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Volumn 9, Issue 3, 2007, Pages

Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; ESTROGEN RECEPTOR; GLYCOPROTEIN GP 130; INTERLEUKIN 6; JANUS KINASE; PROGESTERONE RECEPTOR; PROTEIN TYROSINE KINASE; STAT3 PROTEIN; GLYCOPROTEIN; GLYCOPROTEIN 130, HUMAN; PHOSPHOTYROSINE; UNCLASSIFIED DRUG;

EID: 34548549283     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr1680     Document Type: Article
Times cited : (208)

References (47)
  • 1
    • 7244245445 scopus 로고    scopus 로고
    • Roles and regulation of stat family transcription factors in human breast cancer
    • 1618660 15509516
    • Clevenger CV: Roles and regulation of stat family transcription factors in human breast cancer. Am J Pathol 2004, 165:1449-1460. 1618660 15509516
    • (2004) Am J Pathol , vol.165 , pp. 1449-1460
    • Clevenger, C.V.1
  • 2
    • 1042302005 scopus 로고    scopus 로고
    • The STATs of cancer - New molecular targets come of age
    • 14964307
    • Yu H Jove R: The STATs of cancer - new molecular targets come of age. Nat Rev Cancer 2004, 4:97-105. 14964307
    • (2004) Nat Rev Cancer , vol.4 , pp. 97-105
    • Yu, H.1    Jove, R.2
  • 3
    • 0030840464 scopus 로고    scopus 로고
    • STATs and gene regulation
    • 10.1126/science.277.5332.1630 9287210
    • Darnell JE Jr: STATs and gene regulation. Science 1997, 277:1630-1635. 10.1126/science.277.5332.1630 9287210
    • (1997) Science , vol.277 , pp. 1630-1635
    • Darnell Jr., J.E.1
  • 4
    • 0036251154 scopus 로고    scopus 로고
    • Stat proteins and oncogenesis
    • 150969 11994401 10.1172/JCI200215617
    • Bromberg J: Stat proteins and oncogenesis. J Clin Invest 2002, 109:1139-1142. 150969 11994401 10.1172/JCI200215617
    • (2002) J Clin Invest , vol.109 , pp. 1139-1142
    • Bromberg, J.1
  • 5
    • 33645067376 scopus 로고    scopus 로고
    • Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3
    • 10.1158/0008-5472.CAN-05-2203 16510571
    • Leslie K Lang C Devgan G Azare J Berishaj M Gerald W Kim YB Paz K Darnell JE Albanese C: Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3. Cancer Res 2006, 66:2544-2552. 10.1158/ 0008-5472.CAN-05-2203 16510571
    • (2006) Cancer Res , vol.66 , pp. 2544-2552
    • Leslie, K.1    Lang, C.2    Devgan, G.3    Azare, J.4    Berishaj, M.5    Gerald, W.6    Kim, Y.B.7    Paz, K.8    Darnell, J.E.9    Albanese, C.10
  • 6
    • 31544458469 scopus 로고    scopus 로고
    • Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells
    • 10.1158/1078-0432.CCR-04-1752 16397018
    • Gritsko T Williams A Turkson J Kaneko S Bowman T Huang M Nam S Eweis I Diaz N Sullivan D: Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells. Clin Cancer Res 2006, 12:11-19. 10.1158/ 1078-0432.CCR-04-1752 16397018
    • (2006) Clin Cancer Res , vol.12 , pp. 11-19
    • Gritsko, T.1    Williams, A.2    Turkson, J.3    Kaneko, S.4    Bowman, T.5    Huang, M.6    Nam, S.7    Eweis, I.8    Diaz, N.9    Sullivan, D.10
  • 7
    • 31544460437 scopus 로고    scopus 로고
    • Activation of stat3 in primary tumors from high-risk breast cancer patients is associated with elevated levels of activated SRC and survivin expression
    • 10.1158/1078-0432.CCR-04-1749 16397019
    • Diaz N Minton S Cox C Bowman T Gritsko T Garcia R Eweis I Wloch M Livingston S Seijo E: Activation of stat3 in primary tumors from high-risk breast cancer patients is associated with elevated levels of activated SRC and survivin expression. Clin Cancer Res 2006, 12:20-28. 10.1158/1078-0432.CCR-04-1749 16397019
    • (2006) Clin Cancer Res , vol.12 , pp. 20-28
    • Diaz, N.1    Minton, S.2    Cox, C.3    Bowman, T.4    Gritsko, T.5    Garcia, R.6    Eweis, I.7    Wloch, M.8    Livingston, S.9    Seijo, E.10
  • 9
    • 2342588122 scopus 로고    scopus 로고
    • Cell-to-cell adhesion modulates Stat3 activity in normal and breast carcinoma cells
    • 10.1038/sj.onc.1207378 15007380
    • Vultur A Cao J Arulanandam R Turkson J Jove R Greer P Craig A Elliott B Raptis L: Cell-to-cell adhesion modulates Stat3 activity in normal and breast carcinoma cells. Oncogene 2004, 23:2600-2616. 10.1038/ sj.onc.1207378 15007380
    • (2004) Oncogene , vol.23 , pp. 2600-2616
    • Vultur, A.1    Cao, J.2    Arulanandam, R.3    Turkson, J.4    Jove, R.5    Greer, P.6    Craig, A.7    Elliott, B.8    Raptis, L.9
  • 11
    • 0037316938 scopus 로고    scopus 로고
    • Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis
    • 12576423
    • Dolled-Filhart M Camp RL Kowalski DP Smith BL Rimm DL: Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis: Clin Cancer Res 2003, 9:594-600. 12576423
    • (2003) Clin Cancer Res , vol.9 , pp. 594-600
    • Dolled-Filhart, M.1    Camp, R.L.2    Kowalski, D.P.3    Smith, B.L.4    Rimm, D.L.5
  • 12
    • 0037124102 scopus 로고    scopus 로고
    • Autocrine-mediated activation of STAT3 correlates with cell proliferation in breast carcinoma lines
    • 10.1074/jbc.M109962200 11859072
    • Li L Shaw PE: Autocrine-mediated activation of STAT3 correlates with cell proliferation in breast carcinoma lines. J Biol Chem 2002, 277:17397-17405. 10.1074/jbc.M109962200 11859072
    • (2002) J Biol Chem , vol.277 , pp. 17397-17405
    • Li, L.1    Shaw, P.E.2
  • 13
    • 0035799531 scopus 로고    scopus 로고
    • Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells
    • 10.1038/sj.onc.1204349 11420660
    • Garcia R Bowman TL Niu G Yu H Minton S Muro-Cacho CA Cox CE Falcone R Fairclough R Parsons S: Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells. Oncogene 2001, 20:2499-2513. 10.1038/sj.onc.1204349 11420660
    • (2001) Oncogene , vol.20 , pp. 2499-2513
    • Garcia, R.1    Bowman, T.L.2    Niu, G.3    Yu, H.4    Minton, S.5    Muro-Cacho, C.A.6    Cox, C.E.7    Falcone, R.8    Fairclough, R.9    Parsons, S.10
  • 15
    • 0028923658 scopus 로고
    • Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts
    • 7710952
    • Watson CJ Miller WR: Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts. Br J Cancer 1995, 71:840-844. 7710952
    • (1995) Br J Cancer , vol.71 , pp. 840-844
    • Watson, C.J.1    Miller, W.R.2
  • 16
    • 3242676769 scopus 로고    scopus 로고
    • Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C
    • 489981 15249664 10.1073/pnas.0404100101
    • Dechow TN Pedranzini L Leitch A Leslie K Gerald WL Linkov I Bromberg JF: Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C. Proc Natl Acad Sci USA 2004, 101:10602-10607. 489981 15249664 10.1073/pnas.0404100101
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 10602-10607
    • Dechow, T.N.1    Pedranzini, L.2    Leitch, A.3    Leslie, K.4    Gerald, W.L.5    Linkov, I.6    Bromberg, J.F.7
  • 17
    • 0346024125 scopus 로고    scopus 로고
    • Stat5a is tyrosine phosphorylated and nuclear localized in a high proportion of human breast cancers
    • 10.1002/ijc.11619 14696092
    • Cotarla I Ren S Zhang Y Gehan E Singh B Furth PA: Stat5a is tyrosine phosphorylated and nuclear localized in a high proportion of human breast cancers. Int J Cancer 2004, 108:665-671. 10.1002/ijc.11619 14696092
    • (2004) Int J Cancer , vol.108 , pp. 665-671
    • Cotarla, I.1    Ren, S.2    Zhang, Y.3    Gehan, E.4    Singh, B.5    Furth, P.A.6
  • 18
    • 33645464650 scopus 로고    scopus 로고
    • Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein
    • 10.1158/1535-7163.MCT-05-0268 16546976
    • Kotha A Sekharam M Cilenti L Siddiquee K Khaled A Zervos AS Carter B Turkson J Jove R: Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein. Mol Cancer Ther 2006, 5:621-629. 10.1158/1535-7163.MCT-05-0268 16546976
    • (2006) Mol Cancer Ther , vol.5 , pp. 621-629
    • Kotha, A.1    Sekharam, M.2    Cilenti, L.3    Siddiquee, K.4    Khaled, A.5    Zervos, A.S.6    Carter, B.7    Turkson, J.8    Jove, R.9
  • 19
    • 4944250270 scopus 로고    scopus 로고
    • Inhibition of gp130 signaling in breast cancer blocks constitutive activation of Stat3 and inhibits in vivo malignancy
    • 10.1158/0008-5472.CAN-03-2516 15466183
    • Selander KS Li L Watson L Merrell M Dahmen H Heinrich PC Muller-Newen G Harris KW: Inhibition of gp130 signaling in breast cancer blocks constitutive activation of Stat3 and inhibits in vivo malignancy. Cancer Res 2004, 64:6924-6933. 10.1158/0008-5472.CAN-03-2516 15466183
    • (2004) Cancer Res , vol.64 , pp. 6924-6933
    • Selander, K.S.1    Li, L.2    Watson, L.3    Merrell, M.4    Dahmen, H.5    Heinrich, P.C.6    Muller-Newen, G.7    Harris, K.W.8
  • 20
    • 20444446371 scopus 로고    scopus 로고
    • Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors
    • 10.1158/0008-5472.CAN-04-4281 15958548
    • Alvarez JV Febbo PG Ramaswamy S Loda M Richardson A Frank DA: Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors. Cancer Res 2005, 65:5054-5062. 10.1158/0008-5472.CAN-04-4281 15958548
    • (2005) Cancer Res , vol.65 , pp. 5054-5062
    • Alvarez, J.V.1    Febbo, P.G.2    Ramaswamy, S.3    Loda, M.4    Richardson, A.5    Frank, D.A.6
  • 21
    • 16844368861 scopus 로고    scopus 로고
    • Knockdown of STAT3 expression by RNA interference inhibits the induction of breast tumors in immunocompetent mice
    • 10.1158/0008-5472.CAN-04-2425 15805244
    • Ling X Arlinghaus RB: Knockdown of STAT3 expression by RNA interference inhibits the induction of breast tumors in immunocompetent mice. Cancer Res 2005, 65:2532-2536. 10.1158/0008-5472.CAN-04-2425 15805244
    • (2005) Cancer Res , vol.65 , pp. 2532-2536
    • Ling, X.1    Arlinghaus, R.B.2
  • 22
    • 33746764457 scopus 로고    scopus 로고
    • Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis
    • 10.1016/j.cell.2006.05.047 16901783
    • Guo W Pylayeva Y Pepe A Yoshioka T Muller WJ Inghirami G Giancotti FG: Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis. Cell 2006, 126:489-502. 10.1016/j.cell.2006.05.047 16901783
    • (2006) Cell , vol.126 , pp. 489-502
    • Guo, W.1    Pylayeva, Y.2    Pepe, A.3    Yoshioka, T.4    Muller, W.J.5    Inghirami, G.6    Giancotti, F.G.7
  • 24
    • 0036328973 scopus 로고    scopus 로고
    • Epidermal growth factor receptor dependence of radiation-induced transcription factor activation in human breast carcinoma cells
    • 117308 12134064 10.1091/mbc.01-12-0572
    • Amorino GP Hamilton VM Valerie K Dent P Lammering G Schmidt-Ullrich RK: Epidermal growth factor receptor dependence of radiation-induced transcription factor activation in human breast carcinoma cells. Mol Biol Cell 2002, 13:2233-2244. 117308 12134064 10.1091/mbc.01-12-0572
    • (2002) Mol Biol Cell , vol.13 , pp. 2233-2244
    • Amorino, G.P.1    Hamilton, V.M.2    Valerie, K.3    Dent, P.4    Lammering, G.5    Schmidt-Ullrich, R.K.6
  • 25
    • 0037122897 scopus 로고    scopus 로고
    • An unexpected biochemical and functional interaction between gp130 and the EGF receptor family in breast cancer cells
    • 10.1038/sj.onc.1205100 11821958
    • Grant SL Hammacher A Douglas AM Goss GA Mansfield RK Heath JK Begley CG: An unexpected biochemical and functional interaction between gp130 and the EGF receptor family in breast cancer cells. Oncogene 2002, 21:460-474. 10.1038/sj.onc.1205100 11821958
    • (2002) Oncogene , vol.21 , pp. 460-474
    • Grant, S.L.1    Hammacher, A.2    Douglas, A.M.3    Goss, G.A.4    Mansfield, R.K.5    Heath, J.K.6    Begley, C.G.7
  • 26
    • 33947414063 scopus 로고    scopus 로고
    • Significance of interleukin-6 (IL-6) in breast cancer (review)
    • 10.1007/s10549-006-9328-3 16927176
    • Knupfer H Preiss R: Significance of interleukin-6 (IL-6) in breast cancer (review). Breast Cancer Res Treat 2007, 102:129-135. 10.1007/ s10549-006-9328-3 16927176
    • (2007) Breast Cancer Res Treat , vol.102 , pp. 129-135
    • Knupfer, H.1    Preiss, R.2
  • 27
    • 17644368573 scopus 로고    scopus 로고
    • Interleukin-6: From basic science to medicine - 40 years in immunology
    • 10.1146/annurev.immunol.23.021704.115806 15771564
    • KishimotoFT: Interleukin-6: from basic science to medicine - 40 years in immunology. Annu Rev Immunol 2005, 23:1-21. 10.1146/ annurev.immunol.23.021704.115806 15771564
    • (2005) Annu Rev Immunol , vol.23 , pp. 1-21
    • Kishimoto, T.1
  • 28
    • 0037603113 scopus 로고    scopus 로고
    • Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures
    • 10.1016/S1046-2023(03)00032-X 12798140
    • Debnath J Muthuswamy SK Brugge JS: Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods 2003, 30:256-268. 10.1016/ S1046-2023(03)00032-X 12798140
    • (2003) Methods , vol.30 , pp. 256-268
    • Debnath, J.1    Muthuswamy, S.K.2    Brugge, J.S.3
  • 30
    • 33745603978 scopus 로고    scopus 로고
    • An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen
    • 10.1038/sj.onc.1209415 16491124
    • Doane AS Danso M Lal P Donaton M Zhang L Hudis C Gerald WL: An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen. Oncogene 2006, 25:3994-4008. 10.1038/sj.onc.1209415 16491124
    • (2006) Oncogene , vol.25 , pp. 3994-4008
    • Doane, A.S.1    Danso, M.2    Lal, P.3    Donaton, M.4    Zhang, L.5    Hudis, C.6    Gerald, W.L.7
  • 31
    • 33750728891 scopus 로고    scopus 로고
    • Interleukin-6, multidrug resistance protein-1 expression and response to paclitaxel in women with metastatic breast cancer: Results of cancer and leukemia group B trial 159806
    • 10.1007/s10549-006-9251-7 16773437
    • Rincon M Broadwater G Harris L Crocker A Weaver D Dressler L Berry D Sutton L Michaelson R Messino M: Interleukin-6, multidrug resistance protein-1 expression and response to paclitaxel in women with metastatic breast cancer: Results of cancer and leukemia group B trial 159806. Breast Cancer Res Treat 2006, 100:301-308. 10.1007/s10549-006-9251-7 16773437
    • (2006) Breast Cancer Res Treat , vol.100 , pp. 301-308
    • Rincon, M.1    Broadwater, G.2    Harris, L.3    Crocker, A.4    Weaver, D.5    Dressler, L.6    Berry, D.7    Sutton, L.8    Michaelson, R.9    Messino, M.10
  • 32
    • 0031025240 scopus 로고    scopus 로고
    • Role of epidermal growth factor receptor and STAT-3 activation in autonomous proliferation of SUM-102PT human breast cancer cells
    • 9041204
    • Sartor CI Dziubinski ML Yu CL Jove R Ethier SP: Role of epidermal growth factor receptor and STAT-3 activation in autonomous proliferation of SUM-102PT human breast cancer cells. Cancer Res 1997, 57:978-987. 9041204
    • (1997) Cancer Res , vol.57 , pp. 978-987
    • Sartor, C.I.1    Dziubinski, M.L.2    Yu, C.L.3    Jove, R.4    Ethier, S.P.5
  • 33
    • 33845348577 scopus 로고    scopus 로고
    • The JAK-STAT pathway: A therapeutic target in hematological malignancies
    • 10.2174/156800906779010227 17168672
    • Ferrajoli A FadeAl S Ravandi F Estrov Z: The JAK-STAT pathway: a therapeutic target in hematological malignancies. Curr Cancer Drug Targets 2006, 6:671-679. 10.2174/156800906779010227 17168672
    • (2006) Curr Cancer Drug Targets , vol.6 , pp. 671-679
    • Ferrajoli, A.1    Faderl, S.2    Ravandi, F.3    Estrov, Z.4
  • 34
    • 33746347333 scopus 로고    scopus 로고
    • Tyrphostins and other tyrosine kinase inhibitors
    • 10.1146/annurev.biochem.75.103004.142657 16756486
    • Levitzki A Mishani E: Tyrphostins and other tyrosine kinase inhibitors. Annu Rev Biochem 2006, 75:93-109. 10.1146/ annurev.biochem.75.103004.142657 16756486
    • (2006) Annu Rev Biochem , vol.75 , pp. 93-109
    • Levitzki, A.1    Mishani, E.2
  • 35
    • 27144452311 scopus 로고    scopus 로고
    • JAK protein kinase inhibitors
    • 10.1358/dnp.2005.18.5.904198 16193102
    • Thompson JE: JAK protein kinase inhibitors Drug News Perspect 2005, 18:305-310. 10.1358/dnp.2005.18.5.904198 16193102
    • (2005) Drug News Perspect , vol.18 , pp. 305-310
    • Thompson, J.E.1
  • 36
    • 33750298971 scopus 로고    scopus 로고
    • Pyridone 6, a pan-janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells
    • 10.1158/0008-5472.CAN-05-4280 17018630
    • Pedranzini L Dechow T Berishaj M Comenzo R Zhou P Azare J Bornmann W Bromberg J: Pyridone 6, a pan-janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells. Cancer Res 2006, 66:9714-9721. 10.1158/0008-5472.CAN-05-4280 17018630
    • (2006) Cancer Res , vol.66 , pp. 9714-9721
    • Pedranzini, L.1    Dechow, T.2    Berishaj, M.3    Comenzo, R.4    Zhou, P.5    Azare, J.6    Bornmann, W.7    Bromberg, J.8
  • 38
    • 27144547509 scopus 로고    scopus 로고
    • Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells
    • 10.1158/0008-5472.CAN-05-1731 16230377
    • Nam S Kim D Cheng JQ Zhang S Lee JH Buettner R Mirosevich J Lee FY Jove R: Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells. Cancer Res 2005, 65:9185-9189. 10.1158/ 0008-5472.CAN-05-1731 16230377
    • (2005) Cancer Res , vol.65 , pp. 9185-9189
    • Nam, S.1    Kim, D.2    Cheng, J.Q.3    Zhang, S.4    Lee, J.H.5    Buettner, R.6    Mirosevich, J.7    Lee, F.Y.8    Jove, R.9
  • 39
    • 33745243692 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival
    • 10.1158/0008-5472.CAN-05-4620 16740687
    • Song L Morris M Bagui T Lee FY Jove R Haura EB: Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res 2006, 66:5542-5548. 10.1158/0008-5472.CAN-05-4620 16740687
    • (2006) Cancer Res , vol.66 , pp. 5542-5548
    • Song, L.1    Morris, M.2    Bagui, T.3    Lee, F.Y.4    Jove, R.5    Haura, E.B.6
  • 40
    • 0035476803 scopus 로고    scopus 로고
    • The tyrosine kinase inhibitor ZD1839 ("Iressa") inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells
    • 11585753
    • Moasser MM Basso A Averbuch SD Rosen N: The tyrosine kinase inhibitor ZD1839 ("Iressa") inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells. Cancer Res 2001, 61:7184-7188. 11585753
    • (2001) Cancer Res , vol.61 , pp. 7184-7188
    • Moasser, M.M.1    Basso, A.2    Averbuch, S.D.3    Rosen, N.4
  • 42
    • 33745905938 scopus 로고    scopus 로고
    • STAT3: A multifaceted oncogene
    • 1502425 16801534 10.1073/pnas.0604042103
    • LAvy DE Inghirami G: STAT3: a multifaceted oncogene. Proc Natl Acad Sci USA 2006, 103:10151-10152. 1502425 16801534 10.1073/pnas.0604042103
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 10151-10152
    • Levy, D.E.1    Inghirami, G.2
  • 43
    • 13944250650 scopus 로고    scopus 로고
    • In vivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: Implications for cancer therapy
    • 10.1038/sj.onc.1208316 15592503
    • Xi S Gooding WE Grandis JR: In vivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: Implications for cancer therapy. Oncogene 2005, 24:970-979. 10.1038/sj.onc.1208316 15592503
    • (2005) Oncogene , vol.24 , pp. 970-979
    • Xi, S.1    Gooding, W.E.2    Grandis, J.R.3
  • 44
    • 5444237088 scopus 로고    scopus 로고
    • STAT proteins as novel targets for cancer drug discovery
    • 10.1517/14728222.8.5.409 15469392
    • Turkson J: STAT proteins as novel targets for cancer drug discovery. Expert Opin Ther Targets 2004, 8:409-422. 10.1517/14728222.8.5.409 15469392
    • (2004) Expert Opin Ther Targets , vol.8 , pp. 409-422
    • Turkson, J.1
  • 45
    • 25444513779 scopus 로고    scopus 로고
    • A novel platinum compound inhibits constitutive Stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells
    • 10.1074/jbc.M502694200 16046414
    • Turkson J Zhang S Mora LB Burns A Sebti S Jove R: A novel platinum compound inhibits constitutive Stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells. J Biol Chem 2005, 280:32979-32988. 10.1074/jbc.M502694200 16046414
    • (2005) J Biol Chem , vol.280 , pp. 32979-32988
    • Turkson, J.1    Zhang, S.2    Mora, L.B.3    Burns, A.4    Sebti, S.5    Jove, R.6
  • 46
    • 2542478996 scopus 로고    scopus 로고
    • The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response
    • 10.1146/annurev.immunol.22.091003.090312 15032587
    • Alexander WS Hilton DJ: The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response. Annu Rev Immunol 2004, 22:503-529. 10.1146/annurev.immunol.22.091003.090312 15032587
    • (2004) Annu Rev Immunol , vol.22 , pp. 503-529
    • Alexander, W.S.1    Hilton, D.J.2
  • 47
    • 33947524972 scopus 로고    scopus 로고
    • Expression of SOCS1 and SOCS3 genes is differentially regulated in breast cancer cells in response to proinflammatory cytokine and growth factor signals
    • 10.1038/sj.onc.1209993 17001312
    • Evans MK Yu CR Lohani A Mahdi RM Liu X Trzeciak AR Egwuagu CE: Expression of SOCS1 and SOCS3 genes is differentially regulated in breast cancer cells in response to proinflammatory cytokine and growth factor signals. Oncogene 2007, 26:1941-1948. 10.1038/sj.onc.1209993 17001312
    • (2007) Oncogene , vol.26 , pp. 1941-1948
    • Evans, M.K.1    Yu, C.R.2    Lohani, A.3    Mahdi, R.M.4    Liu, X.5    Trzeciak, A.R.6    Egwuagu, C.E.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.