332
-
-
Park, J.-I.1
Lee, M.-G.2
Cho, K.3
Park, B.-J.4
Chae, K.-S.5
Byun, D.-S.6
Ryu, B.-K.7
Park, Y.-K.8
Chi, S.-G.9
-
39
-
-
0027942090
-
Interleukin-6 functions as an autocrine growth factor in a cholangiocarcinoma cell line
-
K. Okada, Y. Shimizu, S. Nambu, K. Higuchi, and A. Watanabe Interleukin-6 functions as an autocrine growth factor in a cholangiocarcinoma cell line J Gastroenterol Hepatol 9 5 1994 462 467 (Pubitemid 24312840)
-
(1994)
Journal of Gastroenterology and Hepatology
, vol.9
, Issue.5
, pp. 462-467
-
-
Okada, K.1
Shimizu, Y.2
Nambu, S.3
Higuchi, K.4
Watanabe, A.5
|