Zerumbone inhibits interleukin-6 and induces apoptosis and cell cycle arrest in ovarian and cervical cancer cells

International Immunopharmacology

Volumn 12, Issue 4, 2012, Pages 594-602

  Abdelwahab, Siddig Ibrahim ^a   Abdul, Ahmad Bustamam ^b   Zain, Zetty Nadia Mohd ^b   Hadi, A Hamid A ^a  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b UNIVERSITY PUTRA MALAYSIA   (Malaysia)

Author keywords

Apoptosis; Cell cycle arrest; Gynecological cancers; Interleukin; Zerumbone

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CISPLATIN; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; ZERUMBONE;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER GROWTH; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG CYTOTOXICITY; FEMALE; FLOW CYTOMETRY; HELA CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; NICK END LABELING; OVARY CANCER; PRIORITY JOURNAL; UTERINE CERVIX CANCER;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; FEMALE; HELA CELLS; HUMANS; INTERLEUKIN-6; OVARIAN NEOPLASMS; SESQUITERPENES; UTERINE CERVICAL NEOPLASMS;

EID: 84857931155     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2012.01.014     Document Type: Article

References (38)

1. P.H. Sugarbaker Cytoreductive surgery and perioperative intraperitoneal chemotherapy for the treatment of advanced primary and recurrent ovarian cancer Curr Opin Obstet Gynecol 21 2009 15
2. P. Jasen From the "silent killer" to the "whispering disease": ovarian cancer and the uses of metaphor Med History 53 2009 489 501
3. R.F. Ozols, B.N. Bundy, B.E. Greer, J.M. Fowler, D. Clarke-Pearson, and R.A. Burger Phase III trial of carboplatin and paclitaxel compared with cisplatin and paclitaxel in patients with optimally resected stage III ovarian cancer: a Gynecologic Oncology Group study J Clin Oncol 21 2003 3194
4. R. Sankaranarayanan, B.M. Nene, S.S. Shastri, K. Jayant, R. Muwonge, and A.M. Budukh HPV screening for cervical cancer in rural India N Engl J Med 360 2009 1385 1394
5. D.R. Hodge, E.M. Hurt, and W.L. Farrar The role of IL-6 and STAT3 in inflammation and cancer Eur J Cancer 41 2005 2502 2512 (Pubitemid 41540626)
6. Song M, Kellum JA. Interleukin-6 Crit Care Med 33 2005 S463
7. T. Ara, and Y.A. DeClerck Interleukin-6 in bone metastasis and cancer progression Eur J Cancer 46 2010 1223 1231
8. M. Peters, S. Jacobs, M. Ehlers, P. Vollmer, J. MÃllberg, and E. Wolf The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6 J Exp Med 183 1996 1399
9. G. Lazennec, and C. Jorgensen Concise review: adult multipotent stromal cells and cancer: risk or benefit? Stem Cells 26 2008 1387 1394
10. E.S. Costanzo, S.K Lutgendorf, A.K. Sood, B. Anderson, J. Sorosky, and D.M. Lubaroff Psychosocial factors and interleukin-6 among women with advanced ovarian cancer Cancer 104 2005 305 313 (Pubitemid 40993257)
11. T. Hirano, and T. Kishimoto Interleukin-6: possible implications in human diseases Int J Clin Lab Res 19 1989 1 10 (Pubitemid 19158828)
12. S.I.A. Wahab, A.B. Abdul, A.S. Alzubairi, M.M. Elhassan, and S. Mohan In vitro ultramorphological assessment of apoptosis induced by zerumbone on (HeLa) microscope (Lieca attached with Q-Floro Software) 18 2009 19
13. M. Kim, S. Miyamoto, Y. Yasui, T. Oyama, A. Murakami, and Tanaka T. Zerumbone a tropical ginger sesquiterpene, inhibits colon and lung carcinogenesis in mice Int J Cancer 124 2009 264 271
14. A. Murakami, R. Hayashi, T. Takana, K.H. Kwon, H. Ohigashi, and R. Safitri Suppression of dextran sodium sulfate-induced colitis in mice by zerumbone, a subtropical ginger sesquiterpene, and nimesulide: separately and in combination Biochem Pharmacol 66 2003 1253 1261 (Pubitemid 37130300)
15. T. Kitayama, K. Yamamoto, R. Utsumi, M. Takatani, R.K. Hill, and Y. Kawai Chemistry of zerumbone. 2. Regulation of ring bond cleavage and unique antibacterial activities of zerumbone derivatives Biosci Biotechnol Biochem 65 2001 2193 2199 (Pubitemid 33617189)
16. T. Kitayama, T. Okamoto, R.K. Hill, Y. Kawai, S. Takahashi, and S. Yonemori Chemistry of zerumbone. 1. Simplified isolation, conjugate addition reactions, and a unique ring contracting transannular reaction of its dibromide J Org Chem 64 1999 2667 2672
17. A. Murakami, D. Takahashi, T. Kinoshita, K. Koshimizu, H.W. Kim, and A. Yoshihiro Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha, beta unsaturated carbonyl group is a prerequisite Carcinogenesis 23 2002 795
18. S. Amslinger The Tunable Functionality of alpha, beta Unsaturated Carbonyl Compounds Enables Their Differential Application in Biological Systems ChemMedChem 5 2010 351 356
19. M. Bazzaro, R.K. Anchoori, M.K.R. Mudiam, O. Issaenko, S. Kumar, and B. Karanam Alpha, beta-Unsaturated Carbonyl System of Chalcone-Based Derivatives Is Responsible for Broad Inhibition of Proteasomal Activity and Preferential Killing of Human Papilloma Virus (HPV) Positive Cervical Cancer Cells J Med Chem 54 2011 449 456
20. Abdelwahab SI, Abdul AB, Mohan S, Taha MME, Syam S, Ibrahim MY, et al. Zerumbone induces apoptosis in T-acute lymphoblastic leukemia cells Leuk Res 35 2011 268 271
21. A.B. Abdul, S.I. Abdelwahab, J.B. Jalinas, A.S. Al-Zubairi, and M.M.E. Taha Combination of zerumbone and cisplatin to treat cervical intraepithelial neoplasia in female balb/c mice Int J Gynecol Cancer 19 2009 1004
22. A.S. Al-Zubairi, A.B. Abdul, and M.M. Syam Evaluation of the genotoxicity of zerumbone in cultured human peripheral blood lymphocytes Toxicol In Vitro 24 2010 707 712
23. M.M.E. Taha, A.B. Abdul, R. Abdullah, T.A.T. Ibrahim, S.I. Abdelwahab, and S. Mohan Potential chemoprevention of diethylnitrosamine-initiated and 2-acetylaminofluorene-promoted hepatocarcinogenesis by zerumbone from the rhizomes of the subtropical ginger (Zingiber zerumbet) Chem Biol Interact 186 2010 295 305
24. X.P. Jiang, D.C. Yang, R.L. Elliott, and J.F. Head Down-regulation of Expression of Interleukin-6 and its Receptor Results in Growth Inhibition of MCF-7 Breast Cancer Cells Anticancer Res 31 2011 2899 2906
25. D. Baskic, S. Popovic, P. Ristic, and N.N. Arsenijevic Analysis of cycloheximide-induced apoptosis in human leukocytes: fluorescence microscopy using annexin V/propidium iodide versus acridin orange/ethidium bromide Cell Biol Int 30 2006 924 932 (Pubitemid 44635308)
26. C.J. Wang, Y.J. Hsieh, C.Y. Chu, Y.L. Lin, and T.H. Tseng Inhibition of cell cycle progression in human leukemia HL-60 cells by esculetin Cancer Lett 183 2002 163 168
27. K. Ishihara, and T. Hirano IL-6 in autoimmune disease and chronic inflammatory proliferative disease Cytokine & Growth Factor Rev 13 2002 357 368
28. M.J. Reed, N.G. Coldham, S.R. Patel, M.W. Ghilchik, and V.H.T. James Interleukin-1 and interleukin-6 in breast cyst fluid: their role in regulating aromatase activity in breast cancer cells J Endocrinol 132 1992 R5
29. J.S. Falconer, K.C. Fearon, C.E. Plester, J.A. Ross, and D.C. Carter Cytokines, the acute-phase response, and resting energy expenditure in cachectic patients with pancreatic cancer Ann Surg 219 1994 325
30. C. Becker, M.C. Fantini, C. Schramm, H.A. Lehr, S. Wirtz, and A. Nikolaev TGF-[beta] Suppresses Tumor Progression in Colon Cancer by Inhibition of IL-6 trans-Signaling Immunity 21 2004 491 501 (Pubitemid 39370505)
31. A. Horiguchi, M. Oya, K. Marumo, and M. Murai STAT3, but not ERKs, mediates the IL-6-R induced proliferation of renal cancer cells, ACHN and 769P Kidney Int 61 2002 926 938 (Pubitemid 34175461)
32. M.M. Moradi, L.F. Carson, L.B. Twiggs, J.B. Weinberg, A.F. Haney, and S. Ramakrishnan Serum and ascitic fluid levels of interleukin-1, interleukin-6, and tumor necrosis factor alpha in patients with ovarian epithelial cancer Cancer 72 1993 2433 2440 (Pubitemid 23299609)
33. R. Kurzrock The role of cytokines in cancer-related fatigue Cancer 92 2001 1684 1688 (Pubitemid 32939175)
34. M.G. Kelly, A.B. Alvero, R. Chen, D.A. Silasi, V.M. Abrahams, and S. Chan TLR-4 signaling promotes tumor growth and paclitaxel chemoresistance in ovarian cancer Cancer Res 66 2006 3859
35. M. Iyori, T. Zhang, H. Pantel, B.A. Gagne, and C.L. Sentman TRAIL/DR5 Plays a Critical Role in NK Cell-Mediated Negative Regulation of Dendritic Cell Cross-Priming of T Cells J Immunol 187 2011 3087 3095
36. G.F. Shust, S. Cho, M. Kim, R.P. Madan, E.M. Guzman, and M. Pollack Female genital tract secretions inhibit herpes simplex virus infection: correlation with soluble mucosal immune mediators and impact of hormonal contraception Am J Reprod Immunol (New York, NY:1989) 63 2010 110 121
37. R.U. Beetz, T. P, W. O, KR A., M. R, and D. M NF-KB and AP-1 are responsible for inducibility of the IL-6 promoter by ionizing radiation in HeLa cells Int J Radiat Biol 76 2000 1443 1453
38. D.L. Vaux, S. Cory, and J.M. Adams Bcl-2 and cell survival Nature 335 1988 440 442