메뉴 건너뛰기




Volumn 18, Issue 1, 2015, Pages

Animal and human mucosal tissue models to study HIV biomedical interventions: Can we predict success?

Author keywords

Ex vivo challenge; HIV prevention; Humanized mouse; Macaque; Microbicide; Mucosal tissue; Non human primate; Pre exposure prophylaxis

Indexed keywords

ANTIRETROVIRUS AGENT; ANTIINFECTIVE AGENT;

EID: 84959378242     PISSN: None     EISSN: 17582652     Source Type: Journal    
DOI: 10.7448/IAS.18.1.20301     Document Type: Review
Times cited : (10)

References (120)
  • 1
    • 84904438190 scopus 로고    scopus 로고
    • HIV infection: Epidemiology, pathogenesis, treatment, and prevention
    • Maartens G, Celum C, Lewin SR. HIV infection: epidemiology, pathogenesis, treatment, and prevention. Lancet. 2014;384:258-71.
    • (2014) Lancet , vol.384 , pp. 258-271
    • Maartens, G.1    Celum, C.2    Lewin, S.R.3
  • 2
    • 0023388002 scopus 로고
    • Small animals are not susceptible to human immunodeficiency virus infection
    • Morrow WJ, Wharton M, Lau D, Levy JA. Small animals are not susceptible to human immunodeficiency virus infection. J Gen Virol. 1987;68(Pt 8): 2253-7.
    • (1987) J Gen Virol , vol.68 , pp. 2253-2257
    • Morrow, W.J.1    Wharton, M.2    Lau, D.3    Levy, J.A.4
  • 3
    • 0023028190 scopus 로고
    • The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain
    • Maddon PJ, Dalgleish AG, McDougal JS, Clapham PR, Weiss RA, Axel R. The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell. 1986;47:333-48.
    • (1986) Cell , vol.47 , pp. 333-348
    • Maddon, P.J.1    Dalgleish, A.G.2    McDougal, J.S.3    Clapham, P.R.4    Weiss, R.A.5    Axel, R.6
  • 5
    • 0033779574 scopus 로고    scopus 로고
    • Multiple blocks to human immunodeficiency virus type 1 replication in rodent cells
    • Bieniasz PD, Cullen BR. Multiple blocks to human immunodeficiency virus type 1 replication in rodent cells. J Virol. 2000;74:9868-77.
    • (2000) J Virol , vol.74 , pp. 9868-9877
    • Bieniasz, P.D.1    Cullen, B.R.2
  • 6
    • 0024213526 scopus 로고
    • Engraftment of immune-deficient mice with human hematopoietic stem cells
    • Kamel-Reid S, Dick JE. Engraftment of immune-deficient mice with human hematopoietic stem cells. Science. 1988;242:1706-9.
    • (1988) Science , vol.242 , pp. 1706-1709
    • Kamel-Reid, S.1    Dick, J.E.2
  • 7
    • 0023753744 scopus 로고
    • The SCID-hu mouse: Murine model for the analysis of human hematolymphoid differentiation and function
    • McCune JM, Namikawa R, Kaneshima H, Shultz LD, Lieberman M, Weissman IL. The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function. Science. 1988;241:1632-9.
    • (1988) Science , vol.241 , pp. 1632-1639
    • McCune, J.M.1    Namikawa, R.2    Kaneshima, H.3    Shultz, L.D.4    Lieberman, M.5    Weissman, I.L.6
  • 8
    • 0023734130 scopus 로고
    • Transfer of a functional human immune system to mice with severe combined immunodeficiency
    • Mosier DE, Gulizia RJ, Baird SM, Wilson DB. Transfer of a functional human immune system to mice with severe combined immunodeficiency. Nature. 1988;335:256-9.
    • (1988) Nature , vol.335 , pp. 256-259
    • Mosier, D.E.1    Gulizia, R.J.2    Baird, S.M.3    Wilson, D.B.4
  • 9
    • 32144462082 scopus 로고    scopus 로고
    • Discovery of 2, 5-dimethoxy-substituted 5-bromopyridyl thiourea (PHI-236) as a potent broad-spectrum anti-human immunodeficiency virus microbicide
    • D'Cruz OJ, Uckun FM. Discovery of 2, 5-dimethoxy-substituted 5-bromopyridyl thiourea (PHI-236) as a potent broad-spectrum anti-human immunodeficiency virus microbicide. Mol Hum Reprod. 2005;11:767-77.
    • (2005) Mol Hum Reprod , vol.11 , pp. 767-777
    • D'Cruz, O.J.1    Uckun, F.M.2
  • 10
    • 0042128299 scopus 로고    scopus 로고
    • Inhibition of vaginal transmission of HIV-1 in hu-SCID mice by the nonnucleoside reverse transcriptase inhibitor TMC120 in a gel formulation
    • Di Fabio S, Van Roey J, Giannini G, van den Mooter G, Spada M, Binelli A, et al. Inhibition of vaginal transmission of HIV-1 in hu-SCID mice by the nonnucleoside reverse transcriptase inhibitor TMC120 in a gel formulation. AIDS. 2003;17:1597-604.
    • (2003) AIDS , vol.17 , pp. 1597-1604
    • Di Fabio, S.1    Van Roey, J.2    Giannini, G.3    Van Den Mooter, G.4    Spada, M.5    Binelli, A.6
  • 11
    • 79958812814 scopus 로고    scopus 로고
    • Humanized Rag1-/-gammac-/-mice support multilineage hematopoiesis and are susceptible to HIV-1 infection via systemic and vaginal routes
    • Akkina R, Berges BK, Palmer BE, Remling L, Neff CP, Kuruvilla J, et al. Humanized Rag1-/-gammac-/-mice support multilineage hematopoiesis and are susceptible to HIV-1 infection via systemic and vaginal routes. PLoS One. 2011;6:e20169.
    • (2011) PLoS One , vol.6 , pp. e20169
    • Akkina, R.1    Berges, B.K.2    Palmer, B.E.3    Remling, L.4    Neff, C.P.5    Kuruvilla, J.6
  • 12
    • 84864073114 scopus 로고    scopus 로고
    • IL-2 receptor gamma-chain molecule is critical for intestinal T-cell reconstitution in humanized mice
    • Denton PW, Nochi T, Lim A, Krisko JF, Martinez-Torres F, Choudhary SK, et al. IL-2 receptor gamma-chain molecule is critical for intestinal T-cell reconstitution in humanized mice. Mucosal Immunol. 2012;5(5):555-66.
    • (2012) Mucosal Immunol , vol.5 , Issue.5 , pp. 555-566
    • Denton, P.W.1    Nochi, T.2    Lim, A.3    Krisko, J.F.4    Martinez-Torres, F.5    Choudhary, S.K.6
  • 13
    • 79961003836 scopus 로고    scopus 로고
    • Superior human leukocyte reconstitution and susceptibility to vaginal HIV transmission in humanized NOD-scid IL-2Rgamma-/-(NSG) BLT mice
    • Stoddart CA, Maidji E, Galkina SA, Kosikova G, Rivera JM, Moreno ME, et al. Superior human leukocyte reconstitution and susceptibility to vaginal HIV transmission in humanized NOD-scid IL-2Rgamma-/-(NSG) BLT mice. Virology. 2011;417:154-60.
    • (2011) Virology , vol.417 , pp. 154-160
    • Stoddart, C.A.1    Maidji, E.2    Galkina, S.A.3    Kosikova, G.4    Rivera, J.M.5    Moreno, M.E.6
  • 15
    • 84855466746 scopus 로고    scopus 로고
    • Antibody-based protection against HIV infection by vectored immunoprophylaxis
    • Balazs AB, Chen J, Hong CM, Rao DS, Yang L, Baltimore D. Antibody-based protection against HIV infection by vectored immunoprophylaxis. Nature. 2012;481:81-4.
    • (2012) Nature , vol.481 , pp. 81-84
    • Balazs, A.B.1    Chen, J.2    Hong, C.M.3    Rao, D.S.4    Yang, L.5    Baltimore, D.6
  • 17
    • 84865295305 scopus 로고    scopus 로고
    • Topical gel formulation of broadly neutralizing anti-HIV-1 monoclonal antibody VRC01 confers protection against HIV-1 vaginal challenge in a humanized mouse model
    • Veselinovic M, Neff CP, Mulder LR, Akkina R. Topical gel formulation of broadly neutralizing anti-HIV-1 monoclonal antibody VRC01 confers protection against HIV-1 vaginal challenge in a humanized mouse model. Virology. 2012; 432:505-10.
    • (2012) Virology , vol.432 , pp. 505-510
    • Veselinovic, M.1    Neff, C.P.2    Mulder, L.R.3    Akkina, R.4
  • 18
    • 38849136442 scopus 로고    scopus 로고
    • Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice
    • Denton PW, Estes JD, Sun Z, Othieno FA, Wei BL, Wege AK, et al. Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice. PLoS Med. 2008;5:e16.
    • (2008) PLoS Med , vol.5 , pp. e16
    • Denton, P.W.1    Estes, J.D.2    Sun, Z.3    Othieno, F.A.4    Wei, B.L.5    Wege, A.K.6
  • 19
    • 77952475729 scopus 로고    scopus 로고
    • Systemic administration of antiretrovirals prior to exposure prevents rectal and intravenous HIV-1 transmission in humanized BLT mice
    • Denton PW, Krisko JF, Powell DA, Mathias M, Kwak YT, Martinez-Torres F, et al. Systemic administration of antiretrovirals prior to exposure prevents rectal and intravenous HIV-1 transmission in humanized BLT mice. PLoS One. 2010;5:e8829.
    • (2011) PLoS One , vol.5 , pp. e8829
    • Denton, P.W.1    Krisko, J.F.2    Powell, D.A.3    Mathias, M.4    Kwak, Y.T.5    Martinez-Torres, F.6
  • 20
    • 79960417636 scopus 로고    scopus 로고
    • One percent tenofovir applied topically to humanized BLT mice and used according to the CAPRISA 004 experimental design demonstrates partial protection from vaginal HIV infection, validating the BLT model for evaluation of new microbicide candidates
    • Denton PW, Othieno F, Martinez-Torres F, Zou W, Krisko JF, Fleming E, et al. One percent tenofovir applied topically to humanized BLT mice and used according to the CAPRISA 004 experimental design demonstrates partial protection from vaginal HIV infection, validating the BLT model for evaluation of new microbicide candidates. J Virol. 2011;85:7582-93.
    • (2011) J Virol , vol.85 , pp. 7582-7593
    • Denton, P.W.1    Othieno, F.2    Martinez-Torres, F.3    Zou, W.4    Krisko, J.F.5    Fleming, E.6
  • 21
    • 84875201880 scopus 로고    scopus 로고
    • Rectal transmission of transmitted/founder HIV-1 is efficiently prevented by topical 1% tenofovir in BLT humanized mice
    • Chateau ML, Denton PW, Swanson MD, McGowan I, Garcia JV. Rectal transmission of transmitted/founder HIV-1 is efficiently prevented by topical 1% tenofovir in BLT humanized mice. PLoS One. 2013;8:e60024.
    • (2013) PLoS One , vol.8 , pp. e60024
    • Chateau, M.L.1    Denton, P.W.2    Swanson, M.D.3    McGowan, I.4    Garcia, J.V.5
  • 22
    • 77955930318 scopus 로고    scopus 로고
    • Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women
    • Abdool Karim Q, Abdool Karim SS, Frohlich JA, Grobler AC, Baxter C, Mansoor LE, et al. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science. 2010;329:1168-74.
    • (2011) Science , vol.329 , pp. 1168-1174
    • Abdool Karim, Q.1    Abdool Karim, S.S.2    Frohlich, J.A.3    Grobler, A.C.4    Baxter, C.5    Mansoor, L.E.6
  • 23
    • 76349095131 scopus 로고    scopus 로고
    • RNAi-mediated CCR5 silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT mice
    • Kim SS, Peer D, Kumar P, Subramanya S, Wu H, Asthana D, et al. RNAi-mediated CCR5 silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT mice. Mol Ther. 2010;18:370-6.
    • (2011) Mol Ther , vol.18 , pp. 370-376
    • Kim, S.S.1    Peer, D.2    Kumar, P.3    Subramanya, S.4    Wu, H.5    Asthana, D.6
  • 24
    • 84879691173 scopus 로고    scopus 로고
    • Durable knockdown and protection from HIV transmission in humanized mice treated with gel-formulated CD4 aptamer-siRNA chimeras
    • Wheeler LA, Vrbanac V, Trifonova R, Brehm MA, Gilboa-Geffen A, Tanno S, et al. Durable knockdown and protection from HIV transmission in humanized mice treated with gel-formulated CD4 aptamer-siRNA chimeras. Mol Ther. 2013;21:1378-89.
    • (2013) Mol Ther , vol.21 , pp. 1378-1389
    • Wheeler, L.A.1    Vrbanac, V.2    Trifonova, R.3    Brehm, M.A.4    Gilboa-Geffen, A.5    Tanno, S.6
  • 25
    • 84905459118 scopus 로고    scopus 로고
    • HIV pre-exposure prophylaxis: Mucosal tissue drug distribution of RT inhibitor Tenofovir and entry inhibitor Maraviroc in a humanized mouse model
    • Veselinovic M, Yang KH, LeCureux J, Sykes C, Remling-Mulder L, Kashuba AD, et al. HIV pre-exposure prophylaxis: mucosal tissue drug distribution of RT inhibitor Tenofovir and entry inhibitor Maraviroc in a humanized mouse model. Virology. 2014;464-5:253-63.
    • (2014) Virology , vol.4645 , pp. 253-263
    • Veselinovic, M.1    Yang, K.H.2    LeCureux, J.3    Sykes, C.4    Remling-Mulder, L.5    Kashuba, A.D.6
  • 27
    • 84873858944 scopus 로고    scopus 로고
    • MTN-001: Randomized pharmacokinetic cross-over study comparing tenofovir vaginal gel and oral tablets in vaginal tissue and other compartments
    • Hendrix CW, Chen BA, Guddera V, Hoesley C, Justman J, Nakabiito C, et al. MTN-001: randomized pharmacokinetic cross-over study comparing tenofovir vaginal gel and oral tablets in vaginal tissue and other compartments. PLoS One. 2013;8:e55013.
    • (2013) PLoS One , vol.8 , pp. e55013
    • Hendrix, C.W.1    Chen, B.A.2    Guddera, V.3    Hoesley, C.4    Justman, J.5    Nakabiito, C.6
  • 28
    • 84907487933 scopus 로고    scopus 로고
    • Expanding the genetic editing tool kit: ZFNs, TALENs, and CRISPR-Cas9
    • Gupta RM, Musunuru K. Expanding the genetic editing tool kit: ZFNs, TALENs, and CRISPR-Cas9. J Clin Invest. 2014;124:4154-61.
    • (2014) J Clin Invest , vol.124 , pp. 4154-4161
    • Gupta, R.M.1    Musunuru, K.2
  • 29
    • 84908507106 scopus 로고    scopus 로고
    • Generation of improved humanized mouse models for human infectious diseases
    • Brehm MA, Wiles MV, Greiner DL, Shultz LD. Generation of improved humanized mouse models for human infectious diseases. J Immunol Methods. 2014;410:3-17.
    • (2014) J Immunol Methods , vol.410 , pp. 3-17
    • Brehm, M.A.1    Wiles, M.V.2    Greiner, D.L.3    Shultz, L.D.4
  • 30
    • 84900541836 scopus 로고    scopus 로고
    • Broad scope method for creating humanized animal models for animal health and disease research through antibiotic treatment and human fecal transfer
    • Hintze KJ, Cox JE, Rompato G, Benninghoff AD, Ward RE, Broadbent J, et al. Broad scope method for creating humanized animal models for animal health and disease research through antibiotic treatment and human fecal transfer. Gut Microbes. 2014;5:183-91.
    • (2014) Gut Microbes , vol.5 , pp. 183-191
    • Hintze, K.J.1    Cox, J.E.2    Rompato, G.3    Benninghoff, A.D.4    Ward, R.E.5    Broadbent, J.6
  • 32
    • 0026561435 scopus 로고
    • Interactions between Trichomonas vaginalis and vaginal flora in a mouse model
    • Meysick KC, Garber GE. Interactions between Trichomonas vaginalis and vaginal flora in a mouse model. J Parasitol. 1992;78:157-60.
    • (1992) J Parasitol , vol.78 , pp. 157-160
    • Meysick, K.C.1    Garber, G.E.2
  • 35
    • 0021932338 scopus 로고
    • Serologic identification and characterization of a macaque T-lymphotropic retrovirus closely related to HTLV-III
    • Kanki PJ, McLane MF, King NW, Jr, Letvin NL, Hunt RD, Sehgal P, et al. Serologic identification and characterization of a macaque T-lymphotropic retrovirus closely related to HTLV-III. Science. 1985;228:1199-201.
    • (1985) Science , vol.228 , pp. 1199-1201
    • Kanki, P.J.1    McLane, M.F.2    King, N.W.3    Letvin, N.L.4    Hunt, R.D.5    Sehgal, P.6
  • 36
    • 77949409948 scopus 로고    scopus 로고
    • Targeting early infection to prevent HIV-1 mucosal transmission
    • Haase AT. Targeting early infection to prevent HIV-1 mucosal transmission. Nature. 2010;464:217-23.
    • (2011) Nature , vol.464 , pp. 217-223
    • Haase, A.T.1
  • 38
    • 0032540418 scopus 로고    scopus 로고
    • Gastrointestinal tract as a major site of CD4-T cell depletion and viral replication in SIV infection
    • Veazey RS, DeMaria M, Chalifoux LV, Shvetz DE, Pauley DR, Knight HL, et al. Gastrointestinal tract as a major site of CD4-T cell depletion and viral replication in SIV infection. Science. 1998;280:427-31.
    • (1998) Science , vol.280 , pp. 427-431
    • Veazey, R.S.1    DeMaria, M.2    Chalifoux, L.V.3    Shvetz, D.E.4    Pauley, D.R.5    Knight, H.L.6
  • 39
    • 3242769788 scopus 로고    scopus 로고
    • Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques
    • Hazuda DJ, Young SD, Guare JP, Anthony NJ, Gomez RP, Wai JS, et al. Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques. Science. 2004;305:528-32.
    • (2004) Science , vol.305 , pp. 528-532
    • Hazuda, D.J.1    Young, S.D.2    Guare, J.P.3    Anthony, N.J.4    Gomez, R.P.5    Wai, J.S.6
  • 40
    • 0028791836 scopus 로고
    • Prevention of SIV infection in macaques by (R)-9-(2-phosphonylmethoxypropyl) adenine
    • Tsai CC, Follis KE, Sabo A, Beck TW, Grant RF, Bischofberger N, et al. Prevention of SIV infection in macaques by (R)-9-(2-phosphonylmethoxypropyl) adenine. Science. 1995;270:1197-9.
    • (1995) Science , vol.270 , pp. 1197-1199
    • Tsai, C.C.1    Follis, K.E.2    Sabo, A.3    Beck, T.W.4    Grant, R.F.5    Bischofberger, N.6
  • 41
    • 1542319002 scopus 로고    scopus 로고
    • Susceptibility of HIV-2 SIV and SHIV to various anti-HIV-1 compounds: Implications for treatment and postexposure prophylaxis
    • Witvrouw M, Pannecouque C, Switzer WM, Folks TM, De Clercq E, Heneine W. Susceptibility of HIV-2, SIV and SHIV to various anti-HIV-1 compounds: implications for treatment and postexposure prophylaxis. Antivir Ther. 2004;9:57-65.
    • (2004) Antivir Ther , vol.9 , pp. 57-65
    • Witvrouw, M.1    Pannecouque, C.2    Switzer, W.M.3    Folks, T.M.4    De Clercq, E.5    Heneine, W.6
  • 43
    • 0026769190 scopus 로고
    • Infection of cynomolgus monkeys with a chimeric HIV-1/SIVmac virus that expresses the HIV-1 envelope glycoproteins
    • Li J, Lord CI, Haseltine W, Letvin NL, Sodroski J. Infection of cynomolgus monkeys with a chimeric HIV-1/SIVmac virus that expresses the HIV-1 envelope glycoproteins. J Acquir Immune Defic Syndr. 1992;5:639-46.
    • (1992) J Acquir Immune Defic Syndr , vol.5 , pp. 639-646
    • Li, J.1    Lord, C.I.2    Haseltine, W.3    Letvin, N.L.4    Sodroski, J.5
  • 44
    • 0029085036 scopus 로고
    • Animal model for the therapy of acquired immunodeficiency syndrome with reverse transcriptase inhibitors
    • Uberla K, Stahl-Hennig C, Bottiger D, Matz-Rensing K, Kaup FJ, Li J, et al. Animal model for the therapy of acquired immunodeficiency syndrome with reverse transcriptase inhibitors. Proc Natl Acad Sci USA. 1995;92:8210-4.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 8210-8214
    • Uberla, K.1    Stahl-Hennig, C.2    Bottiger, D.3    Matz-Rensing, K.4    Kaup, F.J.5    Li, J.6
  • 45
    • 84868508717 scopus 로고    scopus 로고
    • Animal models of antiretroviral prophylaxis for HIV prevention
    • Garcia-Lerma JG, Heneine W. Animal models of antiretroviral prophylaxis for HIV prevention. Curr Opin HIV AIDS. 2012;7:505-13.
    • (2012) Curr Opin HIV AIDS , vol.7 , pp. 505-513
    • Garcia-Lerma, J.G.1    Heneine, W.2
  • 46
    • 84880331943 scopus 로고    scopus 로고
    • Animal models for microbicide safety and efficacy testing
    • Veazey RS. Animal models for microbicide safety and efficacy testing. Curr Opin HIV AIDS. 2013;8:295-303.
    • (2013) Curr Opin HIV AIDS , vol.8 , pp. 295-303
    • Veazey, R.S.1
  • 48
    • 19944428117 scopus 로고    scopus 로고
    • Multiple vaginal exposures to low doses of R5 simian-human immunodeficiency virus: Strategy to study HIV preclinical interventions in nonhuman primates
    • Otten RA, Adams DR, Kim CN, Jackson E, Pullium JK, Lee K, et al. Multiple vaginal exposures to low doses of R5 simian-human immunodeficiency virus: strategy to study HIV preclinical interventions in nonhuman primates. J Infect Dis. 2005;191:164-73.
    • (2005) J Infect Dis , vol.191 , pp. 164-173
    • Otten, R.A.1    Adams, D.R.2    Kim, C.N.3    Jackson, E.4    Pullium, J.K.5    Lee, K.6
  • 49
    • 33745937659 scopus 로고    scopus 로고
    • Repetitive exposures with simian/human immunodeficiency viruses: Strategy to study HIV pre-clinical interventions in non-human primates
    • Kim CN, Adams DR, Bashirian S, Butera S, Folks TM, Otten RA. Repetitive exposures with simian/human immunodeficiency viruses: strategy to study HIV pre-clinical interventions in non-human primates. J Med Primatol. 2006; 35:210-6.
    • (2006) J Med Primatol , vol.35 , pp. 210-216
    • Kim, C.N.1    Adams, D.R.2    Bashirian, S.3    Butera, S.4    Folks, T.M.5    Otten, R.A.6
  • 50
    • 82455198719 scopus 로고    scopus 로고
    • SIVmac251 is inefficiently transmitted to rhesus macaques by penile inoculation with a single SIVenv variant found in ramp-up phase plasma
    • Ma ZM, Keele BF, Qureshi H, Stone M, Desilva V, Fritts L, et al. SIVmac251 is inefficiently transmitted to rhesus macaques by penile inoculation with a single SIVenv variant found in ramp-up phase plasma. AIDS Res Hum Retroviruses. 2011;27:1259-69.
    • (2011) AIDS Res Hum Retroviruses , vol.27 , pp. 1259-1269
    • Ma, Z.M.1    Keele, B.F.2    Qureshi, H.3    Stone, M.4    Desilva, V.5    Fritts, L.6
  • 51
    • 84863116109 scopus 로고    scopus 로고
    • Low-dose penile SIVmac251 exposure of rhesus macaques infected with adenovirus type 5 (Ad5) and then immunized with a replication-defective Ad5-based SIV gag/pol/nef vaccine recapitulates the results of the phase IIb step trial of a similar HIV-1 vaccine
    • Qureshi H, Ma ZM, Huang Y, Hodge G, Thomas MA, DiPasquale J, et al. Low-dose penile SIVmac251 exposure of rhesus macaques infected with adenovirus type 5 (Ad5) and then immunized with a replication-defective Ad5-based SIV gag/pol/nef vaccine recapitulates the results of the phase IIb step trial of a similar HIV-1 vaccine. J Virol. 2012;86:2239-50.
    • (2012) J Virol , vol.86 , pp. 2239-2250
    • Qureshi, H.1    Ma, Z.M.2    Huang, Y.3    Hodge, G.4    Thomas, M.A.5    DiPasquale, J.6
  • 53
    • 56649105122 scopus 로고    scopus 로고
    • Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): A double-blind, randomised, placebo-controlled, test-of-concept trial
    • Buchbinder SP, Mehrotra DV, Duerr A, Fitzgerald DW, Mogg R, Li D, et al. Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial. Lancet. 2008;372:1881-93.
    • (2008) Lancet , vol.372 , pp. 1881-1893
    • Buchbinder, S.P.1    Mehrotra, D.V.2    Duerr, A.3    Fitzgerald, D.W.4    Mogg, R.5    Li, D.6
  • 54
    • 39849100140 scopus 로고    scopus 로고
    • Prevention of rectal SHIV transmission in macaques by daily or intermittent prophylaxis with emtricitabine and tenofovir
    • Garcia-Lerma JG, Otten RA, Qari SH, Jackson E, Cong ME, Masciotra S, et al. Prevention of rectal SHIV transmission in macaques by daily or intermittent prophylaxis with emtricitabine and tenofovir. PLoS Med. 2008;5:e28.
    • (2008) PLoS Med , vol.5 , pp. e28
    • Garcia-Lerma, J.G.1    Otten, R.A.2    Qari, S.H.3    Jackson, E.4    Cong, M.E.5    Masciotra, S.6
  • 55
    • 84905985162 scopus 로고    scopus 로고
    • Tenofovir diphosphate concentrations and prophylactic effect in a macaque model of rectal simian HIV transmission
    • Anderson PL, Glidden DV, Bushman LR, Heneine W, Garcia-Lerma JG. Tenofovir diphosphate concentrations and prophylactic effect in a macaque model of rectal simian HIV transmission. J Antimicrob Chemother. 2014;69: 2470-6.
    • (2014) J Antimicrob Chemother , vol.69 , pp. 2470-2476
    • Anderson, P.L.1    Glidden, D.V.2    Bushman, L.R.3    Heneine, W.4    Garcia-Lerma, J.G.5
  • 56
    • 84906793896 scopus 로고    scopus 로고
    • Uptake of pre-exposure prophylaxis, sexual practices, and HIV incidence in men and transgender women who have sex with men: A cohort study
    • Grant RM, Anderson PL, McMahan V, Liu A, Amico KR, Mehrotra M, et al. Uptake of pre-exposure prophylaxis, sexual practices, and HIV incidence in men and transgender women who have sex with men: a cohort study. Lancet Infect Dis. 2014;14:820-9.
    • (2014) Lancet Infect Dis , vol.14 , pp. 820-829
    • Grant, R.M.1    Anderson, P.L.2    McMahan, V.3    Liu, A.4    Amico, K.R.5    Mehrotra, M.6
  • 57
    • 84455192446 scopus 로고    scopus 로고
    • The pharmacokinetics of tenofovir following intravaginal and intrarectal administration of tenofovir gel to rhesus macaques
    • Nuttall J, Kashuba A, Wang R, White N, Allen P, Roberts J, et al. The pharmacokinetics of tenofovir following intravaginal and intrarectal administration of tenofovir gel to rhesus macaques. Antimicrob Agents Chemother. 2011;56:103-9.
    • (2011) Antimicrob Agents Chemother , vol.56 , pp. 103-109
    • Nuttall, J.1    Kashuba, A.2    Wang, R.3    White, N.4    Allen, P.5    Roberts, J.6
  • 58
    • 84922480285 scopus 로고    scopus 로고
    • Order of orifices: Sequence of condom use and ejaculation by orifice during anal intercourse among women: Implications for HIV transmission
    • Gorbach PM, Pines H, Javanbakht M, Weiss RE, Jeffries R, Cranston RD, et al. Order of orifices: sequence of condom use and ejaculation by orifice during anal intercourse among women: implications for HIV transmission. J Acquir Immune Defic Syndr. 2014;67:424-9.
    • (2014) J Acquir Immune Defic Syndr , vol.67 , pp. 424-429
    • Gorbach, P.M.1    Pines, H.2    Javanbakht, M.3    Weiss, R.E.4    Jeffries, R.5    Cranston, R.D.6
  • 59
    • 83155177076 scopus 로고    scopus 로고
    • Penetration of tenofovir and emtricitabine in mucosal tissues: Implications for prevention of HIV-1 transmission
    • Patterson KB, Prince HA, Kraft E, Jenkins AJ, Shaheen NJ, Rooney JF, et al. Penetration of tenofovir and emtricitabine in mucosal tissues: implications for prevention of HIV-1 transmission. Sci Transl Med. 2011;3:112re114.
    • (2011) Sci Transl Med , vol.3 , pp. 112-114
    • Patterson, K.B.1    Prince, H.A.2    Kraft, E.3    Jenkins, A.J.4    Shaheen, N.J.5    Rooney, J.F.6
  • 60
    • 84950273803 scopus 로고    scopus 로고
    • Predicting effective truvada((R)) PrEP dosing strategies with a novel PK-PD model incorporating tissue active metabolites and endogenous nucleotides (EN
    • Cottrell ML, Yang KH, Prince HM, Sykes C, White N, Malone S, et al. Predicting effective truvada((R)) PrEP dosing strategies with a novel PK-PD model incorporating tissue active metabolites and endogenous nucleotides (EN). AIDS Res Hum Retroviruses. 2014;30(Suppl 1):A60.
    • (2014) AIDS Res Hum Retroviruses , vol.30 , pp. A60
    • Cottrell, M.L.1    Yang, K.H.2    Prince, H.M.3    Sykes, C.4    White, N.5    Malone, S.6
  • 61
    • 84881255827 scopus 로고    scopus 로고
    • Lack of prophylactic efficacy of oral maraviroc in macaques despite high drug concentrations in rectal tissues
    • Massud I, Aung W, Martin A, Bachman S, Mitchell J, Aubert R, et al. Lack of prophylactic efficacy of oral maraviroc in macaques despite high drug concentrations in rectal tissues. J Virol. 2013;87:8952-61.
    • (2013) J Virol , vol.87 , pp. 8952-8961
    • Massud, I.1    Aung, W.2    Martin, A.3    Bachman, S.4    Mitchell, J.5    Aubert, R.6
  • 62
    • 28244469774 scopus 로고    scopus 로고
    • Molecular cloning and radioligand binding characterization of the chemokine receptor CCR5 from rhesus macaque and human
    • Napier C, Sale H, Mosley M, Rickett G, Dorr P, Mansfield R, et al. Molecular cloning and radioligand binding characterization of the chemokine receptor CCR5 from rhesus macaque and human. Biochem Pharmacol. 2005;71:163-72.
    • (2005) Biochem Pharmacol , vol.71 , pp. 163-172
    • Napier, C.1    Sale, H.2    Mosley, M.3    Rickett, G.4    Dorr, P.5    Mansfield, R.6
  • 63
    • 84959378160 scopus 로고    scopus 로고
    • Protection against rectal chimeric simian/human immunodeficiency virus transmission in macaques by rectal-specific gel formulations of maraviroc and tenofovir
    • Epub ahead of print]
    • Dobard CW, Taylor A, Sharma S, Anderson PL, Bushman LR, Chuong D, et al. Protection against rectal chimeric simian/human immunodeficiency virus transmission in macaques by rectal-specific gel formulations of maraviroc and tenofovir. J Infect Dis. 2015. [Epub ahead of print].
    • (2015) J Infect Dis
    • Dobard, C.W.1    Taylor, A.2    Sharma, S.3    Anderson, P.L.4    Bushman, L.R.5    Chuong, D.6
  • 64
  • 65
    • 77955673220 scopus 로고    scopus 로고
    • Protection of rhesus macaques from vaginal infection by vaginally delivered maraviroc, an inhibitor of HIV-1 entry via the CCR5 co-receptor
    • Veazey RS, Ketas TJ, Dufour J, Moroney-Rasmussen T, Green LC, Klasse PJ, et al. Protection of rhesus macaques from vaginal infection by vaginally delivered maraviroc, an inhibitor of HIV-1 entry via the CCR5 co-receptor. J Infect Dis. 2010;202:739-44.
    • (2011) J Infect Dis , vol.202 , pp. 739-744
    • Veazey, R.S.1    Ketas, T.J.2    Dufour, J.3    Moroney-Rasmussen, T.4    Green, L.C.5    Klasse, P.J.6
  • 66
  • 67
    • 1542288934 scopus 로고    scopus 로고
    • The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys
    • Stremlau M, Owens CM, Perron MJ, Kiessling M, Autissier P, Sodroski J. The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys. Nature. 2004;427:848-53.
    • (2004) Nature , vol.427 , pp. 848-853
    • Stremlau, M.1    Owens, C.M.2    Perron, M.J.3    Kiessling, M.4    Autissier, P.5    Sodroski, J.6
  • 68
    • 53549135475 scopus 로고    scopus 로고
    • A new strategy to understand how HIV infects women: Identification of a window of vulnerability during the menstrual cycle
    • Wira CR, Fahey JV. A new strategy to understand how HIV infects women: identification of a window of vulnerability during the menstrual cycle. AIDS. 2008;22:1909-17.
    • (2008) AIDS , vol.22 , pp. 1909-1917
    • Wira, C.R.1    Fahey, J.V.2
  • 69
    • 77149122114 scopus 로고    scopus 로고
    • Identification of rhesus macaque genital microbiota by 16S pyrosequencing shows similarities to human bacterial vaginosis: Implications for use as an animal model for HIV vaginal infection
    • Spear GT, Gilbert D, Sikaroodi M, Doyle L, Green L, Gillevet PM, et al. Identification of rhesus macaque genital microbiota by 16S pyrosequencing shows similarities to human bacterial vaginosis: implications for use as an animal model for HIV vaginal infection. AIDS Res Hum Retroviruses. 2010; 26:193-200.
    • (2011) AIDS Res Hum Retroviruses , vol.26 , pp. 193-200
    • Spear, G.T.1    Gilbert, D.2    Sikaroodi, M.3    Doyle, L.4    Green, L.5    Gillevet, P.M.6
  • 70
    • 84893157111 scopus 로고    scopus 로고
    • Vivo evaluation of safety and toxicity of a Lactobacillus jensenii producing modified cyanovirin-N in a rhesus macaque vaginal challenge model
    • Brichacek B, Lagenaur LA, Lee PP, Venzon D, Hamer DH. In vivo evaluation of safety and toxicity of a Lactobacillus jensenii producing modified cyanovirin-N in a rhesus macaque vaginal challenge model. PLoS One. 2013;8:78817.
    • (2013) PLoS One , vol.8 , pp. 78817
    • Brichacek, B.1    Lagenaur, L.A.2    Lee, P.P.3    Venzon, D.4    Hamer, D.H.5
  • 71
    • 80054955393 scopus 로고    scopus 로고
    • Prevention of vaginal SHIV transmission in macaques by a live recombinant Lactobacillus
    • Lagenaur LA, Sanders-Beer BE, Brichacek B, Pal R, Liu X, Liu Y, et al. Prevention of vaginal SHIV transmission in macaques by a live recombinant Lactobacillus. Mucosal Immunol. 2011;4:648-57.
    • (2011) Mucosal Immunol , vol.4 , pp. 648-657
    • Lagenaur, L.A.1    Sanders-Beer, B.E.2    Brichacek, B.3    Pal, R.4    Liu, X.5    Liu, Y.6
  • 72
    • 79960625207 scopus 로고    scopus 로고
    • Development of a pigtail macaque model of sexually transmitted infection/HIV coinfection using Chlamydia trachomatis, Trichomonas vaginalis, and SHIV(SF162P3
    • Henning T, Fakile Y, Phillips C, Sweeney E, Mitchell J, Patton D, et al. Development of a pigtail macaque model of sexually transmitted infection/HIV coinfection using Chlamydia trachomatis, Trichomonas vaginalis, and SHIV(SF162P3). J Med Primatol. 2011;40:214-23.
    • (2011) J Med Primatol , vol.40 , pp. 214-223
    • Henning, T.1    Fakile, Y.2    Phillips, C.3    Sweeney, E.4    Mitchell, J.5    Patton, D.6
  • 73
    • 84910015088 scopus 로고    scopus 로고
    • Increased susceptibility to vaginal simian/human immunodeficiency virus transmission in pig-tailed macaques coinfected with Chlamydia trachomatis and Trichomonas vaginalis
    • Henning TR, Butler K, Hanson D, Sturdevant G, Ellis S, Sweeney EM, et al. Increased susceptibility to vaginal simian/human immunodeficiency virus transmission in pig-tailed macaques coinfected with Chlamydia trachomatis and Trichomonas vaginalis. J Infect Dis. 2014;210(8):1239-47.
    • (2014) J Infect Dis , vol.210 , Issue.8 , pp. 1239-1247
    • Henning, T.R.1    Butler, K.2    Hanson, D.3    Sturdevant, G.4    Ellis, S.5    Sweeney, E.M.6
  • 74
    • 84898816076 scopus 로고    scopus 로고
    • Development of a rectal sexually transmitted infection -HIV coinfection model utilizing Chlamydia trachomatis and SHIVSF162p3
    • Henning T, Butler K, Mitchell J, Ellis S, Deyounks F, Farshy C, et al. Development of a rectal sexually transmitted infection -HIV coinfection model utilizing Chlamydia trachomatis and SHIVSF162p3. J Med Primatol. 2014; 43:135-43.
    • (2014) J Med Primatol , vol.43 , pp. 135-143
    • Henning, T.1    Butler, K.2    Mitchell, J.3    Ellis, S.4    Deyounks, F.5    Farshy, C.6
  • 76
    • 38049074585 scopus 로고    scopus 로고
    • Seminal plasma reduces the effectiveness of topical polyanionic microbicides
    • Patel S, Hazrati E, Cheshenko N, Galen B, Yang H, Guzman E, et al. Seminal plasma reduces the effectiveness of topical polyanionic microbicides. J Infect Dis. 2007;196:1394-402.
    • (2007) J Infect Dis , vol.196 , pp. 1394-1402
    • Patel, S.1    Hazrati, E.2    Cheshenko, N.3    Galen, B.4    Yang, H.5    Guzman, E.6
  • 77
    • 80053129854 scopus 로고    scopus 로고
    • Pigtailed macaque model refinement: Topical microbicide safety in the presence of coitus
    • Sweeney YT, Angeles RO, Cummings PK, Smith AD, Patton DL. Pigtailed macaque model refinement: topical microbicide safety in the presence of coitus. J Med Primatol. 2011;40:327-34.
    • (2011) J Med Primatol , vol.40 , pp. 327-334
    • Sweeney, Y.T.1    Angeles, R.O.2    Cummings, P.K.3    Smith, A.D.4    Patton, D.L.5
  • 78
    • 34447320193 scopus 로고    scopus 로고
    • Seminal plasma differentially regulates inflammatory cytokine gene expression in human cervical and vaginal epithelial cells
    • Sharkey DJ, Macpherson AM, Tremellen KP, Robertson SA. Seminal plasma differentially regulates inflammatory cytokine gene expression in human cervical and vaginal epithelial cells. Mol Hum Reprod. 2007;13:491-501.
    • (2007) Mol Hum Reprod , vol.13 , pp. 491-501
    • Sharkey, D.J.1    Macpherson, A.M.2    Tremellen, K.P.3    Robertson, S.A.4
  • 79
    • 84857483300 scopus 로고    scopus 로고
    • Seminal fluid induces leukocyte recruitment and cytokine and chemokine mRNA expression in the human cervix after coitus
    • Sharkey DJ, Tremellen KP, Jasper MJ, Gemzell-Danielsson K, Robertson SA. Seminal fluid induces leukocyte recruitment and cytokine and chemokine mRNA expression in the human cervix after coitus. J Immunol. 2012;188: 2445-54.
    • (2012) J Immunol , vol.188 , pp. 2445-2454
    • Sharkey, D.J.1    Tremellen, K.P.2    Jasper, M.J.3    Gemzell-Danielsson, K.4    Robertson, S.A.5
  • 80
    • 0346207752 scopus 로고    scopus 로고
    • Fatal Cercopithecine herpesvirus 1 (B Virus) infection following a mucocutaneous exposure and interim recommendations for worker protection
    • Sonja A. Rasmusseni editor Morbidity and mortality weekly report. Atlanta, GA
    • Perlino C, Hilliard J, Koehler J. Fatal Cercopithecine herpesvirus 1 (B Virus) infection following a mucocutaneous exposure and interim recommendations for worker protection. In: Sonja A. Rasmussen, editor. Morbidity and mortality weekly report. Atlanta, GA: Centers for Disease Control and Prevention; 1998. p. 1073-6.
    • (1998) Centers for Disease Control and Prevention , pp. 1073-1076
    • Perlino, C.1    Hilliard, J.2    Koehler, J.3
  • 82
    • 0034033172 scopus 로고    scopus 로고
    • Development of an in vitro organ culture model to study transmission of HIV-1 in the female genital tract
    • Collins KB, Patterson BK, Naus GJ, Landers DV, Gupta P. Development of an in vitro organ culture model to study transmission of HIV-1 in the female genital tract. Nat Med. 2000;6:475-9.
    • (2000) Nat Med , vol.6 , pp. 475-479
    • Collins, K.B.1    Patterson, B.K.2    Naus, G.J.3    Landers, D.V.4    Gupta, P.5
  • 83
    • 0034034688 scopus 로고    scopus 로고
    • Parameters of human immunodeficiency virus infection of human cervical tissue and inhibition by vaginal virucides
    • Greenhead P, Hayes P, Watts PS, Laing KG, Griffin GE, Shattock RJ. Parameters of human immunodeficiency virus infection of human cervical tissue and inhibition by vaginal virucides. J Virol. 2000;74:5577-86.
    • (2000) J Virol , vol.74 , pp. 5577-5586
    • Greenhead, P.1    Hayes, P.2    Watts, P.S.3    Laing, K.G.4    Griffin, G.E.5    Shattock, R.J.6
  • 84
    • 59849108852 scopus 로고    scopus 로고
    • HIV-1 infection of human penile explant tissue and protection by candidate microbicides
    • Fischetti L, Barry SM, Hope TJ, Shattock RJ. HIV-1 infection of human penile explant tissue and protection by candidate microbicides. AIDS. 2009;23: 319-28.
    • (2009) AIDS , vol.23 , pp. 319-328
    • Fischetti, L.1    Barry, S.M.2    Hope, T.J.3    Shattock, R.J.4
  • 85
    • 33745842280 scopus 로고    scopus 로고
    • Ex vivo culture of human colorectal tissue for the evaluation of candidate microbicides
    • Fletcher PS, Elliott J, Grivel JC, Margolis L, Anton P, McGowan I, et al. Ex vivo culture of human colorectal tissue for the evaluation of candidate microbicides. AIDS. 2006;20:1237-45.
    • (2006) AIDS , vol.20 , pp. 1237-1245
    • Fletcher, P.S.1    Elliott, J.2    Grivel, J.C.3    Margolis, L.4    Anton, P.5    McGowan, I.6
  • 86
    • 59849088564 scopus 로고    scopus 로고
    • Cyanovirin-N potently inhibits human immunodeficiency virus type 1 infection in cellular and cervical explant models
    • Buffa V, Stieh D, Mamhood N, Hu Q, Fletcher P, Shattock RJ. Cyanovirin-N potently inhibits human immunodeficiency virus type 1 infection in cellular and cervical explant models. J Gen Virol. 2009;90:234-43.
    • (2009) J Gen Virol , vol.90 , pp. 234-243
    • Buffa, V.1    Stieh, D.2    Mamhood, N.3    Hu, Q.4    Fletcher, P.5    Shattock, R.J.6
  • 87
    • 59749098155 scopus 로고    scopus 로고
    • Inhibition of human immunodeficiency virus type 1 infection by the candidate microbicide dapivirine, a nonnucleoside reverse transcriptase inhibitor
    • Fletcher P, Harman S, Azijn H, Armanasco N, Manlow P, Perumal D, et al. Inhibition of human immunodeficiency virus type 1 infection by the candidate microbicide dapivirine, a nonnucleoside reverse transcriptase inhibitor. Antimicrob Agents Chemother. 2009;53:487-95.
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 487-495
    • Fletcher, P.1    Harman, S.2    Azijn, H.3    Armanasco, N.4    Manlow, P.5    Perumal, D.6
  • 88
    • 23844482064 scopus 로고    scopus 로고
    • The nonnucleoside reverse transcriptase inhibitor UC-781 inhibits human immunodeficiency virus type 1 infection of human cervical tissue and dissemination by migratory cells
    • Fletcher P, Kiselyeva Y, Wallace G, Romano J, Griffin G, Margolis L, et al. The nonnucleoside reverse transcriptase inhibitor UC-781 inhibits human immunodeficiency virus type 1 infection of human cervical tissue and dissemination by migratory cells. J Virol. 2005;79:11179-86.
    • (2005) J Virol , vol.79 , pp. 11179-11186
    • Fletcher, P.1    Kiselyeva, Y.2    Wallace, G.3    Romano, J.4    Griffin, G.5    Margolis, L.6
  • 89
    • 33749541969 scopus 로고    scopus 로고
    • Candidate polyanion microbicides inhibit HIV-1 infection and dissemination pathways in human cervical explants
    • Fletcher PS, Wallace GS, Mesquita PM, Shattock RJ. Candidate polyanion microbicides inhibit HIV-1 infection and dissemination pathways in human cervical explants. Retrovirology. 2006;3:46.
    • (2006) Retrovirology , vol.3 , pp. 46
    • Fletcher, P.S.1    Wallace, G.S.2    Mesquita, P.M.3    Shattock, R.J.4
  • 90
    • 84860194483 scopus 로고    scopus 로고
    • Preclinical evaluation of the HIV-1 fusion inhibitor L'644 as a potential candidate microbicide
    • Harman S, Herrera C, Armanasco N, Nuttall J, Shattock RJ. Preclinical evaluation of the HIV-1 fusion inhibitor L'644 as a potential candidate microbicide. Antimicrob Agents Chemother. 2012;56:2347-56.
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 2347-2356
    • Harman, S.1    Herrera, C.2    Armanasco, N.3    Nuttall, J.4    Shattock, R.J.5
  • 92
    • 80055005719 scopus 로고    scopus 로고
    • Colorectal microbicide design: Triple combinations of reverse transcriptase inhibitors are optimal against HIV-1 in tissue explants
    • Herrera C, Cranage M, McGowan I, Anton P, Shattock RJ. Colorectal microbicide design: triple combinations of reverse transcriptase inhibitors are optimal against HIV-1 in tissue explants. AIDS. 2011;25:1971-9.
    • (2011) AIDS , vol.25 , pp. 1971-1979
    • Herrera, C.1    Cranage, M.2    McGowan, I.3    Anton, P.4    Shattock, R.J.5
  • 93
    • 33646891072 scopus 로고    scopus 로고
    • Cellulose acetate 1, 2-benzenedicarboxylate inhibits infection by cell-free and cell-Associated primary HIV-1 isolates
    • Lu H, Zhao Q, Wallace G, Liu S, He Y, Shattock R, et al. Cellulose acetate 1, 2-benzenedicarboxylate inhibits infection by cell-free and cell-Associated primary HIV-1 isolates. AIDS Res Hum Retroviruses. 2006;22:411-8.
    • (2006) AIDS Res Hum Retroviruses , vol.22 , pp. 411-418
    • Lu, H.1    Zhao, Q.2    Wallace, G.3    Liu, S.4    He, Y.5    Shattock, R.6
  • 94
    • 65549099593 scopus 로고    scopus 로고
    • Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component
    • O'Keefe BR, Vojdani F, Buffa V, Shattock RJ, Montefiori DC, Bakke J, et al. Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component. Proc Natl Acad Sci USA. 2009;106:6099-104.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 6099-6104
    • O'Keefe, B.R.1    Vojdani, F.2    Buffa, V.3    Shattock, R.J.4    Montefiori, D.C.5    Bakke, J.6
  • 95
    • 0034694084 scopus 로고    scopus 로고
    • Candidate microbicides block HIV-1 infection of human immature Langerhans cells within epithelial tissue explants
    • Kawamura T, Cohen SS, Borris DL, Aquilino EA, Glushakova S, Margolis LB, et al. Candidate microbicides block HIV-1 infection of human immature Langerhans cells within epithelial tissue explants. J Exp Med. 2000;192: 1491-500.
    • (2000) J Exp Med , vol.192 , pp. 1491-1500
    • Kawamura, T.1    Cohen, S.S.2    Borris, D.L.3    Aquilino, E.A.4    Glushakova, S.5    Margolis, L.B.6
  • 96
    • 45749114155 scopus 로고    scopus 로고
    • Candidate microbicide PPCM blocks human immunodeficiency virus type 1 infection in cell and tissue cultures and prevents genital herpes in a murine model
    • Mesquita PM, Wilson SS, Manlow P, Fischetti L, Keller MJ, Herold BC, et al. Candidate microbicide PPCM blocks human immunodeficiency virus type 1 infection in cell and tissue cultures and prevents genital herpes in a murine model. J Virol. 2008;82:6576-84.
    • (2008) J Virol , vol.82 , pp. 6576-6584
    • Mesquita, P.M.1    Wilson, S.S.2    Manlow, P.3    Fischetti, L.4    Keller, M.J.5    Herold, B.C.6
  • 97
    • 84864392088 scopus 로고    scopus 로고
    • Saquinavir inhibits early events associated with establishment of HIV-1 infection: Potential role for protease inhibitors in prevention
    • Stefanidou M, Herrera C, Armanasco N, Shattock RJ. Saquinavir inhibits early events associated with establishment of HIV-1 infection: potential role for protease inhibitors in prevention. Antimicrob Agents Chemother. 2012;56: 4381-90.
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 4381-4390
    • Stefanidou, M.1    Herrera, C.2    Armanasco, N.3    Shattock, R.J.4
  • 98
    • 80054887588 scopus 로고    scopus 로고
    • Topical tenofovir, a microbicide effective against HIV, inhibits herpes simplex virus-2 replication
    • Andrei G, Lisco A, Vanpouille C, Introini A, Balestra E, van den Oord J, et al. Topical tenofovir, a microbicide effective against HIV, inhibits herpes simplex virus-2 replication. Cell Host Microbe. 2011;10:379-89.
    • (2011) Cell Host Microbe , vol.10 , pp. 379-389
    • Andrei, G.1    Lisco, A.2    Vanpouille, C.3    Introini, A.4    Balestra, E.5    Van Den Oord, J.6
  • 99
    • 75749153257 scopus 로고    scopus 로고
    • A new class of dual-targeted antivirals: Monophosphorylated acyclovir prodrug derivatives suppress both human immunodeficiency virus type 1 and herpes simplex virus type 2
    • Vanpouille C, Lisco A, Derudas M, Saba E, Grivel JC, Brichacek B, et al. A new class of dual-targeted antivirals: monophosphorylated acyclovir prodrug derivatives suppress both human immunodeficiency virus type 1 and herpes simplex virus type 2. J Infect Dis. 2010;201:635-43.
    • (2011) J Infect Dis , vol.201 , pp. 635-643
    • Vanpouille, C.1    Lisco, A.2    Derudas, M.3    Saba, E.4    Grivel, J.C.5    Brichacek, B.6
  • 100
    • 27144527077 scopus 로고    scopus 로고
    • A human colorectal explant culture to evaluate topical microbicides for the prevention of HIV infection
    • Abner SR, Guenthner PC, Guarner J, Hancock KA, Cummins JE, Jr, Fink A, et al. A human colorectal explant culture to evaluate topical microbicides for the prevention of HIV infection. J Infect Dis. 2005;192: 1545-56.
    • (2005) J Infect Dis , vol.192 , pp. 1545-1556
    • Abner, S.R.1    Guenthner, P.C.2    Guarner, J.3    Hancock, K.A.4    Cummins, J.E.5    Fink, A.6
  • 101
    • 34248325562 scopus 로고    scopus 로고
    • Preclinical testing of candidate topical microbicides for anti-human immunodeficiency virus type 1 activity and tissue toxicity in a human cervical explant culture
    • Cummins JE, Jr, Guarner J, Flowers L, Guenthner PC, Bartlett J, Morken T, et al. Preclinical testing of candidate topical microbicides for anti-human immunodeficiency virus type 1 activity and tissue toxicity in a human cervical explant culture. Antimicrob Agents Chemother. 2007;51:1770-9.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 1770-1779
    • Cummins, J.E.1    Guarner, J.2    Flowers, L.3    Guenthner, P.C.4    Bartlett, J.5    Morken, T.6
  • 102
    • 84861123517 scopus 로고    scopus 로고
    • Characterization of UC781-tenofovir combination gel products for HIV-1 infection prevention in an ex vivo ectocervical model
    • Cost M, Dezzutti CS, Clark MR, Friend DR, Akil A, Rohan LC. Characterization of UC781-tenofovir combination gel products for HIV-1 infection prevention in an ex vivo ectocervical model. Antimicrob Agents Chemother. 2012; 56:3058-66.
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 3058-3066
    • Cost, M.1    Dezzutti, C.S.2    Clark, M.R.3    Friend, D.R.4    Akil, A.5    Rohan, L.C.6
  • 104
    • 84904288733 scopus 로고    scopus 로고
    • Development of HIV-1 rectal-specific microbicides and colonic tissue evaluation
    • Dezzutti CS, Russo J, Wang L, Abebe KZ, Li J, Friend DR, et al. Development of HIV-1 rectal-specific microbicides and colonic tissue evaluation. PLoS One. 2014;9:e102585.
    • (2014) PLoS One , vol.9 , pp. e102585
    • Dezzutti, C.S.1    Russo, J.2    Wang, L.3    Abebe, K.Z.4    Li, J.5    Friend, D.R.6
  • 105
    • 84867237428 scopus 로고    scopus 로고
    • Safety and efficacy of tenofovir/IQP-0528 combination gels -A dual compartment microbicide for HIV-1 prevention
    • Dezzutti CS, Shetler C, Mahalingam A, Ugaonkar SR, Gwozdz G, Buckheit KW, et al. Safety and efficacy of tenofovir/IQP-0528 combination gels -A dual compartment microbicide for HIV-1 prevention. Antiviral Res. 2012; 96(2):221-5.
    • (2012) Antiviral Res , vol.96 , Issue.2 , pp. 221-225
    • Dezzutti, C.S.1    Shetler, C.2    Mahalingam, A.3    Ugaonkar, S.R.4    Gwozdz, G.5    Buckheit, K.W.6
  • 106
  • 108
    • 84943585457 scopus 로고    scopus 로고
    • Pharmacodynamic activity of dapivirine and maraviroc single entity and combination topical gels for HIV-1 prevention
    • Dezzutti CS, Yandura S, Wang L, Moncla B, Teeple EA, Devlin B, et al. Pharmacodynamic activity of dapivirine and maraviroc single entity and combination topical gels for HIV-1 prevention. Pharm Res. 2015;32:3768-81.
    • (2015) Pharm Res , vol.32 , pp. 3768-3781
    • Dezzutti, C.S.1    Yandura, S.2    Wang, L.3    Moncla, B.4    Teeple, E.A.5    Devlin, B.6
  • 110
    • 84867873165 scopus 로고    scopus 로고
    • Sustained local delivery of structurally diverse HIV-1 microbicides released from sublimation enthalpy controlled matrices
    • Gunaseelan S, Gallay PA, Bobardt MD, Dezzutti CS, Esch T, Maskiewicz R. Sustained local delivery of structurally diverse HIV-1 microbicides released from sublimation enthalpy controlled matrices. Pharm Res. 2012;29:3156-68.
    • (2012) Pharm Res , vol.29 , pp. 3156-3168
    • Gunaseelan, S.1    Gallay, P.A.2    Bobardt, M.D.3    Dezzutti, C.S.4    Esch, T.5    Maskiewicz, R.6
  • 111
    • 80054959394 scopus 로고    scopus 로고
    • Enhanced HIV-1 replication in ex vivo ectocervical tissues from post-menopausal women correlates with increased inflammatory responses
    • Rollenhagen C, Asin SN. Enhanced HIV-1 replication in ex vivo ectocervical tissues from post-menopausal women correlates with increased inflammatory responses. Mucosal Immunol. 2011;4:671-81.
    • (2011) Mucosal Immunol , vol.4 , pp. 671-681
    • Rollenhagen, C.1    Asin, S.N.2
  • 112
    • 77951454202 scopus 로고    scopus 로고
    • HIV-1 sexual transmission: Early events of HIV-1 infection of human cervicovaginal tissue in an optimized ex vivo model
    • Saba E, Grivel JC, Vanpouille C, Brichacek B, Fitzgerald W, Margolis L, et al. HIV-1 sexual transmission: early events of HIV-1 infection of human cervicovaginal tissue in an optimized ex vivo model. Mucosal Immunol. 2010;3: 280-90.
    • (2011) Mucosal Immunol , vol.3 , pp. 280-290
    • Saba, E.1    Grivel, J.C.2    Vanpouille, C.3    Brichacek, B.4    Fitzgerald, W.5    Margolis, L.6
  • 113
    • 84900532147 scopus 로고    scopus 로고
    • Herpes simplex virus type-2 stimulates HIV-1 replication in cervical tissues: Implications for HIV-1 transmission and efficacy of anti-HIV-1 microbicides
    • Rollenhagen C, Lathrop MJ, Macura SL, Doncel GF, Asin SN. Herpes simplex virus type-2 stimulates HIV-1 replication in cervical tissues: implications for HIV-1 transmission and efficacy of anti-HIV-1 microbicides. Mucosal Immunol. 2014;7:1165-74.
    • (2014) Mucosal Immunol , vol.7 , pp. 1165-1174
    • Rollenhagen, C.1    Lathrop, M.J.2    Macura, S.L.3    Doncel, G.F.4    Asin, S.N.5
  • 114
    • 84868474359 scopus 로고    scopus 로고
    • RMP-02/MTN-006: A phase 1 rectal safety, acceptability, pharmacokinetic, and pharmacodynamic study of tenofovir 1% gel compared with oral tenofovir disoproxil fumarate
    • Anton PA, Cranston RD, Kashuba A, Hendrix CW, Bumpus NN, Richardson-Harman N, et al. RMP-02/MTN-006: a phase 1 rectal safety, acceptability, pharmacokinetic, and pharmacodynamic study of tenofovir 1% gel compared with oral tenofovir disoproxil fumarate. AIDS Res Hum Retroviruses. 2012; 28:1412-21.
    • (2012) AIDS Res Hum Retroviruses , vol.28 , pp. 1412-1421
    • Anton, P.A.1    Cranston, R.D.2    Kashuba, A.3    Hendrix, C.W.4    Bumpus, N.N.5    Richardson-Harman, N.6
  • 115
    • 80053248640 scopus 로고    scopus 로고
    • First phase 1 double-blind, placebo-controlled, randomized rectal microbicide trial using UC781 gel with a novel index of ex vivo efficacy
    • Anton PA, Saunders T, Elliott J, Khanukhova E, Dennis R, Adler A, et al. First phase 1 double-blind, placebo-controlled, randomized rectal microbicide trial using UC781 gel with a novel index of ex vivo efficacy. PLoS One. 2011; 6:e23243.
    • (2011) PLoS One , vol.6 , pp. e23243
    • Anton, P.A.1    Saunders, T.2    Elliott, J.3    Khanukhova, E.4    Dennis, R.5    Adler, A.6
  • 116
    • 84908611833 scopus 로고    scopus 로고
    • Correlation between compartmental tenofovir concentrations and an ex vivo rectal biopsy model of tissue infectibility in the RMP-02/MTN-006 phase 1 study
    • Richardson-Harman N, Hendrix CW, Bumpus NN, Mauck C, Cranston RD, Yang K, et al. Correlation between compartmental tenofovir concentrations and an ex vivo rectal biopsy model of tissue infectibility in the RMP-02/MTN-006 phase 1 study. PLoS One. 2014;9:e111507.
    • (2014) PLoS One , vol.9 , pp. e111507
    • Richardson-Harman, N.1    Hendrix, C.W.2    Bumpus, N.N.3    Mauck, C.4    Cranston, R.D.5    Yang, K.6
  • 117
    • 84868529632 scopus 로고    scopus 로고
    • Dose-response relationship between tissue concentrations of UC781 and explant infectibility with HIV type 1 in the RMP-01 rectal safety study
    • Richardson-Harman N, Mauck C, McGowan I, Anton P. Dose-response relationship between tissue concentrations of UC781 and explant infectibility with HIV type 1 in the RMP-01 rectal safety study. AIDS Res Hum Retroviruses. 2012;28:1422-33.
    • (2012) AIDS Res Hum Retroviruses , vol.28 , pp. 1422-1433
    • Richardson-Harman, N.1    Mauck, C.2    McGowan, I.3    Anton, P.4
  • 119
    • 84944448396 scopus 로고    scopus 로고
    • Phase 1 safety, pharmacokinetics, and pharmacodynamics of dapivirine and maraviroc vaginal rings: A double-blind randomized trial
    • Epub ahead of print
    • Chen BA, Panther L, Marzike M, Hendrix C, Hoesley C, van der Straten A, et al. Phase 1 safety, pharmacokinetics, and pharmacodynamics of dapivirine and maraviroc vaginal rings: a double-blind randomized trial. J Acquir Immune Defic Syndr. 2015. [Epub ahead of print].
    • (2015) J Acquir Immune Defic Syndr
    • Chen, B.A.1    Panther, L.2    Marzike, M.3    Hendrix, C.4    Hoesley, C.5    Van Der Straten, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.