Activation of a positive feedback loop involving IL-6 and aromatase promotes intratumoral 17β-estradiol biosynthesis in endometrial carcinoma microenvironment

International Journal of Cancer

Volumn 135, Issue 2, 2014, Pages 282-294

  Che, Qi ^a   Liu, Bin Ya ^a   Liao, Yun ^a   Zhang, Hui Juan ^b   Yang, Ting Ting ^a   He, Yin Yan ^a   Xia, Yu Hong ^b   Lu, Wen ^a   He, Xiao Ying ^b   Chen, Zheng ^a   Wang, Fang Yuan ^a   Wan, Xiao Ping ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

aromatase; endometrial carcinoma; estrogen; IL 6; tumor microenvironment

Indexed keywords

AROMATASE; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; MESSENGER RNA; STAT3 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AROMATASE GENE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOMETRIUM CARCINOMA; ESTROGEN SYNTHESIS; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LASER CAPTURE MICRODISSECTION; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR MICROENVIRONMENT;

AROMATASE; ENDOMETRIAL CARCINOMA; ESTROGEN; IL-6; TUMOR MICROENVIRONMENT;

ANIMALS; AROMATASE; BLOTTING, WESTERN; COCULTURE TECHNIQUES; ENDOMETRIAL NEOPLASMS; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESTRADIOL; FEEDBACK, PHYSIOLOGICAL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; INTERLEUKIN-6; LASER CAPTURE MICRODISSECTION; MICE; MICE, NUDE; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STROMAL CELLS; TUMOR MICROENVIRONMENT;

EID: 84900035813     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.28679     Document Type: Article

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